Review
Pharmacology & Pharmacy
Xichuan Li, Wanting Wang, Suying Yan, Weipeng Zhao, Hui Xiong, Cuiping Bao, Jinqian Chen, Yuan Yue, Yanjun Su, Chunze Zhang
Summary: The COVID-19 outbreak has caused significant global health and economic losses. This review examines drug-induced liver injury (DILI) in COVID-19 patients treated with antiviral drugs, such as favipiravir, remdesivir, lopinavir/ritonavir, and hydroxychloroquine. We discuss the incidence, mechanisms, and surveillance strategies of DILI, as well as medication recommendations for preserving liver function in COVID-19 patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Hyo-In Rhyou, Young-Hee Nam, Su-Chin Kim, Go-Eun Doo, Chae-Yeon Ha, Hee-Joo Nam, Sung-Dae Woo, Youngsoo Lee, Jae-Hyuk Jang, Hyun-Young Lee, Young-Min Ye
Summary: This study investigated the incidence rates and clinical features of cefaclor-associated adverse drug reactions in Korea, finding that hypersensitivity and anaphylaxis were more common for cefaclor compared to other cephalosporins. Factors such as female sex, age younger than 65 years, concomitant use of drugs, and serious ADRs were found to be more strongly associated with hypersensitivity to cefaclor. The incidence of cefaclor-induced adverse drug reactions, particularly hypersensitivity and anaphylaxis, was high in the nationwide database for the Korean population.
Review
Gastroenterology & Hepatology
Xiaoyun Li, Jieting Tang, Yimin Mao
Summary: The epidemiology and aetiology of drug-induced liver injury (DILI) vary across different countries and populations. Antibiotics are the leading cause of DILI in Western countries, while traditional Chinese medicine is the primary cause in Eastern countries. The incidence of hepatotoxicity induced by herbal and dietary supplements is increasing globally. Although several risk factors for DILI have been described, there are no confirmed risk factors for all-cause DILI.
LIVER INTERNATIONAL
(2022)
Review
Pharmacology & Pharmacy
Xinghui Li, Jiaqi Ni, Li Chen
Summary: This review focuses on the diagnosis, screening, and management of Acetaminophen (APAP)-induced liver injury (AILI), which is a significant cause of drug-induced liver injury and acute liver failure. It summarizes recent research progress, highlights current issues, and provides recommendations for future research.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Hao Niu, Judith Sanabria-Cabrera, Ismael Alvarez-Alvarez, Mercedes Robles-Diaz, Simona Stankeviciute, Guruprasad P. Aithal, Einar S. Bjornsson, Raul J. Andrade, M. Isabel Lucena
Summary: This systematic review analyzed the design and findings of RCTs in the prevention and management of idiosyncratic drug-induced liver injury (DILI) and found limited efficacy of tested agents. Heterogeneity in DILI case qualification and methodologic quality was evident among studies, highlighting the need for international research networks to establish a framework on RCTs design and therapeutic endpoints.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Bewket Tiruneh, Ensieh Fooladi, Gayle McLelland, Virginia Plummer
Summary: This study investigated the incidence, mortality, and factors associated with primary postpartum hemorrhage in northwest Ethiopia. The incidence of primary postpartum hemorrhage was found to be 8.8%, with 7.4% resulting in maternal deaths. Several factors were identified as independently associated with primary postpartum hemorrhage, including age, duration of labor, vaginal or cervical lacerations, instrumental-assisted birth, retained placenta, antepartum hemorrhage, referral from primary health centers, and births managed by medical interns.
Review
Infectious Diseases
Angelo Del Gaudio, Carlo Covello, Federica Di Vincenzo, Sara Sofia De Lucia, Teresa Mezza, Alberto Nicoletti, Valentina Siciliano, Marcello Candelli, Antonio Gasbarrini, Enrico Celestino Nista
Summary: Acute pancreatitis is an inflammation of the pancreas caused by the activation of digestive enzymes. It is mainly caused by gallstones and alcohol abuse, but drugs can also be a cause. We reviewed the association between antimicrobial and antiviral drugs and acute pancreatitis and found 51 suspected associations. However, different classification systems have inconsistencies in assigning probability classes to these drugs.
Article
Multidisciplinary Sciences
Ziqi Chen, Bo Peng, Vassilis N. Ioannidis, Mufei Li, George Karypis, Xia Ning
Summary: Effective and successful clinical trials are crucial for developing new drugs and advancing treatments. However, the high costs and low success rates of clinical trials have prompted research on extracting knowledge from existing trials. In this manuscript, we introduce the construction of the first publicly available Clinical Trials Knowledge Graph (CTKG), which includes medical entities in trials and their relationships. Our analysis shows the potential utilities of CTKG in applications like drug repurposing and similarity search.
SCIENTIFIC REPORTS
(2022)
Article
Gastroenterology & Hepatology
Karina Cardenas-Jaen, Livia Archibugi, Goran Poropat, Taija Korpela, Patrick Maisonneuve, Jose R. Aparicio, Marianne Udd, Davor Stimac, Paolo G. Arcidiacono, Niccolo De Pretis, Roberto Valente, Emilio Di Giulio, Juan A. Casellas, Leena Kylanpaa, Goran Hauser, Alberto Mariani, Armando Gabbrielli, Matthias Lohr, Giuseppe Vanella, Mia Rainio, Lorenzo Brozzi, Urban Arnelo, Niklas Fagerstrom, Gabriele Capurso, Enrique de-Madaria
Summary: This study found that the use of statins or aspirin is not associated with a lower risk or a milder course of post-ERCP acute pancreatitis. Protective factors against PEP included alcohol abuse and previous endoscopic biliary sphincterotomy, while risk factors included multiple pancreatic guidewire passages, normal bilirubin values, and a procedure duration exceeding 20 minutes.
DIGESTIVE ENDOSCOPY
(2021)
Editorial Material
Gastroenterology & Hepatology
Elena Genova, Gabriele Stocco, Giuliana Decorti
Summary: Drug-induced pancreatitis is a common gastrointestinal adverse effect, particularly for IBD patients taking thiopurines as immunosuppressants. Current methods for prevention and research of this adverse reaction are still insufficient, highlighting the need for more effective research tools, such as using iPSCs for investigation.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Food Science & Technology
Nadeeya Mad-adam, Siribhon Madla, Narissara Lailerd, Poonsit Hiransai, Potchanapond Graidist
Summary: In this study, a low piperine fractional Piper nigrum extract (PFPE) was used as a dietary supplement during breast cancer treatment to reduce tumor formation risk and decrease the side effects of chemotherapeutic drugs. The research showed that PFPE-CH was safe and did not cause any mortality or adverse effects at high doses, and it did not harm the kidney or liver function of rats. Moreover, PFPE-CH demonstrated effectiveness in reducing tumor incidence and improving the immune response without adverse effects, and it also reduced the toxicity of chemotherapeutic drugs in rats with mammary tumors.
Article
Medicine, General & Internal
Eric Landa, Ismail Ganim, Erika Vigandt, Talhah Siraj, Ying Zhu
Summary: Drug-induced pancreatitis is a serious condition, with over 525 drugs identified by the WHO as potential causes. Leading drugs like mesalamine, azathioprine, and simvastatin are well-known triggers. Incidence has increased in recent years, accounting for up to 5% of cases in some studies. Early recognition and removal of offending agents are crucial in managing this condition.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Gastroenterology & Hepatology
Lauren V. V. Collen, Paul D. D. Mitchell, Victor L. L. Fox, Amit S. S. Grover
Summary: The objective of this study was to describe the prevalence of pancreatitis-associated medication (PAM) use at admission and discharge in pediatric and young adult patients hospitalized with acute pancreatitis (AP) and to describe the prevalence of PAM use at admission in patients classified as having idiopathic AP. The results showed that 50% of patients were using a PAM at admission and 67% were taking a PAM at discharge. 44% of patients classified as having idiopathic pancreatitis were taking a PAM on admission.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2023)
Article
Surgery
Thomas K. Maatman, Megan E. Nicolas, Alexandra M. Roch, Kyle A. Lewellen, Hayder H. Al-Azzawi, Eugene P. Ceppa, Michael G. House, Attila Nakeeb, Christian M. Schmidt, Nicholas J. Zyromski
Summary: This study investigated the incidence, risk factors, and outcomes of colon involvement in patients with necrotizing pancreatitis. The study found that colon involvement is common and is associated with a higher incidence and mortality rate. Risk factors for developing colon pathology include tobacco use, coronary artery disease, and respiratory failure.
Article
Multidisciplinary Sciences
Yuyan Xu, Maoyuan Gong, Yue Wang, Yang Yang, Shu Liu, Qibing Zeng
Summary: Breast cancer is a major global public health challenge, and studies on its trends are crucial for prevention, control, and improving health. This study analyzed global burden, incidence, deaths, and risk factors of breast cancer from 1990 to 2019, and predicted the global burden until 2050 to inform control efforts. The findings suggest that regions with low socio-demographic index will have the highest disease burden in the future. Metabolic risks were the leading global risk factor for breast cancer deaths in 2019, followed by behavioral risks. This study highlights the urgent need for comprehensive cancer prevention and control strategies to reduce disease burden.