Article
Food Science & Technology
Yue Leng, Li Ren, Shu Niu, Tiehua Zhang, Jie Zhang
Summary: The metabolites of plasticizers did not show direct effects on the glucocorticoid receptor, but they could synergistically activate the receptor in combination with dexamethasone. The study found that monobutyl phthalate (MBP) in combination with dexamethasone enhanced the expression of specific genes and proteins regulated by the glucocorticoid receptor. The interactions between MBP and the glucocorticoid receptor were influenced by the chemical properties of MBP, with hydrophobic and hydrogen bonding interactions playing crucial roles in stabilizing the complex.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Environmental Sciences
Liru Liu, Jingjing Miao, Peipei Liu, Anran Zhao, Linlin Yao, Luqing Pan
Summary: Endocrine disrupting chemicals (EDCs) in estuaries and coastal habitats have caused global concern. Bivalves were thought to be less sensitive to these substances compared to vertebrates, but a computational simulation revealed the weak activation ability of bivalve estrogen receptors (ERs) in response to steroids and EDCs. The presence of an active ER in bivalve molluscs was confirmed, providing a promising tool for screening marine environmental pollutants and understanding underlying mechanisms.
ENVIRONMENTAL POLLUTION
(2023)
Article
Toxicology
Marcella Tapias Passoni, Gabriele Palu, Nicole Grechi, Bruna Andreotti da Silva Amaral, Caroline Gomes, Claudia Ruelker, Bennard van Ravenzwaay, Anderson Joel Martino-Andrade
Summary: Through in vivo and in vitro studies, it was found that dipyrone and its metabolites do not exhibit estrogenic or antiestrogenic activity in rats and yeast cells.
TOXICOLOGY LETTERS
(2021)
Article
Environmental Sciences
Jin Tae Kim, Hong Jin Lee, Hee-Seok Lee
Summary: The study revealed that four organophosphorus pesticides may induce adipogenesis by interacting with the estrogen receptor, leading to lipid droplet accumulation and regulation of gene expression related to fat metabolism.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Joanna Stragierowicz, Sylwia Stypula-Trebas, Lidia Radko, Andrzej Posyniak, Marzenna Nasiadek, Michal Klimczak, Anna Kilanowicz
Summary: The study found that 1,2,3,5,6,7-hexachloronaphthalane (PCN67) exhibited antiestrogenic activity, while both 1,3,5,8-tetrachloronaphthalene (PCN43) and PCN67 showed strong antiandrogenic effects. Exposure to PCNs, along with other endocrine disrupting chemicals, may contribute to the deregulation of sex steroid hormone signaling.
Review
Endocrinology & Metabolism
Shi-Yu Qi, Xue-Ling Xu, Wen-Zhi Ma, Shou-Long Deng, Zheng-Xing Lian, Kun Yu
Summary: This article introduces the effects of organochlorine pollutants on women's lactation ability and infant health. It emphasizes the accumulation of organochlorine contaminants in breast milk fat and their transfer to infants through breastfeeding. Additionally, the article mentions the transmission of toxic substances from the mother to the fetus through the placenta, and provides measures for controlling organochlorine pollutants.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Fisheries
Makito Kobayashi, Mai Kijima, Yuiko Matsuzuka, Youichi Hayakawa, Eri Iwata, Takeji Kimura
Summary: This study clarified the long-term effects of environmental estrogen on male reproductive activity in goldfish, leading to some fish exhibiting active spawning behavior without producing milt. This could result in a substantial decrease in population size of wild fish.
Review
Biochemistry & Molecular Biology
Lea Clusan, Francois Ferriere, Gilles Flouriot, Farzad Pakdel
Summary: Breast cancer, the most common and deadliest cancer among women worldwide, is closely associated with estrogen signaling. Hormone therapy using antiestrogens is the standard treatment, but resistance inevitably occurs through various biological mechanisms. Understanding the estrogen pathway is crucial for the development of new therapies for hormone-dependent breast cancer. This mini-review summarizes the current literature on estrogen receptors in breast cancer, including their signalization, mechanisms of action, and clinical implications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Environmental
Helena Iuele, Alessio Bucciarelli, Nicholas Ling
Summary: This study investigates the presence of selected estrogenic compounds during the treatment processes of drinkable water and wastewater in Hamilton, New Zealand. The results indicate that the primary treatments used in the plants are not effective in removing estrogens and bisphenolic plastics, leading to a deterioration in water quality.
Article
Public, Environmental & Occupational Health
Vicente Mustieles, Juan-Pedro Arrebola, Miquel Porta
Summary: Citizens should have access to regulatory changes and policies that prioritize the needs of humans, the climate, and nature. We draw on past experiences of preventable human suffering and economic losses caused by delayed regulation of both old and new pollutants. It is crucial for health professionals, the media, and citizens' organizations to increase awareness of environmental health issues. Improving the translation of research into clinical practices and policies is necessary to reduce the burden of diseases caused by exposure to environmental chemicals. There are valuable lessons to be learned from previous science-to-policy processes and current trends in regulating pollutants.
PREVENTIVE MEDICINE
(2023)
Article
Environmental Sciences
Mark Stanojevic, Marija Sollner Dolenc, Marjan Vracko
Summary: Endocrine-disrupting chemicals (EDCs) are exogenous substances that interfere with the normal function of the human endocrine system. These chemicals can affect specific nuclear receptors, such as androgen receptors (ARs) or estrogen receptors (ERα and ERβ), which play a crucial role in regulating complex physiological processes in humans. It is now more crucial than ever to identify EDCs and reduce exposure to them.
Review
Endocrinology & Metabolism
Fernando Lizcano
Summary: Women are more susceptible to cardiovascular risks such as obesity and diabetes after menopause due to constitutional changes. Estrogens and androgens play a role in controlling fat distribution and regulating hunger and satiety. The absence of estrogen during menopause is the main factor contributing to cardiovascular alterations in women. The mechanisms by which estrogens regulate energy metabolism are not fully understood, but they involve specific receptors in the steroid receptor superfamily.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Handule Lee, Juyoung Park, Kwangsik Park
Summary: Unlike environmental pollutants, chemicals in consumer products may pose higher risks to human health depending on their usage and interaction. A recent study detected endocrine disrupting chemicals in various consumer products, suggesting a wide range of exposures. The study also found that predictions of mixture activity by appropriate models can support the risk assessment and regulation of these chemicals.
Review
Biochemistry & Molecular Biology
Lea Clusan, Pascale Le Goff, Gilles Flouriot, Farzad Pakdel
Summary: Breast cancer is the most common cancer among women worldwide. While most ER-positive breast cancer cases initially respond to antiestrogen therapies, a high percentage develop resistance over time. Research on mutated forms of ER alpha has led to potential developments in new antiestrogen treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pathology
Shi Wei
Summary: Breast cancer is the most common cancer affecting women, and estrogen receptor (ER) signaling plays a crucial role in its development. ER expression levels are strongly correlated with the therapeutic effects of endocrine therapies targeting ER. Controversies exist regarding the biology and prognostic power of progesterone receptor (PR) status, especially in uncommon subtypes of breast cancer.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Environmental Sciences
Neil J. Rowan, Niall Murray, Yuansong Qiao, E. O'Neill, Eoghan Clifford, Damia Barcelo, Deborah M. Power
Summary: This paper describes the digital transformation of paludiculture, highlighting the potential benefits and opportunities for improving efficiency and addressing climate change through the use of digital technologies. Digitization can reduce costs, increase productivity, and promote sustainability.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Multidisciplinary Sciences
Kuo He, Liulan Zhao, Zihao Yuan, Adelino Canario, Qiao Liu, Siyi Chen, Jiazhong Guo, Wei Luo, Haoxiao Yan, Dongmei Zhang, Lisen Li, Song Yang
Summary: A high-quality chromosome-level reference genome of the largemouth bass was obtained using advanced sequencing technologies, providing a fundamental resource for studying its adaptation to new environments, genetic breeding, and other research.
Article
Biology
Ying Lu, Wenhao Li, Yalin Li, Wanying Zhai, Xuming Zhou, Zhichao Wu, Shouwen Jiang, Taigang Liu, Huamin Wang, Ruiqin Hu, Yan Zhou, Jun Zou, Peng Hu, Guijun Guan, Qianghua Xu, Adelino V. M. Canario, Liangbiao Chen
Summary: By sequencing the genome of the icefish Chionodraco hamatus and analyzing genomic data from 52 individuals, researchers discovered that the formation of separate icefish populations and species divergence in Antarctica was driven by geographic separation and adaptation to local habitats, which are periodically influenced by glacial cycles. Specific genes involved in immune responses, cardiovascular development, and photoperception showed differential selection sweeps among populations, correlated with population-specific microbial communities and acquisition of distinct morphological features.
Article
Chemistry, Medicinal
Sandra Lage, Pedro Reis Costa, Adelino V. M. Canario, Jose P. Da Silva
Summary: This study used LC-HRMS to search for emerging PSTs in mussels contaminated after an intense Gymnodinium catenatum bloom in the Tagus estuary (Lisbon, Portugal). Five M-toxins were detected in the mussels' whole-soft body tissue, but no GC-toxins were found. The classical PSTs also comprised the largest fraction of the profile. The presence of unregulated PSTs in edible mussel samples suggests potential seafood safety risks, urging further research into these analogues and their toxicity.
Article
Chemistry, Applied
Sandra Lage, Ines I. Afonso, Pedro Reis Costa, Adelino V. M. Canario, Jose P. Da Silva
Summary: TTX and its analogues were found in the tissues of trumpet shell specimens purchased in a market in southern Portugal, suggesting the potential risk of consuming these edible gastropods. Regular monitoring of TTX and analogues in trumpet shell and other edible gastropods is recommended to prevent poisoning incidents.
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2023)
Article
Horticulture
Melina C. da Silva, Patricia I. S. Pinto, Rui Guerra, Amilcar Duarte, Deborah M. Power, Natalia T. Marques
Summary: This study investigated the transcriptome changes in Citrus macrophylla in response to drought stress and identified thousands of differentially expressed transcripts. The results showed that drought stress can induce the up- and down-regulation of various genes in the stem tissue of Citrus macrophylla, some of which may be associated with drought tolerance in this species.
SCIENTIA HORTICULTURAE
(2023)
Article
Genetics & Heredity
Yu-Qing Wang, Qi Liu, Yan Zhou, Lizhi Chen, Yue-Ming Yang, Xue Shi, Deborah M. Power, Yi-Feng Li
Summary: In this study, transcriptome analysis of different developmental stages of the mussel, Mytilus coruscus, was conducted to uncover the molecular mechanisms underlying larval settlement and metamorphosis. The results showed that highly upregulated differentially expressed genes at the pediveliger stage were enriched in immune-related genes. The findings suggest that the larvae utilize molecules of the immune system to sense and respond to external chemical cues and neuroendocrine signaling pathways. The upregulation of adhesive protein genes linked to byssal thread secretion indicates the anchoring capacity required for larval settlement arises prior to metamorphosis. The results of gene expression support the role of the immune and neuroendocrine systems in mussel metamorphosis and provide a foundation for future studies.
Article
Fisheries
Ana Patricia Mateus, Rita A. Costa, Bastien Sadoul, Marie-Laure Begout, Xavier Cousin, Adelino VM. Canario, Deborah M. Power
Summary: Fish skin is a versatile tissue influenced by epigenetic marks during embryonic development. This study examined the effects of egg incubation temperature on the regeneration of skin wounds in juvenile European sea bass. Results showed that fish from eggs incubated at higher temperatures immediately up-regulated the expression of pcna gene after skin damage, while fish from eggs incubated at lower temperatures up-regulated the expression of krt2 gene one day after damage. Regenerated epidermis was thinner in fish from eggs incubated at lower temperatures, with fewer goblet cells and melanomacrophages. Overall, thermal imprinting of eggs altered the damage-repair response in juvenile sea bass skin.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Chemistry, Medicinal
Sandra Lage, Felicitas ten Brink, Adelino V. M. Canario, Jose P. Da Silva
Summary: In a comprehensive project to understand emergent toxins in edible marine organisms, TTX analogues were detected in the soft tissues of European fiddler crabs and green crabs harvested in southern Portugal. No TTX was detected, but three TTX analogues were found. These results emphasize the need to monitor TTX and its analogues in edible marine species to protect consumers and provide information to the European Food Safety Authority.
Article
Plant Sciences
Susana A. Dandlen, Jose P. Da Silva, Maria Graca Miguel, Amilcar Duarte, Deborah M. Power, Natalia Tomas Marques
Summary: The susceptibility of Citrus macrophylla (CM) to the severe Citrus tristeza virus (CTV), T36, is higher than that of Citrus aurantium (CA). The impact of host-virus interactions on host physiology remains largely unknown. This study evaluated the metabolite profile and antioxidant activity in the phloem sap of healthy and infected CA and CM plants. The results showed that the antioxidant enzyme activity increased significantly in infected CM plants and decreased in infected CA plants. Furthermore, CTV infection resulted in a drastic reduction in secondary metabolites in CA but not in CM.
Article
Chemistry, Analytical
Renato Ferreira, Paulo A. Ribeiro, Adelino V. M. Canario, Maria Raposo
Summary: Prostate cancer is one of the most prevalent tumors in men, and early diagnosis is crucial. In this study, an electronic tongue prototype was developed for detecting prostate cancer.
Article
Fisheries
Carmen S. V. Sousa, Deborah M. Power, Pedro M. Guerreiro, Bruno Louro, Liangbiao Chen, Adelino V. M. Canario
Summary: The environmental conditions and isolation in the Antarctic have driven the evolution of a unique biodiversity. This study investigates the possible adaptation of the Notothenia coriiceps immune system to the cold environment and unique microbial community of the Southern Ocean. The findings suggest that the immune processes in N. coriiceps differ from other teleost fish.
Article
Multidisciplinary Sciences
Liliana Anjos, Joao Estevao, Carlos Infante, Lalia Mantecon, Deborah Mary Power
Summary: This article presents a method for protein extraction from microalgae using bead milling and centrifugation, resulting in high-quality protein extracts. The method is cost-effective, efficient, scalable for industrial applications, and compatible with other processes. In addition, the article proposes the use of stabilizing agents for protein solubility and fractionation of low molecular weight proteins to enhance the value of the end product.
