Article
Nutrition & Dietetics
Ingmar Staufenbiel, Knut Adam, Andreas Hahn, Felix Kerlikowsky, Marco Flohr, Nadine Schlueter, Kirstin Vach
Summary: This clinical study aimed to assess the association of specific food ingredients and physical activity on local and systemic inflammatory signs in experimentally induced gingivitis. The results showed that nutrition and physical activity have an influence on periodontal inflammation signs.
Article
Agriculture, Dairy & Animal Science
M. O. Caldeira, R. M. Bruckmaier, O. Wellnitz
Summary: This study found that meloxicam did not limit the inflammatory response in the mammary gland and did not impair the mammary immune system. Interestingly, intramammary meloxicam appeared to stimulate leukocyte recruitment into the milk in quarters challenged with a low dose of LPS.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Psychology, Clinical
David M. Huebner, Larissa A. McGarrity, Nicholas S. Perry, Leigh A. Spivey, Timothy W. Smith
Summary: This study found that minority stress may impact the health of LGB individuals through cardiovascular and endocrine mechanisms. Additionally, the physiological signature of minority stress may differ from other social stress, with implications for health and emotion regulation more broadly.
Article
Multidisciplinary Sciences
Masahiro Yoshida, Kaylee B. Worlock, Ni Huang, Rik G. H. Lindeboom, Colin R. Butler, Natsuhiko Kumasaka, Cecilia Dominguez Conde, Lira Mamanova, Liam Bolt, Laura Richardson, Krzysztof Polanski, Elo Madissoon, Josephine L. Barnes, Jessica Allen-Hyttinen, Eliz Kilich, Brendan C. Jones, Angus de Wilton, Anna Wilbrey-Clark, Waradon Sungnak, J. Patrick Pett, Elena Prigmore, Henry Yung, Puja Mehta, Aarash Saleh, Anita Saigal, Vivian Chu, Jonathan M. Cohen, Clare Cane, Aikaterini Iordanidou, Soichi Shibuya, Ann-Kathrin Reuschl, Ivan T. Herczeg, A. Christine Argento, Richard G. Wunderink, Sean B. Smith, Taylor A. Poor, Catherine A. Gao, Jane E. Dematte, Gary Reynolds, Muzlifah Haniffa, Georgina S. Bowyer, Matthew Coates, Menna R. Clatworthy, Fernando J. Calero-Nieto, Berthold Goettgens, Christopher O'Callaghan, Neil J. Sebire, Clare Jolly, Paolo de Coppi, Claire M. Smith, Alexander Misharin, Sam M. Janes, Sarah A. Teichmann, Marko Z. Nikolic, Kerstin B. Meyer
Summary: Higher innate interferon responses in children may restrict viral replication and disease progression, while the response to SARS-CoV-2 infection differs between children and adults.
Article
Chemistry, Multidisciplinary
Erin A. Baker, Mackenzie M. Fleischer, Alexander D. Vara, Meagan R. Salisbury, Kevin C. Baker, Paul T. Fortin, Craig R. Friedrich
Summary: The study characterized the effects of different TiNT surface morphologies on rat bone marrow cell attachment and overall response, showing that TiNT surfaces can promote osseointegration and have no significant differences in body and blood parameters in rats. However, the trabecular TiNT group had higher aluminum levels in the lungs compared to controls.
Article
Biotechnology & Applied Microbiology
Maha G. Soliman, Hanaa A. Mansour, Wedad A. Hassan, Eman Shawky
Summary: Probiotics have a potential protective effect on acute diverticulitis disease by modifying gut microbiota.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Plant Sciences
Zalan Czekus, Nadeem Iqbal, Boglarka Pollak, Atina Martics, Attila Ordog, Peter Poor
Summary: Plant defense responses can be triggered by the application of elicitors such as chitosan, leading to rapid stomatal closure and production of reactive oxygen species and nitric oxide. These responses are influenced by phytohormones like ethylene and external factors such as light, with the expression of hormone-mediated defense genes playing a crucial role.
JOURNAL OF PLANT PHYSIOLOGY
(2021)
Review
Immunology
George Hajishengallis, Triantafyllos Chavakis
Summary: Periodontitis is causally linked to the development of other chronic inflammatory diseases outside the oral mucosa, and intervention studies have shown that local treatment of periodontitis can ameliorate surrogate markers of comorbid conditions. Experimental animal studies have further strengthened the potential causal link by establishing biologically plausible and clinically consistent mechanisms. Understanding the impact of disseminated periodontal pathogens and systemic inflammation associated with periodontitis on extra-oral pathologies may lead to new therapeutic options to reduce the risk of periodontitis-associated comorbidities.
NATURE REVIEWS IMMUNOLOGY
(2021)
Article
Plant Sciences
Yalin Li, Xinyu Yang, HaiJiang Liu, Wei Wang, Chuang Wang, Guangda Ding, Fangsen Xu, Sheliang Wang, Hongmei Cai, John P. Hammond, Philip J. White, Sergey Shabala, Min Yu, Lei Shi
Summary: This study reveals the mechanistic basis of locally and systemically regulated responses of Brassica napus root architecture to heterogeneous Pi distribution, providing new insights into the molecular and physiological basis of root plasticity.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Immunology
Arezou Khosrojerdi, Sara Soudi, Ahmad Zavaran Hosseini, Sahar Ghaffari Khaligh, Seyed Mahmoud Hashemi
Summary: The study demonstrated a dose-dependent effect of imipenem on inflammatory responses in sepsis mice. Treatment with a low dose (25 mg/kg) of imipenem resulted in decreased bacterial load, endotoxin level, and inflammatory cytokine production, improved pathology, and increased survival rate in sepsis mice compared to other groups.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Javier Raya-Gonzalez, Jonathan Odilon Ojeda-Rivera, Javier Mora-Macias, Araceli Oropeza-Aburto, Leon Francisco Ruiz-Herrera, Jose Lopez-Bucio, Luis Herrera-Estrella
Summary: This study assessed the role of the MED16 subunit in Arabidopsis root system remodeling in response to phosphate limitation, showing that it modulates the expression of a large set of low-phosphate-induced genes to increase phosphate absorption in roots. The findings suggest that MED16 is critical for the transcriptional activation of STOP1 targets, including the membrane permease ALMT1, in order to enhance malate exudation in response to low phosphate, shedding light on how plant cells orchestrate root morphogenesis to gene expression with the STOP1-ALMT1 module.
Article
Pharmacology & Pharmacy
Joseph J. Bivona, Madeleine M. Mank, Renee D. Stapleton, D. Clark Files, Michael J. Toth, Matthew E. Poynter
Summary: Skeletal muscle is an important contributor to local and systemic cytokine abundance during inflammatory events. The study reveals the critical involvement of muscle fibers in the early systemic inflammatory cytokine response to endotoxin, showing the direct contribution of myofibers to systemic cytokine production.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Tracy X. Cui, Alexander E. Brady, Ying-Jian Zhang, Christina T. Fulton, Antonia P. Popova
Summary: Prematurity and bronchopulmonary dysplasia (BPD) increase the risk of asthma later in life. Supplemental oxygen therapy is a risk factor for chronic respiratory symptoms in infants with BPD. In this study, researchers found that hyperoxia increases the number of specific cell types in the lungs and enhances the immune response to rhinovirus infection. The use of the F-actin severing protein gelsolin can attenuate these inflammatory responses and protect alveolarization.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Jason Yongsheng Chan, Grace Fangmin Tan, Joe Yeong, Chee Wee Ong, Dave Yong Xiang Ng, Elizabeth Lee, Joanna Koh, Cedric Chuan-Young Ng, Jing Yi Lee, Wei Liu, Ru Xin Wong, Chin-Ann Johnny Ong, Mohamad Farid, Bin Tean Teh, Khee Chee Soo
Summary: This study found a correlation between peripheral blood neutrophil-to-lymphocyte ratio (NLR) and intra-tumoral immune profiles in angiosarcomas, with higher NLR associated with worse overall survival. Additionally, high NLR was positively correlated with oncogenic pathway scores in the tumor microenvironment, suggesting a potential link between systemic and local immune responses and chemotherapy outcomes in these patients.
NPJ PRECISION ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Deepika Awasthi, Sahil Chopra, Byuri A. Cho, Alexander Emmanuelli, Tito A. Sandoval, Sung-Min Hwang, Chang-Suk Chae, Camilla Salvagno, Chen Tan, Liliana Vasquez-Urbina, Jose J. Fernandez Rodriguez, Sara F. Santagostino, Takao Iwawaki, E. Alfonso Romero-Sandoval, Mariano Sanchez Crespo, Diana K. Morales, Iliyan D. Iliev, Tobias M. Hohl, Juan R. Cubillos-Ruiz
Summary: Infection with Candida albicans triggers hyperactivation of IRE1 alpha, leading to kidney immunopathology. Activation of MyD88 and dectin-1 by C. albicans causes ROS generation, ER stress, and overexpression of inflammatory mediators through IRE1 alpha. Inhibiting IRE1 alpha can mitigate inflammation and improve survival in systemic C. albicans infection.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Medicine, General & Internal
Joanne M. George, Alex M. Pagnozzi, Samudragupta Bora, Roslyn N. Boyd, Paul B. Colditz, Stephen E. Rose, Robert S. Ware, Kerstin Pannek, Jane E. Bursle, Jurgen Fripp, Karen Barlow, Kartik Iyer, Shaneen J. Leishman, Rebecca L. Jendra
Article
Pharmacology & Pharmacy
Meng-Wong Taing, Pauline J. Ford, Christopher Freeman
JOURNAL OF THE AMERICAN PHARMACISTS ASSOCIATION
(2020)
Article
Dentistry, Oral Surgery & Medicine
Nicole Stormon, Christopher Sexton, Pauline J. Ford, Diann S. Eley
Summary: The study found associations between personality and mental health among dentistry students, with students high in self-directedness, cooperativeness, and persistence demonstrating better overall well-being. Positive perceptions of the learning environment were also found to help reduce stress.
EUROPEAN JOURNAL OF DENTAL EDUCATION
(2022)
Article
Environmental Sciences
Eman S. Almabadi, Adrian Bauman, Rahena Akhter, Jessica Gugusheff, Joseph Van Buskirk, Michelle Sankey, Janet E. Palmer, David J. Kavanagh, Gregory J. Seymour, Mary P. Cullinan, Joerg Eberhard
Summary: This study evaluated the effectiveness of a personalized oral health education program combined with routine dental care in a low socioeconomic community through a randomized controlled clinical trial. The results showed that the personalized education program did not significantly improve the clinical outcomes of periodontal health compared to routine dental care.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Substance Abuse
Pauline J. Ford, Alison M. Rich
Summary: Tobacco use can lead to various oral health complications, including oral squamous cell carcinoma and periodontitis, increasing financial and health burdens on individuals and society. Dental practitioners play a crucial role in examining oral health status, providing interventions to help patients quit smoking.
Article
Dentistry, Oral Surgery & Medicine
L. J. Walsh, P. J. Ford, T. McGuire, M. van Driel, S. A. Hollingworth
Summary: Australian dentists prescribed nearly 7 million antibiotics over 12 years, with amoxicillin, amoxicillin + clavulanic acid, and metronidazole being the most commonly prescribed. The use of these top three antibiotics constituted over 80% of all prescriptions and increased dramatically over time. There was a significant increase in the prescribing of broad-spectrum antibiotics, particularly from 2011 to 2016.
AUSTRALIAN DENTAL JOURNAL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Nicole Stormon, Deanna Beckett, Suzanne Gardner, Smita Keshoor, Karen Smart, Linda Wallace, Pauline J. Ford, Julie Satur, Diann Eley
Summary: This study investigated the demographic and personality characteristics of oral health students in Australia and New Zealand, revealing that most students exhibit high levels of persistence and cooperativeness and are interested in working in regional areas after graduation. Further research is needed to explore barriers and enablers in recruiting and retaining males in this predominantly female profession.
EUROPEAN JOURNAL OF DENTAL EDUCATION
(2022)
Article
Dentistry, Oral Surgery & Medicine
Nicole Stormon, Susan Clifford, Katherine Lange, Clare Mangoyana, Pauline Ford, Melissa Wake, Ratilal Lalloo
Summary: The study found a high level of concordance in gingival health between parents and children, supporting familial and behavioral links established in previous research. Children had poorer oral hygiene but fewer visible dental caries lesions, indicating a need for preventive interventions targeting children's oral hygiene.
COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Eman S. Almabadi, Gregory J. Seymour, Rahena Akhter, Adrian Bauman, Mary P. Cullinan, Joerg Eberhard
Summary: This study demonstrated that personalised oral health education combined with routine dental treatment was associated with a significant reduction in hsCRP levels subsequent to dietary behavioural changes, suggesting beneficial effects on general health. Developing an oral health program that educates on modifiable common risk factors for general health should be a priority component to improve oral and general health, particularly for at-risk communities.
JOURNAL OF DENTISTRY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Arosha Tania Weerakoon, Crystal Cooper, Kamil Andrzej Sokolowski, Ian Arthur Meyers, David Thomson, Pauline Jane Ford, Christopher Sexton, Anne Louise Symons
Summary: In this study, the adhesion between dentine and adhesives was investigated using micro-CT and Xe PFIB-SEM. The results showed that adhesive durability was not affected by different depths and locations, although microscopic differences were observed.
EUROPEAN JOURNAL OF ORAL SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
L. Harrison-Barry, K. Elsworthy, M. Pukallus, S. J. Leishman, H. Boocock, L. J. Walsh, W. K. Seow
Summary: This study investigated caries predictors in 378 children and compared the efficacy of home visits and telephone contacts for early childhood caries prevention. The results showed that mutans streptococci, developmental defects of enamel, and low socioeconomic status are strongly correlated with early childhood caries. Home visits were more effective than telephone contacts in preventing caries.
JDR CLINICAL & TRANSLATIONAL RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Nebu Philip, Shaneen J. Leishman, H. M. H. N. Bandara, Laurence Walsh
ORAL HEALTH & PREVENTIVE DENTISTRY
(2020)
Article
Dentistry, Oral Surgery & Medicine
N. Philip, S. J. Leishman, H. M. H. N. Bandara, D. L. Healey, L. J. Walsh
JDR CLINICAL & TRANSLATIONAL RESEARCH
(2020)
Article
Dentistry, Oral Surgery & Medicine
Nicole Stormon, Pauline J. Ford, Ratilal Lalloo
PEDIATRIC DENTISTRY
(2020)
Article
Public, Environmental & Occupational Health
Kelsey Pateman, Jialin Huang, Pauline J. Ford, Allyson Mutch, Christopher R. Freeman, Meng-Wong Taing
HEALTH & SOCIAL CARE IN THE COMMUNITY
(2020)