Article
Immunology
Xiaofei Xu, Errol Prens, Edwin Florencia, Pieter Leenen, Luis Boon, Patrick Asmawidjaja, Anne-Marie Mus, Erik Lubberts
Summary: The up-regulation of IL-19 and IL-24 induced by IL-17A in skin stromal cells contributes to keratinocyte proliferation. Depletion of IL-10 leads to increased expression of IL-23/IL-17 pathway related cytokines followed by significant up-regulation of IL-19 and IL-24.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Wei Zhang, Ruohao Zhang, Zhiguang Chang, Xiaobo Wang
Summary: Resveratrol, a natural product, has been shown to have anti-tumor effects. This study found that resveratrol inhibits the growth of lung adenocarcinoma by modulating the activation of tumor-associated macrophages and CD8T cells.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ruixin Sun, Yifan Liu, Chuanlong Wu, Min Zhou, Hong Luo, Guoxiu Du, Zhengyang Liu, Yansha Sun, Yiwei Dong, Jingwen Su, Mingliang Fan, Bizhi Shi, Hua Jiang, Zonghai Li
Summary: Previously, EGFRvIII-targeting CAR-T cells showed limited anti-tumor efficacy in treating advanced breast cancer, possibly due to reduced accumulation and persistence of therapeutic T cells. CXCR2 was found to significantly improve the trafficking and tumor specific accumulation of CAR-T cells, but weakened the anti-tumor effect due to T cell apoptosis. Co-expression of IL-15 or IL-18 in CXCR2 CAR-T cells effectively suppressed exhaustion and apoptosis, enhancing the anti-tumor activity without causing toxicity. These findings suggest a potential therapy strategy for advanced breast cancer in the future.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Guangming Su, Wei Yang, Shengjiao Wang, Chunhui Geng, Xiuru Guan
Summary: Ferroptosis is associated with atherosclerosis, and activation of SIRT1 can inhibit ferroptosis and IL-1(3 and IL-18 levels in foam cells, providing a novel therapeutic target for AS.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Immunology
Wolfgang Glienke, Anna Christina Dragon, Katharina Zimmermann, Alexandra Martyniszyn-Eiben, Mira Mertens, Hinrich Abken, Claudia Rossig, Bianca Altvater, Krasimira Aleksandrova, Lubomir Arseniev, Christina Kloth, Andriana Stamopoulou, Thomas Moritz, Holger N. Lode, Nikolai Siebert, Rainer Blasczyk, Lilia Goudeva, Axel Schambach, Ulrike Koehl, Britta Eiz-Vesper, Ruth Esser
Summary: This study demonstrates the feasibility of translating the manufacturing method of CAR T cells to produce TRUCKs, which secrete IL-18. Using the CliniMACS Prodigy (R) system and a lentiviral vector, IL-18-secreting TRUCKs targeting GD(2) tumor antigen were successfully generated. The engineered T cells obtained from two donors showed similar functionality to laboratory-scale TRUCKs and exhibited specific cytotoxicity towards GD(2)-expressing target cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Peripheral Vascular Disease
Jordyn M. Thomas, Yeong H. Ling, Brooke Huuskes, Maria Jelinic, Prerna Sharma, Narbada Saini, Dorota M. Ferens, Henry Diep, Shalini M. Krishnan, Barbara K. Kemp-Harper, Paul M. O'Connor, Eicke Latz, Thiruma V. Arumugam, Tomasz J. Guzik, Michael J. Hickey, Ashley Mansell, Christopher G. Sobey, Antony Vinh, Grant R. Drummond
Summary: IL-18 is elevated in hypertensive patients, and its production by tubular epithelial cells contributes to elevated blood pressure, renal inflammation, and fibrosis in a low-renin hypertension mouse model. This suggests IL-18 as a promising therapeutic target for hypertension and kidney disease.
Article
Multidisciplinary Sciences
Ousheng Liu, Junji Xu, Fu Wang, Wenwen Jin, Peter Zanvit, Dandan Wang, Nathan Goldberg, Alexander Cain, Nancy Guo, Yichen Han, Andrew Bynum, Guowu Ma, Songlin Wang, Zhangui Tang, Wanjun Chen
Summary: Research has shown that ADSCs can produce IL-33 in response to stimulation, which alleviates autoimmune diseases by promoting the proliferation of regulatory T cells (Tregs). This previously unrecognized immunoregulatory function of ADSCs through IL-33 production may have potential clinical applications.
Review
Biochemistry & Molecular Biology
Youwen Mei, Zi Lv, Liling Xiong, Hanwen Zhang, Nanlin Yin, Hongbo Qi
Summary: IL-27, a member of the IL-6/IL-12 family, plays a dual role in CD4+T cells as both agonist and antagonist, with underlying mechanisms not fully defined. Researchers aim to better understand its context-dependent function in CD4+T cells and propose a possible mechanism that could aid in developing appropriate clinical treatments.
MOLECULAR IMMUNOLOGY
(2021)
Article
Immunology
Patricia Ramos-Ramirez, Carina Malmhall, Omar Tliba, Madeleine Radinger, Apostolos Bossios
Summary: Adiponectin/AdipoR1 axis promotes IL-10 release by Tregs, mainly in Helios(-) Tregs, and the effect was amplified by T2 inflammation in Helios(+) Tregs. This suggests a potential role of adiponectin in regulating Treg function in human inflammatory conditions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Kenta Fujimura, Tadayoshi Karasawa, Takanori Komada, Naoya Yamada, Yoshiko Mizushina, Chintogtokh Baatarjav, Takayoshi Matsumura, Kinya Otsu, Norihiko Takeda, Hiroaki Mizukami, Kazuomi Kario, Masafumi Takahashi
Summary: Sepsis is a life-threatening syndrome, and its associated mortality is increased when cardiac dysfunction and damage (septic cardiomyopathy [SCM]) occur. The NLRP3 inflammasome plays a critical role in the pathophysiology of SCM, with the activation of IL-1 beta and IL-18 contributing to the development of SCM.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Article
Cell Biology
Junjun Luan, Jingqi Fu, Congcong Jiao, Xiangnan Hao, Zixuan Feng, Lingzi Zhu, Yixiao Zhang, Guangyu Zhou, Hongyu Li, Wei Yang, Peter S. T. Yuen, Jeffrey B. Kopp, Jingbo Pi, Hua Zhou
Summary: This study investigated the role of interleukin-18 (IL-18) in the progression from acute kidney injury (AKI) to chronic kidney disease (CKD). The results showed that IL-18 deficiency can attenuate renal tubular damage, necroptosis, cell transdifferentiation, and fibrosis, and this renoprotective effect may be mediated by reducing the switch from M1 to profibrotic M2 macrophages.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Brielle Jones, Chaoyang Li, Min Sung Park, Anne Lerch, Vimal Jacob, Nicholas Johnson, Jin-Qiang Kuang, Sandeep Dhall, Malathi Sathyamoorthy
Summary: The study compared the gene expression differences between amniotic stromal cells (ASCs) and chorionic stromal cells (CSCs), revealing that CSCs have superior angiogenic potential while ASCs exhibit increased anti-inflammatory properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Jordyn M. Thomas, Brooke M. Huuskes, Christopher G. Sobey, Grant R. Drummond, Antony Vinh
Summary: Chronic kidney disease (CKD) is an inflammatory condition, and the inflammasome and pro-inflammatory cytokine IL-18 play important roles in its development. Regulating the signaling pathways of the inflammasome and IL-18 may serve as potential targets for CKD treatment.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Oncology
Siyu Zhu, Chen Zhang, Qian Sun, Yang Wang, Wenwen Yu, Feng Wei, Xiubao Ren
Summary: This study establishes a CD3+CD56+ NKT-like cell model and investigates its role and mechanism in antitumor and antiviral immune responses through simulating the effects of cytokines.
JOURNAL OF ONCOLOGY
(2022)
Article
Oncology
Siyu Zhu, Chen Zhang, Qian Sun, Yang Wang, Wenwen Yu, Feng Wei, Xiubao Ren
Summary: Our study demonstrated that cytokines IL-12/15/18 can induce enhanced training immunity in CD3+CD56+ NKT-like cells, leading to a memory-like phenomenon characterized by increased IFN-gamma production, improved cell function, and proliferation potential. Additionally, IL-12/15/18 showed efficacy in promoting antitumor immune responses in NK-cell-sensitive tumor cells.
JOURNAL OF ONCOLOGY
(2022)
Article
Hematology
Nicolas Duployez, Laura A. Jamrog, Vincent Fregona, Camille Hamelle, Laurene Fenwarth, Sophie Lejeune, Nathalie Helevaut, Sandrine Geffroy, Aurelie Caillault, Alice Marceau-Renaut, Stephanie Poulain, Catherine Roche-Lestienne, Laetitia Largeaud, Nais Prade, Stephanie Dufrechou, Sylvie Hebrard, Celine Berthon, Brigitte Nelken, Jose Fernandes, Celine Villenet, Martin Figeac, Bastien Gerby, Eric Delabesse, Claude Preudhomme, Cyril Broccardo
Article
Hematology
Baptiste Eluard, Stephanie Nuan-Aliman, Nathalie Faumont, Davi Collares, Didier Bordereaux, Aurelie Montagne, Isabelle Martins, Nicolas Cagnard, Martial Caly, Oussama Taoui, Leonardo Lordello, Jacqueline Lehmann-Che, Bruno Tesson, Jose-Angel Martinez-Climent, Christiane Copie-Bergman, Corinne Haioun, Herve Tilly, Benjamin Bonsang, Anne Vincent-Salomon, Jean-Philippe Jais, Fabrice Jardin, Karen Leroy, Maria Chiara Maiuri, Guido Kroemer, Thierry Jo Molina, Jean Feuillard, Veronique Baud
Summary: RelB activation is frequently observed in DLBCL and defines a new subset of patients with distinct gene expression profile and mutational pattern. RelB positivity is associated with poor prognosis after immunochemotherapy, and it confers resistance to doxorubicin-induced apoptosis in DLBCL cells.
Article
Biochemical Research Methods
Gildas Bertho, Leonardo Lordello, Xi Chen, Covadonga Lucas-Torres, Imed Eddine Oumezziane, Cedric Caradeuc, Mathieu Baudin, Stephanie Nuan-Aliman, Catherine Thieblemont, Veronique Baud, Nicolas Giraud
Summary: Ultrahigh-resolution NMR has attracted considerable attention in complex sample analysis. Pure shift methods have shown to be suitable for deciphering metabolite mixtures.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Martine Perrot-Applanat, Cynthia Pimpie, Sophie Vacher, Ivan Bieche, Marc Pocard, Veronique Baud
Summary: This study found that the expression of IDO1 and PD1 is significantly increased in intestinal gastric cancer, while the expression of IDO1-TDO2 and PD-L1 is lower in diffuse gastric cancer, with less infiltration of immune cells. Tryptophan metabolism and AhR activation play an important role in immune regulation in gastric cancer.
Article
Hematology
Marina Lafage-Pochitaloff, Bastien Gerby, Veronique Baccini, Laetitia Largeaud, Vincent Fregona, Nais Prade, Pierre-Yves Juvin, Laura Jamrog, Pierre Bories, Sylvie Hebrard, Stephanie Lagarde, Veronique Mansat-De Mas, Oliver M. Dovey, Kosuke Yusa, George S. Vassiliou, Joop H. Jansen, Tobias Tekath, David Rombaut, Genevieve Ameye, Carole Barin, Audrey Bidet, John Boudjarane, Marie-Agnes Collonge-Rame, Carine Gervais, Antoine Ittel, Christine Lefebvre, Isabelle Luquet, Lucienne Michaux, Nathalie Nadal, Helene A. Poirel, Isabelle Radford-Weiss, Benedicte Ribourtout, Steven Richebourg, Stephanie Struski, Christine Terre, Isabelle Tigaud, Dominique Penther, Virginie Eclache, Michaela Fontenay, Cyril Broccardo, Eric Delabesse
Summary: This study investigated 113 cases of MDS and MDS/MPN with del(11q), revealing clinical features such as female predominance, similar survival prognosis to other MDS, low monocyte count, and abnormal megakaryopoiesis. The study also identified the common deleted region at 11q23.2, which is located between CADM1 and NXPE2 genes.
Article
Biology
Elodie Pronier, Aygun Imanci, Dorothee Selimoglu-Buet, Bouchra Badaoui, Raphael Itzykson, Thierry Roger, Chloe Jego, Audrey Naimo, Maela Francillette, Marie Breckler, Orianne Wagner-Ballon, Maria E. Figueroa, Marine Aglave, Daniel Gautheret, Francoise Porteu, Olivier A. Bernard, William Vainchenker, Francois Delhommeau, Eric Solary, Nathalie M. Droin
Summary: This study demonstrates that TET2 downregulation promotes the production of MIF, a chemokine associated with clonal TET2 downregulation in myeloid cells. Targeting MIF could be a potential therapeutic strategy for conditions associated with TET2 mutations.
COMMUNICATIONS BIOLOGY
(2022)
Letter
Oncology
Vilma Barroca, Elia Henry, Nathalie Dechamps, Laurent Renou, Paul Chaintreuil, Rohan Kulkarni, Saiyirami Devanand, Arnaud Jacquel, Guillaume Robert, Patrick Auberger, Francoise Pflumio, Marie-Laure Arcangeli
Article
Cell & Tissue Engineering
Maelle Givelet, Virginie Firlej, Bruno Lassalle, Anne Sophie Gille, Clementine Lapoujade, Isabelle Holtzman, Amandine Jarysta, Farahd Haghighirad, Florent Dumont, Sebastien Jacques, Franck Letourneur, Francoise Pflumio, Isabelle Allemand, Catherine Patrat, Nicolas Thiounn, Jean Philippe Wolf, Lydia Riou, Virginie Barraud-Lange, Pierre Fouchet
Summary: Researchers have established an exhaustive transcriptome of human spermatogenesis by analyzing the characteristics of human germ cells, revealing the molecular networks and key transcriptional regulators involved in the regulation of human spermatogonial stem cells.
Article
Immunology
Diogo F. T. Veiga, Mathieu Tremblay, Bastien Gerby, Sabine Herblot, Andre Haman, Patrick Gendron, Sebastien Lemieux, Juan Carlos Zuniga-Pflucker, Josee Hebert, Joseph Paul Cohen, Trang Hoang
Summary: Early T-cell development is controlled by E proteins, NOTCH1 and pre-TCR signaling. Perturbations of these pathways are implicated in leukemogenesis. This study investigates the individual roles of HEB, E2A, NOTCH1, and Tcf12 in T-ALL using gene-deficient mice. The findings suggest that HEB and E2A restrain cell proliferation, Tcf12 gene dosage is essential for the clonal expansion of pre-leukemic stem cells, and HEB acts as a tumor suppressor in T-ALL.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Yanis Pelinski, Donia Hidaoui, Anne Stolz, Francois Hermetet, Rabie Chelbi, M'boyba Khadija Diop, Amir M. Chioukh, Francoise Porteu, Emilie Elvira-Matelot
Summary: Ionizing radiation leads to loss of HSC function, associated with loss of H3K9me3 at intronic LINE-1 of HSC genes. The TNF-alpha/NF-kappa B/H3K9me3/LINE-1 axis maintains HSC gene expression and function independently of DNA damage.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Chemistry, Analytical
X. Chen, C. Caradeuc, A. Montagne, V. Baud, G. Bertho, C. Lucas-Torres, N. Giraud
Summary: Accurate quantification of metabolites by NMR is crucial for understanding metabolic pathways and addressing diseases. A new analytical protocol using pure shift library of calibration reference spectra has been developed to determine metabolite concentrations. This method, validated through model mixtures, provides quantitative and high-resolution vision of metabolic processes in a time compatible with metabolomics studies. Furthermore, it has been successfully applied to determine absolute metabolite concentrations in a lymphoma extracellular medium.
ANALYTICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Awatef Allouch, Laurent Voisin, Yanyan Zhang, Syed Qasim Raza, Yann Lecluse, Julien Calvo, Dorothee Selimoglu-Buet, Stephane de Botton, Fawzia Louache, Francoise Pflumio, Eric Solary, Jean-Luc Perfettini
Summary: Targeting the reprogramming and phagocytic capacities of tumor-associated macrophages (TAMs) offers a therapeutic opportunity for cancer treatment. In this study, the authors demonstrate that overexpressing CDKN1A/p21 in engineered macrophages reduces leukemia tumor burden and extends survival in mouse models of T-ALL.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Marie-Berengere Troadec, Francoise Porteu, Marie -Laure Arcangeli, Adlen Foudi, Dominique Bluteau, Paulo De Sepulveda, Christel Guillouf, Nathalie M. Mazure, Fabienne Meggetto, Philippe Brunet De La Grange, Cyril Broccardo
Summary: This article summarizes the presentations from the 2021 scientific meeting of the Club Hematopoiesis and Oncogenesis. The meeting focused on hematopoiesis and oncogenic mechanisms, covering topics such as expansion of hematopoietic stem cells, the role of stem cell niches, the intersection of hematology and immunology, the importance of metabolism in hematopoiesis, solid tumors and oncogenesis, the noncoding genome, inflammation in monocyte differentiation and leukemia, as well as recent advances in myeloid malignancies, lymphoid leukemia, and lymphoma.
BULLETIN DU CANCER
(2023)
Article
Chemistry, Physical
Karen Dos Santos, Gildas Bertho, Cedric Caradeuc, Veronique Baud, Aurelie Montagne, Daniel Abergel, Nicolas Giraud, Mathieu Baudin
Summary: Researchers used a new technique to study the metabolic changes of glutamine in cancer cells. They used [5-C-13] glutamine and [1,4-C-13] asparagine as molecular probes, studied the actions of several enzymes, and explored the use of hyperpolarized substrates to probe metabolic pathways. They also proposed a highly concentrated sample formulation for fast imaging applications.
Article
Biology
Maria Eugenia Marques Da Costa, Sakina Zaidi, Jean-Yves Scoazec, Robin Droit, Wan Ching Lim, Antonin Marchais, Jerome Salmon, Sarah Cherkaoui, Raphael J. Morscher, Anouchka Laurent, Sebastien Malinge, Thomas Mercher, Severine Tabone-Eglinger, Isabelle Goddard, Francoise Pflumio, Julien Calvo, Francoise Redini, Natacha Entz-Werle, Aroa Soriano, Alberto Villanueva, Stefano Cairo, Pascal Chastagner, Massimo Moro, Cormac Owens, Michela Casanova, Raquel Hladun-Alvaro, Pablo Berlanga, Estelle Daudigeos-Dubus, Philippe Dessen, Laurence Zitvogel, Ludovic Lacroix, Gaelle Pierron, Olivier Delattre, Gudrun Schleiermacher, Didier Surdez, Birgit Geoerger
Summary: This study developed patient-derived-xenograft (PDX) models for pediatric patients with recurrent and refractory cancers, providing essential support for research and treatment development in advanced pediatric malignancies.
COMMUNICATIONS BIOLOGY
(2023)
