Article
Pharmacology & Pharmacy
P. Vukicevic, A. Klisic, J. Kotur-Stevuljevic, A. Mikic, N. Bogavac-Stanojevic, M. Matkovic, S. Putnik, N. Aleksic, V Tutus, G. A. Karikas
Summary: This study investigated the effects of OPCAB grafting on oxidative stress compared to traditional CABG using CPB. It found a significant decrease in OS markers after both surgeries, with a higher reduction in PON1 activity in CPB patients. There was a negative correlation between SS values and PON1 activity, and models incorporating OS parameters could predict postoperative complications accurately, especially in CPB patients.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Abdolkarim Mahrooz, Yasaman Shokri, Atena Variji, Mehryar Zargari, Ahad Alizadeh, Ehsan Mehtarian
Summary: Developing laboratory assays to evaluate HDL functions and improving cardiovascular disease risk assessment by investigating new cardiometabolic risk factors based on substituting paraoxonase 1 (PON1) as a critical enzyme in the functionality of HDL for that of HDL-C may help predict the risk of coronary artery disease. The study found that the new cardiometabolic ratios remained significant as independent variables after multivariate adjustment, providing optimal discriminating cutoffs for CAD. Substituting PON1 activity for HDL-C in atherogenic lipid ratios can enhance CAD risk assessment by providing an index of HDL activity.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Review
Biochemistry & Molecular Biology
Angelo Zinellu, Stefania Sedda, Arduino A. Mangoni
Summary: The presence of a pro-oxidant state in patients with schizophrenia may contribute to the higher risk of atherosclerosis and cardiovascular disease in this group. This study investigated the associations between paraoxonase-1 levels and oxidative stress in schizophrenia patients. The results suggest that alterations in paraoxonase-1 may reflect a pro-oxidant state in specific subgroups of patients with schizophrenia.
Article
Clinical Neurology
Milan Vecsey-Nagy, Balint Szilveszter, Marton Kolossvary, Melinda Boussoussou, Borbala Vattay, Xenia Gonda, Zoltan Rihmer, Bela Merkely, Pal Maurovich-Horvat, Janos Nemcsik
Summary: The study found that elevated hyperthymic affective temperament scores significantly decreased the odds of severe CAD, while dyslipidemia and cyclothymic affective temperament scores were positively associated with CAD. Ideal cutoff values for hyperthymic, cyclothymic, and irritable temperament scores were independently linked to severe CAD based on ROC analysis.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Medicine, General & Internal
Yu-Wen Chen, Wei-Chieh Lee, Hsiu-Yu Fang, Cheuk-Kwan Sun, Jiunn-Jye Sheu
Summary: This study compared the outcomes of percutaneous coronary intervention (PCI) and coronary artery bypass graft surgery (CABG) for revascularization in patients with reduced ejection fraction (EF) and severe coronary artery disease (CAD). The results showed that compared to PCI, CABG was associated with a lower incidence of heart failure (HF) hospitalization but worse survival outcomes.
Review
Biochemistry & Molecular Biology
Marco Zuin, Valentina Rosta, Alessandro Trentini, Cristina Bosi, Giovanni Zuliani, Carlo Cervellati
Summary: Cumulative evidence suggests a link between environmental toxicants, particularly organophosphate pesticides, and the development of Alzheimer's disease (AD). The enzyme Paraoxonase 1 (PON1) plays a role in neutralizing these toxicants and protecting against their harmful effects. Previous studies have shown a partial association between PON1 activity and AD, but a comprehensive examination is lacking. In this meta-analysis, data from seven studies comparing PON1 activity in AD patients and healthy controls were analyzed, revealing a significant reduction in PON1 activity in the AD group.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Review
Biochemistry & Molecular Biology
Sana Ashiq, Kanwal Ashiq
Summary: This study analyzed the association of PON1 gene polymorphisms with CAD and found that the Q192R polymorphism increased the risk of CAD while the L55M polymorphism showed no significant association. More studies with larger sample sizes are needed for a more definitive conclusion in the future.
BIOCHEMICAL GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Oznur Copur, Havva Yazici, Erhan Canbay, Burak Durmaz, Ebru Canda, Sema Kalkan Ucar, Mahmut Coker, Eser Yildirim Sozmen
Summary: This study explores the oxidative stress, antioxidant parameters, and pro-inflammatory cytokine levels in MPS patients. The results suggest that inflammation plays a role in MPS patients, especially in untreated MPS III and MPS VI patients. The study also highlights potential targets for treatment development.
Article
Biotechnology & Applied Microbiology
Marco Zuin, Alessandro Trentini, Judit Marsillach, Andrea D'Amuri, Cristina Bosi, Loris Roncon, Angelina Passaro, Giovanni Zuliani, Mike Mackness, Carlo Cervellati
Summary: This study reviewed and compared the PON-1 arylesterase activity between coronary artery disease (CAD) and non-CAD patients. The results showed that CAD patients had significantly lower PON-1 arylesterase activity compared to controls, and CAD patients without diabetes mellitus (DM) had significantly higher PON-1 arylesterase activity.
Review
Biochemistry & Molecular Biology
Zahra Najafi Arab, Danial Khayatan, Seyed Mehrad Razavi, Kimia Zare, Elnaz Kheradkhah, Saeideh Momtaz, Gianna Ferretti, Tiziana Bacchetti, Thozhukat Sathyapalan, Seyed Ahmad Emami, Amir Hossein Abdolghaffari, Amirhossein Sahebkar
Summary: Chronic diseases such as cardiovascular disease, atherosclerosis, chronic liver disease, and neurodegenerative diseases are major causes of mortality, with oxidative stress and free radicals playing important roles in their development. Antioxidants, including paraoxonases (PONs), can scavenge free radicals and mitigate their adverse effects. Modulating the expression of PON1, an important antioxidant enzyme, can have beneficial effects in various diseases by regulating inflammatory and oxidative stress signaling pathways. Dietary factors can influence PON1 expression and activity, making them important for disease prevention and treatment.
Article
Medicine, General & Internal
Lourdes Vicent, Jesus Alvarez-Garcia, Rafael Vazquez-Garcia, Jose R. Gonzalez-Juanatey, Miguel Rivera, Javier Segovia, Domingo Pascual-Figal, Ramon Bover, Fernando Worner, Francisco Fernandez-Aviles, Albert Ariza-Sole, Manuel Martinez-Selles
Summary: The aim of this study was to determine the prognostic impact of coronary artery disease (CAD) on heart failure with reduced ejection fraction (HFrEF) mortality and readmissions. A total of 583 patients with left ventricular ejection fraction <40% were included in the study, among which 266 had CAD and 137 had idiopathic dilated cardiomyopathy (DCM). The study found that one-year mortality and readmissions were similar between patients with CAD and idiopathic DCM, but patients with idiopathic DCM were more likely to receive a heart transplant.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Sara N. Koenig, Holly C. Sucharski, Elizabeth M. Jose, Emma K. Dudley, Francesca Madiai, Omer Cavus, Aaron D. Argall, Jordan L. Williams, Nathaniel P. Murphy, Caullin B. R. Keith, Mona El Refaey, Richard J. Gumina, Konstantinos D. Boudoulas, M. Wesley Milks, Gbemiga Sofowora, Sakima A. Smith, Thomas J. Hund, Nathan T. Wright, Elisa A. Bradley, Karolina M. Zareba, Loren E. Wold, Ernest L. Mazzaferri, Peter J. Mohler
Summary: Elevated HDL-C is associated with improved cardiovascular outcomes, but clinical trials targeting HDL-C have not been successful. Rare compound heterozygous variants in SCARB1 have been found to cause severe CAD through Mendelian inheritance. These findings support the disease-contributing capability of loss-of-function SCARB1 variants.
CIRCULATION RESEARCH
(2021)
Article
Medicine, General & Internal
Jun Watanabe, Kazuhiko Kotani, Yoshitaka Iwazu, Alejandro Gugliucci
Summary: Chronic renal failure (CRF) is linked to cardiovascular disease (CVD), and paraoxonase 1 (PON1) has shown potential as a therapeutic marker for CRF. However, there is a lack of systematic analysis on the association between PON1 activity and renal replacement therapy (RRT) in CRF. This meta-analysis examined the available data on PON1 in CRF patients undergoing RRT and found that PON1 activity is higher in CRF patients with RRT, particularly in renal transplantation (RTx), followed by hemodialysis (HD) and peritoneal dialysis (PD). Measuring PON1 activity may be helpful for the management of RRT in CRF.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Geetika Aggarwal, Linda S. May-Zhang, Valery Yermalitsky, Sergey Dikalov, Maxim A. Voynov, Venkataraman Amarnath, Valentina Kon, MacRae F. Linton, Kasey C. Vickers, Sean S. Davies
Summary: Research has shown that the association of MPO with HDL can lead to reduced PON1 activity through IsoLG-mediated modifications, increasing the risk of atherosclerosis. Blocking this modification could potentially reduce the development of atherosclerosis.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Cardiac & Cardiovascular Systems
Nattawut Wongpraparut, Ploy Pengchata, Sudarat Piyophirapong, Pariya Panchavinnin, Rungtiwa Pongakasira, Noppadol Arechep, Kanda Kasetsinsombat, Kittipong Maneechotesuwan
Summary: The study found that IDO, kynurenine, and hs-TnT levels were associated with the severity of CAD in patients. Patients with left main disease had higher 1-year mortality, and lower levels of IDO may predict an increased risk of mortality within one year.
BMC CARDIOVASCULAR DISORDERS
(2021)
