Biotransformation and bioactivation reactions of alicyclic amines in drug molecules

Direct Oxidation and Covalent Binding of Isoniazid to Rodent Liver and Human Hepatic Microsomes: Humans Are More Like Mice than Rats

(2012) Imir G. Metushi et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Glucuronidation of trans-3′-hydroxycotinine by UGT2B17 and UGT2B10

(2012) Gang Chen et al.   Pharmacogenetics and Genomics

Immunomodulatory effects of clozapine and their clinical implications: What have we learned so far?

(2012) Rasmus Røge et al.   SCHIZOPHRENIA RESEARCH

Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States

(2011) Antonia F. Stepan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Role of Cyclic Tertiary Amine Bioactivation to Reactive Iminium Species: Structure Toxicity Relationship

(2011) Lucija Peterlin Masic   CURRENT DRUG METABOLISM

Biosynthesis and Identification of an N-Oxide/N-Glucuronide Metabolite and First Synthesis of an N-O-Glucuronide Metabolite of Lu AA21004

(2011) H. K. Uldam et al.   DRUG METABOLISM AND DISPOSITION

Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients

(2011) X. Meng et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Metabolism of 4-Aminopiperidine Drugs by Cytochrome P450s: Molecular and Quantum Mechanical Insights into Drug Design

(2011) Hao Sun et al.   ACS Medicinal Chemistry Letters

Identification and hit-to-lead exploration of a novel series of histamine H4 receptor inverse agonists

(2010) Sue Cramp et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Role of Human GlutathioneS-Transferases in the Inactivation of Reactive Metabolites of Clozapine

(2010) Sanja Dragovic et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Metabolism, Pharmacokinetics, and Excretion of the 5-Hydroxytryptamine1B Receptor Antagonist Elzasonan in Humans

(2010) A. Kamel et al.   DRUG METABOLISM AND DISPOSITION

Metabolism and Excretion of Asenapine in Healthy Male Subjects

(2010) S. F. M. van de Wetering-Krebbers et al.   DRUG METABOLISM AND DISPOSITION

Metabolic bioactivation and drug-related adverse effects: current status and future directions from a pharmaceutical research perspective

(2009) Wei Tang et al.   DRUG METABOLISM REVIEWS

Discontinued psychiatric drugs in 2008

(2009) Victoria D Kirchhoff et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Biotransformation and in vitro assessment of metabolism-associated drug–drug interaction for CRx-102, a novel combination drug candidate

(2009) Zhi-Yi Zhang et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

In Vitro Screening Techniques for Reactive Metabolites for Minimizing Bioactivation Potential in Drug Discovery

(2008) Chandra Prakash et al.   CURRENT DRUG METABOLISM

Benzodiazepine Metabolism: An Analytical Perspective

(2008) Roberto Mandrioli et al.   CURRENT DRUG METABOLISM

Covalent Binding and Tissue Distribution/Retention Assessment of Drugs Associated with Idiosyncratic Drug Toxicity

(2008) H. Takakusa et al.   DRUG METABOLISM AND DISPOSITION

Detection of Novel Reactive Metabolites of Trazodone: Evidence for CYP2D6-Mediated Bioactivation of m-Chlorophenylpiperazine

(2008) B. Wen et al.   DRUG METABOLISM AND DISPOSITION

Comparison of the Bioactivation Potential of the Antidepressant and Hepatotoxin Nefazodone with Aripiprazole, a Structural Analog and Marketed Drug

(2008) J. N. Bauman et al.   DRUG METABOLISM AND DISPOSITION

Arylamine N-acetyltransferases: From Structure to Function

(2008) Edith Sim et al.   DRUG METABOLISM REVIEWS

Discovery and Evaluation of 4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one (BMS-695735), an Orally Efficacious Inhibitor of Insulin-like Growth Factor-1 Receptor Kinase with Broad Spectrum in Vivo Antitumor Activity

(2008) Upender Velaparthi et al.   JOURNAL OF MEDICINAL CHEMISTRY

In Vitro Assessment of Mitochondrial Dysfunction and Cytotoxicity of Nefazodone, Trazodone, and Buspirone

(2008) James A. Dykens et al.   TOXICOLOGICAL SCIENCES

Strategies to preventN-acetyltransferase-mediated metabolism in a series of piperazine-containing pyrazalopyrimidine compounds

(2008) J. Rawal et al.   XENOBIOTICA

Metabolism of prazosin in rat and characterization of metabolites in plasma, urine, faeces, brain and bile using liquid chromatography/mass spectrometry (LC/MS)

(2008) J. C. L. Erve et al.   XENOBIOTICA

Idiosyncratic Drug Reactions: Past, Present, and Future

(2007) Jack Uetrecht   CHEMICAL RESEARCH IN TOXICOLOGY