Review
Clinical Neurology
Stefano Calzetti, Anna Negrotti
Summary: Secondary parkinsonism induced by certain medications can be completely reversible in most patients after drug withdrawal, but in some cases it may become progressive or even permanent. Tardive parkinsonism, a controversial condition, may fulfill the criteria of permanent non-progressive parkinsonism and its long-term course and clinical features are not well understood.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Article
Medicine, General & Internal
Siin Kim, Hae Sun Suh
Summary: This retrospective cohort study analyzed treatment changes and prognoses of patients with incident drug-induced parkinsonism (DIP). Using a national database, patients diagnosed with DIP and prescribed offending drugs (antipsychotics, gastrointestinal motility drugs, or flunarizine) during 2004-2013 were assessed. The study found that treatment changes and prognoses varied based on the offending drug type, with over 25% of patients experiencing DIP recurrence or persistence, emphasizing the need for effective prevention strategies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biophysics
Ankush Garg, Sharmistha Sinha
Summary: The aggregation of alpha-synuclein is a key characteristic of Parkinson's disease and is influenced by the chemotherapeutic drug doxorubicin. The study reveals that doxorubicin interacts with the aggregation-prone region of alpha-synuclein, destabilizing it and promoting aggregation. Additionally, the combination of doxorubicin and L-DOPA drugs inhibits alpha-synuclein aggregation.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Pharmacology & Pharmacy
Xichuan Li, Wanting Wang, Suying Yan, Weipeng Zhao, Hui Xiong, Cuiping Bao, Jinqian Chen, Yuan Yue, Yanjun Su, Chunze Zhang
Summary: The COVID-19 outbreak has caused significant global health and economic losses. This review examines drug-induced liver injury (DILI) in COVID-19 patients treated with antiviral drugs, such as favipiravir, remdesivir, lopinavir/ritonavir, and hydroxychloroquine. We discuss the incidence, mechanisms, and surveillance strategies of DILI, as well as medication recommendations for preserving liver function in COVID-19 patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Elena E. Vaiman, Natalia A. Shnayder, Aiperi K. Khasanova, Anna Strelnik, Arseny J. Gayduk, Mustafa Al-Zamil, Margarita R. Sapronova, Natalia G. Zhukova, Daria A. Smirnova, Regina F. Nasyrova
Summary: Drug-induced parkinsonism (DIP) is a common neurologic adverse reaction in patients with schizophrenia treated with antipsychotics. It is caused by drugs that affect dopamine receptors and disrupt the signaling pathways of various neurotransmitter systems. The mechanisms of DIP development are still poorly understood despite existing theories.
Review
Pharmacology & Pharmacy
Xinghui Li, Jiaqi Ni, Li Chen
Summary: This review focuses on the diagnosis, screening, and management of Acetaminophen (APAP)-induced liver injury (AILI), which is a significant cause of drug-induced liver injury and acute liver failure. It summarizes recent research progress, highlights current issues, and provides recommendations for future research.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Hyo-In Rhyou, Young-Hee Nam, Su-Chin Kim, Go-Eun Doo, Chae-Yeon Ha, Hee-Joo Nam, Sung-Dae Woo, Youngsoo Lee, Jae-Hyuk Jang, Hyun-Young Lee, Young-Min Ye
Summary: This study investigated the incidence rates and clinical features of cefaclor-associated adverse drug reactions in Korea, finding that hypersensitivity and anaphylaxis were more common for cefaclor compared to other cephalosporins. Factors such as female sex, age younger than 65 years, concomitant use of drugs, and serious ADRs were found to be more strongly associated with hypersensitivity to cefaclor. The incidence of cefaclor-induced adverse drug reactions, particularly hypersensitivity and anaphylaxis, was high in the nationwide database for the Korean population.
Article
Psychology, Developmental
Soo Min Jeon, Yu Jin Lee, Jin-Won Kwon
Summary: This study investigates the prevalence and risk of drug-induced Parkinsonism (DIP) in pediatric patients, finding an increasing trend in the prevalence of DIP, especially among non-psychotic patients. Atypical antipsychotics pose the highest risk for DIP.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Review
Medicine, Research & Experimental
H. Fischer, T. Maleitzke, C. Eder, S. Ahmad, U. Stoeckle, K. F. Braun
Summary: Proximal femur fractures are a leading cause of hospitalization in elderly patients and require careful perioperative management to reduce complications. Special attention should be given to the unique needs and comorbidities of elderly patients for optimal treatment outcomes.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2021)
Article
Nutrition & Dietetics
Laura Hoen, Daniel Pfeffer, Rico Zapf, Andrea Raabe, Janosch Hildebrand, Johannes Kraft, Stefan Kalkhof
Summary: Elderly patients, especially those with mild cognitive impairment or dementia, are at increased risk of dehydration. This study utilized bioelectrical impedance vector analysis (BIVA) to identify differences in hydration status based on medication and diseases in geriatric patients. The findings suggest that drug treatment and underlying conditions play a significant role in the hydration status of patients, potentially affecting their prognosis.
Article
Multidisciplinary Sciences
Bewket Tiruneh, Ensieh Fooladi, Gayle McLelland, Virginia Plummer
Summary: This study investigated the incidence, mortality, and factors associated with primary postpartum hemorrhage in northwest Ethiopia. The incidence of primary postpartum hemorrhage was found to be 8.8%, with 7.4% resulting in maternal deaths. Several factors were identified as independently associated with primary postpartum hemorrhage, including age, duration of labor, vaginal or cervical lacerations, instrumental-assisted birth, retained placenta, antepartum hemorrhage, referral from primary health centers, and births managed by medical interns.
Article
Medicine, General & Internal
Zoe K. McQuilten, Le Thi Phuong Thao, Sant-Rayn Pasricha, Andrew S. Artz, Michael Bailey, Andrew T. T. Chan, Harvey Jay Cohen, Jessica E. Lockery, Anne M. Murray, Mark R. Nelson, Hans G. Schneider, Rory Wolfe, Robyn L. Woods, Erica M. Wood, John J. McNeil
Summary: This study is a post hoc analysis of the effect of low-dose aspirin on anemia and iron deficiency in older adults. The results showed that low-dose aspirin increased the incidence of anemia and led to a decline in ferritin levels. It suggests that periodic monitoring of hemoglobin should be considered in older persons on long-term aspirin therapy.
ANNALS OF INTERNAL MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Xiaoyun Li, Jieting Tang, Yimin Mao
Summary: The epidemiology and aetiology of drug-induced liver injury (DILI) vary across different countries and populations. Antibiotics are the leading cause of DILI in Western countries, while traditional Chinese medicine is the primary cause in Eastern countries. The incidence of hepatotoxicity induced by herbal and dietary supplements is increasing globally. Although several risk factors for DILI have been described, there are no confirmed risk factors for all-cause DILI.
LIVER INTERNATIONAL
(2022)
Article
Pharmacology & Pharmacy
Jiajun Weng, Lei Zhang, Wenjuan Yu, Nan Zhao, Binggen Zhu, Chengyu Ye, Zhanxing Zhang, Changlin Ma, Yan Li, Yiming Yu, Huafang Li
Summary: This study aimed to explore the risk factors, clinical correlates, and social functions of drug-induced parkinsonism (DIP) in Chinese schizophrenia patients. It found that age, high D2 receptor antagonist antipsychotic dose, and valproate dose were risk factors for DIP. DIP was significantly correlated with psychiatric symptoms and social performance. Rational application or discontinuation of valproate is necessary, and early intervention and treatment of DIP can improve schizophrenia patients' prognosis and social performance.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Hao Niu, Judith Sanabria-Cabrera, Ismael Alvarez-Alvarez, Mercedes Robles-Diaz, Simona Stankeviciute, Guruprasad P. Aithal, Einar S. Bjornsson, Raul J. Andrade, M. Isabel Lucena
Summary: This systematic review analyzed the design and findings of RCTs in the prevention and management of idiosyncratic drug-induced liver injury (DILI) and found limited efficacy of tested agents. Heterogeneity in DILI case qualification and methodologic quality was evident among studies, highlighting the need for international research networks to establish a framework on RCTs design and therapeutic endpoints.
PHARMACOLOGICAL RESEARCH
(2021)