Melatonin and Pancreatic Islets: Interrelationships between Melatonin, Insulin and Glucagon

Heteromerization of G Protein-Coupled Receptors: Relevance to Neurological Disorders and Neurotherapeutics

(2012) Laura Albizu et al.   CNS & Neurological Disorders-Drug Targets

Phosphorylation of cyclic AMP-response element-binding protein (CREB) is influenced by melatonin treatment in pancreatic rat insulinoma β-cells (INS-1)

(2012) Ivonne Bazwinsky-Wutschke et al.   JOURNAL OF PINEAL RESEARCH

Evidence of the receptor-mediated influence of melatonin on pancreatic glucagon secretion via the Gαq protein-coupled and PI3K signaling pathways

(2012) Ina Bähr et al.   JOURNAL OF PINEAL RESEARCH

Melatonin influences insulin secretion primarily via MT1 receptors in rat insulinoma cells (INS-1) and mouse pancreatic islets

(2012) Eckhard Mühlbauer et al.   JOURNAL OF PINEAL RESEARCH

Regulation of core clock genes in human islets

(2012) Jelena A. Stamenkovic et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Melatonin membrane receptors in peripheral tissues: Distribution and functions

(2012) Radomir M. Slominski et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes

(2012) Amélie Bonnefond et al.   NATURE GENETICS

No effect by the common gene variant rs10830963 of the melatonin receptor 1B on the association between sleep disturbances and type 2 diabetes: results from the Nord-Trøndelag Health Study

(2011) L. Olsson et al.   DIABETOLOGIA

The insulin–melatonin antagonism: studies in the LEW.1AR1-iddm rat (an animal model of human type 1 diabetes mellitus)

(2011) E. Peschke et al.   DIABETOLOGIA

Molecular pharmacology of the mouse melatonin receptors MT1 and MT2

(2011) Séverine Devavry et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

GLP-1 for type 2 diabetes

(2011) Bo Ahrén   EXPERIMENTAL CELL RESEARCH

Melatonin Receptor 1A Gene Polymorphism Associated with Polycystic Ovary Syndrome

(2011) Chao Li et al.   GYNECOLOGIC AND OBSTETRIC INVESTIGATION

Melatonin inhibits insulin secretion in rat insulinoma β-cells (INS-1) heterologously expressing the human melatonin receptor isoform MT2

(2011) Eckhard Mühlbauer et al.   JOURNAL OF PINEAL RESEARCH

Distribution of melatonin receptors in murine pancreatic islets

(2011) Cecilia L. F. Nagorny et al.   JOURNAL OF PINEAL RESEARCH

Melatonin stimulates glucagon secretion in vitro and in vivo

(2011) Ina Bähr et al.   JOURNAL OF PINEAL RESEARCH

Catecholamines are the key for explaining the biological relevance of insulin-melatonin antagonisms in type 1 and type 2 diabetes

(2011) E. Peschke et al.   JOURNAL OF PINEAL RESEARCH

New evidence for a role of melatonin in glucose regulation

(2010) Elmar Peschke et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Circadian Rhythms and Metabolic Syndrome

(2010) Eleonore Maury et al.   CIRCULATION RESEARCH

MTNR1B G24E Variant Associates With BMI and Fasting Plasma Glucose in the General Population in Studies of 22,142 Europeans

(2010) E. A. Andersson et al.   DIABETES

Molecular organization and dynamics of the melatonin MT1 receptor/RGS20/Gi protein complex reveal asymmetry of receptor dimers for RGS and Gi coupling

(2010) Pascal Maurice et al.   EMBO JOURNAL

Adrenoceptor Expression and Diurnal Rhythms of Melatonin and Its Precursors in the Pineal Gland of Type 2 Diabetic Goto-Kakizaki Rats

(2010) Andreas Gunter Bach et al.   ENDOCRINOLOGY

Investigational melatonin receptor agonists

(2010) Rüdiger Hardeland   EXPERT OPINION ON INVESTIGATIONAL DRUGS

A Single Night of Partial Sleep Deprivation Induces Insulin Resistance in Multiple Metabolic Pathways in Healthy Subjects

(2010) Esther Donga et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Signal transduction of receptor-mediated antiproliferative action of melatonin on human prostate epithelial cells involves dual activation of Gαs and Gαq proteins

(2010) Stephen Y. W. Shiu et al.   JOURNAL OF PINEAL RESEARCH

Long-term enteral administration of melatonin reduces plasma insulin and increases expression of pineal insulin receptors in both Wistar and type 2-diabetic Goto-Kakizaki rats

(2010) Elmar Peschke et al.   JOURNAL OF PINEAL RESEARCH

Melatonin Induces Akt Phosphorylation through Melatonin Receptor- and PI3K-Dependent Pathways in Primary Astrocytes

(2010) Pil-Jae Kong et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes

(2010) Biliana Marcheva et al.   NATURE

International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, Classification, and Pharmacology of G Protein-Coupled Melatonin Receptors

(2010) M. L. Dubocovich et al.   PHARMACOLOGICAL REVIEWS

Exocytotic Properties of Human Pancreatic β-cells

(2009) Matthias Braun et al.   Annals of the New York Academy of Sciences

Reducing oxidative/nitrosative stress: a newly-discovered genre for melatonin

(2009) Russel J. Reiter et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Common Genetic Variation Near Melatonin Receptor MTNR1B Contributes to Raised Plasma Glucose and Increased Risk of Type 2 Diabetes Among Indian Asians and European Caucasians

(2009) J. C. Chambers et al.   DIABETES

Gene Variants in the Novel Type 2 Diabetes Loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B Affect Different Aspects of Pancreatic  -Cell Function

(2009) A. M. Simonis-Bik et al.   DIABETES

Melatonin receptors in pancreatic islets: good morning to a novel type 2 diabetes gene

(2009) H. Mulder et al.   DIABETOLOGIA

Loss of melatonin signalling and its impact on circadian rhythms in mouse organs regulating blood glucose

(2009) Eckhard Mühlbauer et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mild Sleep Restriction Acutely Reduces Plasma Glucagon Levels in Healthy Men

(2009) Sebastian M. Schmid et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Melatonin ameliorates high fat diet-induced diabetes and stimulates glycogen synthesis via a PKCζ-Akt-GSK3β pathway in hepatic cells

(2009) Jiunn-Min Shieh et al.   JOURNAL OF PINEAL RESEARCH

Pineal melatonin synthesis is decreased in type 2 diabetic Goto–Kakizaki rats

(2009) Thomas Frese et al.   LIFE SCIENCES

Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes

(2009) Bo Ahrén   NATURE REVIEWS DRUG DISCOVERY

Prolonged melatonin administration in 6-month-old Sprague-Dawley rats: metabolic alterations

(2008) B. Bojková et al.   ACTA PHYSIOLOGICA HUNGARICA

Oxidative stress: the vulnerable β-cell

(2008) Sigurd Lenzen   BIOCHEMICAL SOCIETY TRANSACTIONS

Pancreatic α-cell dysfunction in diabetes

(2008) R. Burcelin et al.   DIABETES & METABOLISM

The PDZ Protein Mupp1 Promotes GiCoupling and Signaling of the Mt1Melatonin Receptor

(2008) Jean-Luc Guillaume et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physiology of the pancreatic α-cell and glucagon secretion: role in glucose homeostasis and diabetes

(2008) Ivan Quesada et al.   JOURNAL OF ENDOCRINOLOGY

Development of an in vivo adeno-associated virus-mediated siRNA approach to knockdown tyrosine hydroxylase in the lateral retrochiasmatic area of the ovine brain

(2008) Laurence Dufourny et al.   JOURNAL OF NEUROSCIENCE METHODS

The Gαiand Gαqproteins mediate the effects of melatonin on steroid/thyroid hormone receptor transcriptional activity and breast cancer cell proliferation

(2008) Ling Lai et al.   JOURNAL OF PINEAL RESEARCH

Function and expression of melatonin receptors on human pancreatic islets

(2008) Reshma D. Ramracheya et al.   JOURNAL OF PINEAL RESEARCH

Increased melatonin synthesis in pineal glands of rats in streptozotocin induced type 1 diabetes

(2008) Elmar Peschke et al.   JOURNAL OF PINEAL RESEARCH

Involvement of the cGMP pathway in mediating the insulin-inhibitory effect of melatonin in pancreatic β-cells

(2008) Ina Stumpf et al.   JOURNAL OF PINEAL RESEARCH

Modulation of the cGMP signaling pathway by melatonin in pancreaticβ-cells

(2008) Ina Stumpf et al.   JOURNAL OF PINEAL RESEARCH

A Generic Approach for the Purification of Signaling Complexes That Specifically Interact with the Carboxyl-terminal Domain of G Protein-coupled Receptors

(2008) Pascal Maurice et al.   MOLECULAR & CELLULAR PROTEOMICS

Oscillatory control of insulin secretion

(2008) A TENGHOLM et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

(2008) Valeriya Lyssenko et al.   NATURE GENETICS

Variants in MTNR1B influence fasting glucose levels

(2008) Inga Prokopenko et al.   NATURE GENETICS

A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk

(2008) Nabila Bouatia-Naji et al.   NATURE GENETICS

Circadian Control of the Daily Plasma Glucose Rhythm: An Interplay of GABA and Glutamate

(2008) Andries Kalsbeek et al.   PLoS One

Polymorphisms within the Novel Type 2 Diabetes Risk Locus MTNR1B Determine β-Cell Function

(2008) Harald Staiger et al.   PLoS One

Slow-wave sleep and the risk of type 2 diabetes in humans

(2008) E. Tasali et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent methodological advances in the discovery of GPCR-associated protein complexes

(2008) Avais M. Daulat et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

MT1 melatonin receptor internalization underlies melatonin-induced morphologic changes in Chinese hamster ovary cells and these processes are dependent on Gi proteins, MEK 1/2 and microtubule modulation

(2007) C. Dominic Bondi et al.   JOURNAL OF PINEAL RESEARCH

Role for the Pineal and Melatonin in Glucose Homeostasis: Pinealectomy Increases Night-Time Glucose Concentrations

(2003) S. E. La Fleur et al.   JOURNAL OF NEUROENDOCRINOLOGY