Review
Oncology
Arnaud Martel, Lauris Gastaud, Christelle Bonnetaud, Sacha Nahon-Esteve, Kevin Washetine, Olivier Bordone, Myriam Salah, Virginie Tanga, Julien Fayada, Virginie Lespinet, Maryline Allegra, Salome Lalvee, Katia Zahaf, Stephanie Baillif, Corine Bertolotto, Baharia Mograbi, Sandra Lassalle, Paul Hofman
Summary: This study aims to present the challenges faced in obtaining biospecimens for research purposes in ophthalmic malignancies, and provides a detailed description of a dedicated biobank for ophthalmic malignancies. Currently, the number of biobanks dedicated to ophthalmic malignancies worldwide is very limited. The two main objectives in establishing an ophthalmic malignancy biobank are to collect scarce ophthalmic tumor samples and conduct large-scale translational research to better understand pathogenesis and discover new biomarkers for early diagnosis and targeted treatment.
Article
Biochemistry & Molecular Biology
Quanpeng Qiu, Gang Guo, Xiaolong Guo, Xiake Hu, Tianyu Yu, Gaixia Liu, Haowei Zhang, Yinnan Chen, Junjun She
Summary: Barrett's esophagus (BE) is a precancerous lesion of esophageal adenocarcinoma (EAC) characterized by the replacement of squamous epithelium with columnar epithelium. Loss of P53 is a risk factor for the progression of BE. In this study, P53-deficient esophageal epithelial cells were exposed to acidic bile salt treatment, which resulted in reduced P53 protein expression and enhanced cell survival. Acidic bile salt exposure also impaired cell adhesion through repression of the JAK/STAT signaling pathway and activation of VEGFR/AKT in P53-deficient esophageal cells. Furthermore, the expression levels of P53, ICAM1, STAT3, and VEGFR were correlated in clinical samples of EAC, providing potential therapeutic targets for EAC.
Article
Oncology
Yoon Jin Choi, Kyungdo Han, Eun Hyo Jin, Joo Hyun Lim, Cheol Min Shin, Dong Ho Lee
Summary: Allergic diseases, such as allergic rhinitis, asthma, and atopic dermatitis, were found to reduce the risk of gastrointestinal (GI) cancers, including esophageal, stomach, colorectal, and liver cancers. This inverse association suggests that allergic diseases may have a protective effect against GI cancers, possibly through enhanced immune defenses and reduced inflammation. This finding has important implications for the prevention and treatment of GI cancers.
Review
Oncology
Michael Sestito, Hillary Pratt, Carl Schmidt, Alan Thomay
Summary: Recent prospective trials have shown encouraging results for esophageal cancer, gastric cancer, and gastrointestinal stromal tumor (GIST). Immunotherapy dominates the current clinical trial landscape, but targeted biologic therapies and standard chemotherapy are still critical for the treatment of gastric and esophageal cancer, while imatinib remains the backbone for advanced or metastatic GISTs. Surgical resection remains important for potential cure in all three cancers.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Agricultural Engineering
Roxane Limousin, Feriel Guendoul, Canelle Vibert, Karina Antoun, Cesar Segovia, Isabelle Ziegler-Devin, Nicolas Brosse
Summary: The valorization of hop stem, a co-product of hop cultivation, was investigated in this study. Steam explosion was found to be an efficient defibration method for producing high-quality fibers. It was also discovered that hop single cell fiber has characteristics similar to hemp and can be used for producing adhesive-free panels with good mechanical properties.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Review
Oncology
Quan Lin, Shi-Wei Guan, Hai-Bo Yu
Summary: Research has shown that the gut and intratumor microbiome play a significant role in the development of gastrointestinal malignancies. By modulating the immune and tumor microenvironments, they can influence tumor progression. Exploring the relationship between gastrointestinal malignancies and the gut and intratumor microbiome is crucial for providing new insights into potential therapies.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2023)
Article
Oncology
Whitney Johnson, Quan H. Phung, Vishal R. Patel, Alexander K. Tsai, Nivedita Arora, Mark A. Klein, Anders D. Westanmo, Anne H. Blaes, Arjun Gupta
Summary: This retrospective analysis examined contact days among veterans with stage IV gastrointestinal cancer and found a U-shaped pattern in the percentage of contact days over the course of illness. These findings have important implications for improving care delivery.
Article
Public, Environmental & Occupational Health
Wing Ching Chan, Iona Y. Millwood, Christiana Kartsonaki, Huaidong Du, Yu Guo, Yiping Chen, Zheng Bian, Robin G. Walters, Jun Lv, Pan He, Chen Hu, Liming Li, Ling Yang, Zhengming Chen
Summary: The study found that higher consumption of spicy food was associated with lower risks of certain gastrointestinal-tract cancers in Chinese adults, especially among individuals who never smoked or drank alcohol regularly.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
MinJeong Kim, Kum Ju Chae, Jong-Hun Kim, Yeon-Hee Han
Summary: A 52-year-old male patient presented with continuous dull pain from the throat to the epigastric region with dysphagia. Imaging tests confirmed the presence of a pedunculated mass inside the esophagus, which was strongly suggestive of esophageal cancer. The mass was surgically excised and histologic examination confirmed the presence of a fibrovascular polyp with chronic ulcerative inflammation.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Nutrition & Dietetics
Wenmin Liu, Tianpei Wang, Meng Zhu, Guangfu Jin
Summary: This study found that a healthy diet can reduce the risk of UGI cancer, and individuals with high genetic risk can attenuate UGI cancer risk by adopting a healthy diet. Among participants with high genetic risk, the absolute five-year incidence risk of UGI cancer was significantly reduced by having a healthy diet.
Editorial Material
Agricultural Engineering
Reeta Rani Singhania, Wenshan Guo, Luciana Porto de Souza Vendenberghe, Giorgio Mannina, Sang-Hyoun Kim
Summary: The 3rd International Conference for Bioresource Technology for Bioenergy, Bioproducts & Environmental Sustainability (BIORESTEC) was held online from 17 to 19 May 2021 with more than 120 participants from all over the world. The conference aimed to facilitate knowledge and idea exchange among researchers, industry professionals, and policymakers in the field of biorefinery, and to discuss the latest trends in biotechnology, bioenergy, and biobased products. The talks during the conference mainly focused on sustainable practices utilizing microorganisms to produce biomolecules, including bioenergy, from waste residues.
BIORESOURCE TECHNOLOGY
(2022)
Article
Behavioral Sciences
Nike Zoe Welander, Gaia Olivo, Claudia Pisanu, Gull Rukh, Helgi Birgir Schioth, Jessica Mwinyi
Summary: Migraine was significantly associated with irritable bowel syndrome and peptic ulcers, but there was a weaker link between migraine and Helicobacter pylori infection, celiac disease, Crohn's disease, and ulcerative colitis.
BRAIN AND BEHAVIOR
(2021)
Article
Oncology
Nazlisadat Seyed Khoei, Karl-Heinz Wagner, Robert Carreras-Torres, Marc J. Gunter, Neil Murphy, Heinz Freisling
Summary: The study showed that higher prediagnostic circulating bilirubin levels were associated with a lower risk of esophageal adenocarcinoma, but the association with colorectal cancer risk was less robust. On the other hand, bilirubin levels were positively associated with hepatobiliary cancer risk, indicating underlying liver disease processes. Further studies are needed to replicate these findings for specific gastrointestinal cancers.
Review
Nanoscience & Nanotechnology
Fanghua Li, Yiwei Li, K. S. Novoselov, Feng Liang, Jiashen Meng, Shih-Hsin Ho, Tong Zhao, Hui Zhou, Awais Ahmad, Yinlong Zhu, Liangxing Hu, Dongxiao Ji, Litao Jia, Rui Liu, Seeram Ramakrishna, Xingcai Zhang
Summary: This article summarizes the upgrading of high availability and low utilization biomass (HALUB) for sustainable energy, environment, and biomedicine, with a focus on circular economy, sustainability, and carbon neutrality. The technologies of thermochemical conversion (TC), biochemical conversion (BC), electrochemical conversion (EC), and photochemical conversion (PTC) are discussed. Microalgal biomass has the potential to contribute to biofuel production with high heating value and economic benefits. Lignocellulosic biomass can be efficiently converted into bio-stimulants and biofertilizers, and also contribute to electricity generation. Electrochemical and photochemical conversions can selectively synthesize bioresources. Machine learning, techno-economic analysis, and life cycle analysis are important for HALUB upgrading approaches. The article also highlights sustainable biomaterials, living materials, and technologies for biomedical and multifunctional applications, as well as new techniques and systems for the complete conversion and utilization of HALUB for new energy and materials.
NANO-MICRO LETTERS
(2023)
Review
Biotechnology & Applied Microbiology
Ruihua Wang, Mei Chen, Xiaojun Ye, Karen Poon
Summary: ARID1A is a newly discovered tumor suppressor gene that plays a crucial role in various biological behaviors and molecular mechanisms associated with carcinogenesis. Mutations in ARID1A have been increasingly reported in various digestive malignancies, impacting the prognosis of these cancers. The potential of molecular pathologic epidemiology (MPE) to provide insights into environment-tumor-host interactions is also discussed.
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
(2021)
Article
Oncology
A. M. Mongan, N. Lynam-Lennon, R. Casey, S. Maher, G. Pidgeon, J. V. Reynolds, J. O'Sullivan
CLINICAL & TRANSLATIONAL ONCOLOGY
(2016)
Correction
Oncology
A. M. Mongan, N. Lynam-Lennon, R. Casey, S. Maher, G. Pidgeon, J. V. Reynolds, J. O'Sullivan
CLINICAL & TRANSLATIONAL ONCOLOGY
(2016)
Article
Nutrition & Dietetics
Melissa J. Conroy, Margaret R. Dunne, Claire L. Donohoe, John V. Reynolds
PROCEEDINGS OF THE NUTRITION SOCIETY
(2016)
Article
Oncology
N. J. O'Farrell, R. Feighery, S. L. Picardo, N. Lynam-Lennon, M. Biniecka, S. A. McGarrigle, J. J. Phelan, F. MacCarthy, D. O'Toole, E. J. Fox, N. Ravi, J. V. Reynolds, J. O'Sullivan
Article
Oncology
Maria E. Kavanagh, Melissa J. Conroy, Niamh E. Clarke, Niamh T. Gilmartin, Katie E. O'Sullivan, Ronan Feighery, Finbar MacCarthy, Dermot O'Toole, Narayanasamy Ravi, John V. Reynolds, Jacintha O'Sullivan, Joanne Lysaght
Article
Cell Biology
Melissa J. Conroy, Karen C. Galvin, Suzanne L. Doyle, Maria E. Kavanagh, Ann-Marie Mongan, Aoife Cannon, Gillian Y. Moore, John V. Reynolds, Joanne Lysaght
Article
Oncology
Mohamed Mahmoud M. Abdel-Latif, Hiroyasu Inoue, Dermot Kelleher, John V. Reynolds
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2016)
Article
Cell Biology
Melissa J. Conroy, Vivienne Fitzgerald, Suzanne L. Doyle, Shauna Channon, Zivile Useckaite, Niamh Gilmartin, Cliona O'Farrelly, Narayanasamy Ravi, John V. Reynolds, Joanne Lysaght
JOURNAL OF LEUKOCYTE BIOLOGY
(2016)
Article
Oncology
Siun M. Walsh, Sarah Casey, Raymond Kennedy, Narayanasamy Ravi, John V. Reynolds
JOURNAL OF SURGICAL ONCOLOGY
(2016)
Letter
Oncology
Claire L. Donohoe, John V. Reynolds
RADIOTHERAPY AND ONCOLOGY
(2016)
Article
Multidisciplinary Sciences
Shane P. Duggan, Fiona M. Behan, Murat Kirca, Abdul Zaheer, Sarah A. McGarrigle, John V. Reynolds, Gisela M. F. Vaz, Mathias O. Senge, Dermot Kelleher
SCIENTIFIC REPORTS
(2016)
Review
Endocrinology & Metabolism
Claire L. Donohoe, Joanne Lysaght, Jacintha O'Sullivan, John V. Reynolds
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2017)
Article
Surgery
Jessie A. Elliott, Neil G. Docherty, Hans-Georg Eckhardt, Suzanne L. Doyle, Emer M. Guinan, Narayanasamy Ravi, John V. Reynolds, Carel W. le Roux
Review
Surgery
Helen O' Brien, Helen Mohan, Celia O' Hare, John Vincent Reynolds, Rose Anne Kenny
Article
Surgery
Alexandra Zaborowski, Siun M. Walsh, Narayanasamy Ravi, John V. Reynolds
CASE REPORTS IN SURGERY
(2016)