Article
Pediatrics
Stephen Trinidad, Amanda Jensen, Monica Holder, Allison Elsner, Nelson Rosen, Aaron Garrison, Beth Rymeski, Jason S. Frischer
Summary: This study evaluated the outcomes of sacral nerve stimulation (SNS) in patients with medically refractory fecal incontinence or severe constipation. A retrospective cohort study was conducted on patients who underwent SNS placement after failed medical management at a single center. The rates of involuntary bowel movements were compared pre- and post-SNS using a bowel severity score questionnaire.
JOURNAL OF PEDIATRIC SURGERY
(2023)
Article
Gastroenterology & Hepatology
Judith Evers, P. Ronan O'Connell, James F. X. Jones
Summary: This study investigated the changes in the transmission of sensory anorectal stimuli in a rodent model of fecal incontinence and the effects of sacral nerve stimulation on defecation behavior. The results showed that chronic sacral nerve stimulation using miniature telemetric devices is feasible in rats and can improve fecal incontinence symptoms. The amplitude of anorectal evoked potentials was found to be negatively correlated with the behavioral signs of fecal incontinence.
DISEASES OF THE COLON & RECTUM
(2022)
Article
Surgery
Luigi Brusciano, Antonio Brillantino, Gianluca Pellino, Franco Marinello, Coen I. M. Baeten, Alex Digesu, Gabriele Naldini, Claudio Gambardella, Francesco Saverio Lucido, Alessandro Sturiale, Giorgia Gualtieri, Stefan Riss, Ludovico Docimo
Summary: Sacral nerve modulation is a safe and effective treatment for fecal and double incontinence, improving symptoms, quality of life, and sexual function in the long term.
UPDATES IN SURGERY
(2023)
Review
Neurosciences
Aleksi Kokkonen, Emma A. Honkanen, Daniel T. Corp, Juho Joutsa
Summary: Deep brain stimulation (DBS) is an effective treatment for various brain disorders, but its mechanisms of action and detailed molecular effects still need further investigation.
Article
Gastroenterology & Hepatology
Aaron J. Dawes, Juan O. Mariscal, Peter J. White, Emily F. Midura, Anne E. Sirany, Ann C. Lowry, Christine C. Jensen, Amy J. Thorsen
Summary: This study aimed to determine whether patients with rectoanal intussusception achieve similar benefits from device implantation to patients without rectoanal intussusception. The results showed that rectoanal intussusception does not affect the clinical outcomes or quality of life after sacral nerve stimulation for fecal incontinence. Therefore, patients with fecal incontinence and rectoanal intussusception can be considered for sacral nerve stimulation placement.
DISEASES OF THE COLON & RECTUM
(2023)
Review
Medicine, General & Internal
Alfonso Javier Ibanez-Vera, Rosa Maria Mondejar-Ros, Vanessa Franco-Bernal, Guadalupe Molina-Torres, Esther Diaz-Mohedo
Summary: This review aims to determine the effectiveness of posterior tibial nerve stimulation (PTNS) in reducing episodes of fecal incontinence in adults. However, the results are inconclusive and more research is needed to support its recommendation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Gerrit E. Gmel, Paul F. Vollebregt, Marjolein E. G. Thijssen, Rosana Santos Escapa, Eleanor McAlees, Dave Mugan, John L. Parker, Charles H. Knowles
Summary: This study aimed to determine if electrophysiological responses can be recorded directly from the S3 sacral nerve during therapeutic SNM in patients with fecal incontinence, and to characterize such responses in order to better understand the mechanism of action (MOA) and changes in stimulation with posture. The findings show both neural and myoelectric responses, highlighting the heterogeneity of these responses and confirming that electrode lead position can change with posture.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Surgery
A. Picciariello, M. Rinaldi, R. Dibra, G. Trigiante, G. Tomasicchio, G. Lantone, M. De Fazio
Summary: Sacral nerve modulation (SNM) has been a major advancement in the treatment of fecal incontinence. While short-medium term success has been demonstrated, long-term follow-up shows a progressive deterioration in the success rate of SNM.
UPDATES IN SURGERY
(2022)
Article
Gastroenterology & Hepatology
C. Seifarth, N. Slavova, C. Degro, K. S. Lehmann, M. E. Kreis, B. Weixler
Summary: This study evaluated the use of sacral nerve stimulation (SNS) in patients with high stool frequency or fecal incontinence after proctocolectomy with IPAA. The results showed that SNS improved symptoms in over two-thirds of patients, suggesting its feasibility as a therapeutic option in this patient population.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Article
Neurosciences
Maximilian Grosch, Leonie Beyer, Magdalena Lindner, Lena Kaiser, Seyed-Ahmad Ahmadi, Anna Stockbauer, Peter Bartenstein, Marianne Dieterich, Matthias Brendel, Andreas Zwergal, Sibylle Ziegler
Summary: Metabolic connectivity patterns based on [F-18]-FDG PET were used to classify rats after unilateral labyrinthectomy, achieving high accuracy compared to random and machine learning classification. This novel statistical method shows potential for supporting PET-based diagnostic decisions in neurological disorders.
Article
Gastroenterology & Hepatology
Charlotte Desprez, Audrey Grange, Guillaume Gourcerol, Alexis Deperrois, Oriane Garconnet, Clemence Leroux, Gregory Mosni, Laurence Poux, Justine Breemeersch, Cecile Goblot, Sebastien Kepka, Julie Ruillon, Margot Vannier, Valerie Bridoux, Anne-Marie Leroi
Summary: Regular follow-up and reprogramming of stimulation parameters in patients with implanted SNM devices can optimize the efficacy of treatment for fecal incontinence.
COLORECTAL DISEASE
(2022)
Article
Multidisciplinary Sciences
Hyunsoo Shin, Hyeonseok Jeong, Wooseok Ryu, Geunhu Lee, Jaeho Lee, Doyu Kim, In-Uk Song, Yong-An Chung, Sungon Lee
Summary: A custom-TMS robot was developed for better TMS coil placement, which reduced the rTMS preparation time by 53% and significantly decreased position and orientation errors compared to the manual method. Clinical and neuroimaging assessments indicated comparable improvements in depression severity and regional cerebral blood flow between the robotic and manual rTMS groups.
SCIENTIFIC REPORTS
(2023)
Article
Surgery
Charlotte Desprez, Henri Damon, Guillaume Meurette, Diane Mege, Jean-Luc Faucheron, Charlene Brochard, Elsa Lambrescak, Guillaume Gourcerol, Francois Mion, Vincent Wyart, Igor Sielezneff, Laurent Siproudhis, Isabelle Etienney, Nadine Ajamie, Paul-Antoine Lehur, Thomas Duflot, Valerie Bridoux, Anne-Marie Leroi
Summary: The effectiveness of sacral nerve modulation (SNM) was assessed in a large cohort of patients implanted for at least 10 years. The study found that approximately half of the patients with fecal incontinence maintained long-term efficacy after SNM treatment.
Article
Endocrinology & Metabolism
Kelly Smart, Heather Liu, David Matuskey, Ming-Kai Chen, Kristen Torres, Nabeel Nabulsi, David Labaree, Jim Ropchan, Ansel T. Hillmer, Yiyun Huang, Richard E. Carson
Summary: The study suggests that the tissue influx and binding potential of the positron emission tomography radioligand [C-11]UCB-J are influenced by neural activation, while the volume of distribution remains stable. K(1) significantly increased during stimulation in the primary visual cortex, correlating with fMRI BOLD response.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Review
Surgery
Qi Jin, Ying Zhu, Ping Yin, Xiaojia Li
Summary: This study conducted a systematic review and meta-analysis to evaluate the efficacy of tibial nerve stimulation (TNS) therapy for fecal incontinence (FI). The results showed that TNS could reduce the number of weekly episodes of FI, improve clinical symptoms, and enhance anal physiological function. Despite the low quality of overall evidence, TNS shows potential as a safe treatment for FI.
UPDATES IN SURGERY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Birgitte Brinkmann Olsen, Albert Gjedde, Mie Holm Vilstrup, Iben Birgit Gade Johnsen, Gudrun Neumann, Drew Avedis Torigian, Abass Alavi, Poul Flemming Hoilund-Carlsen
MOLECULAR IMAGING AND BIOLOGY
(2019)
Article
Clinical Neurology
Sasan Andalib, Mahnaz Talebi, Ebrahim Sakhinia, Mehdi Farhoudi, Homayoun Sadeghi-Bazargani, Nooshin Masoudian, Tanja M. Michel, Manouchehr Seyedi Vafaee, Albert Gjedde
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2019)
Article
Clinical Neurology
Anne M. Landau, Aage Kristian Olsen Alstrup, Ove Noer, Michael Winterdahl, Helene Audrain, Arne Moller, Poul Videbech, Gregers Wegener, Albert Gjedde, Doris J. Doudet
JOURNAL OF PSYCHOPHARMACOLOGY
(2019)
Article
Neurosciences
Kristian Nygaard Mortensen, Simon Sanggaard, Humberto Mestre, Hedok Lee, Serhii Kostrikov, Anna L. R. Xavier, Albert Gjedde, Helene Benveniste, Maiken Nedergaard
JOURNAL OF NEUROSCIENCE
(2019)
Article
Neurosciences
Jeeun Kang, Haichong K. Zhang, Shilpa D. Kadam, Julie Fedorko, Heather Valentine, Adarsha P. Malle, Ping Yan, Maged M. Harraz, Jin U. Kang, Arman Rahmim, Albert Gjedde, Leslie M. Loew, Dean F. Wong, Emad M. Boctor
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Engineering, Biomedical
Jeeun Kang, Shilpa D. Kadam, Joshua S. Elmore, Brennan J. Sullivan, Heather Valentine, Adarsha P. Malla, Maged M. Harraz, Arman Rahmim, Jin U. Kang, Leslie M. Loew, Michael H. Baumann, Anthony A. Grace, Albert Gjedde, Emad M. Boctor, Dean F. Wong
JOURNAL OF NEURAL ENGINEERING
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anne M. Landau, Ove Noer, Aage Kristian Olsen Alstrup, Helene Audrain, Gregers Wegener, Albert Gjedde, Doris J. Doudet, Michael Winterdahl
MOLECULAR IMAGING AND BIOLOGY
(2020)
Article
Behavioral Sciences
Jessica Justinussen, Camilla Dall, Ditte Dencker, Albert Gjedde, Anders Fink-Jensen, Morgane Thomsen
BEHAVIOURAL BRAIN RESEARCH
(2020)
Article
Neurosciences
Annika Billefeld Bornebusch, Graeme F. Mason, Simone Tonetto, Jakob Damsgaard, Albert Gjedde, Anders Fink-Jensen, Morgane Thomsen
Summary: The study tested the use of β-hydroxybutyrate and a ketogenic diet during alcohol withdrawal to alleviate acute withdrawal symptoms. Results showed that adding β-hydroxybutyrate to the diet was effective in reducing handling-induced convulsions and anxiety-like behaviors during early withdrawal.
PSYCHOPHARMACOLOGY
(2021)
Article
Clinical Neurology
Alireza Majdi, Saeed Sadigh-Eteghad, Albert Gjedde
Summary: The systematic review and meta-analysis of 31 publications involving 978 subjects found that transdermal nicotine administration has significant positive effects on attention, but the effects on memory were non-significant in healthy non-smoking adults. Further studies are encouraged to explore the therapeutic potential of nicotine patches in cognitive disorders.
ACTA NEUROLOGICA SCANDINAVICA
(2021)
Article
Neurosciences
Anne Korning Sigvard, Mette Odegaard Nielsen, Albert Gjedde, Kirsten Borup Bojesen, Dan Fuglo, Karen Tangmose, Yoshitaka Kumakura, Kim Helto, Bjorn H. Ebdrup, Lars Thorbjorn Jensen, Egill Rostrup, Birte Yding Glenthoj
Summary: High baseline decarboxylation rates were associated with more positive symptoms at baseline and with symptom improvement after treatment. Specific parameters for the putamen and nucleus accumbens were associated with psychotic symptoms.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Neuroimaging
Natalie Hong Siu Chang, Yoshitaka Kumakura, Arne Moller, Jakob Linnet, Dirk Bender, Doris J. Doudet, Manouchehr Seyedi Vafaee, Albert Gjedde
Summary: The study revealed that individuals with high sensation-seeking have lower dopamine turnover in the caudate nucleus, leading to higher levels of extracellular dopamine and receptor density. Conversely, those with low sensation-seeking exhibit faster dopamine recycling and oxidation rates, along with lower levels of extracellular dopamine and receptor density. The modulation of dopaminergic neurotransmission associated with sensation-seeking is found to be a state rather than a personality trait following abnormal regulation of dopaminergic neurotransmission.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Neurosciences
Rachele Rossi, Simone Larsen Baerentzen, Majken B. Thomsen, Caroline C. Real, Gregers Wegener, Rodrigo Grassi-Oliveira, Albert Gjedde, Anne M. Landau
Summary: This study explores whether the density of synaptic vesicle glycoprotein 2A (SV2A) in target brain areas associated with cocaine-induced boost of dopaminergic neurotransmission changes after a single exposure during adolescence. The results show a significant increase in SV2A density in the hippocampus 7 days after cocaine administration, but no differences were observed 1 hour after injection.
ACTA NEUROPSYCHIATRICA
(2023)
Meeting Abstract
Endocrinology & Metabolism
M. Naghavi-Behzad, R. Piri, S. Hvidsten, C. Baun, A. Gjedde, M. Seyedi-Vafaee
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2019)
Meeting Abstract
Endocrinology & Metabolism
A. Majdi, C. Constantinescu, K. Pedersen, L. Wermuth, A. Gjedde, E. Segtnan
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2019)