Journal
EMBO REPORTS
Volume 11, Issue 11, Pages 848-853Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/embor.2010.155
Keywords
crystal structure; germ cell; Nanos; RNA-binding protein; translational regulation
Categories
Funding
- KAKENHI
- Japanese Ministry of Education, Culture, Sports, Science and Technology
Ask authors/readers for more resources
Nanos is an RNA-binding protein that is involved in the development and maintenance of germ cells. In combination with Pumilio, Nanos binds to the 3' untranslated region of a messenger RNA and represses its translation. Nanos has two conserved Cys-Cys-His-Cys zinc-finger motifs that are indispensable for its function. In this study, we have determined the crystal structure of the zinc-finger domain of zebrafish Nanos, for the first time revealing that Nanos adopts a novel zinc-finger structure. In addition, Nanos has a conserved basic surface that is directly involved in RNA binding. Our results provide the structural basis for further studies to clarify Nanos function.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available