A tale of two CLCs: biophysical insights toward understanding ClC-5 and ClC-7 function in endosomes and lysosomes

Lysosomal Physiology

(2015) Haoxing Xu et al.   Annual Review of Physiology

ClC-5: Physiological role and biophysical mechanisms

(2015) Michael Pusch et al.   CELL CALCIUM

13C NMR detects conformational change in the 100-kD membrane transporter ClC-ec1

(2015) Sherwin J. Abraham et al.   JOURNAL OF BIOMOLECULAR NMR

Multiple Discrete Transitions Underlie Voltage-Dependent Activation in CLC Cl−/H+ Antiporters

(2014) Matthias Grieschat et al.   BIOPHYSICAL JOURNAL

Transport activity and presence of ClC-7/Ostm1 complex account for different cellular functions

(2014) S. Weinert et al.   EMBO REPORTS

Conformational changes required for H+/Cl− exchange mediated by a CLC transporter

(2014) Daniel Basilio et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ClC-3 Is an Intracellular Chloride/Proton Exchanger with Large Voltage-Dependent Nonlinear Capacitance

(2013) Raul E. Guzman et al.   ACS Chemical Neuroscience

Common Gating of Both CLC Transporter Subunits Underlies Voltage-dependent Activation of the 2Cl−/1H+Exchanger ClC-7/Ostm1

(2013) Carmen F. Ludwig et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A single point mutation reveals gating of the human ClC-5 Cl−/H+antiporter

(2013) Silvia De Stefano et al.   JOURNAL OF PHYSIOLOGY-LONDON

Water access points and hydration pathways in CLC H+/Cl−transporters

(2013) Wei Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Receptor-mediated endocytosis and endosomal acidification is impaired in proximal tubule epithelial cells of Dent disease patients

(2013) C. M. Gorvin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chloride in Vesicular Trafficking and Function

(2012) Tobias Stauber et al.   Annual Review of Physiology

Surprises from an Unusual CLC Homolog

(2012) Sabrina Phillips et al.   BIOPHYSICAL JOURNAL

On the Mechanism of Gating Charge Movement of ClC-5, a Human Cl−/H+ Antiporter

(2012) Giovanni Zifarelli et al.   BIOPHYSICAL JOURNAL

Glutamate 268 Regulates Transport Probability of the Anion/Proton Exchanger ClC-5

(2012) Matthias Grieschat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular mechanism of proton transport in CLC Cl-/H+ exchange transporters

(2012) L. Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fluoride resistance and transport by riboswitch-controlled CLC antiporters

(2012) R. B. Stockbridge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The CLC-5 2Cl−/H+ exchange transporter in endosomal function and Dent's disease

(2012) Jonathan D. Lippiat et al.   Frontiers in Physiology

Lysosomal Acidification Mechanisms

(2011) Joseph A. Mindell   Annual Review of Physiology

ClC-7 is a slowly voltage-gated 2Cl−/1H+-exchanger and requires Ostm1 for transport activity

(2011) Lilia Leisle et al.   EMBO JOURNAL

Extracellular Determinants of Anion Discrimination of the Cl−/H+Antiporter Protein CLC-5

(2011) Silvia De Stefano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of a Slow CLC Cl−/H+Antiporter from a Cyanobacterium

(2010) Hariharan Jayaram et al.   BIOCHEMISTRY

CLC channels and transporters: Proteins with borderline personalities

(2010) Alessio Accardi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Voltage-dependent charge movement associated with activation of the CLC-5 2Cl−/1H+ exchanger

(2010) Andrew J. Smith et al.   FASEB JOURNAL

Sorting Motifs of the Endosomal/Lysosomal CLC Chloride Transporters

(2010) Tobias Stauber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Late Endosomal ClC-6 Mediates Proton/Chloride Countertransport in Heterologous Plasma Membrane Expression

(2010) Ioana Neagoe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A cation counterflux supports lysosomal acidification

(2010) Benjamin E. Steinberg et al.   JOURNAL OF CELL BIOLOGY

Direct endosomal acidification by the outwardly rectifying CLC-5 Cl−/H+exchanger

(2010) Andrew J. Smith et al.   JOURNAL OF PHYSIOLOGY-LONDON

The proline 160 in the selectivity filter of the Arabidopsis NO3−/H+ exchanger AtCLCa is essential for nitrate accumulation in planta

(2010) Stefanie Wege et al.   PLANT JOURNAL

Lysosomal Pathology and Osteopetrosis upon Loss of H+-Driven Lysosomal Cl- Accumulation

(2010) S. Weinert et al.   SCIENCE

Structure of a Eukaryotic CLC Transporter Defines an Intermediate State in the Transport Cycle

(2010) Liang Feng et al.   SCIENCE

Endosomal Chloride-Proton Exchange Rather Than Chloride Conductance Is Crucial for Renal Endocytosis

(2010) G. Novarino et al.   SCIENCE

Proton Transport Pathway in the ClC Cl−/H+ Antiporter

(2009) Dong Wang et al.   BIOPHYSICAL JOURNAL

Substrate-driven conformational changes in ClC-ec1 observed by fluorine NMR

(2009) Shelley M Elvington et al.   EMBO JOURNAL

Conversion of the 2 Cl−/1 H+ antiporter ClC-5 in a NO3−/H+ antiporter by a single point mutation

(2009) Giovanni Zifarelli et al.   EMBO JOURNAL

Intracellular regulation of human ClC-5 by adenine nucleotides

(2009) Giovanni Zifarelli et al.   EMBO REPORTS

Residues Important for Nitrate/Proton Coupling in Plant and Mammalian CLC Transporters

(2009) Eun-Yeong Bergsdorf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Channel-like slippage modes in the human anion/proton exchanger ClC-4

(2009) Alexi K. Alekov et al.   JOURNAL OF GENERAL PHYSIOLOGY

Intracellular Proton-Transfer Mutants in a CLC Cl−/H+Exchanger

(2009) Hyun-Ho Lim et al.   JOURNAL OF GENERAL PHYSIOLOGY

Basis of substrate binding and conservation of selectivity in the CLC family of channels and transporters

(2009) Alessandra Picollo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Intracellular Proton Regulation of ClC-0

(2008) Giovanni Zifarelli et al.   JOURNAL OF GENERAL PHYSIOLOGY

The Cl-/H+ antiporter ClC-7 is the primary chloride permeation pathway in lysosomes

(2008) Austin R. Graves et al.   NATURE

The ClC-0 chloride channel is a 'broken' Cl−/H+ antiporter

(2008) Jiří Lísal et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ion permeation through a Cl--selective channel designed from a CLC Cl-/H+ exchanger

(2008) H. Jayaram et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA