Letter
Oncology
Tim Batchelor, Jurjees Hasan, Fergus Macbeth, Michael Shackcloth, Tom Treasure
Summary: Pulmonary metastasectomy for sarcoma lacks proven benefits, and should be questioned in light of a randomized controlled trial in colorectal cancer patients.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Severin Schmid, Heiko Becker, Ralph Fritsch, Johannes Bausch, Natalie Hunter, Carolin Jenkner, Mohamed Hassan, Bernward Passlick
Summary: This multicentre prospective randomised controlled trial aims to investigate the effects of pulmonary metastasectomy in patients with resectable pulmonary metastases from colorectal carcinoma. The study aims to demonstrate a difference in overall survival, as well as explore other endpoints such as quality of life and impact of mutational status. Designing well-powered trials in metastasised colorectal cancer has been challenging due to the heterogeneity and complexity of the disease and treatment trajectories.
FRONTIERS IN ONCOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Norman R. Williams, Hannah Patrick, Francesca Fiorentino, Alexander Allen, Manuj Sharma, Misel Milosevic, Fergus Macbeth, Tom Treasure
Summary: The objective of this review was to assess the nature and tone of the published responses to the Pulmonary Metastasectomy in Colorectal Cancer (PulMiCC) randomized controlled trial. The study found that most of the citations did not adequately represent the PulMiCC data and the overall textual tone was dismissive. Despite the trial being underpowered, there was an acceptance that the 5-year survival rate was higher than widely assumed.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Gastroenterology & Hepatology
Hayley M. Fenton, Paul J. Finan, Richard Milton, Michael Shackcloth, John C. Taylor, Tom Treasure, Eva J. A. Morris
Summary: The study revealed significant variation in the rates of pulmonary metastasectomy for colorectal cancer across the English NHS and a 5-year survival rate of 50.8% following the surgery.
COLORECTAL DISEASE
(2021)
Article
Oncology
Martijn van Dorp, Constantia Trimbos, Wilhelmina H. Schreurs, Chris Dickhoff, David J. Heineman, Bart Torensma, Geert Kazemier, Frank J. C. van den Broek, Ben J. Slotman, Max Dahele
Summary: In this retrospective cohort study, pulmonary metastasectomy and SABR showed comparable overall survival, local recurrence-free survival, and complication rates in patients with colorectal pulmonary metastases, despite significantly lower progression-free survival and local control rates in the SABR group.
Article
Oncology
Ju Sik Yun, Eunchong Kim, Kook Joo Na, Sang Yun Song, In Seok Jeong, Sang Gi Oh
Summary: This study confirms the effectiveness of thoracoscopic metastasectomy for colorectal cancer (CRC) and identifies several prognostic factors such as age, pathological stage, preoperative carcinoembryonic antigen level. Older age and prior extrathoracic metastasis are independent poor prognostic factors. Overall, VATS for pulmonary metastasectomy for CRC can be performed safely with comparable long-term survival rates to other studies.
Article
Cardiac & Cardiovascular Systems
Erin M. Corsini, Kyle G. Mitchell, Arlene Correa, Van K. Morris, Mara B. Antonoff
Summary: Colorectal cancer location may affect survival after pulmonary metastasectomy, with patients with left-sided tumors experiencing a survival benefit. Additional research is needed to confirm these findings and assess the impact of tumor location on prognosis in patients eligible for pulmonary metastasectomy.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Oncology
Gustavo C. L. Gossling, Marcio F. Chedid, Fernando S. Pereira, Rafaela K. da Silva, Leonardo B. Andrade, Nicolas Peruzzo, Mauricio G. Saueressig, Gilberto Schwartsmann, Aparna R. Parikh
Summary: This study aimed to identify clinicopathological and molecular features associated with progression-free survival (PFS) and overall survival (OS) after pulmonary metastasectomy for metastatic colorectal cancer. The findings suggest that disease-free interval, synchronous presentation, and number and size of lesions are significant prognostic factors for OS, while presenting with more than one lesion is predictive for PFS but not for OS.
Article
Public, Environmental & Occupational Health
Mette Bach Larsen, Mette Hedelund, Louisa Flander, Berit Andersen
Summary: This study aimed to test whether combining the standard invitation procedure with a pre-notification and/or an extra reminder can increase participation in colorectal cancer (CRC) screening. The results showed that the four-staged invitation procedure was the most effective, especially for the youngest age group.
PREVENTIVE MEDICINE
(2022)
Article
Respiratory System
Kensuke Kataoka, Osamu Nishiyama, Takashi Ogura, Yoshihiro Mori, Ryo Kozu, Shinichi Arizono, Tohru Tsuda, Hiromi Tomioka, Keisuke Tomii, Koji Sakamoto, Hiroshi Ishimoto, Michiko Kagajo, Hiroyuki Ito, Kazuya Ichikado, Hajime Sasano, Seiichirou Eda, Machiko Arita, Yasuhiro Goto, Osamu Hataji, Satoshi Fuke, Ryota Shintani, Hirotsugu Hasegawa, Masahiko Ando, Tomoya Ogawa, Masashi Shiraishi, Fumiko Watanabe, Koichi Nishimura, Takuma Sasaki, Shinjiro Miyazaki, Hideo Saka, Yasuhiro Kondoh
Summary: This open-label randomized controlled trial investigated the effects of long-term pulmonary rehabilitation on exercise tolerance in patients with IPF. The results showed that pulmonary rehabilitation significantly improved endurance time, but did not have a significant effect on 6-minute walking distance.
Article
Oncology
Woo Sik Yu, Mi Kyung Bae, Jung Kyu Choi, Young Ki Hong, In Kyu Park
Summary: The study aimed to investigate the prognostic factors for overall survival in patients who had undergone pulmonary metastasectomy for colorectal cancer. It found that pulmonary metastasectomy provided long-term survival for patients, with female sex, distally located colorectal cancer, and high-volume hospital centers being positive prognostic factors for survival.
CANCER RESEARCH AND TREATMENT
(2021)
Article
Primary Health Care
Jon D. Emery, Mark A. Jenkins, Sibel Saya, Patty Chondros, Jasmeen Oberoi, Shakira Milton, Kitty Novy, Emily Habgood, Napin Karnchanachari, Marie Pirotta, Lyndal Trevena, Adrian Bickerstaffe, Richard De Abreu Lourenco, Anna Crothers, Driss Ait Ouakrim, Louisa Flander, James G. Dowty, Fiona M. Walter, Malcolm Clark, Sally Doncovio, Dariush Etemadmoghadam, George Fishman, Finlay Macrae, Ingrid Winship, Jennifer G. McIntosh
Summary: Using a risk assessment and decision support tool can increase the rate of risk-appropriate colorectal cancer screening. It is important to start screening for colorectal cancer at the appropriate age and choose the most cost-effective testing method.
BRITISH JOURNAL OF GENERAL PRACTICE
(2023)
Article
Respiratory System
Irina R. Strambu, Christian A. Seemayer, Liesbeth M-C. A. Fagard, Paul A. Ford, Tom A. K. Van der Aa, Angela A. de Haas-Amatsaleh, Vikas Modgill, Eva Santermans, Eric N. Sondag, Eric G. Helmer, Toby M. Maher, Ulrich Costabel, Vincent Cottin
Summary: This study assessed the efficacy, safety, and tolerability of GLPG1205 for the treatment of idiopathic pulmonary fibrosis (IPF). The results showed that GLPG1205 did not have a significant difference in the decline of lung function compared to placebo, but it had a poorer safety and tolerability profile.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Review
Oncology
Junfeng Huang, Qing Zang, Yaokai Wen, Zhe Pan, Zhiyuan Yao, Mingkai Huang, Jiongqiang Huang, Jingsong Chen, Rongchang Wang
Summary: This study found that KRAS mutation is associated with worse overall survival and recurrence free survival in colorectal cancer patients undergoing pulmonary metastasectomy, along with 18 other factors showing significant effects. This supports the use of a comprehensive model including clinicopathological and biological factors for optimal patient selection and prognosis in surgical treatment.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Oncology
Martijn van Dorp, Semih uenal, Simone Gooijer, Chris Dickhoff, Frank Jozef Christiaan van den Broek, Geert Kazemier, Wilhelmina Hendrika Schreurs, Famke Lorelei Schneiders, Max Dahele, David Jonathan Heineman
Summary: This study describes the experience with salvage surgery in 17 patients who had local recurrence of colorectal pulmonary metastases following stereotactic ablative radiotherapy (SABR). The results show that salvage resection is a feasible option with acceptable morbidity and good oncological outcome in a highly selected cohort.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Health Care Sciences & Services
Ryan Palmer, Martin Utley, Naomi J. Fulop, Stephen O'Connor
HEALTH INFORMATICS JOURNAL
(2020)
Article
Operations Research & Management Science
Ryan Palmer, Martin Utley
ANNALS OF OPERATIONS RESEARCH
(2020)
Review
Management
Luca Grieco, Martin Utley, Sonya Crowe
Summary: Efficient deployment of resources in home-based care is crucial for sustainable health and social care systems globally. This study aimed to identify operational research approaches to support decision-making in home health care, highlighting a lack of guidance and coherence in the literature for effective decisions. Insights from other areas of application may provide direction for future research to address this shortfall.
JOURNAL OF THE OPERATIONAL RESEARCH SOCIETY
(2021)
Editorial Material
Mathematical & Computational Biology
Vern Farewell, Tony Johnson
STATISTICS IN MEDICINE
(2021)
Article
Management
Sonya Crowe, Martin Utley
Summary: Operational researchers in healthcare face challenges related to flexibility, team maturity, organizational motivations, intuition, altruism, and creative risk-taking, all of which can impact the success of their work. Understanding these behavioral factors is crucial for achieving effective operational research outcomes in the field of healthcare.
JOURNAL OF THE OPERATIONAL RESEARCH SOCIETY
(2022)
Article
Oncology
L. J. Fallowfield, D. Farewell, H. Jones, S. L. May, S. L. Catt, R. L. Starkings, V. L. Jenkins
Summary: Comparing knowledge levels of gene expression profiling (GEP) tests and recurrence risks after reading an information leaflet versus watching an information film, it was found that watching the film improved knowledge and was preferred by participants.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
Lesley Fallowfield, Ivonne Solis-Trapala, Rachel Starkings, Shirley May, Lucy Matthews, Diana Eccles, D. Gareth Evans, Clare Turnbull, Gillian Crawford, Valerie Jenkins
Summary: This study developed and evaluated an educational workshop called TRUSTING, which aimed to improve healthcare professionals' ability to discuss the risks and uncertainties of genetic testing. The workshop significantly improved participants' knowledge, communication skills, and self-confidence.
BRITISH JOURNAL OF CANCER
(2022)
Article
Management
Sonya Crowe, Luca Grieco, Tom Monks, Brad Keogh, Marion Penn, Mike Clancy, Samer Elkhodair, Cecilia Vindrola-Padros, Naomi J. Fulop, Martin Utley
Summary: Hospital emergency department overcrowding is a global issue. Most previous studies focus on bespoke models for improvement but ignore the organizational context and have limited impact. This study introduces a configurable approach that combines quantitative modeling, qualitative analysis, and assessment of the implementation context, which successfully informed strategy in one hospital and had mixed results in three other hospitals.
JOURNAL OF THE OPERATIONAL RESEARCH SOCIETY
(2023)
Biographical-Item
Mathematical & Computational Biology
Vern Farewell
STATISTICS IN MEDICINE
(2023)
Article
Health Policy & Services
Meetali Kakad, Martin Utley, Fredrik A. A. Dahl
Summary: Finding alternatives to acute hospital admission is a priority, and Norway's decentralised municipal acute units (MAUs) were established to divert low-acuity patients away from hospitals. However, MAUs have faced criticism for low occupancy and not relieving pressures on hospitals. Through a simulation model, we found that merging MAUs alone may not substantially increase mean occupancy, but it offers potential for bed capacity reduction without affecting service provision. Our work has relevance for other admissions avoidance units and provides a method for estimating unconstrained demand for beds in absence of historical data.
Article
Medicine, Research & Experimental
Sally Wheelwright, Lucy Matthews, Valerie Jenkins, Shirley May, Daniel Rea, Pat Fairbrother, Claire Gaunt, Jennie Young, Sarah Pirrie, Matthew G. Wallis, Lesley Fallowfield
Summary: Recruitment to the LORIS study was challenging despite strategies aimed at both patients and site staff. The most common reasons for accepting randomisation were altruism and belief in the trial's efficacy, while concerns about randomisation and external influences were the most frequent reasons for declining. Communication workshops improved site staff knowledge and confidence, but only half said they would participate in the study themselves.
Article
Oncology
James Dilley, Aleksandra Gentry-Maharaj, Andy Ryan, Matthew Burnell, Ranjit Manchanda, Jatinderpal Kalsi, Naveena Singh, Robert Woolas, Aarti Sharma, Karin Williamson, Tim Mould, Lesley Fallowfield, Stuart Campbell, Steven J. Skates, Alistair McGuire, Mahesh Parmar, Ian Jacobs, Usha Menon
Summary: This study aims to compare symptoms in pre-clinical and clinically diagnosed early-stage cancers. The results suggest that early symptoms of early-stage cancer may be related to gastrointestinal issues and systemic fatigue, indicating the need to reconsider alert symptoms for early ovarian cancer.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
Usha Menon, Aleksandra Gentry-Maharaj, Matthew Burnell, Andy Ryan, Naveena Singh, Ranjit Manchanda, Jatinderpal K. Kalsi, Robert Woolas, Rupali Arora, Laura Casey, Anne Dawnay, Aarti Sharma, Karin Williamson, Sophia Apostolidou, Lesley Fallowfield, Alistair J. Mcguire, Stuart Campbell, Steven J. Skates, Ian J. Jacobs, Mahesh K. B. Parmar
Summary: This article presents the results of the UKCTOCS study, which found that screening can detect high-grade serous cancer at earlier stages and potentially improve short-term treatment outcomes. However, the potential survival benefit for patients with high-grade serous cancer was small, likely due to limited gains in early detection and treatment improvement, as well as tumor biology.
Article
Health Policy & Services
Luca Grieco, Mariya Melnychuk, Angus Ramsay, Abigail Baim-Lance, Simon Turner, Andrew Wilshere, Naomi Fulop, Steve Morris, Martin Utley
Summary: Large-scale immunisation programmes against seasonal influenza face logistical challenges in vaccinating large cohorts of people in a short amount of time. This study in England focused on child vaccination in schools, analyzing staffing and workflow aspects to document processes and analyze times and costs associated with different models. Data collection and statistical analysis helped identify factors influencing vaccine delivery time and informed the development of a simulation tool for vaccination sessions.
Article
Multidisciplinary Sciences
Jasmina Panovska-Griffiths, Luca Grieco, Edwin van Leeuwen, Peter Grove, Martin Utley
Article
Oncology
Yuchao Liu, Zijia Liu, Liangyan Zhang, Yuelun Zhang, Ningchen Zhang, Yue Han, Le Shen
Summary: This study found an association between preoperative 6-min walk distance and postoperative complications in patients undergoing laparoscopic gastrointestinal cancer surgery.
Review
Oncology
Matteo Pavone, Rosa Autorino, Nicolo Bizzarri, Giuditta Chilorio, Vincenzo Valentini, Giacomo Corrado, Gabriella Ferrandina, Gabriella Macchia, Maria Antonietta Gambacorta, Giovanni Scambia, Denis Querleu
Summary: Ovarian transposition is an established method for protecting the ovaries from radiation, while surgical procedures for protecting the uterus are still under investigation. This study conducted a systematic review of uterine displacement techniques and performed dose simulation to assess the radiation dose received by the uterus. The results showed that the transposition approach was the most protective.
Article
Oncology
Silvia Ministrini, Maria Bencivenga, Federica Filippini, Gianni Mura, Carlo Milandri, Maria Antonietta Mazzei, Giulio Bagnacci, Mattia Berselli, Manlio Monti, Paolo Morgagni, Leonardo Solaini, Daniele Marrelli, Stefania Piccioni, Stefano De Pascale, Luigina Graziosi, Rossella Reddavid, Fausto Rosa, Claudio Belluco, Guido Tiberio
Summary: The Italian Research Group for Gastric Cancer developed a prospective database to evaluate the impact of a pragmatic attitude on the management of stage IV gastric cancer patients. The study found that different metastatic sites did not affect survival rates, but multiple metastatic sites were associated with worse survival. Patients who could undergo curative resection had better survival rates. A more accurate diagnostic workup and staging had a favorable impact on survival.
Article
Oncology
Luca Lambertini, Fabrizio Di Maida, Anna Cadenar, Samuele Nardoni, Antonio Andrea Grosso, Francesca Valastro, Pietro Spinelli, Riccardo Fantechi, Agostino Tuccio, Gianni Vittori, Andrea Mari, Lorenzo Masieri, Andrea Minervini
Summary: The aim of this study was to evaluate the functional outcomes of Florence intracorporeal neobladder (FloRIN) configuration technique performed with a stentless procedure. The results showed that the stentless procedure was associated with shorter console time and lower estimated blood loss compared to the stent group. There were no significant differences in terms of perioperative features and mid-term functional outcomes between the two groups.
Article
Oncology
Geun-Jeon Kim, Jooin Bang, Hyun-Il Shin, Sang-Yeon Kim, Dong -Il Sun
Summary: This study evaluated the outcome of tonsillar cancer managed with neoadjuvant chemotherapy followed by surgery. The results showed that neoadjuvant chemotherapy reduced tumor volume and pathological adverse features, significantly decreasing the need for adjuvant therapy. A greater reduction in tumor volume predicted a complete pathologic response. There was no significant difference in survival rates between the groups.
Article
Oncology
Alexandra Nassar, Stylianos Tzedakis, Ugo Marchese, Gaanan Naveendran, Remy Sindayigaya, Martin Gaillard, Francois Cauchy, Mickael Lesurtel, Brice Gayet, Olivier Soubrane, David Fuks
Summary: This study identified recurrence between the two stages and a larger tumor size in the future liver remnant as critical factors contributing to the failure of two-stage hepatectomy for bilobar colorectal liver metastases. These findings have important clinical implications for the selection and evaluation of TSH surgery.
Letter
Oncology
Michele Fiore, Gian Marco Petrianni, Gabriele D'Ercole, Pasquale Trecca, Sara Ramella
Review
Oncology
Harry Farrow, Oliver J. Pickering, James A. Gossage, Philip H. Pucher
Summary: The inclusion or exclusion of the thoracic duct in radical esophagectomy for esophageal cancer is a controversial issue. While removing the thoracic duct may increase lymph node yield, it may also lead to higher morbidity without any survival benefit.
Article
Oncology
Xiaokun Li, Siyuan Luan, Chi Zhang, Weili Kong, Xin Xiao, Haowen Zhang, Jianfeng Zhou, Yushang Yang, Yang Xu, Yong Qiang, Pinhao Fang, Yi Shen, Yong Yuan
Summary: This study proposes a new staging system based on ypTNM stage and cN status for early stage ESCC patients after nCRT. The new ypTNM-cN staging system demonstrates superior predictive ability and classification efficacy compared to the AJCC 8th ypTNM staging system. It provides new insights for accurately stratifying ypI stage ESCC patients.
