Article
Chemistry, Applied
Huong Thi Hoang, Trung Thang Vu, Viswanathan Karthika, Sung-Han Jo, Yi-Jun Jo, Jeong-Woo Seo, Chul-Woong Oh, Sang-Hyug Park, Kwon Taek Lim
Summary: A physically and chemically double-crosslinked hydrogel derived from chitosan oligosaccharide/alginate was developed for the delivery of ketoprofen. The hydrogel showed outstanding hydrophobic drug loading and sustained release, as well as pH responsiveness, making it a potential candidate for hydrophobic drug delivery.
CARBOHYDRATE POLYMERS
(2022)
Article
Polymer Science
Weronika Szczesna, Marta Tsirigotis-Maniecka, Lilianna Szyk-Warszynska, Sebastian Balicki, Piotr Warszynski, Kazimiera A. Wilk
Summary: In this study, multilayered alginate/chitosan microparticles were fabricated to enhance the oral administration of large cranberry fruit extracts. The size and properties of the microparticles were influenced by the outermost layer composition. The microparticles showed good drug entrapment efficiency and release profiles.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Food Science & Technology
Jia Cao, Xiaohong Tong, Mengmeng Wang, Tian Tian, Sai Yang, Mingyue Sun, Bo Lyu, Xinru Cao, Huan Wang, Lianzhou Jiang
Summary: The study investigated the effects of sodium alginate and pH value on the formation and properties of soybean protein isolate/sodium alginate microparticles, revealing changes in protein structure, surface characteristics, and thermal stability. Under pH 9.0, the microparticles exhibited optimal physicochemical properties.
Article
Chemistry, Applied
Meng Cheng, Yingjun Cui, Yanli Guo, Peixin Zhao, Juan Wang, Rongfei Zhang, Xiangyou Wang
Summary: pH-responsive CC/SA/CA hydrogels were prepared using CC and SA as wall materials, with the hydrogel formation attributed to electrostatic interactions and hydrogen bonding. The hydrogels exhibited improved thermostability with increasing CC content, as well as increased swelling degree with higher pH of the buffer solution. CA release from the hydrogels was mainly controlled by Fickian diffusion, and the release rate was positively correlated with temperature and environmental pH, allowing for on-demand release of CA. The hydrogels also showed good storage stability, antioxidant and antibacterial activities, and biocompatibility, making them a promising platform for environmentally-responsive preservatives with precise release and intelligent preservation capabilities.
Article
Biochemistry & Molecular Biology
Nadia Hussein A. Al-Assady, Hussain A. Badran, Sarah A. Kamil, Ryadh Ch. Abo-Alhal
Summary: Rifampicin-loaded sodium alginate/chitosan polyelectrolyte microparticles were prepared using CaCl2 as a cross-linking agent. The influence of sodium alginate and chitosan concentrations on particle size, surface properties, and drug release behavior was investigated. The results showed that by increasing the concentration of the polymer, the release of rifampicin decreased, and drug release followed zero-order kinetics frequently influenced by diffusion.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Biochemistry & Molecular Biology
Olimpia Frent, Laura Vicas, Narcis Duteanu, Claudia Morgovan, Tunde Jurca, Annamaria Pallag, Mariana Muresan, Sanda Filip, Roxana-Liana Lucaciu, Eleonora Marian
Summary: Sodium alginate is a natural polymer that has been extensively studied for its low cost, low toxicity, biocompatibility, biodegradability, and gel-forming capacity in the presence of Ca2+ ions. It can be included in controlled-release pharmaceutical systems to enhance drug capture capacity and extend drug release from the pharmaceutical form.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Applied
Huijuan Jing, Xin Huang, Xiaojing Du, Ling Mo, Chaoyang Ma, Hongxin Wang
Summary: In this study, a novel synthesis strategy utilizing hydrogen bonds was used to prepare sodium alginate/carboxymethyl chitosan hydrogel beads. The beads demonstrated excellent pH sensitivity, reversibility, and protein loading capacity, making them a potential carrier for oral delivery of proteins.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Applied
Miao Zhang, Xiaoni Qiao, Wenwei Han, Tianze Jiang, Fei Liu, Xia Zhao
Summary: A novel composite hydrogel was fabricated, promoting cell proliferation and migration for wound healing, while also exhibiting significant antibacterial activity. This study highlights the potential of marine carbohydrate composite hydrogels in wound care management.
CARBOHYDRATE POLYMERS
(2021)
Article
Food Science & Technology
Shenghui Cao, Shuo Wang, Qingqing Wang, Gang Lin, Baolong Niu, Ruijie Guo, Hong Yan, Huifang Wang
Summary: A pH-sensitive bilayer film with antioxidant and antibacterial activities was prepared by anchoring anthocyanins (ACNs) with sodium alginate (SA) as the sensing inner layer and incorporating TiO2 in chitosan (CS) as the protective outer layer. The film exhibited a wide range of color variations at pH 2-13 and had high bactericidal rates against E. coli and S. aureus. It could extend pork's shelf life and monitor pork quality in real-time, showing potential for meat preservation and freshness monitoring.
Review
Chemistry, Multidisciplinary
Slaven Juric, Marina Juric, Anet Rezek Jambrak, Marko Vincekovic
Summary: This work reviews the recent development of biopolymer-based delivery systems for agricultural application, emphasizing the protection and targeted delivery of active agents through encapsulation into biopolymer microparticles with controlled release for ecological and sustainable plant production. The encapsulation of biological agents provides protection, increases survivability, and offers a safe environment for growth. Additionally, the application of microparticles loaded with chemical and biological agents presents an innovative way to stimulate plant metabolites synthesis, enhancing plants' defense against pests and pathogens and resulting in the production of higher quality food.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Yue Wang, Jinhui Tang, Yuanbo Zeng, Xuemei Liu, Mingrui Chen, Jianwu Dai, Suqing Li, Wen Qin, Yaowen Liu
Summary: Nanofibrous composite membranes consisting of PVA, SA, CS-Nano-ZnO, and Cur were prepared through ultrasonic processing and electrospinning. The composite fiber membrane with a mass ratio of 5:5 exhibited the best performance in terms of water vapor permeability, strain, stress, and inhibitory rates against E. coli and S. aureus. The use of these membranes for grape packaging extended the shelf life of the fruits and maintained their quality.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Guo Yi, Junhong Ling, Yongjun Jiang, YuQing Lu, Li-Ye Yang, Xiao-kun Ouyang
Summary: In this study, pH-sensitive chito-oligosaccharide nano-drug-loaded particles were developed with good bio-compatibility, biodegradation, and controlled drug delivery. The nanoparticles demonstrated site targeting under weak acidic tumor conditions, improved drug efficacy, and reduced toxic side effects.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Polymer Science
Zi-Ang Yao, Ling Xu, Bai-Xiang Wang, Ting-Ting Ye, Yan-Feng Li, Hai-Ge Wu
Summary: Sodium alginate, extracted from brown algae, is a marine polysaccharide that has been widely utilized in food and medicine fields. This study focused on optimizing the preparation process of sulfated alginate oligosaccharide (S-AOS) and investigating its structure, characterization, and biological activity. The results showed that S-AOS had enhanced biological activity and potential applications in biomedicine.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Chemistry, Applied
Feuangthit Niyamissara Sorasitthiyanukarn, Chawanphat Muangnoi, Pornchai Rojsitthisak, Pranee Rojsitthisak
Summary: In this study, ATX-loaded chitosan oligosaccharide/alginate nanoparticles (ATX-COANPs) were successfully fabricated with optimized conditions. These nanoparticles exhibited good stability and sustained release characteristics under various conditions. Encapsulation within COANPs led to increased in vitro bioaccessibility, bioavailability, and antioxidant activity of ATX, suggesting potential applications in developing an effective oral delivery system for nutraceuticals or functional foods.
FOOD HYDROCOLLOIDS
(2022)
Article
Pharmacology & Pharmacy
M. Cirri, F. Maestrelli, S. Scuota, V Bazzucchi, P. Mura
Summary: Metronidazole-loaded vaginal multiparticulate systems were developed to improve drug release, with the best formulation demonstrating efficacy in treating local diseases based on various performance tests conducted.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Victor Fritz, Petros Martirosian, Juergen Machann, Rolf Daniels, Fritz Schick
Summary: The study investigated the suitability of different emulsifiers in oil-in-water emulsions used as tissue analogs for MRI experiments. It was found that soy lecithin is the preferred emulsifier due to its high stabilizing ability and invisibility in MRI experiments. Additionally, lecithin can adjust relaxation times and ADC values of water, making it an alternative means for MRI experiments.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Mirjana D. Timotijevic, Tanja Ilic, Snezana Savic, Ivana Pantelic
Summary: This paper explores the changes in topical film-forming systems (FFS) after solvent displacement, emphasizing their skin transformation as an area of special interest. The lack of appropriate characterization techniques is addressed and a comprehensive set of methods to evaluate FFS skin performance is proposed. The study investigates the physico-chemical, mechanical, and sensory properties of FFS and resulting films, and includes in vivo assessments of skin irritation, friction, and substantivity. The findings suggest that the type of film former affects transepidermal water loss, and that a hydrophobic methacrylate copolymer-based film reduces water loss by 40-50%, indicating a semi-occlusive effect. The analysis of tribological parameters and friction curves provides valuable insights, demonstrating the importance of reaching the plateau as the onset of the secondary formulation. The in vivo study confirms the high substantivity of all samples and supports the optimal ratio of hydrophobic cationic and hydrophilic polymers found during early screening.
Article
Biochemistry & Molecular Biology
Mirjana D. Timotijevic, Tanja Ilic, Bojan Markovic, Danijela Randjelovic, Nebojsa Cekic, Ines Nikolic, Snezana Savic, Ivana Pantelic
Summary: Polymeric film-forming systems have been studied for their properties and a combination of hydrophobic polymers has been found to achieve sustained and immediate drug delivery through the skin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Ines Nikolic, Mitar Simic, Ivana Pantelic, Goran Stojanovic, Jelena Antic Stankovic, Bojan Markovic, Snezana Savic
Summary: Various approaches have been proposed for improving dermal drug delivery, such as chemical penetration enhancers and electrical current methods like iontophoresis. In this study, curcumin-loaded nanoemulsions with and without monoterpenes as penetration enhancers, as well as an adhesive dermal delivery system based on iontophoresis, were designed and evaluated. The results showed that iontophoresis was equally efficient as other methods in terms of curcumin penetration through superficial skin layers. Further improvement of iontophoresis as a mobile adhesive system would be a practical contribution in the field of dermal drug application.
Article
Pharmacology & Pharmacy
Manuel Bunk, Rolf Daniels
Summary: This study focused on the development of foamable emulsions based on aqueous phospholipid blends. The type of cosurfactant and oil phase were found to affect the quality of the resulting foam. Foam formulations are safe and effective therapy options for the treatment of chronic skin conditions.
Article
Pharmacology & Pharmacy
Jelena B. Dokovic, Sotiria Demisli, Sanela M. Savic, Bojan D. Markovic, Nebojsa D. Cekic, Danijela V. Randjelovic, Jelena R. Mitrovic, Dominique Jasmin Lunter, Vassiliki Papadimitriou, Aristotelis Xenakis, Snezana D. Savic
Summary: A nanotechnology-based approach to drug delivery is an important trend in biomedical science, offering advantages such as increased active concentration, bioavailability, and safety compared to conventional drug delivery systems. Nanoemulsions, as biodegradable, biocompatible and relatively easy to manufacture nanocarriers, have gained attention in the field. This study assessed the impact of oil phase selection on the physicochemical characteristics and injectability of curcumin-loaded PEGylated nanoemulsions. The results showed that the oil phase had a structural impact on the stabilizing layer of the nanoemulsions, and different oil phase selections significantly influenced the critical quality attributes of the PEGylated nanoemulsions.
Article
Pharmacology & Pharmacy
Nuno F. da Costa, Rolf Daniels, Ana I. Fernandes, Joao F. Pinto
Summary: This work evaluates the stability of amorphous and co-amorphous olanzapine (OLZ) in tablets manufactured by direct compression. The study found that the flowability of amorphous and co-amorphous OLZ powders decreased compared to crystalline OLZ, but resulted in enhanced water solubility. However, the release rate of the drug decreased in tablets with amorphous OLZ. The research highlights the stability of amorphous and co-amorphous OLZ during tableting and the positive effect of compaction pressure on the formation of co-amorphous OLZ.
Article
Biochemistry & Molecular Biology
Nuno F. da Costa, Rolf Daniels, Ana Fernandes, Joao F. Pinto
Summary: The preparation of amorphous and co-amorphous systems effectively addresses solubility and bioavailability issues. This study evaluated the stability of amorphous olanzapine and olanzapine co-amorphous systems during wet granulation and pelletization. The results showed that the co-amorphous systems were more stable and had higher solubility and dissolution rate, suggesting the potential to reduce production costs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Ann-Kathrin Widmann, Martin A. Wahl, Dietmar R. Kammerer, Rolf Daniels
Summary: The study investigated the extraction of Curcuma longa rhizomes using supercritical carbon dioxide at different pressure and temperature conditions, with the optimum yield achieved at 425 bar and 75 degrees C. A comparison was made between supercritical carbon dioxide extraction and solvent extraction using methanol and n-hexane, and the stability of the extracts under different storage conditions was monitored.
Article
Biochemistry & Molecular Biology
Ana Gledovic, Aleksandra Janosevic-Lezaic, Slobodanka Tamburic, Snezana Savic
Summary: This study assessed and improved the oxidative stability of red raspberry seed oil and identified potential natural antioxidants for protection. Additionally, it explored the use of biodegradable polyglycerol esters-based surfactants for preparing stable nanoemulsions.
Article
Biochemistry & Molecular Biology
Lilo K. Mailaender, Peter Lorenz, Hannes Bitterling, Florian C. Stintzing, Rolf Daniels, Dietmar R. Kammerer
Summary: Matricaria recutita L., or German chamomile, is a widely used medicinal plant with proven efficacy. This study focused on the less explored roots of chamomile and found various active compounds. The root extracts showed antioxidant and antibacterial activities. The results highlight the potential medicinal value of chamomile roots.
Review
Pharmacology & Pharmacy
Tanja Ilic, Jelena B. B. Dokovic, Ines Nikolic, Jelena R. R. Mitrovic, Ivana Pantelic, Snezana D. Savic, Miroslav M. M. Savic
Summary: Contemporary trends in combinatorial chemistry and drug design focus on developing lipophilic drugs with poor water solubility to improve delivery across the blood-brain barrier. Lipid nanocarriers, with innovative excipients/ligands, offer a promising solution to overcome the challenges of drug delivery through the blood-brain barrier. However, the lack of standardized methods and experimental conditions in the literature hinders systematic comparison and slows down the advancement in brain-targeting using lipid-based nanoparticles. This review provides an overview of commonly used methods in preclinical testing of lipid nanoparticles, such as liposomes, nanoemulsions, solid lipid nanoparticles, and nanostructured lipid carriers for CNS disorder treatment via parenteral route.
Article
Pharmacology & Pharmacy
Mila Vukasinovic, Sanela Savic, Nebojsa Cekic, Tanja Ilic, Ivana Pantelic, Snezana D. Savic
Summary: This study proposes a combination of in silico, instrumental tools and simplified sensory studies to efficiently characterize emulsions. By using experimental design method, the optimal formulation content was determined and the physical properties and sensory characteristics of each formulation were analyzed, providing guidance for early-stage development applications.
Review
Immunology
Brankica Filipic, Ivana Pantelic, Ines Nikolic, Dragomira Majhen, Zorica Stojic-Vukanic, Snezana Savic, Danina Krajisnik
Summary: Since the development of the first vaccine, vaccination has had a significant impact on global health, reducing the burden of infectious diseases. Modern vaccines rely on nanotechnology platforms, which can induce a broader immune response and are easy to manufacture and use. This review provides an overview of promising nanoadjuvants and nanoparticulate delivery systems, discussing their technological and immunological advantages, drawbacks, and possible side effects.
Article
Engineering, Chemical
Ana Gledovic, Danica Bajuk-Bogdanovic, Snezana Uskokovic-Markovic, Leposava Pavun, Snezana Savic, Aleksandra Janosevic Lezaic
Summary: In this study, several essential oils (EOs) were incorporated into nanoemulsions (NEs) as potential carriers for natural bioactives. The type of EO, surfactant, and oil mix concentration were found to be crucial factors for NE properties and stability. Raman spectra of the EOs confirmed the active ingredients and their interaction with the nanocarrier. Overall, oregano-loaded NEs were the most effective and stable system, preserving its high antioxidant activity during storage.
HEMIJSKA INDUSTRIJA
(2022)
