Review
Endocrinology & Metabolism
Jose Miguel Hinojosa-Amaya, Cesar Ernesto Lam-Chung, Daniel Cuevas-Ramos
Summary: Corticotroph tumors are pituitary neoplasms arising from the Tpit lineage, with functioning CTs causing Cushing's disease and non-functioning or silent CTs and Crooke's cell subtypes more frequently manifesting as macroadenomas. Tumorigenesis involves disruption of cell-cycle regulators through genetic, epigenetic, and post-transcriptional mechanisms, potentially becoming therapeutic targets. Treatment options include targeted therapies like EGFR inhibitors and HSP90 inhibitors, as well as BRAF inhibitors for specific mutations.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Engineering, Environmental
Di Zhang, Li Chen, Shengkun Dong, Jiayi Luo, Zuxin Xu, Wenhai Chu
Summary: This study investigates the impacts of urea degradants on urea degradation and disinfection byproduct formation. It finds that while the combination of urea degradant and chlorine can effectively remove urea, it leads to a significant increase in the concentration of disinfection byproducts, particularly brominated DBPs. Therefore, the use of urea degradants together with chlorine should be carefully considered due to potential DBP-related health risks.
Article
Medicine, General & Internal
Kangpyo Kim, Jaeho Cho, Ju Hyung Moon, Eui-Hyun Kim, Hong In Yoon
Summary: The efficacy of radiation therapy (RT) for recurrent or residual pituitary macroadenoma (PMA) invading extrasellar regions was evaluated in this study. The results showed that conventional RT is safe and effective for the local control of recurrent or residual PMA. Immediate postoperative RT may be beneficial for recurrent or residual PMA.
YONSEI MEDICAL JOURNAL
(2022)
Review
Clinical Neurology
Mohammadmahdi Sabahi, Paniz Ghasemi-Nesari, Seyed Farzad Maroufi, Taha Shahbazi, Omid Yousefi, Seyed Alireza Shahtaheri, Othman Bin-Alamer, Rocco Dabecco, Nathalia Velasquez, Karla M. Arce, Badih Adada, Carolina G. Benjamin, Hamid Borghei-Razavi
Summary: This study performed a systematic review and meta-analysis on the therapeutic management of recurrent CD patients. It found that transsphenoidal surgery had a higher remission rate compared to radiotherapy and medical therapy. However, caution should be taken when interpreting the data of medical therapy due to the small number of included cases and wide confidence interval range.
WORLD NEUROSURGERY
(2023)
Article
Endocrinology & Metabolism
Sevda Ismailogullari, Zuleyha Karaca, Sedat Tarik Firat, Kursad Unluhizarci, Fahrettin Kelestimur
Summary: This study evaluated the sleep parameters of patients with Cushing syndrome (CS) and found that their sleep structure was disturbed, partially reversible after treatment. However, the risk of obstructive sleep apnea remained even a year after treatment, emphasizing the importance of early diagnosis and treatment.
HORMONE AND METABOLIC RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Heiko Geisler, Sophia Harringer, Dominik Wenisch, Richard Urban, Michael A. Jakupec, Wolfgang Kandioller, Bernhard K. Keppler
Summary: The cytotoxicities of seven dimeric metal species, including rhodium(III) and iridium(III), have been investigated in human cancer cell lines, revealing surprising activity in ovarian malignancies.
Article
Medicine, General & Internal
Suluma Aslan, Gloria Ngajilo, Azan Nyundo
Summary: This case discusses the complex neuropsychiatric manifestations, including complex visual hallucinations and visual impairment, in geriatrics due to recurrent pituitary macroadenoma. Remission of hallucination occurred within 2 weeks of oral administration of 1.5 mg of haloperidol once daily; this is a rare case of Charles Bonnet syndrome after recurrent pituitary macroadenoma.
CLINICAL CASE REPORTS
(2023)
Article
Oncology
Niantao Deng, Andre Minoche, Kate Harvey, Meng Li, Juliane Winkler, Andrei Goga, Alex Swarbrick
Summary: In this study, deep whole genome sequencing was conducted on commonly used breast cancer cell lines and patient-derived xenograft models, leading to the identification of novel genomic alterations and features. This provides a comprehensive genome sequencing resource for these models.
BREAST CANCER RESEARCH
(2022)
Article
Endocrinology & Metabolism
P. J. Monaghan, A. Kyriacou, C. Sturgeon, A. Davies, P. J. Trainer, A. White, C. E. Higham
CLINICAL ENDOCRINOLOGY
(2016)
Article
Endocrinology & Metabolism
Evelien F. Gevers, Suzanne Meredith, Pratik Shah, John Torpiano, Catherine Peters, Neil J. Sebire, Olga Slater, Anne White, Mehul T. Dattani
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2017)
Article
Oncology
Jennifer L. Bryant, Roben G. Gieling, Suzanne L. Meredith, Tiffany-Jayne Allen, Leanne Walker, Brian A. Telfer, Claudiu T. Supuran, Kaye J. Williams, Anne White
INTERNATIONAL JOURNAL OF CANCER
(2018)
Article
Biochemistry & Molecular Biology
Shaun C. Offerman, Manikandan Kadirvel, Osama H. Abusara, Jennifer L. Bryant, Brian A. Telfer, Gavin Brown, Sally Freeman, Anne White, Kaye J. Williams, Harmesh S. Aojula
Article
Endocrinology & Metabolism
Alexandra S. Cross, E. Helen Kemp, Anne White, Leanne Walker, Suzanne Meredith, Pooja Sachdev, Nils P. Krone, Richard J. Ross, Neil P. Wright, Charlotte J. Elder
CLINICAL ENDOCRINOLOGY
(2018)
Article
Endocrinology & Metabolism
Thanuja Gali Ramamoorthy, Tiffany-Jayne Allen, Alison Davies, Erika Harno, Charlotte Sefton, Christopher Murgatroyd, Anne White
INTERNATIONAL JOURNAL OF OBESITY
(2018)
Review
Physiology
Erika Harno, Thanuja Gali Ramamoorthy, Anthony P. Coll, Anne White
PHYSIOLOGICAL REVIEWS
(2018)
Article
Endocrinology & Metabolism
Peter Kirwan, Richard G. Kay, Bas Brouwers, Vicente Herranz-Perez, Magdalena Jura, Pierre Larraufie, Julie Jerber, Jason Pembroke, Theresa Bartels, Anne White, Fiona M. Gribble, Frank Reimann, I. Sadaf Farooqi, Stephen O'Rahilly, Florian T. Merkle
MOLECULAR METABOLISM
(2018)
Article
Endocrinology & Metabolism
Jonathan R. Wray, Alison Davies, Charlotte Sefton, Tiffany-Jayne Allen, Antony Adamson, Philip Chapman, Brian Y. H. Lam, Giles S. H. Yeo, Anthony P. Coll, Erika Harno, Anne White
MOLECULAR METABOLISM
(2019)
Article
Endocrinology & Metabolism
Eline S. van der Valk, Lotte Kleinendorst, Patric J. D. Delhanty, Bibian van der Voorn, Jenny A. Visser, M. M. van Haelst, Laura C. G. de Graaff, Martin Huisman, Anne White, Shosuke Ito, Kazumasa Wakamatsu, Yolanda B. de Rijke, Erica L. T. van den Akker, Anand M. Iyer, Elisabeth F. C. van Rossum
Summary: Patients with a novel POMC gene variant presented with obesity, hyperphagia, and hypocortisolism, related to an ACTH defect at the prohormone convertase 2 cleavage site. The study demonstrated that adequate cleavage of ACTH to alpha-MSH and d-alpha-MSH is also crucial for feeding control in humans.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Mehdi Boutagouga Boudjadja, Isabella Culotta, Gabriela C. De Paula, Erika Harno, Jenna Hunter, Joao Paulo Cavalcanti-de-Albuquerque, Simon M. Luckman, Matthew Hepworth, Anne White, Gabriella Aviello, Giuseppe D'Agostino
Summary: This study reveals the immunoregulatory functions of hypothalamic AgRP neurons in negative energy balance and endotoxemia. Endotoxemia sustains the activity of AgRP neurons and reduces their sensitivity to inhibitory signals. The study also highlights the role of endogenous glucocorticoids in this process.
Article
Endocrinology & Metabolism
Ilaria Coppola, Bas Brouwers, Leanne Walker, Ceyhun Alar, Sandra Meulemans, Anne White, Bruno Ramos-Molina, John W. M. Creemers
Summary: This study investigates the role of FURIN in hypothalamic neurons controlling glucose and feeding. The researchers found that FURIN plays an important role in the cleavage of POMC and is involved in the regulation of feeding behavior and glucose homeostasis. The deletion of FURIN in mice resulted in hyperphagia, increased body weight, and altered POMC processing. These findings challenge the previous understanding of POMC cleavage and have implications for understanding the mechanisms of glucose and feeding regulation.
MOLECULAR METABOLISM
(2022)
Article
Endocrinology & Metabolism
Timothy S. Jarvela, Surbhi, Manita Shakya, Tomas Bachor, Anne White, Malcolm J. Low, Iris Lindberg
Article
Endocrinology & Metabolism
Charlotte Sefton, Alison Davies, Tiffany-Jayne Allen, Jonathan R. Wray, Rosemary Shoop, Antony Adamson, Neil Humphreys, Anthony P. Coll, Anne White, Erika Harno
Article
Endocrinology & Metabolism
Gabrielle Page-Wilson, Kim T. Nguyen, Deniz Atalayer, Kana Meece, Heather A. Bainbridge, Judith Korner, Rebecca J. Gordon, Sunil K. Panigrahi, Anne White, Richard Smiley, Sharon L. Wardlaw
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2017)
