Transcription goes digital

Regulation of the Probability of Mouse Odorant Receptor Gene Choice

(2011) Mona Khan et al.   CELL

Cellular Decision Making and Biological Noise: From Microbes to Mammals

(2011) Gábor Balázsi et al.   CELL

Impulse Control: Temporal Dynamics in Gene Transcription

(2011) Nir Yosef et al.   CELL

Assembly of the transcription machinery: ordered and stable, random and dynamic, or both?

(2011) Timothy J. Stasevich et al.   CHROMOSOMA

What do expression dynamics tell us about the mechanism of transcription?

(2011) Daniel R Larson   CURRENT OPINION IN GENETICS & DEVELOPMENT

Fast transcription rates of RNA polymerase II in human cells

(2011) Paolo Maiuri et al.   EMBO REPORTS

A genomic model of condition-specific nucleosome behavior explains transcriptional activity in yeast

(2011) J. B. Zaugg et al.   GENOME RESEARCH

Negative Elongation Factor Accelerates the Rate at Which Heat Shock Genes Are Shut off by Facilitating Dissociation of Heat Shock Factor

(2011) S. K. B. Ghosh et al.   MOLECULAR AND CELLULAR BIOLOGY

Nascent transcript sequencing visualizes transcription at nucleotide resolution

(2011) L. Stirling Churchman et al.   NATURE

Variegated gene expression caused by cell-specific long-range DNA interactions

(2011) Daan Noordermeer et al.   NATURE CELL BIOLOGY

General properties of transcriptional time series in Escherichia coli

(2011) Lok-hang So et al.   NATURE GENETICS

A transgenic mouse for in vivo detection of endogenous labeled mRNA

(2011) Timothée Lionnet et al.   NATURE METHODS

Separating intrinsic from extrinsic fluctuations in dynamic biological systems

(2011) A. Hilfinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian Genes Are Transcribed with Widely Different Bursting Kinetics

(2011) D. M. Suter et al.   SCIENCE

Stochastic Pulse Regulation in Bacterial Stress Response

(2011) J. C. W. Locke et al.   SCIENCE

Real-Time Observation of Transcription Initiation and Elongation on an Endogenous Yeast Gene

(2011) D. R. Larson et al.   SCIENCE

Genome-wide transcription factor binding: beyond direct target regulation

(2011) Kyle L. MacQuarrie et al.   TRENDS IN GENETICS

Dynamic Analysis of Stochastic Transcription Cycles

(2011) Claire V. Harper et al.   PLOS BIOLOGY

Systematic Protein Location Mapping Reveals Five Principal Chromatin Types in Drosophila Cells

(2010) Guillaume J. Filion et al.   CELL

Pausing of RNA Polymerase II Disrupts DNA-Specified Nucleosome Organization to Enable Precise Gene Regulation

(2010) Daniel A. Gilchrist et al.   CELL

Transcriptional Memory: Staying in the Loop

(2010) Jason H. Brickner   CURRENT BIOLOGY

Methylation of H3K4 Is Required for Inheritance of Active Transcriptional States

(2010) Tetsuya Muramoto et al.   CURRENT BIOLOGY

FRAP and kinetic modeling in the analysis of nuclear protein dynamics: what do we really know?

(2010) Florian Mueller et al.   CURRENT OPINION IN CELL BIOLOGY

Bursts and pulses: insights from single cell studies into transcriptional mechanisms

(2010) Jonathan R Chubb et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Digital nature of the immediate-early transcriptional response

(2010) M. Stevense et al.   DEVELOPMENT

Nucleosome-Depleted Regions in Cell-Cycle-Regulated Promoters Ensure Reliable Gene Expression in Every Cell Cycle

(2010) Lu Bai et al.   DEVELOPMENTAL CELL

Variability in gene expression underlies incomplete penetrance

(2010) Arjun Raj et al.   NATURE

Functional roles for noise in genetic circuits

(2010) Avigdor Eldar et al.   NATURE

Single-cell NF-κB dynamics reveal digital activation and analogue information processing

(2010) Savaş Tay et al.   NATURE

Discovery and characterization of chromatin states for systematic annotation of the human genome

(2010) Jason Ernst et al.   NATURE BIOTECHNOLOGY

Non-genetic heterogeneity from stochastic partitioning at cell division

(2010) Dann Huh et al.   NATURE GENETICS

Single-allele analysis of transcription kinetics in living mammalian cells

(2010) Sharon Yunger et al.   NATURE METHODS

Transcription of functionally related constitutive genes is not coordinated

(2010) Saumil J Gandhi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Quantifying E. coli Proteome and Transcriptome with Single-Molecule Sensitivity in Single Cells

(2010) Y. Taniguchi et al.   SCIENCE

Transcription by the numbers redux: experiments and calculations that surprise

(2010) Hernan G. Garcia et al.   TRENDS IN CELL BIOLOGY

Imaging Transcription in Living Cells

(2009) Xavier Darzacq et al.   Annual Review of Biophysics

Chromatin Signatures in Multipotent Human Hematopoietic Stem Cells Indicate the Fate of Bivalent Genes during Differentiation

(2009) Kairong Cui et al.   Cell Stem Cell

Visualization of Individual Scr mRNAs during Drosophila Embryogenesis Yields Evidence for Transcriptional Bursting

(2009) Adam Paré et al.   CURRENT BIOLOGY

The basal initiation machinery: beyond the general transcription factors

(2009) Timothy W. Sikorski et al.   CURRENT OPINION IN CELL BIOLOGY

Stalled Hox promoters as chromosomal boundaries

(2009) V. S. Chopra et al.   GENES & DEVELOPMENT

Transcription Dynamics

(2009) Gordon L. Hager et al.   MOLECULAR CELL

Histone modifications at human enhancers reflect global cell-type-specific gene expression

(2009) Nathaniel D. Heintzman et al.   NATURE

The logic of chromatin architecture and remodelling at promoters

(2009) Bradley R. Cairns   NATURE

Imaging intracellular RNA distribution and dynamics in living cells

(2009) Sanjay Tyagi   NATURE METHODS

Transcription factories: gene expression in unions?

(2009) Heidi Sutherland et al.   NATURE REVIEWS GENETICS

Nucleosome positioning and gene regulation: advances through genomics

(2009) Cizhong Jiang et al.   NATURE REVIEWS GENETICS

Using movies to analyse gene circuit dynamics in single cells

(2009) James C. W. Locke et al.   NATURE REVIEWS MICROBIOLOGY

Elongation dynamics shape bursty transcription and translation

(2009) Maciej Dobrzyński et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synchronous and Stochastic Patterns of Gene Activation in theDrosophilaEmbryo

(2009) Alistair N. Boettiger et al.   SCIENCE

A single molecule view of gene expression

(2009) Daniel R. Larson et al.   TRENDS IN CELL BIOLOGY

Burstiness and memory in complex systems

(2008) K.-I. Goh et al.   EPL

A genomic analysis of RNA polymerase II modification and chromatin architecture related to 3' end RNA polyadenylation

(2008) Z. Lian et al.   GENOME RESEARCH

Two strategies for gene regulation by promoter nucleosomes

(2008) I. Tirosh et al.   GENOME RESEARCH

Modulation of RNA Polymerase Assembly Dynamics in Transcriptional Regulation

(2008) Stanislaw A. Gorski et al.   MOLECULAR CELL

Frequency-modulated nuclear localization bursts coordinate gene regulation

(2008) Long Cai et al.   NATURE

Chromatin decouples promoter threshold from dynamic range

(2008) Felix H. Lam et al.   NATURE

Imaging individual mRNA molecules using multiple singly labeled probes

(2008) Arjun Raj et al.   NATURE METHODS

Single-RNA counting reveals alternative modes of gene expression in yeast

(2008) Daniel Zenklusen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Concurrent Fast and Slow Cycling of a Transcriptional Activator at an Endogenous Promoter

(2008) T. S. Karpova et al.   SCIENCE

Nascent RNA Sequencing Reveals Widespread Pausing and Divergent Initiation at Human Promoters

(2008) Leighton J. Core et al.   SCIENCE

Distinct Modes of Regulation by Chromatin Encoded through Nucleosome Positioning Signals

(2008) Yair Field et al.   PLoS Computational Biology