Article
Biotechnology & Applied Microbiology
Mingzhu Luo, Junyu Lu, Chao Li, Bo Wen, Wenbin Chu, Xiangchen Dang, Yujiao Zhang, Gaihong An, Jing Wang, Rong Fan, Xuewei Chen
Summary: This study found that hydrogen water improves exercise endurance and reprograms skeletal muscle glucose metabolism by activating the Ppar gamma/Pgc-1 alpha/Tfam signaling pathway.
Article
Biochemistry & Molecular Biology
Yi Li, Yu-Fan Feng, Xiao-Tian Liu, Yu-Chen Li, Hui-Min Zhu, Meng-Ru Sun, Ping Li, Baolin Liu, Hua Yang
Summary: Songorine protects cardiac contractive function against endotoxin insult by activating Nrf2, suppressing mitochondrial reactive oxygen species production, and promoting mitochondrial biogenesis, ultimately enhancing cardioprotection.
Review
Biochemistry & Molecular Biology
Jara Tabitha Hees, Angelika Bettina Harbauer
Summary: Mitochondria play a critical role in neuronal function by providing ATP and buffering Ca2+. The regulation of mitochondrial biogenesis at the transcriptional and translational level is necessary for neurons to adapt to local differences in mitochondrial demand. Defects in the localization of mRNAs encoding mitochondrial proteins and contact site formation between mitochondria and endolysosomes can lead to mitochondrial dysfunction in various neurological disorders.
Article
Chemistry, Multidisciplinary
Qing Zheng, Hanghang Liu, Hao Zhang, Yaobao Han, Jiaxin Yuan, Tingting Wang, Yifan Gao, Zhen Li
Summary: This study reports the use of Cu2-xSe-based nanoparticles functionalized with curcumin and wrapped with DSPE-PEG(2000)-TPP-modified macrophage membrane (CSCCT NPs) to promote mitochondrial biogenesis and ameliorate mitochondrial dysfunction for the treatment of Parkinson's disease.
Article
Cell Biology
Ruzhou Zhao, Yixin Xu, Xiaobo Wang, Xiang Zhou, Yanqi Liu, Shuai Jiang, Lin Zhang, Zhibin Yu
Summary: In extremely hypoxic environments, WA can protect cells by affecting the mitophagy and mitochondrial biogenesis pathways to reduce myocardial damage, maintain cardiac function, and improve survival. Enhanced mitophagy eliminates damaged mitochondria and prevents apoptosis induction, while enhanced mitochondrial biogenesis can supplement functional mitochondria and maintain mitochondrial respiration to ensure mitochondrial ATP production under acute extreme hypoxia.
Article
Biochemistry & Molecular Biology
Mariantonietta Capristo, Valentina Del Dotto, Concetta Valentina Tropeano, Claudio Fiorini, Leonardo Caporali, Chiara La Morgia, Maria Lucia Valentino, Monica Montopoli, Valerio Carelli, Alessandra Maresca
Summary: The study suggests that rapamycin-based therapy may be a promising treatment option for MERRF. The first therapeutic strategy was ineffective in high-mutation load cell lines, while the second strategy showed significant improvement in fibroblasts with intermediate-mutation load, rescuing the bioenergetics defect completely.
MOLECULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Mattia Quattrocelli, Michelle Wintzinger, Karen Miz, Daniel C. Levine, Clara Bien Peek, Joseph Bass, Elizabeth M. McNally
Summary: This study found that the timing of glucocorticoid intake can affect their effects on muscle bioenergetics. In mice, prednisone dosing during the light phase promoted NAD(+) levels and mitochondrial function, while dosing during the dark phase did not have the same effect. These results suggest that the circadian clock and muscle PGC1 alpha activity are important factors in glucocorticoid chronopharmacology for muscle bioenergetics.
Article
Plant Sciences
Chia-Yuan Lin, Yan-Ning Huang, Ru-Huei Fu, Yu-Hsin Liao, Tzu-Yu Kuo, Chia-Wen Tsai
Summary: The neuroprotective mechanism of carnosic acid (CA) from rosemary may involve the regulation of PARIS and PGC-1 alpha expression, enhancing mitochondrial biogenesis to prevent the pathological progression of Parkinson's disease.
Review
Cell Biology
Lei Chen, Yuan Qin, Bilin Liu, Meng Gao, Anqi Li, Xue Li, Guohua Gong
Summary: Mitochondria with structural and functional integrity are crucial for maintaining cardiac homeostasis, and peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha) plays a key role in this process. PGC-1 alpha regulates mitochondrial biogenesis, dynamics, and mitophagy, which are essential for the onset and progression of heart failure.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Agriculture, Multidisciplinary
Ziyuan Wang, Zihui Yang, Jie Liu, Yiming Hao, Baoguo Sun, Jing Wang
Summary: Mitochondria play a crucial role in cellular metabolism, and natural bioactive components in whole grains can improve metabolic disorders by modulating mitochondrial biogenesis and energy metabolism.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Weili Li, Jing Cao, Xiaoping Wang, Yawen Zhang, Qianbin Sun, Yanyan Jiang, Junkai Yao, Chun Li, Yong Wang, Wei Wang
Summary: The study demonstrated that Ferruginol (FGL) exerts cardioprotective effects by enhancing mitochondrial biogenesis and fatty acid oxidation through stimulating the SIRT1-PGC-1 alpha axis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dan Chen, Jing Guo, Longguang Li
Summary: This study demonstrates that catalpol has the potential to promote mitochondrial biogenesis and enhance mitochondrial function in chondrocytes, indicating its possible use in the treatment of joint diseases.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Nan Chen, Meng-Meng Ge, Dan-Yang Li, Xiao-Mei Wang, Dai-Qiang Liu, Da-Wei Ye, Yu-Ke Tian, Ya-Qun Zhou, Jian-Ping Chen
Summary: Formoterol can alleviate chemotherapy-induced neuropathic pain and delay its onset by restoring ADRB2 expression and regulating genes involved in mitochondrial biogenesis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Ying Jiang, Da Li, Zhiqiang Du, Jie Li, Rongrong Lu, Qin Zhou, Qi Wang, Haohao Zhu
Summary: The study investigated the protective effects of Perampanel on mitochondrial biogenesis and bioenergetics in human neuronal cells. Results showed that Perampanel stimulated mitochondrial biogenesis and improved mitochondrial bioenergetics.
ACS CHEMICAL NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Shaofen Kong, Bolin Cai, Qinghua Nie
Summary: The discovery and interpretation of PGC-1 alpha protein in mitochondrial biogenesis, skeletal muscle and adipose tissue development have broad research prospects. PGC-1 alpha plays a key role in regulating mitochondrial biogenesis and is regulated by AMPK and SIRT1, influencing skeletal muscle and adipose metabolism. Dietary resveratrol, with its anti-obesity effect, can promote mitochondrial biosynthesis by activating AMPK/PGC-1 alpha axis.
MOLECULAR GENETICS AND GENOMICS
(2022)
Letter
Pharmacology & Pharmacy
Giuseppe Lippi, Brandon M. Henry, Fabian Sanchis-Gomar
EUROPEAN JOURNAL OF HOSPITAL PHARMACY
(2022)
Review
Food Science & Technology
Jaime Lopez-Seoane, Sergio L. Jimenez, Juan Del Coso, Helios Pareja-Galeano
Summary: This systematic review examines the effects of n-3 PUFA supplementation on lean mass and muscle protein synthesis in individuals without physical training. The review found that n-3 PUFA supplementation had positive effects on skeletal muscle volume and mass, as well as muscle protein synthesis rate. However, there was no significant effect on the mechanisms of mTOR, Akt, and skeletal muscle gene expression.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Laura Gilsanz, Jaime Lopez-Seoane, Sergio L. Jimenez, Helios Pareja-Galeano
Summary: Co-supplementation of beta-alanine and sodium bicarbonate can enhance buffering capacity and improve athletic performance, especially during high-intensity exercises lasting between 30 seconds and 10 minutes.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Rehabilitation
Vladimir E. Martinez-Bello, Maria del Mar Bernabe-Villodre, Yolanda Cabrera Garcia-Ochoa, Laura Torrent-Trilles, Herminia Vega-Perona
Summary: The representation of Paralympic athletes in newspapers has been found to be discriminatory and unfair. Newspapers tend to focus on the personal struggles of Paralympic athletes, while ignoring their personal backgrounds during the Olympic Games. Additionally, women Paralympic athletes receive less attention in the media compared to their counterparts in the Olympic Games. Newspapers depict Paralympic athletes in a pathological manner, portraying them not only as athletes but as having to possess other identities as well.
DISABILITY & SOCIETY
(2023)
Review
Food Science & Technology
Jaime Lopez-Seoane, Marta Buitrago-Morales, Sergio L. Jimenez, Juan Del Coso, Helios Pareja-Galeano
Summary: This study conducted a systematic review and meta-analysis to investigate the effect of concurrent intake of carbohydrates (CHO) and caffeine (CAF) on exercise performance. The results showed that the concurrent ingestion of CHO and CAF can enhance sprint performance and reduce perceived exertion during steady-state exercise. However, the effect on time trial performance was inconclusive. The study also found that higher concentrations of CHO solution and a dose of 4-6.5 mg/kg of CAF were associated with the additive ergogenic effect.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Chemistry, Multidisciplinary
Almudena Sanchez-Sanjuan, Carlos Romero-Morales, Javier Alfaro-Santafe, Alejandro-Jesus Almenar-Arasanz, Antonio Gomez-Bernal, Helios Pareja-Galeano
Summary: This study aimed to investigate the relationship between foot anatomical structural variations and balance in older adults and found that foot conditions such as hallux abductus valgus and tailor's bunion are associated with an increased risk of falls. Women have a higher probability of falling, and older adults with these foot conditions are twice as likely to suffer a fall. These findings highlight the importance of foot morphology in fall risk assessment and prevention in older adults.
APPLIED SCIENCES-BASEL
(2022)
Article
Nutrition & Dietetics
Maria Martinez-Ferran, Luis A. Berlanga, Olga Barcelo-Guido, Michelle Matos-Duarte, Davinia Vicente-Campos, Sandra Sanchez-jorge, Carlos Romero-Morales, Diego Munguia-Izquierdo, Helios Pareja-Galeano
Summary: This study investigated the effects of antioxidant vitamin supplementation with vitamin C and vitamin E on hypertrophic and functional adaptations to resistance training in trained men. The results suggest that vitamin supplementation may attenuate upper body strength and hypertrophy adaptations to resistance training but mitigate gains in visceral adipose tissue.
Editorial Material
Medicine, General & Internal
Giuseppe Lippi, Brandon Michael Henry, Fabian Sanchis-Gomar
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Education & Educational Research
Vladimir E. Martinez-Bello, Herminia Vega-Perona, Laura Monsalve-Lorente, Maria Del Mar Bernabe-Villodre, Paula Robles-Galan, Sandra Molines-Borras, Yolanda Cabrera Garcia-Ochoa
Summary: This study examines the perceptions of early childhood educators and parents regarding the relationship between gender and toddler's physical activity. The findings reveal that while some educators perceive no differences in physical activity patterns between boys and girls, others believe girls are less active due to symbolic play and biological factors. However, families perceive their daughters as physically active with a natural predisposition to movement. This highlights the importance of challenging binary gendered practices in early childhood education.
Review
Cardiac & Cardiovascular Systems
Fernando de la Guia-Galipienso, Koldo Ugedo-Alzaga, Gonzalo Grazioli, Francisco Javier Quesada-Ocete, Eloisa Feliu-Rey, Marco V. Perez, Aurelio Quesada-Dorador, Fabian Sanchis-Gomar
Summary: Arrhythmogenic cardiomyopathy (ACM) is a disease characterized by progressive replacement of myocardium by fibro-adipose material, leading to ventricular arrhythmias and sudden cardiac death. It is more common in males and usually onset in the 2nd to 4th decade of life. ACM is one of the most common causes of sudden cardiac death in young patients, especially athletes. Exercise can worsen right ventricular function in hereditary ACM.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Carl J. Lavie, Charles A. German, Fabian Sanchis-Gomar
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Chemistry, Medicinal
Patricia M. M. Sanz-Barrio, Eric E. E. Noreen, Laura Gilsanz-Estebaranz, Jorge Lorenzo-Calvo, Maria Martinez-Ferran, Helios Pareja-Galeano
Summary: The aim of this systematic review was to investigate the effects of Rhodiola rosea supplementation on muscle damage and physical performance. Thirteen studies were included, showing that acute supplementation had a positive effect on endurance performance and rating of perceived exertion, while chronic supplementation had a positive effect on anaerobic exercise performance and may impact muscle damage during exercise. However, more high-quality studies are needed to establish the clinical efficacy of Rhodiola rosea.
PHYTOTHERAPY RESEARCH
(2023)
Article
Education & Educational Research
Vladimir E. Martinez-Bello, Herminia Vega-Perona, Isaac Estevan, Maria del Mar Bernabe-Villodre, Cristina Menescardi-Royuela, Javier Molina-Garcia
Summary: This study describes the modes of transport to and from early childhood education and care (ECEC) institutions in toddlers, analyzes the role of different barriers and neighborhood characteristics in active commuting, and examines the contribution of active commuting on levels of physical activity (PA) in toddlers. The results show that cars and strollers are the most common modes of transport in toddlers. Perceived distance to school and parents' perceptions of planning/psychosocial barriers are negatively associated with active commuting. There is a significant and positive association between active commuting and total PA levels.
EARLY CHILD DEVELOPMENT AND CARE
(2023)
Article
Education & Educational Research
Vladimir E. Martinez-Bello, Herminia Vega-Perona, Paula Robles-Galan, Patricia Segura-Martinez, Maria del Mar Bernabe-Villodre
Summary: This study aimed to assess the perceptions of early childhood educators and student teachers regarding the knowledge, transmission, curricular practices, and didactic implications of movement opportunities in toddler education. The results showed that structured and non-structured movement opportunities were distinguished, with some recognition of the importance of physical activity (PA) in young children's development but limited knowledge of PA guidelines.
EARLY CHILDHOOD EDUCATION JOURNAL
(2023)
Article
Medicine, General & Internal
Carlos Romero-Morales, Ana Matilde-Cruz, Maria Garcia-Arrabe, Felix Higes-Nunez, Alexandre Dias Lopes, Sergio Jimenez Saiz, Helios Pareja-Galeano, Daniel Lopez-Lopez
Summary: This study aimed to investigate the effects of prophylactic ankle taping on balance, knee valgus, and ankle range of motion in healthy participants. The results showed that ankle taping led to an increase in knee valgus and a decrease in lower limb balance. Therefore, prophylactic ankle taping is not recommended for healthy individuals due to the increased risk of injury.
SAO PAULO MEDICAL JOURNAL
(2023)