Lamins in development, tissue maintenance and stress

Genomic instability and DNA damage responses in progeria arising from defective maturation of prelamin A

(2016) Phillip R. Musich et al.   Aging-US

Local Translation of Extranuclear Lamin B Promotes Axon Maintenance

(2012) Byung C. Yoon et al.   CELL

Oxidative stress induces an ATM-independent senescence pathway through p38 MAPK-mediated lamin B1 accumulation

(2012) Aurelia Barascu et al.   EMBO JOURNAL

B-type lamins and their elusive roles in metazoan cell proliferation and senescence

(2012) Christopher J Hutchison   EMBO JOURNAL

Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA

(2012) H.-J. Jung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A truncated lamin A in the Lmna−/−mouse line

(2012) Daniel Jahn et al.   Nucleus

Stem cell depletion in Hutchinson-Gilford progeria syndrome

(2011) Ylva Rosengardten et al.   AGING CELL

Conserved cysteine residues in the mammalian lamin A tail are essential for cellular responses to ROS generation

(2011) Vanja Pekovic et al.   AGING CELL

Retinoblastoma-independent regulation of cell proliferation and senescence by the p53-p21 axis in lamin A /C-depleted cells

(2011) Olga Moiseeva et al.   AGING CELL

Nuclear Mechanics in Disease

(2011) Monika Zwerger et al.   Annual Review of Biomedical Engineering

The nuclear envelope and its involvement in cellular stress responses

(2011) Ashraf N. Malhas et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Cell autonomous and systemic factors in progeria development: Figure 1.

(2011) Fernando G. Osorio et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The role of DNA damage in laminopathy progeroid syndromes

(2011) Christopher J. Hutchison   BIOCHEMICAL SOCIETY TRANSACTIONS

Clinical and genetic heterogeneity in laminopathies

(2011) Anne T. Bertrand et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

An EDMD Mutation in C. elegans Lamin Blocks Muscle-Specific Gene Relocation and Compromises Muscle Integrity

(2011) Anna Mattout et al.   CURRENT BIOLOGY

The role of nuclear lamin B1 in cell proliferation and senescence

(2011) T. Shimi et al.   GENES & DEVELOPMENT

An absence of both lamin B1 and lamin B2 in keratinocytes has no effect on cell proliferation or the development of skin and hair

(2011) Shao H. Yang et al.   HUMAN MOLECULAR GENETICS

Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts

(2011) Kan Cao et al.   JOURNAL OF CLINICAL INVESTIGATION

Structural and physiological phenotypes of disease-linked lamin mutations in C. elegans

(2011) Erin M. Bank et al.   JOURNAL OF STRUCTURAL BIOLOGY

A laminopathic mutation disrupting lamin filament assembly causes disease-like phenotypes in Caenorhabditis elegans

(2011) Erin M. Bank et al.   MOLECULAR BIOLOGY OF THE CELL

Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons

(2011) Catherine Coffinier et al.   MOLECULAR BIOLOGY OF THE CELL

Recapitulation of premature ageing with iPSCs from Hutchinson–Gilford progeria syndrome

(2011) Guang-Hui Liu et al.   NATURE

Decreased Bone Formation and Osteopenia in Lamin A/C-Deficient Mice

(2011) Wei Li et al.   PLoS One

Differential Temporal and Spatial Progerin Expression during Closure of the Ductus Arteriosus in Neonates

(2011) Regina Bökenkamp et al.   PLoS One

Multiple Sites in αB-Crystallin Modulate Its Interactions with Desmin Filaments Assembled In Vitro

(2011) Scott A. Houck et al.   PLoS One

Mouse B-Type Lamins Are Required for Proper Organogenesis But Not by Embryonic Stem Cells

(2011) Y. Kim et al.   SCIENCE

The lamin protein family

(2011) Travis A Dittmer et al.   GENOME BIOLOGY

Lamins: ‘structure goes cycling’: Figure 1

(2010) Mirta Boban et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A Human iPSC Model of Hutchinson Gilford Progeria Reveals Vascular Smooth Muscle and Mesenchymal Stem Cell Defects

(2010) Jinqiu Zhang et al.   Cell Stem Cell

Mitogen-Activated Protein Kinase Inhibitors Improve Heart Function and Prevent Fibrosis in Cardiomyopathy Caused by Mutation in Lamin A/C Gene

(2010) Wei Wu et al.   CIRCULATION

Functional Coupling between the Extracellular Matrix and Nuclear Lamina by Wnt Signaling in Progeria

(2010) Lidia Hernandez et al.   DEVELOPMENTAL CELL

The spatial dynamics of tissue-specific promoters during C. elegans development

(2010) P. Meister et al.   GENES & DEVELOPMENT

Role of progerin-induced telomere dysfunction in HGPS premature cellular senescence

(2010) E. K. Benson et al.   JOURNAL OF CELL SCIENCE

Nuclear Shield: A Multi-Enzyme Task-Force for Nucleus Protection

(2010) Raffaele Fabrini et al.   PLoS One

Novel roles for A-type lamins in telomere biology and the DNA damage response pathway

(2009) Ignacio Gonzalez-Suarez et al.   EMBO JOURNAL

Impaired nuclear functions lead to increased senescence and inefficient differentiation in human myoblasts with a dominant p.R545C mutation in the LMNA gene

(2009) Sebastian Kandert et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Lamin B1 controls oxidative stress responses via Oct-1

(2009) Ashraf N. Malhas et al.   JOURNAL OF CELL BIOLOGY

Dynamic complexes of A-type lamins and emerin influence adipogenic capacity of the cell via nucleocytoplasmic distribution of  -catenin

(2009) K. Tilgner et al.   JOURNAL OF CELL SCIENCE

Nuclear lamins: key regulators of nuclear structure and activities

(2009) Miron Prokocimer et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Attenuated hypertrophic response to pressure overload in a lamin A/C haploinsufficiency mouse

(2009) Mihaela Cupesi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Characterization of the Head-to-Tail Overlap Complexes Formed by Human Lamin A, B1 and B2 “Half-minilamin” Dimers

(2009) Larisa E. Kapinos et al.   JOURNAL OF MOLECULAR BIOLOGY

Overlapping Functions of Nuclear Envelope Proteins NET25 (Lem2) and Emerin in Regulation of Extracellular Signal-Regulated Kinase Signaling in Myoblast Differentiation

(2009) M. D. Huber et al.   MOLECULAR AND CELLULAR BIOLOGY

NURD keeps chromatin young

(2009) Eran Meshorer et al.   NATURE CELL BIOLOGY

Ageing-related chromatin defects through loss of the NURD complex

(2009) Gianluca Pegoraro et al.   NATURE CELL BIOLOGY

A progeria mutation reveals functions for lamin A in nuclear assembly, architecture, and chromosome organization

(2009) P. Taimen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased mechanosensitivity and nuclear stiffness in Hutchinson–Gilford progeria cells: effects of farnesyltransferase inhibitors

(2008) Valerie L. R. M. Verstraeten et al.   AGING CELL

Does satellite cell dysfunction contribute to disease progression in Emery–Dreifuss muscular dystrophy?

(2008) Viola F. Gnocchi et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Prelamin A is involved in early steps of muscle differentiation

(2008) Cristina Capanni et al.   EXPERIMENTAL CELL RESEARCH

The A- and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription

(2008) T. Shimi et al.   GENES & DEVELOPMENT

Effect of Lamin A/C Knockdown on Osteoblast Differentiation and Function

(2008) Rahima Akter et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Nuclear envelope defects cause stem cell dysfunction in premature-aging mice

(2008) Jesús Espada et al.   JOURNAL OF CELL BIOLOGY

Filaments made from A- and B-type lamins differ in structure and organization

(2008) M. W. Goldberg et al.   JOURNAL OF CELL SCIENCE

Effects of heat shock on the distribution and expression levels of nuclear proteins in HeLa S3 cells

(2008) Nisrine Haddad et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The Supramolecular Organization of the C. elegans Nuclear Lamin Filament

(2008) Kfir Ben-Harush et al.   JOURNAL OF MOLECULAR BIOLOGY

Understanding the Mechanisms of Senile Osteoporosis: New Facts for a Major Geriatric Syndrome

(2008) Gustavo Duque et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Loss of nucleoplasmic LAP2α–lamin A complexes causes erythroid and epidermal progenitor hyperproliferation

(2008) Nana Naetar et al.   NATURE CELL BIOLOGY