Journal
INFLAMMATION
Volume 39, Issue 5, Pages 1729-1736Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10753-016-0407-2
Keywords
inflammation; obesity; cancer; T cells; liver; omentum
Categories
Funding
- Health Research Board of Ireland Health Research Award [HRA_POR/2011/91]
- Health Research Board (HRB) [HRA-POR-2011-91] Funding Source: Health Research Board (HRB)
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In the midst of a worsening obesity epidemic, the incidence of obesity-associated morbidities, including cancer, diabetes, cardiac and liver disease is increasing. Insights into mechanisms underlying pathological obesity-associated inflammation are lacking. Both the omentum, the principal component of visceral fat, and liver of obese individuals are sites of excessive inflammation, but to date the T cell profiles of both compartments have not been assessed or compared in a patient cohort with obesity-associated disease. We have previously identified that omentum is enriched with inflammatory cytokines, chemokines and T cells. Here, we compared the inflammatory profile of T cells in the omentum and liver of patients with the obesity-associated malignancy oesophageal adenocarcinoma (OAC). Furthermore, we assessed the secreted cytokine profile in OAC patient serum, omentum and liver to assess systemic and local inflammation. We observed parallel T cell cytokine profiles and phenotypes in the omentum and liver of OAC patients, in particular CD69(+) and inflammatory effector memory T cells. This study reflects similar processes of inflammation and T cell activation in the omentum and liver, and may suggest common targets to modulate pathological inflammation at these sites.
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