Article
Medicine, General & Internal
Shuzo Kohno, Masahiro Ikegami, Toru Ikegami, Hiroaki Aoki, Masaichi Ogawa, Fumiaki Yano, Ken Eto
Summary: This retrospective study investigated the characteristics of gastroenteropancreatic neuroendocrine tumors using a unified classification. Tumor size, depth, lymphatic invasion, venous invasion, and neuroendocrine tumor grade were significantly correlated with metastasis. Venous invasion was found to be more strongly correlated with metastasis than lymphatic invasion. These findings highlight the importance of a unified classification and standardized assessment framework in neuroendocrine tumor research.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Ru Wang, Ines Godet, Yongkang Yang, Shaima Salman, Haiquan Lu, Yajing Lyu, Qiaozhu Zuo, Yufeng Wang, Yayun Zhu, Chelsey Chen, Jianjun He, Daniele M. Gilkes, Gregg L. Semenza
Summary: This study discovered that HIFs induce the expression of ADAM12, leading to EGFR signaling activation and subsequently promoting breast cancer cell migration, invasion, and metastasis. Inhibition of ADAM12 expression or activity can effectively reduce tumor cell migration, invasion, and lung metastasis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Oncology
Liqi Bao, Hongru Kong, Yang Ja, Chengchao Wang, Lei Qin, Hongwei Sun, Shengjie Dai
Summary: Cancer development and treatment involve complex interactions among factors from mechanics, physics, chemistry, and biology. The tumor microenvironment, with its biomechanical properties, plays a critical role in tumor progression and metastasis by influencing cellular behavior and interactions between cells and the extracellular matrix. Vasculature also has a significant impact on tumor behavior by exerting shear forces and regulating adhesion. Understanding tumor biomechanics is essential for developing effective cancer therapies.
FRONTIERS IN ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Michinobu Umakoshi, Akiko Nakamura, Hiroyuki Tsuchie, Zhuo Li, Yukitsugu Kudo-Asabe, Ken Miyabe, Yukinobu Ito, Makoto Yoshida, Hiroyuki Nagasawa, Kyoji Okada, Hiroshi Nanjo, Daichi Maeda, Naohisa Miyakoshi, Masamitsu Tanaka, Akiteru Goto
Summary: This study examined tumor-associated macrophages in the intratumoral and marginal areas of sarcomas and found that high levels of CD163- and CD204-positive macrophages in the marginal area were associated with poor disease-free survival. However, there was no significant association between macrophage numbers in the intratumoral area and disease-free survival.
SCIENTIFIC REPORTS
(2023)
Review
Oncology
Jingyue Zhang, Yawen Song, Qianqian Shi, Li Fu
Summary: This article discusses the key factors involved in metabolic reprogramming and abnormal lipid metabolism in tumorigenesis, focusing on the roles of fatty acid synthase and monoacylglycerol esterase, as well as their relationship with tumor invasion and metastasis.
FRONTIERS OF MEDICINE
(2021)
Article
Multidisciplinary Sciences
Heng Zou, Zihan Yang, Yuen-San Chan, Sung-king Au Yeung, Md Kowsar Alam, Tongxu Si, Tao Xu, Mengsu Yang
Summary: This research investigated the gene expression and mechanical properties associated with EMT at the single-cell level in non-small cell lung cancer fingers. The study found that leader cells in the cancer fingers were more elastic and less sticky than follower cells. SNAIL and VIM were identified as two key genes that positively correlated with leader cell phenotypes and controlled cancer finger formation.
Review
Plant Sciences
Siqi Wu, Zhe Sun, Zehuai Guo, Peiqin Li, Qianqian Mao, Yang Tang, Hongyu Chen, Huiting Peng, Sisi Wang, Yang Cao
Summary: Blood-activating and stasis-transforming traditional Chinese medicines (BAST) have been proven to improve hemodynamics and micro-flow, prevent thrombosis, and inhibit the invasion and metastasis of lung cancer. This review summarizes the research progress of BAST on lung cancer and explores the underlying molecular mechanisms.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Genetics & Heredity
Meng li, Tingting Yan, Yanqiu Cai, Yingyuan Wei, Qiqi Xie
Summary: Matrix metalloproteinases (MMPs) play a significant role in malignant tumors, including tumor cell invasion, metastasis, and tumor marker expression. This review summarizes the function, classification, and nomenclature of MMPs, and elaborates the correlated expression of MMPs in solid tumors and its association with clinical survival rate and prognosis, providing valuable information for exploring new targets for tumor therapy.
Article
Engineering, Environmental
Fangnon Firmin Fangninou, Zhenyang Yu, Zhuo Li, Awoke Guadie, Wenzhe Li, Lei Xue, Daqiang Yin
Summary: Metastasis is a major cause of cancer mortality, and environmental carcinogens have serious effects on this process. In this study using a fruitfly model, it was found that PCB126, PFOA, and CdCl2 significantly increased tumor invasion rates and decreased larval body weight and locomotion behavior. These effects were associated with disturbances in the expression of target genes in the MAPK and UPR pathways, which were attenuated by inhibitors of p38, JNK, and IRE1. The results highlight the important role of sna/E-cad in connecting the effects of carcinogens on UPR and MAPK regulations and the resultant metastasis.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Review
Oncology
Rushikesh S. Joshi, Samanvi S. Kanugula, Sweta Sudhir, Matheus P. Pereira, Saket Jain, Manish K. Aghi
Summary: The review discusses the importance of cancer-associated fibroblasts (CAFs) in various cancer contexts as potential therapeutic targets. Identification of CAFs and understanding their role in promoting tumor progression may lead to the development of novel cancer therapies.
Article
Chemistry, Medicinal
Jinxin Che, Zegao Jin, Fangjie Yan, Jieqiong You, Jiangfeng Xie, Binhui Chen, Gang Cheng, Hong Zhu, Qiaojun He, Yongzhou Hu, Bo Yang, Ji Cao, Xiaowu Dong
Summary: The compound 4 was identified as a WSB1 degrader, inhibiting the migration capacity of WSB1-overexpressing cells and showing promising anticancer metastatic effects in vivo.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Editorial Material
Oncology
Imran Khan, Patricia S. S. Steeg
Summary: Metastasis is the main cause of cancer patient mortality. Metastasis suppressors are genes that can significantly reduce metastasis without affecting the growth of the primary tumor when reexpressed in metastatic tumor cells. Analysis of more than 30 metastasis suppressors has revealed complex mechanisms of action, including multiple signaling pathways, transcriptional patterns, posttranscriptional regulatory mechanisms, and potential contributions of genomic stability. Clinical testing of strategies to re-establish a validated metastasis suppressor pathway in tumors is best directed to the adjuvant setting, with the goal of inhibiting the outgrowth of occult micrometastases.
CANCER AND METASTASIS REVIEWS
(2023)
Review
Oncology
Stephanie Poon, Laurie E. Ailles
Summary: Accurate in vitro modeling of tumor invasion is crucial for understanding metastasis in cancer research. This review discusses the evolution of invasion assays, with a focus on incorporating cancer-associated fibroblasts (CAFs) and the tumor microenvironment (TME) to provide a clearer picture of the complex process of tumor cell invasion and metastasis. Various in vitro models have been developed to study specific steps in metastasis, highlighting the importance of understanding the interactions between tumor cells, CAFs, and the extracellular matrix for more accurate disease modeling.
Article
Gastroenterology & Hepatology
Goeun Lee, You-Na Sung, Sung Joo Kim, Jae Hoon Lee, Ki-Byung Song, Dae Wook Hwang, Jihun Kim, Sang Soo Lee, Song Cheol Kim, Seung-Mo Hong
Summary: Lymphovascular invasion and a higher T category were worse prognostic factors for recurrence in SPN patients with malignant histologic features. Longer follow-up may be required for SPN patients with malignant histologic features.
Review
Pharmacology & Pharmacy
Shang-Ming Dai, Feng-Jiao Li, Hui-Zhi Long, Zi-Wei Zhou, Hong-Yu Luo, Shuo-Guo Xu, Li-Chen Gao
Summary: Malignant tumors pose a grave threat to human health and are the leading cause of death. Current treatment methods include surgery, chemotherapy, radiotherapy, and immunotherapy, but the low survival rate of patients is still a challenge due to the complex mechanisms of tumor development and high recurrence rate. Individualized treatment, based on understanding molecular mechanisms and differentially expressed genes, is the future direction of tumor treatment. MicroRNAs, a small noncoding RNA, play a critical role in tumor regulation by regulating gene expression. Ferroptosis, a form of programmed cell death induced by iron-dependent lipid peroxidation, has been found to play an important role in tumor development and drug resistance. Increasing evidence suggests that miRNAs can regulate tumor development and drug resistance through the process of ferroptosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Michael F. Sharpnack, Nilini Ranbaduge, Arunima Srivastava, Ferdinando Cerciello, Simona G. Codreanu, Daniel C. Liebler, Celine Mascaux, Wayne O. Miles, Robert Morris, Jason E. McDermott, James L. Sharpnack, Joseph Amann, Christopher A. Maher, Raghu Machiraju, Vicki H. Wysocki, Ramaswami Govindan, Parag Mallick, Kevin R. Coombes, Kun Huang, David P. Carbone
JOURNAL OF THORACIC ONCOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Swagatika Sahoo, Ranjith Kumar Ravi Kumar, Brandon Nicolay, Omkar Mohite, Karthikeyan Sivaraman, Vikas Khetan, Pukhraj Rishi, Suganeswari Ganesan, Krishnakumar Subramanyan, Karthik Raman, Wayne Miles, Sailaja V. Elchuri
Article
Biochemistry & Molecular Biology
Chenyu Lin, Wayne O. Miles
NUCLEIC ACIDS RESEARCH
(2019)
Article
Oncology
Swetha Rajasekaran, Lakshmi Dhevi Nagarajha Selvan, Kathleen Dotts, Ranjith Kumar, Pukhraj Rishi, Vikas Khetan, Madhoolika Bisht, Karthikeyan Sivaraman, Subrmanian Krishnakumar, Debashis Sahoo, Moray J. Campbell, Sailaja Elchuri, Wayne O. Miles
FRONTIERS IN ONCOLOGY
(2019)
Article
Multidisciplinary Sciences
Joan Montero, Cecile Gstalder, Daniel J. Kim, Dorota Sadowicz, Wayne Miles, Michael Manos, Justin R. Cidado, J. Paul Secrist, Adriana E. Tron, Keith Flaherty, F. Stephen Hodi, Charles H. Yoon, Anthony Letai, David E. Fisher, Rizwan Haq
NATURE COMMUNICATIONS
(2019)
Article
Oncology
Cecile Gstalder, David Liu, Diana Miao, Bart Lutterbach, Alexander L. DeVine, Chenyu Lin, Megha Shettigar, Priya Pancholi, Elizabeth Buchbinder, Scott L. Carter, Michael P. Manos, Vanesa Rojas-Rudilla, Ryan Brennick, Evisa Gjini, Pei-Hsuan Chen, Ana Lako, Scott Rodig, Charles H. Yoon, Gordon J. Freeman, David A. Barbie, F. Stephen Hodi, Wayne Miles, Eliezer M. Van Allen, Rizwan Haq
Article
Oncology
Devi D. Nelakurti, Amrit L. Pappula, Swetha Rajasekaran, Wayne O. Miles, Ruben C. Petreaca
Review
Chemistry, Multidisciplinary
Daniel W. Binzel, Xin Li, Nicolas Burns, Eshan Khan, Wen-Jui Lee, Li-Ching Chen, Satheesh Ellipilli, Wayne Miles, Yuan Soon Ho, Peixuan Guo
Summary: RNA nanotechnology involves bottom-up self-assembly of nanometer-scale structures composed mainly of RNA, which possess controlled shape, self-assembly capability, and stability. RNA combines simplicity of DNA and versatility of proteins, making it suitable for applications in pharmaceuticals, nanotechnology, and material science.
Article
Biology
Swetha Rajasekaran, Jalal Siddiqui, Jessica Rakijas, Brandon Nicolay, Chenyu Lin, Eshan Khan, Rahi Patel, Robert Morris, Emanuel Wyler, Myriam Boukhali, Jayashree Balasubramanyam, R. Ranjith Kumar, Capucine Van Rechem, Christine Vogel, Sailaja V. Elchuri, Markus Landthaler, Benedikt Obermayer, Wilhelm Haas, Nicholas Dyson, Wayne Miles
Summary: Swetha Rajasekaran and colleagues integrated multiple types of data to investigate how cells adapt to RB1 inactivation, a hallmark of cancer. They identified key metabolic pathways that may be involved in the growth of RB1-depleted cancer cells and found that RB-depletion resulted in cellular reprogramming. The study also revealed widespread changes in metabolic and cell stress response factors, some of which were not E2F-regulated, suggesting compensatory mechanisms to support the growth of RB-depleted cells.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Robert J. Rabelo-Fernandez, Ginette S. Santiago-Sanchez, Rohit K. Sharma, Abiel Roche-Lima, Kelvin Carrasquillo Carrion, Ricardo A. Noriega Rivera, Blanca I. Quinones-Diaz, Swetha Rajasekaran, Jalal Siddiqui, Wayne Miles, Yasmarie Santana Rivera, Fatima Valiyeva, Pablo E. Vivas-Mejia
Summary: Research has shown that ovarian cancer patients with high levels of RBPMS have longer survival times, while serous ovarian cancer tissues showed weaker RBPMS staining compared to normal ovarian tissues. Experimental CRISPR-mediated RBPMS knockout resulted in faster growth, increased invasiveness, reduced sensitivity to cisplatin, and induced senescence in ovarian cancer cells. RNAseq analysis in the RBPMS knockout clones identified downstream transcripts associated with tumor microenvironment alteration and oncogenic or tumor suppressor capabilities, while proteomic studies showed RBPMS regulates detoxification, RNA processing, and cytoskeleton network proteins. Analysis of the KM plotter database identified potential downstream-RBPMS effectors as prognostic and therapy response biomarkers for ovarian cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Jalal Siddiqui, Wayne O. Miles
Summary: Studies have shown that RNA editing as a molecular marker for predicting response to immunotherapy has high accuracy and confidence, and can clearly distinguish melanoma patients who are sensitive to immunotherapy.
TRANSLATIONAL ONCOLOGY
(2021)
Article
Oncology
Nathan D. Seligson, Joy Tang, Dexter X. Jin, Monica P. Bennett, Julia A. Elvin, Kiley Graim, John L. Hays, Sherri Z. Millis, Wayne O. Miles, James L. Chen
Summary: Leiomyosarcoma (LMS) is a rare, aggressive mesenchymal tumor associated with genomic alterations, particularly in BRCA2. However, unlike carcinomas, there is no overlap with previously published gLOH-associated genes in LMS. Early stage LMS tumors with high gLOH scores have a longer disease-free interval following resection. This suggests that gLOH-LMS is driven by different genomic signals.
NPJ PRECISION ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Marina Capece, Anna Tessari, Joseph Mills, Gian Luca Rampioni Vinciguerra, Darian Louke, Chenyu Lin, Bryan K. McElwain, Wayne O. Miles, Vincenzo Coppola, Alexander E. Davies, Dario Palmieri, Carlo M. Croce
Summary: The discrimination of protein biological functions in different phases of the cell cycle is limited by current experimental approaches. The article introduces a new AID system, which combines cell synchronization techniques to down regulate protein levels in specific cell cycle phases for studying the differential roles of target proteins.
CELL DEATH AND DIFFERENTIATION
(2023)
Review
Oncology
Jocelyn Y. Hsu, Nathan D. Seligson, John L. Hays, Wayne O. Miles, James L. Chen
Summary: CDK4/6 inhibitors have shown limited but significant early clinical success in the treatment of sarcoma. Future targeted clinical research is crucial for unlocking the potential of CDK4/6 inhibition in sarcoma.
JCO PRECISION ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Anisley Valenciaga, Motoyasu Saji, Lianbo Yu, Xiaoli Zhang, Ceimoani Bumrah, Ayse S. Yilmaz, Christina M. Knippler, Wayne Miles, Thomas J. Giordano, Gilbert J. Cote, Matthew D. Ringel
