Article
Biochemistry & Molecular Biology
El Cherif Ibrahim, Victor Gorgievski, Pilar Ortiz-Teba, Raoul Belzeaux, Gustavo Turecki, Etienne Sibille, Guillaume Charbonnier, Eleni T. Tzavara
Summary: Antidepressants are currently the best treatment for moderate to severe major depressive episodes, but the trial-and-error prescription strategy and side effects are concerning. There is a lack of biomarkers to aid in treatment decisions, highlighting the need for further research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Kuan-Lun Huang, Yi-Lung Chen, Robert Stewart, Vincent Chin-Hung Chen
Summary: Liver cancer, particularly hepatocellular carcinoma (HCC), is the third leading cause of cancer deaths globally. A study in Taiwan found that postdiagnosis antidepressant use may be linked to lower mortality rates in patients with HCC, indicating the need for further clinical trials to evaluate this association.
Article
Biochemistry & Molecular Biology
Ahmed Gaber, Walaa F. Alsanie, Majid Alhomrani, Abdulhakeem S. Alamri, Hussain Alyami, Sonam Shakya, Hamza Habeeballah, Heba A. Alkhatabi, Raed Felimban, Abdulwahab Alamri, Abdulhameed Abdullah Alhabeeb, Bassem M. Raafat, Moamen S. Refat
Summary: Depression is a serious mental disorder characterized by symptoms such as low mood and reduced focus. This study investigated the effectiveness of a compound in treating depression and found that it had better results than the individual drug. Theoretical data generated through simulations also provided insights for future research on molecular structures.
Article
Environmental Sciences
Chenyuan Pan, Feng Zhu, Minghong Wu, Lihui Jiang, Xiaoyu Zhao, Ming Yang
Summary: The study investigated the toxicity of Fluoxetine (FLU) and its transformed products formed during UV photolysis using zebrafish embryos as a model. Exposure to UV-irradiated solutions led to delayed hatching time, increased heart rate, and decreased body length of the zebrafish embryos, along with changes in enzyme activity and gene expression levels. The research highlights the importance of considering the formation and persistence of toxic transformation products in aquatic environments.
Article
Marine & Freshwater Biology
Karolina Sloczynska, Justyna Orzel, Aleksandra Murzyn, Justyna Popiol, Agnieszka Gunia-Krzyzak, Paulina Koczurkiewicz-Adamczyk, Elzbieta Pekala
Summary: The widespread use of antidepressant pharmaceuticals has led to their presence in the environment, particularly in waterways, with concentrations ranging from ng L-1 to mu g L-1. Numerous studies have demonstrated the ecotoxicological effects of antidepressants, even at environmentally relevant levels. This review focuses on the individual-level effects of commonly used antidepressants, including their impact on behavior, growth, and survival, and discusses the relationship between their physico-chemical properties and environmental dynamics. It also highlights the advantages of considering behavioral changes as sensitive endpoints in ecotoxicology, as well as current methodological shortcomings such as low standardization, reproducibility, and context-dependency.
AQUATIC TOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
Hu-Jiang Shi, Dan-Lian Wu, Rong Chen, Na Li, Li-Juan Zhu
Summary: The study found that fluoxetine modifies mood behaviors and hippocampal neuroplasticity by disrupting the nNOS-CAPON interaction, which is associated with postsynaptic 5-HT1AR activation.
Article
Environmental Sciences
Jason Henry, Jack A. Brand, Yutao Bai, Jake M. Martin, Bob B. M. Wong, Donald Wlodkowic
Summary: Contamination by pharmaceutical pollutants poses a critical threat to aquatic ecosystems. A study found that long-term exposure to the antidepressant fluoxetine reduces behavioral plasticity and egg mass production in freshwater snails, highlighting the potential harmful effects on non-target organisms and population resilience.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Cosima Rhein, Iulia Zoicas, Lena M. Marx, Stefanie Zeitler, Tobias Hepp, Claudia von Zimmermann, Christiane Muehle, Tanja Richter-Schmidinger, Bernd Lenz, Yesim Erim, Martin Reichel, Erich Gulbins, Johannes Kornhuber
Summary: The study found that ASM activity and SMPD1 mRNA expression levels are related to MDD, and antidepressant drugs can improve MDD symptoms by inhibiting ASM activity. Moreover, SMPD1 mRNA expression levels may serve as a molecular marker for monitoring the treatment and adherence of MDD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Vitoria S. Foletto, Tacieli F. da Rosa, Marissa B. Serafin, Angelita Bottega, Laisa N. Franco, Bruno R. de Paula, Rosmari Horner
Summary: The combination of antidepressants fluoxetine and paroxetine with the antibiotic ciprofloxacin showed significant synergism in treating infections caused by multidrug-resistant bacteria, particularly against certain bacterial strains. Additional in vivo studies are needed to further understand the mechanisms of action of these drugs.
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2021)
Article
Biology
Lucinda C. Aulsebrook, Bob B. M. Wong, Matthew D. Hall
Summary: The study investigates the threat of pharmaceutical pollutants to aquatic ecosystems and the modification of this threat by temperature. Results show that pharmaceutical exposure affects the fecundity, body size, and growth rate of water fleas, with different effects at different temperatures.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Cong-Yuan Xia, Ning-Ning Zhang, Hong Jiang, Yu-Xia Lou, Qian Ren, Xiao-Ling Zhang, Peng-Fei Yang, Qian-Hang Shao, Hao-Yu Zhu, Jiang-Fan Wan, Ya-Ni Zhang, Fang-Fang Li, Xu Yan, Shi-Feng Chu, Yi Zhang, Zhen-Zhen Wang, Nai-Hong Chen
Summary: This study found that lack of therapeutic efficacy and time lag limit the application of fluoxetine for depression treatment. The investigation on the relationship between gap junction and antidepressant effects of fluoxetine revealed that fluoxetine can indirectly improve gap junction, while dysfunction of gap junction blocks the antidepressant effects of fluoxetine.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2023)
Review
Medicine, General & Internal
Marta Mas, Juan Antonio Garcia-Vicente, Anais Estrada-Gelonch, Clara Perez-Mana, Esther Papaseit, Marta Torrens, Magi Farre
Summary: The COVID-19 pandemic has led to the exploration of using existing antidepressant drugs to treat the infection. There is evidence suggesting that some antidepressants can reduce cytokine concentrations and exhibit antiviral activity against SARS-CoV-2. This review evaluates the potential role of antidepressants in treating COVID-19 infection and the benefits and risks for patients with mental disorders. The available evidence, including preclinical studies and clinical trials, supports further exploration of the use of antidepressants for COVID-19 infection.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biology
Bernardo Duarte, Eduardo Feijao, Ricardo Cruz de Carvalho, Irina A. Duarte, Ana Patricia Marques, Marisa Maia, Jasmine Hertzog, Ana Rita Matos, Maria Teresa Cabrita, Isabel Cacador, Andreia Figueiredo, Marta Sousa Silva, Carlos Cordeiro, Vanessa F. Fonseca
Summary: Pharmaceutical compounds may have unknown and undesirable effects on non-target organisms. This study used metabolomics to uncover the mode of action of fluoxetine, an antidepressant, in diatoms, as well as identify potential biomarkers of exposure. The findings highlight the importance of understanding the ecotoxicology of marine organisms and the value of metabolomics approaches.
Article
Neurosciences
Jaena Han, Valentine Andreu, Cory Langreck, Elizabeth A. Pekarskaya, Steven G. Grinnell, Florence Allain, Valerie Magalong, John Pintar, Brigitte L. Kieffer, Alexander Z. Harris, Jonathan A. Javitch, Rene Hen, Katherine M. Nautiyal
Summary: Research has shown that tianeptine can rapidly induce antidepressant-like effects in mice after just one week of treatment. Its mechanism of action differs from fluoxetine in two key aspects, including the requirement for MORs for its chronic antidepressant-like effect and the lack of promotion of hippocampal neurogenesis compared to fluoxetine.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Abbas Aghaeinejad-Meybodi, Amanollah Ebadi, Alireza Khataee, Afshin Dehghani Kiadehi
Summary: The study investigates the degradation of Fluoxetine in water using various oxidation processes, with a focus on catalytic ozonation. The research explores the influence of operational parameters on the efficiency of Fluoxetine degradation. It is found that hydroxyl groups play a major role in catalytic ozonation for Fluoxetine removal.
Article
Chemistry, Analytical
Roya Khodaei, Anita Ahmady, Seyyed Mehdi Khoshfetrat, Soheila Kashanian, Seyed Mohammad Tavangar, Kobra Omidfar
Article
Polymer Science
Arezoo Dadashzadeh, Rana Imani, Saeid Moghassemi, Kobra Omidfar, Nabiollah Abolfathi
Review
Chemistry, Analytical
Nahid Shoaie, Maryam Daneshpour, Mostafa Azimzadeh, Sara Mahshid, Seyyed Mehdi Khoshfetrat, Fatemeh Jahanpeyma, Alieh Gholaminejad, Kobra Omidfar, Mehdi Foruzandeh
Article
Biology
Maryam Nazari, Soheila Kashanian, Ronak Rafipour, Kobra Omidfar
JOURNAL OF BIOSCIENCES
(2019)
Review
Chemistry, Analytical
Leila Syedmoradi, Anita Ahmadi, Michael L. Norton, Kobra Omidfar
Article
Multidisciplinary Sciences
Hossein Siampour, Sara Abbasian, Ahmad Moshaii, Kobra Omidfar, Mosslim Sedghi, Hossein Naderi-Manesh
SCIENTIFIC REPORTS
(2020)
Article
Chemistry, Analytical
Maryam Nazari, Soheila Kashanian, Kobra Omidfar, Sirous Ghobadi, Hector C. Goicoechea, Hui-Wen Gu, Reza Khodarahmi, Ali R. Jalalvand
Summary: This research project investigates the interactions of acarbose with normal human serum albumin and glycated HSA using chemometrics assisted-electrochemical and spectroscopic techniques. By combining various analytical methods and chemometric algorithms, the study sheds light on the binding mechanisms between ACB and HSA/GHSA. Additionally, a novel electrochemical technique was developed for the determination of GHSA as a potential biomarker in diabetes, showing successful validation using synthetic and real samples.
MICROCHEMICAL JOURNAL
(2021)
Article
Engineering, Electrical & Electronic
Anita Ahmadi, Seyyed Mehdi Khoshfetrat, Shima Kabiri, Lida Fotouhi, Parisa Seyed Dorraji, Kobra Omidfar
Summary: Nanocellulose fiber-based papers are ideal for developing electrochemical paper-based analytical devices due to their excellent characteristics; a new ePAD based on cellulose nanofibers for determining glucose concentration from whole blood samples was described by the authors; the biosensing motif showed high sensitivity, reproducibility, selectivity, and stability, making it a versatile platform for analyzing other biomarkers.
IEEE SENSORS JOURNAL
(2021)
Review
Chemistry, Analytical
Leila Syedmoradi, Michael L. Norton, Kobra Omidfar
Summary: Early and timely diagnosis of cancer is crucial for appropriate treatment and improved outcomes. Advances in biosensor technology have led to the development of point-of-care (POC) diagnostic devices that offer faster, more cost-effective testing processes. Incorporation of nanomaterials into sensing platforms has further enhanced sensitivity and reduced complexity. However, translating these innovative POC technologies into clinical settings faces challenges such as sampling procedures, sensitivity levels, and integration requirements.
Article
Chemistry, Analytical
Anita Ahmadi, Seyyed Mehdi Khoshfetrat, Shima Kabiri, Parisa Seyed Dorraji, Bagher Larijani, Kobra Omidfar
Summary: An immunosensor using a sandwich paper-based electrochemiluminescence (ECL) biosensor for detecting glycated hemoglobin has been developed, demonstrating desirable assay performance with a wide response range and low detection limit.
Article
Chemistry, Analytical
Anita Ahmadi, Seyyed Mehdi Khoshfetrat, Zahra Mirzaeizadeh, Shima Kabiri, Javad Rezaie, Kobra Omidfar
Summary: A sandwich-type electrochemical immunosensor using a zinc-based metal-organic framework/Fe3O4-COOH/thionine labeled anti-CTnI monoclonal antibody nanocomposite was developed for sensitive and convenient detection of CTnI levels in clinical practice. This study provides a convenient plan for sensitive detection of bioanalytes and opens a path for the establishment of user-friendly and cost-effective device.
Article
Endocrinology & Metabolism
Mohammad Ali Derakhshan, Niloofar Nazeri, Kamyar Khoshnevisan, Ramin Heshmat, Kobra Omidfar
Summary: In this study, a three-layer electrospun nanofiber wound dressing containing physicochemical and biological active compounds was fabricated, which demonstrated promising effects in improving the healing of diabetic foot ulcers.
JOURNAL OF DIABETES AND METABOLIC DISORDERS
(2022)
Article
Chemistry, Analytical
Mohsen Saeidi, Mohammad Ali Amidian, Sana Sheybanikashani, Hossein Mahdavi, Homayoon Alimohammadi, Leila Syedmoradi, Fatemeh Mohandes, Ali Zarrabi, Elnaz Tamjid, Kobra Omidfar, Abdolreza Simchi
Summary: This study proposes a multilayer nanostructure to improve the accuracy and reliability of cardiac troponin-I (cTnI) electrochemical immunosensors. The nanostructure consists of Fe3O4-COOH labeled anti-cTnI monoclonal antibody and anti-cTnI polyclonal antibody conjugated on Au-Ag nanoparticles, which enhances the performance of the immunosensor through signal amplification and increased surface area.
Review
Endocrinology & Metabolism
Kobra Omidfar, Anita Ahmadi, Leila Syedmoradi, Seyyed Mehdi Khoshfetrat, Bagher Larijani
JOURNAL OF DIABETES AND METABOLIC DISORDERS
(2020)
Review
Engineering, Electrical & Electronic
Anita Ahmadi, Shima Kabiri, Kobra Omidfar
IEEE SENSORS JOURNAL
(2020)
