Journal
EMBO REPORTS
Volume 10, Issue 6, Pages 636-641Publisher
WILEY
DOI: 10.1038/embor.2009.66
Keywords
D-Pax2; Drosophila PNS; Hamlet; Prospero; Sequoia
Categories
Funding
- EMBO
- Howard Hughes Medical Institute
- Nakajima Foundation
- [CA16672]
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The adult Drosophila external sensory organ (ESO), comprising the hair, socket, neuron, sheath and glia cells, arises through the asymmetric division of sensory organ precursor cells (SOPs). In a mosaic screen designed to identify new components in ESO development, we isolated mutations in sequoia, which encodes a putative zinc-finger transcription factor that has previously been shown to have a role in dendritogenesis. Here, we show that adult clones mutant for seq exhibit a loss of hair cells and a gain of socket cells. We propose that the seq mutant phenotype arises, in part, owing to the loss of several crucial transcription factors known to be important in peripheral nervous system development such as D-Pax2, Prospero and Hamlet. Thus, Sequoia is a new upstream regulator of genes that orchestrates cell fate specification during development of the adult ESO lineage.
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