Article
Immunology
Ayantika Sen, Jeanna Enriquez, Mahil Rao, Marla Glass, Yarl Balachandran, Sharjeel Syed, Clare J. Twist, Kenneth Weinberg, Scott D. Boyd, Daniel Bernstein, Amber W. Trickey, Dita Gratzinger, Brent Tan, Mary Gay Lapasaran, Mark A. Robien, Merideth Brown, Brian Armstrong, Dev Desai, George Mazariegos, Clifford Chin, Thomas M. Fishbein, Robert S. Venick, Akin Tekin, Heiner Zimmermann, Ralf U. Trappe, Ioannis Anagnostopoulos, Carlos O. Esquivel, Olivia M. Martinez, Sheri M. Krams
Summary: Post-transplant lymphoproliferative disorder (PTLD) is a serious complication of solid organ transplantation, associated with Epstein-Barr virus (EBV) infection. This study found that miR-194 and several other miRs were significantly decreased in the tumors and circulation of PTLD patients, which may be associated with EBV. These findings suggest the importance of studying the diagnostic and therapeutic potential of miRs in PTLD.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Surgery
James Tang, Jasmijn Kerklaan, Germaine Wong, Martin Howell, Nicole Scholes-Robertson, Chandana Guha, Ayano Kelly, Allison Tong
Summary: Medicine-taking among transplant recipients is a complex task that impacts outcomes significantly. Transplant recipients face threats to identity, uncertainty and distrust, treatment burdens, seeking and gaining confidence, recalibrating to a new normal post-transplant, and preserving graft survival. Interventions supporting adaptation to medicine-taking and addressing treatment burdens may improve patient satisfaction and medication adherence.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Oncology
Ryan J. Stubbins, Ryan Lam, James Zhu, Sunita Ghosh, Curtis Mabilangan, John Kuruvilla, Rashmi S. Goswami, Raymond Lai, Jutta K. Preiksaitis, Michael Jain, Anthea C. Peters
Summary: This study investigated the relevance of the tumor microenvironment (TME) on prognosis in monomorphic post-transplant lymphoproliferative disorder (PTLD). The results showed that low TIL-density was associated with worse progression-free and overall survival in these patients, and combining TIL-density with clinical variables effectively risk-stratified patients. The study suggests that the TME is relevant to prognosis in PTLD.
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2022)
Article
Oncology
Krzysztof Mucha, Rafal Staros, Bartosz Foroncewicz, Bogna Ziarkiewicz-Wroblewska, Maciej Kosieradzki, Slawomir Nazarewski, Beata Naumnik, Joanna Raszeja-Wyszomirska, Krzysztof Zieniewicz, Leszek Paczek
Summary: The study compares the risk and prognostic factors of PTLD between adult kidney and liver transplant recipients. The results showed that PTLD develops earlier in liver transplant recipients, especially in patients over 45 years old, those receiving tacrolimus or not receiving cyclosporin. In kidney transplant recipients, PTLD onset is significantly affected by tacrolimus use, male sex, and age over 45 years old. Survival is longer in liver transplant recipients under 45 years old and they are more likely to achieve complete remission. The factors affecting PTLD development and outcome differ between kidney and liver transplant recipients.
Review
Medicine, Research & Experimental
Rafael Hernani, Asuncion Sancho, Paula Amat, Juan Carlos Hernandez-Boluda, Ariadna Perez, Jose Luis Pinana, Carlos Carretero, Rosa Goterris, Montse Gomez, Ana Saus, Blanca Ferrer, Ana Isabel Teruel, Maria Jose Terol, Carlos Solano
Summary: CAR-T therapy appears to be a feasible treatment option for patients with SOT-related PTLD. Most patients discontinued immunosuppressive drugs after CAR-T therapy, with only a few cases of graft rejection reported.
CURRENT RESEARCH IN TRANSLATIONAL MEDICINE
(2021)
Article
Hematology
Anna Santarsieri, John F. Rudge, Irum Amin, Will Gelson, Jasvir Parmar, Stephen Pettit, Lisa Sharkey, Benjamin J. Uttenthal, George A. Follows
Summary: This study presents the incidence and outcomes of PTLD in a cohort of 5365 SOT recipients over a 20-year period at two UK transplant centers. PTLD incidence varied based on the type of transplant, with shorter overall survival compared to the general population. First-line rituximab monotherapy did not compromise overall survival, but non-lymphoma related mortality remained high.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Review
Surgery
Jing-Yi Liu, Jin-Ming Zhang, Hao-Su Zhan, Li-Ying Sun, Lin Wei
Summary: The study summarized the use of EBV-CTLs in the treatment of PTLD, demonstrating safety and effectiveness. Research from around the world shows that EBV-CTLs can effectively treat refractory PTLD, playing a crucial role in improving patient survival rates and recovery.
TRANSPLANT INTERNATIONAL
(2021)
Review
Immunology
Yangming Tang, Yue Li, Turun Song
Summary: The COVID-19 pandemic has caused a significant burden worldwide, and solid organ transplant recipients (SOTRs) are particularly vulnerable. Nirmatrelvir and ritonavir have the potential to reduce hospitalization and death in mild-to-moderate COVID-19 patients. However, there is a drug-drug interaction between ritonavir and calcineurin inhibitors, commonly prescribed to SOTRs, which requires careful consideration during co-administration with nirmatrelvir/ritonavir.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Virology
Roni Bitterman, Deepali Kumar
Summary: Solid organ transplantation comes with an increased risk of respiratory viral infections, especially problematic for lung transplant recipients. While influenza has treatment options, other respiratory viruses present treatment challenges. Novel antivirals, immunologic treatments, and vaccines are hoped for in the coming years to address this evolving area of concern.
Review
Medicine, General & Internal
Chiara Becchetti, Sarah Gabriela Gschwend, Jean-Francois Dufour, Vanessa Banz
Summary: Liver transplant recipients are vulnerable during the COVID-19 pandemic, with heterogeneous and scarce data available. While gastrointestinal symptoms are common, the overall outcomes are not worse compared to the general population. Caution should be taken with immunosuppressive therapy, especially with mycophenolate mofetil, and close monitoring is necessary for vaccine immunogenicity.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biophysics
Toby A. Eyre, Sophie Caillard, Herve Finel, Ariane Boumendil, Jaimal Kothari, Heiner Zimmermann, Ralf Ulrich Trappe, Virginie De Wilde, Eleni Tholouli, Edward Kanfer, Angus Broom, Gandhi Damaj, Mario Bargetzi, Tomas Kozak, Inken Hilgendorf, Charles Crawley, Tessa Kerre, Marek Trneny, Emmanuel Bachy, Stephen Robinson, Silvia Montoto
Summary: This retrospective analysis of 21 patients who underwent autoSCT for PTLD post solid organ transplant found that although autoSCT is feasible and potentially effective, it is associated with a high non-relapse mortality primarily driven by infectious toxicity. A multidisciplinary approach, expert microbiological input, and stringent patient selection are necessary to optimize outcomes.
BONE MARROW TRANSPLANTATION
(2021)
Article
Surgery
Molly Hayes, Craig L. K. Boge, Anna Sharova, Daniel Vader, Marina Mitrou, Despoina M. Galetaki, Yun Li, Kevin J. Downes
Summary: Toxicities are common with VGCV prophylaxis in pediatric SOT recipients, including kidney injury and neutropenia.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Review
Microbiology
Tirdad T. T. Zangeneh, Mohanad M. M. Al-Obaidi
Summary: Coccidioidomycosis is a fungal infection that is prevalent in certain regions of the United States, Mexico, and Central and South America. It can cause severe infections in immunocompromised patients, such as solid organ transplant recipients. The timely and accurate diagnosis of coccidioidomycosis in these patients is challenging due to limitations of diagnostic methods, making it important to explore alternative approaches. This review discusses available diagnostic modalities and the role of early diagnosis in guiding antifungal therapy for reducing complications in SOT recipients with coccidioidomycosis.
Article
Surgery
David M. Salerno, Douglas L. Jennings, Nicholas W. Lange, Danielle (Bley) Kovac, Tara Shertel, Justin K. Chen, Jessica Hedvat, Jenna Scheffert, Robert S. Brown, Marcus R. Pereira
Summary: The use of Nirmatrelvir/ritonavir (NR) in solid organ transplant recipients (SOTRs) with mild COVID-19 has not been described yet. The objective of this study was to evaluate outcomes among SOTRs and describe the drug-drug interaction of NR. The results show that the clinically significant interaction between NR and immunosuppressive agents can be reasonably managed with a standardized dosing protocol.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Masaki Yamada, Camila Macedo, Kevin Louis, Tiange Shi, Douglas Landsittel, Christina Nguyen, Masayoshi Shinjoh, Marian G. Michaels, Brian Feingold, George V. Mazariegos, Michael Green, Diana Metes
Summary: Chronic Epstein-Barr virus (EBV) infection is a significant problem after pediatric organ transplantation, especially in heart transplant recipients with high viral load. This study analyzed the immune characteristics of CD8(+)/CD4(+) T cells in pediatric heart, kidney, and liver transplant recipients, and identified distinct phenotypic and transcriptomic profiles in heart HVL carriers. The results suggest different incidences of EBV complications and provide insights for risk stratification and clinical management in different types of transplant recipients.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)