Experimental and clinical aspects of melatonin and clock genes in diabetes

Melatonin influences somatostatin secretion from human pancreaticδ-cells via MT1 and MT2 receptors

(2015) Juliane Zibolka et al.   JOURNAL OF PINEAL RESEARCH

A stress response pathway in mice upregulates somatostatin level and transcription in pancreatic delta cells through Gs and β-arrestin 1

(2014) Hong-Mei Wang et al.   DIABETOLOGIA

Melatonin feedback on clock genes: a theory involving the proteasome

(2014) Jerry Vriend et al.   JOURNAL OF PINEAL RESEARCH

Calcium-signaling components in rat insulinomaβ-cells (INS-1) and pancreatic islets are differentially influenced by melatonin

(2014) Ivonne Bazwinsky-Wutschke et al.   JOURNAL OF PINEAL RESEARCH

SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging

(2013) Hung-Chun Chang et al.   CELL

Real-time recording of circadian liver gene expression in freely moving mice reveals the phase-setting behavior of hepatocyte clocks

(2013) C. Saini et al.   GENES & DEVELOPMENT

Clock Gene Expression in the Liver of Streptozotocin-induced and Spontaneous Type 1 Diabetic Rats

(2013) K. Hofmann et al.   HORMONE AND METABOLIC RESEARCH

Melatonin and Pancreatic Islets: Interrelationships between Melatonin, Insulin and Glucagon

(2013) Elmar Peschke et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Influence of melatonin receptor signalling on parameters involved in blood glucose regulation

(2013) Ivonne Bazwinsky-Wutschke et al.   JOURNAL OF PINEAL RESEARCH

Autonomous and self-sustained circadian oscillators displayed in human islet cells

(2012) P. Pulimeno et al.   DIABETOLOGIA

Identification of a new clock-related element EL-box involved in circadian regulation by BMAL1/CLOCK and HES1

(2012) Taichi Ueshima et al.   GENE

Phosphorylation of cyclic AMP-response element-binding protein (CREB) is influenced by melatonin treatment in pancreatic rat insulinoma β-cells (INS-1)

(2012) Ivonne Bazwinsky-Wutschke et al.   JOURNAL OF PINEAL RESEARCH

Evidence of the receptor-mediated influence of melatonin on pancreatic glucagon secretion via the Gαq protein-coupled and PI3K signaling pathways

(2012) Ina Bähr et al.   JOURNAL OF PINEAL RESEARCH

Melatonin influences insulin secretion primarily via MT1 receptors in rat insulinoma cells (INS-1) and mouse pancreatic islets

(2012) Eckhard Mühlbauer et al.   JOURNAL OF PINEAL RESEARCH

Regulation of core clock genes in human islets

(2012) Jelena A. Stamenkovic et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Differential and day-time dependent expression of nuclear receptors RORα, RORβ, RORγ and RXRα in the rodent pancreas and islet

(2012) Eckhard Mühlbauer et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes

(2012) Amélie Bonnefond et al.   NATURE GENETICS

No effect by the common gene variant rs10830963 of the melatonin receptor 1B on the association between sleep disturbances and type 2 diabetes: results from the Nord-Trøndelag Health Study

(2011) L. Olsson et al.   DIABETOLOGIA

Homozygous staggerer (sg/sg) mice display improved insulin sensitivity and enhanced glucose uptake in skeletal muscle

(2011) P. Lau et al.   DIABETOLOGIA

The insulin–melatonin antagonism: studies in the LEW.1AR1-iddm rat (an animal model of human type 1 diabetes mellitus)

(2011) E. Peschke et al.   DIABETOLOGIA

GLP-1 for type 2 diabetes

(2011) Bo Ahrén   EXPERIMENTAL CELL RESEARCH

Melatonin Receptor 1A Gene Polymorphism Associated with Polycystic Ovary Syndrome

(2011) Chao Li et al.   GYNECOLOGIC AND OBSTETRIC INVESTIGATION

Disruption of Circadian Rhythms Accelerates Development of Diabetes through Pancreatic Beta-Cell Loss and Dysfunction

(2011) John E. Gale et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Melatonin inhibits insulin secretion in rat insulinoma β-cells (INS-1) heterologously expressing the human melatonin receptor isoform MT2

(2011) Eckhard Mühlbauer et al.   JOURNAL OF PINEAL RESEARCH

Distribution of melatonin receptors in murine pancreatic islets

(2011) Cecilia L. F. Nagorny et al.   JOURNAL OF PINEAL RESEARCH

Melatonin stimulates glucagon secretion in vitro and in vivo

(2011) Ina Bähr et al.   JOURNAL OF PINEAL RESEARCH

Catecholamines are the key for explaining the biological relevance of insulin-melatonin antagonisms in type 1 and type 2 diabetes

(2011) E. Peschke et al.   JOURNAL OF PINEAL RESEARCH

Transcriptional profiling reveals a role for RORα in regulating gene expression in obesity-associated inflammation and hepatic steatosis

(2011) Hong Soon Kang et al.   PHYSIOLOGICAL GENOMICS

A role for islet somatostatin in mediating sympathetic regulation of glucagon secretion

(2011) Astrid C. Hauge-Evans et al.   Islets

Loss of Bmal1 leads to uncoupling and impaired glucose-stimulated insulin secretion in β-cells

(2011) Jeongkyung Lee et al.   Islets

The Mammalian Circadian Timing System: Organization and Coordination of Central and Peripheral Clocks

(2010) Charna Dibner et al.   Annual Review of Physiology

New evidence for a role of melatonin in glucose regulation

(2010) Elmar Peschke et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

MTNR1B G24E Variant Associates With BMI and Fasting Plasma Glucose in the General Population in Studies of 22,142 Europeans

(2010) E. A. Andersson et al.   DIABETES

An intrinsic circadian clock of the pancreas is required for normal insulin release and glucose homeostasis in mice

(2010) L. A. Sadacca et al.   DIABETOLOGIA

Adrenoceptor Expression and Diurnal Rhythms of Melatonin and Its Precursors in the Pineal Gland of Type 2 Diabetic Goto-Kakizaki Rats

(2010) Andreas Gunter Bach et al.   ENDOCRINOLOGY

Distribution patterns of calcium-binding proteins in pancreatic tissue of non-diabetic as well as type 2 diabetic rats and in rat insulinoma β-cells (INS-1)

(2010) Ivonne Bazwinsky-Wutschke et al.   HISTOCHEMISTRY AND CELL BIOLOGY

A Single Night of Partial Sleep Deprivation Induces Insulin Resistance in Multiple Metabolic Pathways in Healthy Subjects

(2010) Esther Donga et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Signal transduction of receptor-mediated antiproliferative action of melatonin on human prostate epithelial cells involves dual activation of Gαs and Gαq proteins

(2010) Stephen Y. W. Shiu et al.   JOURNAL OF PINEAL RESEARCH

Long-term enteral administration of melatonin reduces plasma insulin and increases expression of pineal insulin receptors in both Wistar and type 2-diabetic Goto-Kakizaki rats

(2010) Elmar Peschke et al.   JOURNAL OF PINEAL RESEARCH

Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes

(2010) Biliana Marcheva et al.   NATURE

Exocytotic Properties of Human Pancreatic β-cells

(2009) Matthias Braun et al.   Annals of the New York Academy of Sciences

Reducing oxidative/nitrosative stress: a newly-discovered genre for melatonin

(2009) Russel J. Reiter et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Common Genetic Variation Near Melatonin Receptor MTNR1B Contributes to Raised Plasma Glucose and Increased Risk of Type 2 Diabetes Among Indian Asians and European Caucasians

(2009) J. C. Chambers et al.   DIABETES

Gene Variants in the Novel Type 2 Diabetes Loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B Affect Different Aspects of Pancreatic  -Cell Function

(2009) A. M. Simonis-Bik et al.   DIABETES

Melatonin receptors in pancreatic islets: good morning to a novel type 2 diabetes gene

(2009) H. Mulder et al.   DIABETOLOGIA

Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells

(2009) M. Braun et al.   DIABETOLOGIA

Glucose Generates Coincident Insulin and Somatostatin Pulses and Antisynchronous Glucagon Pulses from Human Pancreatic Islets

(2009) Bo Hellman et al.   ENDOCRINOLOGY

Transcripts of Calcium/Calmodulin-dependent Kinases are Changed After Forskolin- or IBMX-induced Insulin Secretion due to Melatonin Treatment of Rat Insulinoma β-Cells (INS-1)

(2009) I. Bazwinsky-Wutschke et al.   HORMONE AND METABOLIC RESEARCH

Mild Sleep Restriction Acutely Reduces Plasma Glucagon Levels in Healthy Men

(2009) Sebastian M. Schmid et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Pineal melatonin synthesis is decreased in type 2 diabetic Goto–Kakizaki rats

(2009) Thomas Frese et al.   LIFE SCIENCES

Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes

(2009) Bo Ahrén   NATURE REVIEWS DRUG DISCOVERY

Adverse metabolic and cardiovascular consequences of circadian misalignment

(2009) F. A. J. L. Scheer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian Control of the NAD+ Salvage Pathway by CLOCK-SIRT1

(2009) Y. Nakahata et al.   SCIENCE

Prolonged melatonin administration in 6-month-old Sprague-Dawley rats: metabolic alterations

(2008) B. Bojková et al.   ACTA PHYSIOLOGICA HUNGARICA

Oxidative stress: the vulnerable β-cell

(2008) Sigurd Lenzen   BIOCHEMICAL SOCIETY TRANSACTIONS

Somatostatin Secreted by Islet  -Cells Fulfills Multiple Roles as a Paracrine Regulator of Islet Function

(2008) A. C. Hauge-Evans et al.   DIABETES

Pancreatic α-cell dysfunction in diabetes

(2008) R. Burcelin et al.   DIABETES & METABOLISM

Physiology of the pancreatic α-cell and glucagon secretion: role in glucose homeostasis and diabetes

(2008) Ivan Quesada et al.   JOURNAL OF ENDOCRINOLOGY

Function and expression of melatonin receptors on human pancreatic islets

(2008) Reshma D. Ramracheya et al.   JOURNAL OF PINEAL RESEARCH

Increased melatonin synthesis in pineal glands of rats in streptozotocin induced type 1 diabetes

(2008) Elmar Peschke et al.   JOURNAL OF PINEAL RESEARCH

Involvement of the cGMP pathway in mediating the insulin-inhibitory effect of melatonin in pancreatic β-cells

(2008) Ina Stumpf et al.   JOURNAL OF PINEAL RESEARCH

Modulation of the cGMP signaling pathway by melatonin in pancreaticβ-cells

(2008) Ina Stumpf et al.   JOURNAL OF PINEAL RESEARCH

Oscillatory control of insulin secretion

(2008) A TENGHOLM et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

(2008) Valeriya Lyssenko et al.   NATURE GENETICS

Variants in MTNR1B influence fasting glucose levels

(2008) Inga Prokopenko et al.   NATURE GENETICS

A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk

(2008) Nabila Bouatia-Naji et al.   NATURE GENETICS

Circadian Control of the Daily Plasma Glucose Rhythm: An Interplay of GABA and Glutamate

(2008) Andries Kalsbeek et al.   PLoS One

Polymorphisms within the Novel Type 2 Diabetes Risk Locus MTNR1B Determine β-Cell Function

(2008) Harald Staiger et al.   PLoS One

Slow-wave sleep and the risk of type 2 diabetes in humans

(2008) E. Tasali et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physiological significance of a peripheral tissue circadian clock

(2008) K. A. Lamia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA