Article
Biochemistry & Molecular Biology
Sofia C. Nunes, Joana Sousa, Fernanda Silva, Margarida Silveira, Antonio Guimaraes, Jacinta Serpa, Ana Felix, Luis G. Goncalves
Summary: Ovarian cancer is a major cause of death from gynecological cancer and is the third most common gynecological malignancy worldwide. The cure rate for ovarian carcinoma has not improved due to late diagnosis and resistance to therapy. This study suggests that 1H-NMR metabolomics analysis can distinguish between patients with ovarian cancer and those with benign ovarian tumors, and may be able to predict the malignant potential of tumors. The findings support the use of 1H-NMR metabolomics analysis as a screening method for ovarian cancer and for predicting the malignancy of borderline tumors.
Article
Reproductive Biology
Sigit Purbadi, Tricia Dewi Anggraeni, Angelina Vitria
Summary: This study evaluated the benefit of routine surgical staging for patients with clinical early-stage EOC. The results suggest that routine peritoneal biopsies may not be advantageous for these patients, as further research with a larger cohort is needed to obtain more information.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Oncology
Pu Li, Yuezong Bai, Boer Shan, Wei Zhang, Zhanjie Liu, Yingjie Zhu, Xiaoya Xu, Qian Chen, Xiujie Sheng, Xiaoyang Deng, Zhengchen Guo, Dadong Zhang, Huaying Wang, Yanan Zhang, Yuanjing Hu
Summary: This study established a new model using serum biomarkers to aid in the early diagnosis of epithelial ovarian carcinoma, demonstrating promising accuracy and sensitivity in identifying patients at an early stage.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Xuting Ran, Xinlin He, Zhengyu Li
Summary: This study evaluated the oncologic outcomes of laparoscopy and laparotomy in the management of early-stage ovarian cancer patients. The results showed that there is no difference in prognosis between laparoscopic and open surgery in women with stage I epithelial ovarian cancer. Laparoscopic treatment is safe and feasible for these patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mingxiang Wei, Yu Zhang, Genji Bai, Cong Ding, Haimin Xu, Yao Dai, Shuangqing Chen, Hong Wang
Summary: This study investigated the ability of radiomics based on T2-weighted MRI to differentiate between benign and borderline epithelial ovarian tumors (EOTs) preoperatively. The combined model achieved the best performance, followed by the radiomics model, in distinguishing between benign and borderline EOTs. Radiomics can provide critical diagnostic information for personalized treatment options.
INSIGHTS INTO IMAGING
(2022)
Article
Medicine, General & Internal
Shoichiro Yamanaka, Naoki Kawahara, Ryuji Kawaguchi, Keita Waki, Tomoka Maehana, Yosuke Fukui, Ryuta Miyake, Yuki Yamada, Hiroshi Kobayashi, Fuminori Kimura
Summary: This study evaluates the efficacy of the Copenhagen Index, the risk of ovarian malignancy algorithm, and the R2 predictive index in predicting the malignant transformation of ovarian endometrioma. The results suggest that these indexes can serve as independent factors for predicting ovarian malignancy.
Article
Biochemical Research Methods
Wei Zhou, Jiachen Ma, Han Zhao, Qing Wang, Xiaoli Guo, Linna Chen, Zhonghui Cao, Jiahao Xu, Bei Zhang, Xueyan Zhou
Summary: This study aimed to explore the proteomic profile of serum exosomes from epithelial ovarian cancer (EOC) patients and identify potential diagnostic markers for EOC. The researchers found that serum exosomes from EOC patients contributed to the migration of EOC cells and the level of exosomal LRPI was significantly upregulated in EOC patients, serving as an important diagnostic and prognostic biomarker for EOC.
MOLECULAR & CELLULAR PROTEOMICS
(2023)
Article
Oncology
Yuan Li, Jiashan Ding, Huimin Zheng, Lijiang Xu, Weiru Li, Minshan Zhu, Xiaolu Zhang, Cong Ma, Fangying Zhang, Peiwen Zhong, Dong Liang, Yubin Han, Siyou Zhang, Linsheng He, Jiaqi Li
Summary: For early-stage EOC and HGSOC, the study found that an appropriate number of examined lymph nodes is crucial for avoiding stage migration and improving survival outcomes.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Lian Li, Jing Tian, Liwen Zhang, Luyang Liu, Chao Sheng, Yubei Huang, Hong Zheng, Fengju Song, Kexin Chen
Summary: In this study, NLR, PLR, and LMR were significantly associated with all stages and subtypes of EOC, with optimal cut-off points identified for predictive capability. High NLR and PLR levels increased the risk of endometrioid EOC in low CA125 patients, while low LMR levels were associated with increased risk of serous EOC. Preoperative inflammatory markers may serve as potential predictors for different histotypes of EOC alongside CA125.
Article
Oncology
Mu-En Ko, Yi-Heng Lin, Kuan-Ju Huang, Wen-Chun Chang, Bor-Ching Sheu
Summary: This study examined the treatment outcomes of fertility-sparing surgery (FSS) in patients with stage I epithelial ovarian cancer (EOC) or borderline ovarian tumors (BOTs). FSS was found to be a favorable surgical option for young women with early-stage BOTs or EOC who wish to preserve their fertility.
Article
Oncology
Marie Metairie, Louise Benoit, Meriem Koual, Enrica Bentivegna, Henri Wohrer, Pierre-Adrien Bolze, Yohan Kerbage, Emilie Raimond, Cherif Akladios, Xavier Carcopino, Geoffroy Canlorbe, Jennifer Uzan, Vincent Lavoue, Camille Mimoun, Cyrille Huchon, Martin Koskas, Helene Costaz, Francois Margueritte, Yohann Dabi, Cyril Touboul, Sofiane Bendifallah, Lobna Ouldamer, Nicolas Delanoy, Huyen-Thu Nguyen-Xuan, Anne-Sophie Bats, Henri Azais
Summary: This retrospective multicenter study assessed the prognostic impact of the FIGO staging classification and the initial metastatic location on survival in patients with ovarian cancer. The study found that patients with FIGO stage IVA had a worse prognosis than those with stage IVB, and initial pleural involvement was a poor prognostic factor. The researchers suggested modifying the current FIGO staging classification.
Article
Medicine, General & Internal
Min Hoan Moon, Hee Sun Park, Young Jun Kim, Mi Hye Yu, Sungeun Park, Sung Il Jung
Summary: This study aimed to determine computed tomography (CT) features in differentiating stage 1 borderline ovarian tumors (BOTs) from stage I malignant epithelial ovarian tumors (MEOTs). The results showed that a larger tumor size and a smaller solid component were significantly associated with BOTs. In cases with a solid component, smaller and ill-defined solid component was significantly associated with BOTs.
Article
Reproductive Biology
Yan Rong, Li Li
Summary: The study evaluated the clinical value of early clearance of HE4 and CA125 in predicting platinum sensitivity and prognosis in patients with ovarian cancer. The results showed that early clearance of HE4 and CA125 could predict platinum response and prognosis, aiding in predicting the risk of progression and relapse.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Medicine, General & Internal
Shin Nishio, Takayo Takeno, Takeshi Fukuda, Ayumi Shikama, Hidekatsu Nakai, Hiroko Nakamura, Hideki Tokunaga, Kazuaki Takahashi, Emi Okuma, Masahiko Mori, Yasuhisa Terao, Kimio Ushijima, Nobuo Yaegashi
Summary: This study evaluated the outcomes of pregnancies and deliveries in patients who underwent fertility-preserving surgery for early-stage epithelial ovarian cancer. The results showed a low risk of preterm birth and perinatal abnormalities, with a high rate of cesarean delivery.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Nicolo Bizzarri, Andreas du Bois, Robert Fruscio, Francesca De Felice, Pierandrea De Iaco, Jvan Casarin, Enrico Vizza, Vito Chiantera, Giacomo Corrado, Stefano Cianci, Sonia Magni, Debora Ferrari, Daniela Giuliani, Philipp Harter, Beyhan Ataseven, Mareike Bommert, Anna Myriam Perrone, Giovanni Scambia, Anna Fagotti
Summary: The study evaluated the therapeutic role of systematic lymphadenectomy in patients with early-stage epithelial ovarian cancer, showing that comprehensive lymphadenectomy improved disease-free survival but was associated with higher post-operative complications and delayed chemotherapy initiation. Lymphadenectomy did not significantly impact overall survival.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Oncology
Elena Ioana Braicu, Catherine Linn Krause, Uwe Torsten, Herbert Mecke, Rolf Richter, Lars Hellmeyer, Malgorzata Lanowska, Bodo Mueller, Elisa Koch, Janine Boenness-Zaloum, Kerstin Ames, Radoslav Chekerov, Kati Hasenbein, Mathias Zimmermann, Mandy Mangler, Frank Chen, Rudolf Tauber, Jalid Sehouli
Summary: This study evaluated the diagnostic value of adding HE4, CA125, and ROMA to ultrasound for detecting ovarian cancer in patients with a pelvic mass. The results showed that ROMA and HE4 could be valuable biomarkers to aid in the differentiation between ovarian cancer and endometriosis.
Article
Oncology
Carlotta Keunecke, Hagen Kulbe, Felix Dreher, Eliane T. Taube, Radoslav Chekerov, David Horst, Michael Hummel, Thomas Kessler, Klaus Pietzner, Wanja Kassuhn, Florian Heitz, Mustafa Z. Muallem, Susan M. Lang, Ignace Vergote, Oliver Dorigo, Hedwig Lammert, Andreas du Bois, Tim Angelotti, Christina Fotopoulou, Jalid Sehouli, Elena I. Braicu
Summary: This study aimed to discover and validate a predictive panel for surgical outcome of residual tumor mass after first-line debulking surgery. The Nanostring method and immunohistochemistry testing were used to validate a set of predictive genes and predict the presence of miliary carcinomatosis patterns. The results showed that tissue-based biomarkers cannot reliably predict post-operative residual tumor.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Sofya Marchenko, Iris Piwonski, Inga Hoffmann, Bruno Valentin Sinn, Catarina Alisa Kunze, Nanna Monje, Jonathan Pohl, Hagen Kulbe, Wolfgang Daniel Schmitt, Sylvia Darb-Esfahani, Elena Ioana Braicu, Ann-Christin von Bruenneck, Jalid Sehouli, Carsten Denkert, David Horst, Korinna Joehrens, Eliane Tabea Taube
Summary: The study found that higher proportions of regulatory T cells (Tregs) and lower ratios of T helper 17 cells (Th17 cells) were associated with better overall survival in high-grade serous tubo-ovarian carcinoma. This research is important for understanding the impact of the tumor microenvironment on tumor development.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Jacek Glajzer, Dan Cacsire Castillo-Tong, Rolf Richter, Ignace Vergote, Hagen Kulbe, Adriaan Vanderstichele, Ilary Ruscito, Fabian Trillsch, Alexander Mustea, Caroline Kreuzinger, Charlie Gourley, Hani Gabra, Eliane T. Taube, Oliver Dorigo, David Horst, Carlotta Keunecke, Joanna Baum, Timothy Angelotti, Jalid Sehouli, Elena Ioana Braicu
Summary: This study evaluates the impact of BRCA gene status on tumor dissemination, surgical outcome, and survival in ovarian cancer patients. BRCA mutation was associated with younger age, more extensive tumor involvement, higher debulking rates, and prolonged overall survival. The study suggests considering BRCA mutation status in patient selection for cytoreductive surgery.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Eike Burandt, Niclas C. Blessin, Ann-Christin Rolschewski, Florian Lutz, Tim Mandelkow, Cheng Yang, Elena Bady, Viktor Reiswich, Ronald Simon, Guido Sauter, Sven Mahner, Nikolaus de Gregorio, Ruediger Klapdor, Matthias Kalder, Elena Braicu, Sophie Fuerst, Maximilian Klar, Hans-Georg Strauss, Katharina Prieske, Linn Woelber
Summary: This study examined the densities of tumor infiltrating lymphocytes (TILs) in vulvar squamous cell cancer and found that the density of CD3(+) T-cells at the invasive margin had the strongest prognostic value. The study also identified three major immune phenotypes that were strongly associated with patient outcomes. The findings suggest that analyzing CD3(+) T-cells at the invasive margin can predict patient outcomes in vulvar cancer.
Editorial Material
Oncology
Jacek Glajzer, Dan Cacsire Castillo-Tong, Rolf Richter, Ignace Vergote, Hagen Kulbe, Adriaan Vanderstichele, Ilary Ruscito, Fabian Trillsch, Alexander Mustea, Caroline Kreuzinger, Charlie Gourley, Hani Gabra, Eliane T. Taube, Oliver Dorigo, David Horst, Carlotta Keunecke, Joanna Baum, Timothy Angelotti, Jalid Sehouli, Elena Ioana Braicu
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Oncology
Lukas Chinczewski, Felix Wilhelm Feldhaus, Wolfgang Schmitt, Ioana Braicu, Eva Roser, Jalid Sehouli
Summary: This is a case report on a patient with Lynch syndrome-associated ovarian cancer (OC) who achieved a complete response to immunotherapy with pembrolizumab. The findings suggest that immune checkpoint inhibition is an effective therapy for Lynch syndrome-associated OC that is nonresponsive to standard treatment.
ANTICANCER RESEARCH
(2023)
Article
Oncology
Joanna Baum, Daniel Zickler, Juliane Bolbrinker, Rolf Richter, Elena Ioana Braicu, Jacek Grabowski, Jalid Sehouli
Summary: For patients with severe renal impairment or end-stage renal disease, the use of olaparib is not recommended due to lack of evaluation in this patient group. This study reports the pharmacokinetics, efficacy, safety, and tolerability of olaparib in a patient with recurrent epithelial ovarian cancer and end-stage renal disease undergoing hemodialysis.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rafaela Silva, Karina Biskup, Jessica Katherine Zabala-Jouvin, Clara S. Batzdorf, Caroline Stellmach, Anna S. Morr, Ingolf Sack, Antje Ludwig, Veronique Blanchard, Carmen Infante-Duarte
Summary: This study investigated the changes in glycosaminoglycans (GAGs) composition and metabolism in the brain during neuroinflammation using a mouse model. The results showed that there were alterations in GAG metabolism during early stages of experimental autoimmune encephalomyelitis (EAE), and these changes may contribute to the progression of inflammatory disorders like multiple sclerosis (MS).
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Oncology
Helmut Plett, Enzo Ricciardi, Vlad Vacaru, Jan Phillip Ramspott, Nicoletta Colombo, Jalid Sehouli, Andreas du Bois, Annalisa Garbi, Rolf Richter, Beyhan Ataseven, Giovanni Aletti, Elena Braicu, Florian Heitz, Rosalba Portuesi, Mustafa-Zelal Muallem, Timoleon Dagres, Gabriella Parma, Eva Roser, Alexander Traut, Francesco Multinu, Philipp Harter
Summary: This study aimed to analyze the clinicopathological parameters and their impact on progression-free and overall survival in patients with primary adult granulosa cell tumors. The prognosis of patients with primary adult granulosa cell tumors is mainly determined by the FIGO stage. Fertility-sparing surgery seems to be a safe procedure in FIGO IA stage, while adjuvant chemotherapy is not supported in early and advanced stages of adult granulosa cell tumors.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Oncology
Maximilian Klar, Helmut Plett, Philipp Harter, Florian Heitz, Stefan Kommoss, Andreas Daniel Hartkopf, Marcel Grube, Eva Roser, Jalid Sehouli, Iona Braicu, Bastian Czogalla, Alexander Burges, Michaela Bossart, Mir Fuad Hasanov, Teresa Link, Annette Staebler, Doris Mayr, Paul Buderath, Annette Hasenburg
Summary: This study aims to understand the treatment strategies and survival status of malignant sex cord-stromal cell tumors (SCST) and identify research needs. The findings show that although the recurrence rate is high, overall survival rates of SCST patients are excellent.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Sabine Heublein, Joanna Baum, Anna Jaeger, Donata Grimm-Glang, Julia Olthoff, Elena Ioana Braicu, Osama Azzam Nieto, Kathrin Hassdenteufel, Barbara Schmalfeldt, Lars Hanker, Markus Wallwiener, Andreas Schneeweiss, Jalid Sehouli, Klaus Pietzner
Summary: There is disagreement about the extent of surgical staging and the indication of adjuvant chemotherapy for patients with early-stage ovarian cancer (OC). This study revealed that a significant proportion of early-stage OC patients were not operated on according to the current standard, and highlighted the need for further prospective registries and educational programs to improve clinical management.
Article
Oncology
Wanja Kassuhn, Pedro R. Cutillas, Mirjana Kessler, Jalid Sehouli, Elena I. Braicu, Nils Bluethgen, Hagen Kulbe
Summary: High-grade serous ovarian cancer (HGSOC) is a highly lethal form of ovarian cancer with molecular heterogeneity. In this study, the mesenchymal subtype of HGSOC was characterized and targeted treatment opportunities were identified through bulk and single-cell RNA data analysis. The composition of tumor microenvironment, cell-cell communication, and transcription factor regulation were investigated to find potential therapeutic targets for personalized treatment.
Article
Oncology
I. Vergote, E. Van Nieuwenhuysen, A. Casado, A. Laenen, D. Lorusso, E. I. Braicu, E. Guerra-Alia, P. Zola, P. Wimberger, P. R. Debruyne, E. Falco, A. Ferrero, M. Z. Muallem, J. Kerger, E. Garcia-Martinez, S. Pignata, J. Sehouli, T. Van Gorp, C. Gennigens, M. J. Rubio
Summary: This study aimed to establish the role of nintedanib in first-line recurrent/metastatic cervical cancer. The results showed that nintedanib improved the progression-free survival compared to the carboplatin-paclitaxel group. The nintedanib group had a longer median overall survival and a higher RECIST response rate.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Obstetrics & Gynecology
M. Bossart, H. Plett, B. Kraemer, E. Braicu, B. Czogalla, M. Klar, S. Singer, D. Mayr, A. Staebler, A. du Bois, S. Kommoss, T. Link, A. Burges, F. Heitz, M. Grube, F. Trillsch, P. Harter, P. Wimberger, P. Buderath, A. Hasenburg
Summary: This study aimed to evaluate the anxiety and depression levels of survivors of malignant ovarian germ cell tumors (MOGCT) and sex cord stromal tumors (SCST), and to identify possible factors that could be modified. Multivariate linear regression analysis was used to investigate the effects of factors such as type of surgery, chemotherapy, time since diagnosis, recurrence, second tumor, and pain on anxiety and depression. The findings showed that fertility-conserving surgery was associated with lower levels of mental distress, while pain was associated with higher levels of distress.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)