Journal
EMBO REPORTS
Volume 15, Issue 12, Pages 1286-1296Publisher
WILEY
DOI: 10.15252/embr.201438643
Keywords
embryonic stem cells; Foxd3; NFAT
Categories
Funding
- National Natural Science Foundation [91019023]
- National High Technology Research and Development Program of China [2010CB945201, 2011CB965101, 2013CB967101]
- Chinese Academy of Science [XDA01010102]
Ask authors/readers for more resources
Pluripotency-associated transcription factor Foxd3 is required for maintaining pluripotent cells. However, molecular mechanisms underlying its function are largely unknown. Here, we report that Foxd3 suppresses differentiation induced by calcineurin-NFAT signaling to maintain the ESC identity. Mechanistically, Foxd3 interacts with NFAT proteins and recruits co-repressor Tle4, a member of the Tle repressor family highly expressed in undifferentiated ESCs, to suppress NFATc3's transcriptional activities. Furthermore, global transcriptome analysis shows that Foxd3 and NFATc3 co-regulate a set of differentiation-associated genes in ESCs. Collectively, our study establishes a molecular and functional link between a pluripotency-associated factor and an important ESC differentiation-inducing pathway.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available