Article
Spectroscopy
Barbara Rojek, Maria Gazda, Alina Plenis
Summary: Detection of incompatibility between an active pharmaceutical ingredient (API) and excipients plays a crucial role in the pre-formulation process of solid dosage form technology development. In this study, Fourier transform infrared (FTIR), Raman spectroscopy, and high-temperature X-ray diffraction (HT-XRD) were used to identify incompatibility, while differential scanning calorimetry (DSC) served as a reference. Multivariate analysis was employed to interpret FTIR and Raman data. The experiments revealed the physical incompatibility of naproxen (NPX) with methylcellulose (MC), hydroxypropylmethylcellulose (HPMC), hydroxyethylcellulose (HEC), sodium starch glycolate (SSG), and sodium carboxymethylcellulose (CMC).
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Applied
Najme Molaahmadi Bahraseman, Hajar Shekarchizadeh, Sayed Amir Hossein Goli
Summary: The study found that the interaction between tragacanth gum and gelatin during acidification is influenced by total concentration, biopolymer mixing ratio, and ionic strength. Different types of complexes are formed at specific pH values, affecting the efficiency of complex formation.
Review
Pharmacology & Pharmacy
Marek Wesolowski, Edyta Leyk
Summary: Using multiple measurement techniques ensures reliable interpretation of sample changes during heating, eliminating uncertainty and improving data interpretation. This paper briefly characterizes thermal analysis techniques coupled with spectroscopic or chromatographic techniques. Various design solutions for coupled thermogravimetry (TG) with infrared spectroscopy (FTIR), mass spectrometry (MS), and gas chromatography/mass spectrometry (GC/MS) systems are discussed. The importance of coupled techniques in pharmaceutical technology is highlighted, as they provide insights into the behavior and degradation of medicinal substances during heating, allowing determination of decomposition mechanisms and prediction of shelf life and storage conditions. In addition, design solutions for interpreting differential scanning calorimetry (DSC) curves using observation or simultaneous recording of FTIR spectra and X-ray diffractograms (XRD) are characterized, addressing the inherent non-specificity of DSC.
Article
Pharmacology & Pharmacy
Saeid Mezail Mawazi, Abd Almonem Doolaanea, Hazrina Ab Hadi, Bappaditya Chatterjee
Summary: Crystallinity is crucial in the pharmaceutical industry, affecting drug manufacturing, development processes, and dosage form stability. This study investigated the effects of CBZ crystallinity on drug loading, particle size, and release from microparticles. The results showed that changes in CBZ crystallinity significantly influenced the performance of CBZ microparticles.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Multidisciplinary Sciences
Santosh Koirala, Prabin Nepal, Govinda Ghimire, Rojina Basnet, Ishwori Rawat, Aashma Dahal, Jitendra Pandey, Kalpana Parajuli-Baral
Summary: The project aimed to formulate and characterize mucoadhesive buccal tablets of aceclofenac using different ratios of three polymers. Twelve batches were prepared and evaluated for physicochemical parameters and in vitro dissolution. The study concluded that buccal mucoadhesive aceclofenac tablets can be successfully formulated with appropriate properties.
Article
Materials Science, Textiles
Arumugam Kayambu, Rajkumar Ramasubbu
Summary: The study investigates the characterization and properties of Areca Catechu Fiber (ACF), which is rich in cellulose and has a density of 1.34 g/cc, making it a potential replacement for synthetic fibers. With low wax content, it provides better adhesion between fiber and resin interface, making it a better solution for eco-friendly composite products.
JOURNAL OF NATURAL FIBERS
(2022)
Article
Chemistry, Multidisciplinary
M. Rahim, M. R. H. Mas Haris
Summary: A green biocomposite was prepared with chitosan dispersed in partially cross-linked natural rubber matrices. Chitosan was well dispersed in the matrices, indicating successful stabilization of natural rubber latex by sodium dodecyl sulfate. The biocomposites showed good swelling properties and were used for controlled release of urea.
MATERIALS TODAY CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Y. Alaoui, M. Laourayed, A. Er-rafai, M. Hammi, M. El Moudane, M. Boudalia, Z. Sekkat, I. Warad, A. Guenbour, A. Bellaouchou, A. Zarrouk
Summary: In this study, six aluminum potassium calcium based-phosphate glasses were synthesized and their structural and chemical properties were investigated. The addition of aluminum was found to have a positive effect on the density, glass transition temperature, and crystallization temperature of the glasses, as well as generating new chemical bonds in the glass structure.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Polymer Science
Mohammed Muqtader Ahmed, Farhat Fatima, Aisha Alnami, Mohammad Alsenaidy, Alhussain H. Aodah, Mohammed F. Aldawsari, Bjad Almutairy, Md. Khalid Anwer, Mohammed Jafar
Summary: This study aimed to develop three-dimensional (3D) baricitinib (BAB) pills using polylactic acid (PLA) by fused deposition modeling. The fabricated pills showed the amorphousness of infused BAB in the filament, and the release of the drug was found to be significant. BAB is a novel JAK inhibitor recently approved by the U.S. FDA for treating alopecia areata (AA). Therefore, the proposed 3D printed tablets can be easily fabricated with FDM technology and effectively used in various acute and chronic conditions as personalized medicine at an economical cost.
Article
Materials Science, Textiles
Fereshteh Fadavi, Ali Abdulkhani, Zahra Echresh Zadeh, Yahya Hamzeh
Summary: This study investigated the changes in cellulose II structure in never-dried Lyocell fibers upon swelling with different solvents and aqueous solutions using FTIR, solid-state C-13 NMR spectroscopies, and DSC thermal analysis. Water retention behavior and fiber accessibility were found to be correlated with solvent-induced changes in the fiber structure, in accordance with the results obtained from FTIR and C-13 NMR spectroscopies.
JOURNAL OF NATURAL FIBERS
(2022)
Article
Polymer Science
Katia Rubini, Elisa Boanini, Silvia Parmeggiani, Adriana Bigi
Summary: In this study, curcumin was used as a functionalizing agent to develop antioxidant materials with modulated physico-chemical properties in gelatin films. The functionalized films exhibited remarkable antioxidant properties and sustained curcumin release, suggesting potential applications in various fields. The properties of the materials varied based on the curcumin content and presence of crosslinking agent, demonstrating the versatility of gelatin in different applications.
Article
Polymer Science
C. Naveen, M. Muthuvinayagam
Summary: Magnesium ion conducting biodegradable polymer blend electrolytes were prepared by solution casting technique using Chitosan, Poly-vinyl alcohol (PVA) and Magnesium chloride (MgCl2). The electrolytes were characterized using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Electrochemical impedance spectroscopy (EIS) and Differential scanning calorimetry (DSC). The Chitosan:PVA:MgCl2 polymer electrolyte showed the highest ionic conductivity of 5.9 x 10(-5)S/cm. The thermal stability and glass transition temperature of the electrolytes were also studied using DSC. An electric double layer capacitor (EDLC) was fabricated using the higher conducting polymer electrolyte and its performance was tested.
JOURNAL OF POLYMER RESEARCH
(2023)
Article
Engineering, Aerospace
G. Saravanan, S. Shanmugam, A. R. Veerappan
Summary: This study investigates the physical, chemical, and thermal characteristics of paraffin-blended fuels for potential use in hybrid rockets. Various analytical techniques were used to assess the properties of fuel blends, providing valuable insights for unconventional fuel formulations.
AIRCRAFT ENGINEERING AND AEROSPACE TECHNOLOGY
(2022)
Article
Chemistry, Physical
A. Agnaou, W. Mhaira, R. Essalim, M. Alga, M. Zamama, F. Mauvy, A. Ammar
Summary: The Bi4V1.7(Si.Me)O-0.3(11-δ) system was studied using various techniques, revealing the presence of three main polymorphs at room temperature. Two successive structural transitions were observed in the Bi4Si0.15P0.15V1.70O11-δ compound, while only one structural transition was observed in the Bi(4)Si(0.30)V(1.7)0O(11-δ) compound. UV-vis diffuse reflectance spectroscopy showed that the double-doped Bi4V1.7(Si.Me)O-0.3(11-δ) compounds have a band gap energy ranging from 1.76 to 2.36 eV, with Bi4Si0.15Co0.15V1.70O11-δ having the narrowest band gap.
Article
Physics, Multidisciplinary
A. A. Al-Muntaser, Eman Alzahrani, Hala M. Abo-Dief, Abdu Saeed, F. A. Al-Marhaby, Amani M. Al-Harthi, A. E. Tarabiah
Summary: In this study, composite films made of polyvinyl alcohol (PVA) filled with various coronene concentrations were fabricated via the solution casting method. The effects of coronene on the properties of the PVA films were investigated, and it was found that increasing the coronene levels improved charge carrier mobility and conductivity, while decreasing the semi-crystalline properties. The PVA/coronene composite films also showed superior UV blocking performance and could be potentially used in flexible packaging and optoelectronic devices.
Article
Chemistry, Medicinal
Sachin S. Gaikwad, Rohini D. Avhad, Ramesh S. Kalkotwar
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2020)
Article
Pharmacology & Pharmacy
Umesh D. Laddha, Sanjay J. Kshirsagar, Layba S. Sayyad, Musab T. Ahmed, Sachin S. Gaikwad, Pavan B. Udavant, Abhijeet D. Kulkarni
Summary: Diabetic retinopathy is the most severe complication of diabetes that leads to blindness. The current treatment methods are invasive and associated with pain. This study developed surface-modified PLGA nanoparticles of Curcumin for targeted treatment of diabetic retinopathy. The optimized nanoparticles showed satisfactory results in in vitro and in vivo experiments.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Sachin S. Gaikwad, Akshada M. Kothule, Yogita Y. Morade, Sakshi S. Patil, Umesh D. Laddha, Sanjay J. Kshirsagar, Kishor S. Salunkhe
Summary: The Sediment Delivery Model (SeDeM) is a method that explains the analysis and assessment of powdered substance characterizing parameters, providing relevant data about material suitability for direct compression of tablets. It involves mathematical modeling and the use of software like iTCM to determine the suitability of excipients and active ingredients for direct compression, as well as calculate the API to excipient ratio. The SeDeM model is based on quality by design (QbD) and evaluates critical quality attributes affecting the finished product's quality.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Chemistry, Multidisciplinary
Sachin S. Gaikwad, Snehal R. Pathare, Mayur A. More, Nikita A. Waykhinde, Umesh D. Laddha, Kishor S. Salunkhe, Sanjay J. Kshirsagar, Sakshi S. Patil, Kuldeep H. Ramteke
Summary: A Dry Powder Inhaler (DPI) is a technique and device used for inhaling dry powder formulation to treat respiratory conditions such as COPD, asthma, and cystic fibrosis. This review discusses the methods of preparation and characterization of DPI, including supercritical fluid extraction, spray drying, and milling. It also highlights recent advances in DPI, such as the use of silver nanoparticles for COVID-19 treatment and the development of AI-based DPI for improved drug bioavailability. The study shows that nasally administered drugs can easily cross the blood-brain barrier and enter the CNS, providing effective CNS concentrations at lower dosages. The review supports and guides researchers in the development and evaluation of DPI.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Pharmacology & Pharmacy
Umesh D. Laddha, Priyanka D. Sandhan, Sachin S. Gaikwad, Kailas K. Moravkar, Sanjay J. Kshirsagar
Summary: Dry eye disease (DED) is a common ocular complication with poor patient adherence to current treatment due to frequent ocular instillation. In this study, a pH sensitive in situ gel loaded with pioglitazone nanoparticles was prepared and shown to have sustained drug release and improved tear secretion in mice with DED, indicating its potential as a novel formulation for DED treatment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Multidisciplinary Sciences
Sachin S. Gaikwad, Yogita Y. Morade, Akshada M. Kothule, Sanjay J. Kshirsagar, Umesh D. Laddha, Kishor S. Salunkhe
Summary: Cancer, a major cause of death worldwide, has proven difficult to effectively treat with conventional therapies due to severe adverse effects. Utilizing herbal active constituents and nanotechnologies, such as phytosomes, has shown potential in increasing the effectiveness and bioavailability of cancer treatment. This review focuses on various conventional and novel approaches, as well as the use of phytosomes as a better carrier for herbal constituents in cancer therapy. It also discusses the formulation, characterization technique, drug release mechanism, and challenges and future perspectives related to using phytosomes in cancer treatment.
Review
Multidisciplinary Sciences
Sachin S. Gaikwad, Sanjay J. Kshirsagar
BENI-SUEF UNIVERSITY JOURNAL OF BASIC AND APPLIED SCIENCES
(2020)
