Increased mitochondrial emission of reactive oxygen species and calpain activation are required for doxorubicin-induced cardiac and skeletal muscle myopathy

Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation

(2014) Yoshihiko Ichikawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting mitochondrial cardiolipin and the cytochromec/cardiolipin complex to promote electron transport and optimize mitochondrial ATP synthesis

(2013) A V Birk et al.   BRITISH JOURNAL OF PHARMACOLOGY

The anticancer agent doxorubicin disrupts mitochondrial energy metabolism and redox balance in skeletal muscle

(2013) Laura A.A. Gilliam et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Mitochondrial-Targeted Compound SS-31 Re-Energizes Ischemic Mitochondria by Interacting with Cardiolipin

(2013) A. V. Birk et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Doxorubicin-Induced Cardiotoxicity: From Bioenergetic Failure and Cell Death to Cardiomyopathy

(2013) Filipa S. Carvalho et al.   MEDICINAL RESEARCH REVIEWS

Mitochondrial signaling contributes to disuse muscle atrophy

(2012) Scott K. Powers et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Cross-talk between the calpain and caspase-3 proteolytic systems in the diaphragm during prolonged mechanical ventilation

(2012) W. Bradley Nelson et al.   CRITICAL CARE MEDICINE

Oxidative stress and disuse muscle atrophy

(2012) Scott K. Powers et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Tissue retention of doxorubicin and its effects on cardiac, smooth, and skeletal muscle function

(2012) Reid Hayward et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Mechanistic Links Between Oxidative Stress and Disuse Muscle Atrophy

(2011) Scott K. Powers et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondria-targeted antioxidants protect against mechanical ventilation-induced diaphragm weakness*

(2011) Scott K. Powers et al.   CRITICAL CARE MEDICINE

Calpain-mediated dystrophin disruption may be a potential structural culprit behind chronic doxorubicin-induced cardiomyopathy

(2011) Erica C. Campos et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Role of various proteases in cardiac remodeling and progression of heart failure

(2011) Alison L. Müller et al.   HEART FAILURE REVIEWS

Exercise protects against doxorubicin-induced oxidative stress and proteolysis in skeletal muscle

(2011) Ashley J. Smuder et al.   JOURNAL OF APPLIED PHYSIOLOGY

Mitochondrial-targeted antioxidants protect skeletal muscle against immobilization-induced muscle atrophy

(2011) Kisuk Min et al.   JOURNAL OF APPLIED PHYSIOLOGY

Short-term exercise training protects against doxorubicin-induced cardiac mitochondrial damage independent of HSP72

(2010) Andreas N. Kavazis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Oxidation enhances myofibrillar protein degradation via calpain and caspase-3

(2010) Ashley J. Smuder et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress is required for mechanical ventilation-induced protease activation in the diaphragm

(2010) Melissa A. Whidden et al.   JOURNAL OF APPLIED PHYSIOLOGY

Doxorubicin induces mitochondrial permeability transition and contractile dysfunction in the human myocardium

(2010) David Montaigne et al.   MITOCHONDRION

Doxorubicin causes diaphragm weakness in murine models of cancer chemotherapy

(2010) Laura A.A. Gilliam et al.   MUSCLE & NERVE

Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 5. SkQ1 prolongs lifespan and prevents development of traits of senescence

(2009) V. N. Anisimov et al.   BIOCHEMISTRY-MOSCOW

Doxorubicin Inactivates Myocardial Cytochrome c Oxidase in Rats: Cardioprotection by Mito-Q

(2009) Karunakaran Chandran et al.   BIOPHYSICAL JOURNAL

Direct effects of doxorubicin on skeletal muscle contribute to fatigue

(2009) K van Norren et al.   BRITISH JOURNAL OF CANCER

Endurance exercise training preserves cardiac function in rats receiving doxorubicin and the HER-2 inhibitor GW2974

(2009) Karen Y. Wonders et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Doxorubicin acts through tumor necrosis factor receptor subtype 1 to cause dysfunction of murine skeletal muscle

(2009) Laura A. A. Gilliam et al.   JOURNAL OF APPLIED PHYSIOLOGY

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

(2009) Ethan J. Anderson et al.   JOURNAL OF CLINICAL INVESTIGATION

Atrogin-1 ubiquitin ligase is upregulated by doxorubicin via p38-MAP kinase in cardiac myocytes

(2008) Yasuhiro Yamamoto et al.   CARDIOVASCULAR RESEARCH

Free radicals and muscle fatigue: Of ROS, canaries, and the IOC

(2007) Michael B. Reid   FREE RADICAL BIOLOGY AND MEDICINE