Article
Biochemistry & Molecular Biology
Hongwei Guo, Xianhu Liu, Lan Li, Yanping Chang, Wanqing Yao
Summary: The electronic absorption and vibrational spectra of deprotonated 5,10,15,20-tetrakis(p-hydroxyphenyl)porphyrin (THPP) were studied as a function of solvent polarity in various solvent mixtures. The absorption spectrum of deprotonated THPP showed an unusual solvatochromism, with a bathochromic shift followed by a hypsochromic shift with reduced solvent polarity. The shifts in spectrum could be explained by the cooperative effects of specific interactions (H-bonds) and nonspecific interactions, as well as the solvent polarity scale E-T(30).
Article
Engineering, Chemical
Ioana Baldea, Sorina Danescu, Flaviu Tabaran, Adriana Gabriela Filip, Rodica Mariana Ion, Diana Elena Olteanu, Alexandra Cristina Sevastre-Berghian, Roxana Maria Decea, Cristian Iacovita, Daniela Hanganu, Mihai Cenariu
Summary: The study investigated the anti-melanoma effects of photodynamic therapy (PDT) using meso-5,10,15,20-tetrakis-(4-hydroxyphenyl)-porphyrin (THPP) as a photosensitizer. Results showed that PDT efficiently induced cell death through apoptosis, necrosis, and the inhibition of pro-survival pathways mediated by NFkB, AP1, HIF1 alpha, and MITF in the melanoma coculture models.
Article
Chemistry, Multidisciplinary
Debdulal Sharma, Zeaul H. Mazumder, Devashish Sengupta, Avinaba Mukherjee, Mahuya Sengupta, Ranjan Kumar Das, Monjur Hassan Barbhuiya, Partha Palit, Tarun Jha
Summary: The cis-A(2)B(2) type porphyrin derivative, PN2(OH)(2) and PN2(OH)(2)Zn, synthesized by replacing tetra-p-hydroxyphenyl porphyrin, show more promising photosensitizing and photobiological activities in cancer photodynamic therapy. These derivatives upregulate ROS and downregulate SOD in the A549 cell line, while also exhibiting immunoprotective properties towards noncancerous cells through MPO inhibition and NO downregulation.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Physical
M. A. Gradova, O. V. Gradov, A. V. Bychkova, M. V. Motyakin, I. S. Ionova, A. V. Lobanov
Summary: The interactions between meso-tetra(4-hydroxyphenyl)porphyrin (THPP) and anionic sodium n-dodecyl sulfate (SDS) were studied at different concentrations, revealing the formation of J-type aggregates and changes in fluorescence and light scattering signals. Binding of THPP to SDS micelles and aggregate formation were observed using DLS and EPR spectroscopy. Microscopic observation showed rod-like morphology of microparticles crystallized from dried suspensions of THPP J-aggregates.
Article
Chemistry, Multidisciplinary
Xuejiao Yang, Yuhe Shen, Jiayu Liu, Yuefei Wang, Wei Qi, Rongxin Su, Zhimin He
Summary: By adjusting pH, constituent amino acids, and temperature, the chiral self-assembly behavior of meso-tetrakis (4-carboxyphenyl) porphyrin-amino acid molecules can be precisely controlled, leading to chiral nanostructures with precisely tailored helical pitch and handedness, which provides a certain reference for the design and preparation of chiral nanomaterials and has potential application prospects.
Article
Spectroscopy
Gustavo G. Parra, Daniel S. Correa, Eli Silveira-Alves Jr, Luciane M. Almeida, Marcio A. R. Souza, Leonardo De Boni, Lino Misoguti, Cleber R. Mendonca, Sergio C. Zilio, Newton M. Barbosa Neto, Iouri E. Borissevitch, Pablo J. Goncalves
Summary: The study found that the aggregation of TPPS4 affects its excited-state lifetimes and quantum yields, but does not reduce the contact between the quencher and the excited aggregate. J-aggregates also do not change the contribution of energy transfer mechanisms to triplet state quenching by molecular oxygen. By producing singlet oxygen, having intense absorption in the phototherapeutic window, and efficiently converting light energy into heat, J-aggregates are considered a theranostic agent for photomedicine.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Pharmacology & Pharmacy
Ana-Maria Udrea, Andra Dinache, Angela Staicu, Speranta Avram
Summary: Photodynamic therapy shows potential as a new and effective cancer treatment, although the molecular mechanism remains unclear. This study used molecular docking simulations to predict the binding affinity between a photosensitizer and potential targets in photodynamic treatment. Results indicate that the photosensitizer can bind to multiple receptor targets, including BCL-2 and related proteins. Additionally, it was found that the photosensitizer can bind to human serum albumin and potentially inhibit cancer cells through interactions with specific residues or by its free energy of binding.
Article
Physics, Multidisciplinary
Quan Miao, Erping Sun, Qixin Liu, Rengang Song, Min Liang, Yan Xu
Summary: Due to the special interest and unique advantage of bovine serum albumin, we conducted research on the effects of bovine serum albumin on the photophysical properties of meso-tetrakis(sulfonatophenyl) porphyrin. We used a picosecond pulse laser source with specific parameters and a generalized five-level model for theoretical analysis. The results showed that meso-tetrakis(sulfonatophenyl) porphyrin exhibited prominent optical limiting effects, with slight weakening when bound with bovine serum albumin.
Article
Chemistry, Physical
Jorge Luiz Sonego Milani, Werberson de Almeida Bezerra, Alexandre Moreira Meireles, Alvaro Farias Arruda da Mata, Frederico Henrique do Carmo Ferreira, Luiz Antonio Sodre Costa, Felipe Terra Martins, Dayse Carvalho da Silva Martins, Rafael Pavao das Chagas
Summary: This study reports the catalytic activity and mechanism of new porphyrin complexes with Zn-II, Co-II, and Cu-II as metal centers in the CO2 cycloaddition reaction. The experimental results demonstrate that under mild conditions, these complexes exhibit high selectivity and conversion rates in producing styrene cyclic carbonate, and the activation energy is lowered through synergy between the catalyst and cocatalyst.
MOLECULAR CATALYSIS
(2023)
Article
Chemistry, Analytical
Kailai Wang, Edward P. C. Lai
Summary: An electrochemical method was used to study the redox properties of zinc oxide, zinc peroxide, and sodium-doped zinc peroxide nanoparticles. Cyclic voltammetry analysis showed that the peak currents are linearly related to the mass of deposited nanoparticles. ZnO nanoparticles played a crucial role in enhancing the oxidation current of metabisulfite, while PPy coating suppressed the current enhancement by covering all nanoparticle surfaces. Additionally, meso-tetrakis(4-carboxyphenyl) porphyrin was found to be a good chemical reagent for differentiating ZnO from ZnO2 and nanoparticles.
Article
Chemistry, Physical
Hui Fang, Michael J. Wilhelm, Danielle L. Kuhn, Zachary Zander, Hai-Lung Dai, George A. Petersson
Summary: The electronic and vibrational spectra of TSPP were computationally studied, showing good agreement with experimental measurements. In addition, an infrared absorption feature in the excited states was discovered and used to investigate the vibrational dynamics of the excited state.
JOURNAL OF CHEMICAL PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Valentinos Mouarrawis, Simon Mathew, Eva J. Meeus, Bas de Bruin, Joost Reek
Summary: A facile synthetic strategy has been developed for the synthesis of meso -tetrakis(4-formyl-phenyl)porphyrin and meso -tetrakis(3-formylphenyl)porphyrin. This method provides easy access to practical amounts of these synthons in high purity and good overall yield, without the need of laborious chromatographic separations.
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
(2022)
Article
Chemistry, Multidisciplinary
Chironjit Kumar Shaha, Bithy Sarker, Shurid Kishore Mahalanobish, Md. Sharif Hossain, Subarna Karmaker, Tapan Kumar Saha
Summary: This study investigated the conjugation of chitosan with the insulin-mimetic VO(tpps) in an aqueous medium. The conjugate formation was found to be attributed to the electrostatic interaction between the NH3+ units of chitosan and the SO3- units of VO(tpps). It was also found that chitosan enhances the stability of VO(tpps) in water. The conjugation reaction was best explained by pseudo-second-order kinetic and Langmuir isotherm models.
Article
Biochemistry & Molecular Biology
Andras Micsonai, Eva Moussong, Frank Wien, Eszter Boros, Henrietta Vadaszi, Nikoletta Murvai, Young-Ho Lee, Tamas Molnar, Matthieu Refregiers, Yuji Goto, Agnes Tantos, Jozsef Kardos
Summary: The BeStSel method is a powerful tool for analyzing protein secondary structure composition, providing accurate information and predicting protein folding down to the topology/homology level. It also helps distinguish intrinsically disordered proteins and assists in experimental verification and in silico modeling using CD spectroscopy.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Nunzia Iaccarino, Mingpan Cheng, Dehui Qiu, Bruno Pagano, Jussara Amato, Anna Di Porzio, Jun Zhou, Antonio Randazzo, Jean-Louis Mergny
Summary: The i-motif DNA, a non-canonical DNA secondary structure formed by cytosine-rich sequences, is of growing interest as a target in anticancer therapy. This study analyzed the CD and TDS spectra of 255 DNA sequences using multivariate data analysis to reveal unique spectral regions that could be diagnostic features in the analysis of i-DNA forming sequences.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Applied
Leping Chen, Yanfen Wang, Tingyu Shi, Tiantian Ma, Yang Li, Huayu Qiu, Shouchun Yin, Meier Gu
Summary: This study successfully overcame the limitations of the heavy atom effect by introducing iodine atoms and innovatively enhancing the structure while weakening stacking behavior, achieving high efficiency and precision in photodynamic therapy and photothermal therapy.
Article
Chemistry, Applied
Bingpeng Guo, Honghan Sa, Peng Zhang, Guiwen Hao, Mengyu Li, Qingqing Jiang, Baoying Li, Wei Shu, Changxiang Shao
Summary: The design of ratiometric fluorescence probes with large Stokes shift is of great significance in detecting and imaging target substances in complex organisms. In this study, a novel fluorophore with a large Stokes shift was easily obtained, and a fluorescence probe based on it demonstrated rapid response, high selectivity, and sensitivity towards peroxynitrite. The probe also showed excellent biocompatibility and remarkable mitochondrial targeting ability, making it suitable for proportional imaging of peroxynitrite in living cells and zebrafish.
Review
Chemistry, Applied
Haidong Huang, Xiaohui Wang, Xinyang Li, Yichen Li, Guojin Liu, Lan Zhou, Jianzhong Shao
Summary: This article introduces the application of responsive photonic crystals in anti-counterfeiting technology, with a focus on the preparation principle, classification, and preparation methods.
Article
Chemistry, Applied
Yunpeng Wang, Tao Zhao, Xiaoye Bi, Chencheng Lv
Summary: In this study, three novel carbene dyes were designed to achieve environmentally friendly dyeing processes. The dyes formed covalent bonds with fibers and exhibited good dyeing performance and high color fastness. These findings highlight the potential of the novel carbene dyes in promoting green production in the textile industry.
Review
Chemistry, Applied
Yizhe Yan, Xiaopei Zhu, Jia-Xin Cao, Yuan He, Shaoqing Li, Jian-Yong Wang
Summary: In this paper, 1,3,5-triazine dyes were successfully synthesized and their photophysical properties were studied. Two probes were selected for further investigation, showing promising applications in various fields.
Article
Chemistry, Applied
Xin Hu, Tongsheng Huang, Lihua Chen, Weifeng Zhu, Fengjie Deng, Xiancai Li, Jianwen Tian, Meiying Liu, Xiaoyong Zhang, Yen Wei
Summary: This study presents the synthesis of fluorescent cyclomatrix polyphosphazene spheres with aggregation-induced emission (AIE) feature and biodegradable potential for controlled drug delivery. The resulting micelles exhibit high water dispersibility, desirable fluorescence performance, and high drug loading capacity. They can effectively release the encapsulated drug in physiological solution and show excellent biological imaging ability and cytotoxicity against cancer cells.
Article
Chemistry, Applied
Yanzhu Liu, Yanghui Lei, Dongyan Li, Guangkui Li, Dongping Li, Yongxiu Li
Summary: In this study, luminescent lanthanide nanoparticles were synthesized as a dual emission turn-off probe for detecting 2,6-pyridinedicarboxylic acid (DPA) in water. The nanoparticles showed good dispersion and water stability, and achieved low detection limits for DPA. They also exhibited high recoveries in various samples.
Article
Chemistry, Applied
Jung Jae Do, Jong Ryeol Kwon, Donghan Kim, Jae Woong Jung
Summary: This study presents a defect passivation approach using coumarin dye as a multi-functional passivating agent of perovskite films to boost power conversion efficiency and operating stability of PSCs. The incorporation of coumarin dye improves the film morphology, enhances carrier extraction/transport, and suppresses trap-assisted recombination in the perovskite films. The optimized device demonstrates impressive reliability and practical applicability, maintaining over 90% of its initial PCE after being exposed to continuous indoor lighting irradiation for 2000 hours.
Article
Chemistry, Applied
Gang Wang, Yu-Chang Wang, Jing Lu, Wen-Fu Yan, Juan Jin, Yuan-Peng Wang, Jia-Jia Zhang, Hui-Jie Zhang, Hao Dong, Xi-Guang Liu
Summary: A new Ni(II) compound with good solid-state fluorescence performance and stability was synthesized, and it showed outstanding detection properties for various substances in aqueous solutions. This compound has the potential to be a multifunctional sensor.
Article
Chemistry, Applied
Luyao Wei, Shenglong Shang, Yu Zheng, Jie Liu, Ping Zhu
Summary: This study developed a facile method to create high saturation and durable structural colors on cotton fabrics. The colors are regulated by adjusting the size of magnetic particles and can be conveniently printed on fabrics using photo masks on transparent films.
Article
Chemistry, Applied
Zhao Jiang, Qing Zhang, Zhaoyu Kong, Ruijie Qiao, Zichuan Liu, Linzhou Song, Senqiang Zhu, Rui Liu, Hongjun Zhu
Summary: Three heteroleptic Ir(III) complexes with different electron-donating aryl groups were synthesized and their optical properties were investigated. It was found that all three complexes exhibited aggregation-induced phosphorescence emission (AIPE) behaviors, and the relationship between the size of organic ligands and AIPE behaviors was characterized. Ir-PhCz showed the best imaging of latent fingerprints due to its green light emission and high quantum yield.
Article
Chemistry, Applied
Zhijun Ruan, Chunxia Fan, Xuanrong Wang, Dong Shao, Xiaodong Yang, Wentao He, Tao Xu, Junqi Lin, Zhengfang Tian
Summary: A novel thioketal-based probe has been designed for rapid and accurate detection of mercury (II) ions, showing different fluorescence characteristics in various states. The probe exhibits excellent selectivity and specificity, making it suitable for Hg2+ detection in water solutions.
Article
Chemistry, Applied
Jianjun Huang, Xuan Zhao, Daniel Escudero, Luc Van Meervelt, Dongbin Zheng, Yuyu Fang, Wim Dehaen
Summary: A series of BOAHY compounds were successfully synthesized and showed versatile applications as a platform for designing novel fluorescent probes, especially in selective recognition.
Article
Chemistry, Applied
Roman V. Larkovich, Victoria E. Shambalova, Savva A. Ponomarev, Alexander S. Aldoshin, Boris N. Tarasevich, Konstantin A. Lyssenko, Valentine G. Nenajdenko
Summary: An efficient synthetic protocol for the preparation of novel 1,7-difluorinated BODIPYs was elaborated. Their photophysical properties were studied and the effect of 2,6-substituents was evaluated using DFT calculations.
Article
Chemistry, Applied
Haneul Kim, Byungjin Koo
Summary: In this study, a lithium ion sensing methodology based on fluorinated naphthalene compounds using 19F NMR and UV-vis spectroscopy is reported. The binding of lithium ions to the compounds is confirmed by changes in chemical shifts and peak broadening. Additionally, the effect of different crown ether ring sizes on the binding ability is observed. This study provides a new method for lithium ion sensing using spectroscopy.
