Article
Chemistry, Applied
Handan Basunal Gulmez, Ayhan Topuz
Summary: Phytosterols can reduce cholesterol and low-density lipoprotein concentrations. By using electrospraying technology, the encapsulation of phytosterols improves their absorption and release.
Article
Polymer Science
Muhammad Suhail, Chih-Wun Fang, Arshad Khan, Muhammad Usman Minhas, Pao-Chu Wu
Summary: The study aimed to develop CS/CBP-co-PAA hydrogels for controlled release of diclofenac sodium. Characterizations and experiments were conducted to understand drug release behavior at different pH levels. The prepared hydrogel showed controlled release of the drug according to the Korsmeyer-Peppas model.
Article
Instruments & Instrumentation
Jennifer Walker, Jason Albert, Desheng Liang, Jing Sun, Richard Schutzman, Raj Kumar, Cameron White, Moritz Beck-Broichsitter, Steven P. Schwendeman
Summary: Copolymers of lactic and glycolic acids are commonly used in biomedical applications. This study compared PLGAs from different manufacturers and revealed differences in their properties, providing recommendations for selecting suitable PLGAs.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Engineering, Biomedical
Juan Carlos Flores-Arriaga, Daniel Chavarria-Bolanos, Amaury de Jesus Pozos-Guillen, Vladimir Alonso Escobar-Barrios, Bernardino Isaac Cerda-Cristerna
Summary: The study successfully formulated a Tramadol-Dexketoprofen combination loaded in poly(vinyl alcohol) (PVA) film with different molecular weights and crosslinked with citric acid to control drug release rate. The results showed that crosslinked PVA films have a prolonged release rate compared to non-crosslinked films, indicating potential for promoting local analgesia for postoperative pain control.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2021)
Article
Chemistry, Applied
Jie Yang, Qiwei Zhou, Zehao Huang, Zhengbiao Gu, Li Cheng, Lizhong Qiu, Yan Hong
Summary: This study aimed to investigate the controlled release mechanism of Astaxanthin (AST) from biocompatible double emulsions fabricated with a novel two-step emulsification method using native starch. The results showed that AST-loaded SDEs exhibited excellent storage stability, high encapsulation efficiency, and a sustained release profile, with the diffusion-releasing mechanism being the most suitable model for describing the release kinetics. The interaction between SDEs and AST was also explored, highlighting the potential of SDEs as promising oral delivery carriers for lipophilic ingredients.
FOOD HYDROCOLLOIDS
(2021)
Article
Biophysics
Furqan A. Maulvi, Parth D. Soni, Pooja J. Patel, Ankita R. Desai, Ditixa T. Desai, Manish R. Shukla, Shailesh A. Shah, Dinesh O. Shah, Mark D. P. Willcox
Summary: The research used graphene oxide (GO) to control the release of bimatoprost from contact lenses in order to improve drug uptake, lens swelling, and transmittance. Although GO did not enhance bimatoprost uptake, it improved the in vitro release profile of the drug.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Chemistry, Applied
Chenwei Chen, Lin Zong, Jiaxi Wang, Jing Xie
Summary: The study focused on the impact of MFC content on the properties of ST/PVA films, showing that MFC enhanced the strength of the films and improved their crystallinity while reducing flexibility. The release of CIN from films was controlled by MFC, with potential for inhibiting the growth of putrefaction bacteria.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Inorganic & Nuclear
Atefeh Kamali Dolatabadi, Javad Mokhtari, Nasrin Talebian
Summary: Sol gel method was used to investigate the release of Montelukast drug in silica matrix. Encapsulation of montelukast was examined under different parameters, and the best condition for drug release was found to be the presence of montelukast sodium salt at room temperature. The releasing data were analyzed using mathematical kinetic models, and the suitable models were determined for Montelukast sodium and imidazolium. Various analyses were employed to characterize the sol-gel process and drug encapsulation. The mechanism of drug release was a combination of dissolution and diffusion processes.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Muhammad Suhail, Jia-Yu Liu, Ming-Chia Hung, I-Hui Chiu, Muhammad Usman Minhas, Pao-Chu Wu
Summary: The aim of this study was to develop pH-responsive hydrogels for controlled drug delivery. The hydrogels showed good swelling and drug release properties, with higher concentrations of hydrogel contents leading to increased porosity and drug loading. These hydrogels had a slow degradation rate and exhibited no toxic effects on human colon cancer cells.
Article
Chemistry, Multidisciplinary
Sahariya Priya, Adhigan Murali, Sakar Mohan, A. Lakshminarayanan, S. Sekar, R. Ramesh, M. Devendiran, Sung Soo Han
Summary: In this study, a phenoxyaniline-based macroinitiator was used for the first time to produce phenoxyaniline-block-poly(methyl methacrylate) composites through single electron transfer-living radical polymerization. The structural, thermal, surface and morphological properties of the prepared block copolymer nanocomposites were characterized using various techniques. The developed polymeric nanocomposites exhibited excellent anticancer properties and were successfully applied in the treatment of prostate adenocarcinoma and lung cancer.
NANOSCALE ADVANCES
(2023)
Review
Pharmacology & Pharmacy
Lucien Roulet, Victoria Rollason, Jules Desmeules, Valerie Piguet
Summary: Tapentadol and tramadol share similarities in pharmacological mechanisms, efficacy, and safety profiles, with tapentadol being slightly more potent. Both drugs have similar toxic side effect profiles, but tapentadol may lead to fewer serotonergic adverse effects and more opioid-related adverse effects compared to tramadol. While tramadol has more real-world safety data available, the safety of tapentadol in real-world conditions remains uncertain.
Article
Pharmacology & Pharmacy
Elizabeth Ortega Molina, Maria Josefa Bernad Bernad, Jesus Gracia Mora, Dinorah Vargas Estrada, Luis Ocampo Camberos
Summary: Modified release formulations of tramadol were designed to prolong the release time compared to the commercial product, using different concentrations of poloxamer 407. In vitro studies showed promising results for extended release of tramadol, suggesting potential for further in vivo experiments to confirm conclusions.
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Di Meng, Jinlin Song, Yin Yi, Jihong Li, Ting Zhang, Yu Shu, Xiaohong Wu
Summary: This study aimed to prepare naringin (Ng) liposomes to reduce the burst release of Ng and improve new bone formation. The nanosized Ng liposomes with a high encapsulation efficiency were successfully synthesized and the burst release was dramatically reduced from 74.4% to 23.7% by adding SAIB. In vivo experiment showed that the new bone formation rate in the animals receiving Ng-lipo/SAIB was significantly higher compared with the control group. These results suggest that Ng-lipo/SAIB hybrid depots could serve as candidate materials for drug delivery in bone regeneration applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Surgery
Kathleen Marulanda, Dylan Brokaw, Maria Gambarian, Rajesh Pareta, John P. McQuilling, Emmanuel C. Opara, Sean E. McLean
Summary: The Slit-Robo pathway regulates angiogenesis and cellular function. Slit3 can be effectively encapsulated in alginate microbeads for controlled release, reducing endothelial tube formation and inhibiting cellular migration to impair angiogenesis.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Ghulam Abbas, Akhtar Rasul, M. Fakhar-e-Alam, Malik Saadullah, Saima Muzammil, Omeira Iqbal, M. Atif, Muhammad Hanif, Shahid Shah, Shafiq Ahmad, Sulman Shafeeq, Muhammad Afzal
Summary: The study aimed to formulate nanoparticles of thiolated chitosan with enhanced mucoadhesion and controlled release behavior. Stable nanoparticles were prepared using an ionic gelation method, and their adhesion, swelling, and toxicity were evaluated. Drug release studies of non-thiolated and thiolated nanoparticles showed that the thiolated nanoparticles exhibited better controlled release. Animal experiments confirmed the superior pharmacokinetic properties of the thiolated nanoparticles compared to the marketed formulation.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Review
Chemistry, Multidisciplinary
Michael T. Cook, Marc B. Brown
JOURNAL OF CONTROLLED RELEASE
(2018)
Article
Dermatology
Aditya K. Gupta, Tracey C. Vlahovic, Kelly A. Foley, Nicole Gellings Lowe, Rob Turner, Marc Brown, Steve Hall
JOURNAL OF DERMATOLOGICAL TREATMENT
(2018)
Article
Pharmacology & Pharmacy
Sara Shafaie, Victoria Hutter, Marc B. Brown, Michael T. Cook, David Y. S. Chau
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2018)
Article
Biochemistry & Molecular Biology
Satyajit S. Shetage, Matthew J. Traynor, Marc B. Brown, Robert P. Chilcott
LIPIDS IN HEALTH AND DISEASE
(2018)
Review
Chemistry, Medicinal
Beatrice Pecoraro, Marco Tutone, Ewelina Hoffman, Victoria Hutter, Anna Maria Almerico, Matthew Traynor
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2019)
Article
Biochemical Research Methods
Rob Turner, Sean Robert Wevrett, Suzanne Edmunds, Marc Brown, Robert Atkinson, Tim Shea
BIOMEDICAL CHROMATOGRAPHY
(2019)
Article
Pharmacology & Pharmacy
F. Caserta, M. B. Brown, W. J. McAuley
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2019)
Article
Chemistry, Multidisciplinary
H. A. Farah, M. B. Brown, William J. McAuley
PHARMACEUTICAL RESEARCH
(2019)
Article
Pharmacology & Pharmacy
Avinash Thombre, Susanna Tse, Thean Yeoh, Raymond Chen, Robert North, Marc Brown
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Article
Pharmacology & Pharmacy
Mira Dhiraj Buhecha, Alison B. Lansley, Satyanarayana Somavarapu, Ananth S. Pannala
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2019)
Review
Pharmacology & Pharmacy
Zhenqi Liu, John D. Smart, Ananth S. Pannala
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2020)
Review
Pharmacology & Pharmacy
Daniel Hawthorne, Ananth Pannala, Susan Sandeman, Andrew Lloyd
Summary: This review focuses on the recent trends and developments in the delivery of hydrophilic drugs, including nanomaterials and drug conjugates. It highlights the slow translation of novel technologies into viable pharmaceutical products and the lack of clinical trials. The review also discusses the technical, legislative, and commercial requirements for these novel technologies to be adopted in the real world.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhenqi Liu, Alison B. Lansley, Tu Ngoc Duong, John D. Smart, Ananth S. Pannala
Summary: This study investigated the potential of novel polymer-surfactant-based formulations to improve the solubility and permeability of curcumin. The results showed that formulation A, containing Soluplus (R) and vitamin E TPGs, significantly increased the permeation and cellular uptake of curcumin compared to other samples.
Article
Pharmacology & Pharmacy
Satyanarayana Somavarapu, Acom Sornsute, Jeanne Trill, Hend E. Abdelhakim, Dinithi Goonatilaka, Ananth S. Pannala, Kevin M. G. Taylor
Summary: Novel dry powder formulations of D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) micelles containing the anti-cancer drug artesunate (ART) were developed for inhalation therapy in lung cancer treatment. The study successfully prepared TPGS micelles encapsulating ART using thin-film hydration method and then transformed them into dry powder formulations through spray-drying with lactose and leucine as carrier molecules. Characterization of the dry powder formulation showed a unimodal particle size distribution with a mean particle size of 3.27 μm and a fine particle fraction of 31%. The artesunate-loaded micelle dry powder formulation exhibited higher cytotoxicity against A549 lung cancer cells compared to docetaxel and doxorubicin. This study demonstrates the potential of spray-dried micelles containing artesunate as a dry powder formulation for inhalation therapy in lung cancer.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ajinkya Nitin Nikam, Angela Jacob, Ruchira Raychaudhuri, Gasper Fernandes, Abhijeet Pandey, Vinay Rao, Sheikh F. Ahmad, Ananth S. Pannala, Srinivas Mutalik
Summary: The study developed 5-FU microemulsions (MEs) using continuous manufacturing technology and evaluated their effectiveness in treating skin cancer. The optimized formulation exhibited sustained drug release and skin permeation, indicating its promising pharmacodynamic effects in squamous cell carcinoma (SCC) treatment.
