Review
Pediatrics
Valerie Y. Chock, Anoop Rao, Krisa P. Van Meurs
Summary: Neonates with hypoxic ischemic encephalopathy (HIE) are at significant risk for adverse outcomes. Neuromonitoring provides critical diagnostic and prognostic information. Various modalities such as cEEG, aEEG, NIRS, and heart rate variability can be used for continuous monitoring, while cranial ultrasound and evoked potentials are used for serial bedside monitoring. Integrated use of these techniques, along with therapeutic hypothermia, can predict imaging outcomes and long-term neurodevelopment.
FRONTIERS IN PEDIATRICS
(2023)
Review
Biotechnology & Applied Microbiology
Girish Kumar Rasineni, Nalinikanta Panigrahy, Subha Narayan Rath, Madhurarekha Chinnaboina, Ramesh Konanki, Dinesh Kumar Chirla, Srinivas Madduri
Summary: Perinatal asphyxia and neonatal encephalopathy contribute to neonatal mortality, and a combination of clinical data, neuroimaging, and biochemical parameters is a strategy for improved diagnosis and prognosis. Omics technologies may help identify biomarkers associated with brain injuries and predict disease severity.
BIOENGINEERING-BASEL
(2022)
Article
Pediatrics
Zheng Wang, Dan Zhang, Peng Zhang, Wenhao Zhou, Liyuan Hu, Laishuan Wang, Guoqiang Cheng
Summary: This study retrospectively analyzed data from neonates with mild hypoxic-ischemic encephalopathy (HIE) treated at the Children's Hospital of Fudan University from January 2010 to December 2022. The study aimed to explore the safety and efficacy of therapeutic hypothermia in these neonates. The results showed that therapeutic hypothermia can reduce the incidence of brain injury.
Article
Pediatrics
Abeer Salamah, Doaa El Amrousy, Mai Elsheikh, Mostafa Mehrez
Summary: This study evaluated the effect of citicoline as a neuroprotective drug in neonates with moderate and severe hypoxic-ischemic encephalopathy (HIE). The results showed a significant reduction in the number of neonates having seizures, improved cranial ultrasound and MRI findings, and better neurodevelopmental outcomes at 9 and 12 months in the citicoline treated group compared to the control group. There was also a statistically significant reduction in the duration of seizures, NICU stay, inotrope use, and mechanical ventilation in the treatment group.
ITALIAN JOURNAL OF PEDIATRICS
(2023)
Review
Pediatrics
Dianne G. Kleuskens, Filipe Goncalves Costa, Kim V. Annink, Agnes van den Hoogen, Thomas Alderliesten, Floris Groenendaal, Manon J. N. Benders, Jeroen Dudink
Summary: Cerebral hyperperfusion is a major complication in neonates with HIE, typically occurring within 10-30 minutes after the hypoxic-ischemic event and persisting up to 10 days and even 1 month after birth. This process is characterized by angiogenesis and cerebral vasodilation, mediated by endogenous pathways.
FRONTIERS IN PEDIATRICS
(2021)
Article
Medicine, General & Internal
Tzu-Hua Lin, Chia-Huei Chen, Mary Hsin-Ju Ko, Jeng-Daw Tsai, Mei-Jy Jeng
Summary: This study retrospectively analyzed the medical records of neonates with hypoxic-ischemic encephalopathy (HIE) who received therapeutic hypothermia (TH) with or without erythropoietin (EPO) administration. The results showed that the addition of EPO to TH was safe and may reduce the risk of hypotension in neonates with moderate or severe HIE. However, further research is needed to investigate the effects of EPO on renal and cardiac functions as well as long-term neurological outcomes.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2023)
Article
Pediatrics
Maria Jose Rodriguez, Jose Martinez-Orgado, Araceli Corredera, Irene Serrano, Luis Arruza
Summary: This study assessed diastolic function with tissue Doppler imaging (TDI) in neonates with hypoxic-ischemic encephalopathy (HIE) during therapeutic hypothermia (TH) and rewarming. It found that there was early diastolic dysfunction during TH, which normalized after rewarming, while late diastolic function seemed to be preserved.
FRONTIERS IN PEDIATRICS
(2022)
Article
Clinical Neurology
Pratheek S. Bobba, Ajay Malhotra, Kevin N. Sheth, Sarah N. Taylor, Laura R. Ment, Seyedmehdi Payabvash
Summary: This study quantitatively and objectively characterized the location of hypoxic ischemic lesions in term neonates with varying severity of HIE. The results showed that mild and moderate HIE were associated with subcortical and deep white matter lesions along the border zones of arterial supply territories, while severe HIE also involved basal ganglia, hippocampus, and thalamus.
JOURNAL OF NEUROIMAGING
(2023)
Review
Pediatrics
Iliana Bersani, Fiammetta Piersigilli, Diego Gazzolo, Francesca Campi, Immacolata Savarese, Andrea Dotta, Pietro Paolo Tamborrino, Cinzia Auriti, Corrado Di Mambro
Summary: Heart rate variability (HRV) is considered the most valuable non-invasive test for investigating autonomic nervous system function. Abnormal HRV values have been associated with brain impairment in the perinatal period, making HRV a potential marker for brain damage in cases of hypoxic-ischemic encephalopathy. HRV may offer early information on the severity of brain injury in asphyxiated neonates and assist in designing personalized treatments, but further research is needed to confirm these findings.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Review
Biochemistry & Molecular Biology
Gian Pietro Sechi, Flaminia Bardanzellu, Maria Cristina Pintus, Maria Margherita Sechi, Maria Antonietta Marcialis, Vassilios Fanos
Summary: This review discusses the potential therapeutic role of thiamine and its derivatives in the management of neonatal hypoxic-ischemic encephalopathy (HIE), highlighting its antioxidant properties and ability to rescue mitochondrial function. It suggests a synergistic effect between thiamine treatment and therapeutic hypothermia.
Article
Biochemistry & Molecular Biology
Romane Gaston-Breton, Auriane Maiza Letrou, Rifat Hamoudi, Barbara S. Stonestreet, Aloise Mabondzo
Summary: Our current knowledge of human brain development is mostly based on studies of non-human animals. However, these studies cannot fully replicate human brain development due to species differences and variations in brain maturation. Therefore, three-dimensional brain organoid culture technology can complement animal studies and enhance our understanding of brain-related disorders.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Neurosciences
Ruiyang Zhao, Xiufei Teng, Yanchao Yang
Summary: Hypoxic-ischemic encephalopathy (HIE) is a complex process involving inflammation, oxidative stress, and glucose metabolism, leading to brain damage and impairment. Calpain, a family of Ca2+-dependent cysteine proteases, is involved in cerebral ischemic injury and plays a role in neuronal necrosis and apoptosis pathways. This study reviews the potential role of calpain in treating HIE and provides insights for future research.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Pediatrics
Suresh Victor, Eridan Rocha-Ferreira, Ahad Rahim, Henrik Hagberg, David Edwards
Summary: Around 0.75 million babies suffer from HIE each year, leading to neurodevelopmental impairment. Therapeutic hypothermia is effective but improvements are needed. Challenges for the next decade include better animal models, industry support, and well-designed clinical trials to enhance treatment outcomes.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Pediatrics
Timothy M. Bahr, Robin K. Ohls, Mariana C. Baserga, Shelley M. Lawrence, Sarah L. Winter, Robert D. Christensen
Summary: This study investigated the association between nucleated red blood cell (NRBC) count in neonates with hypoxic-ischemic encephalopathy (HIE) and acute perinatal sentinel events, as well as neurodevelopmental outcomes. The results showed that a normal NRBC count after birth was associated with acute intrapartum events and had modest predictive value for a better prognosis. The elevated NRBC counts may be caused by earlier or chronic hypoxia, and impaired clearance of NRBCs from the blood could be one possible mechanistic explanation.
JOURNAL OF PEDIATRICS
(2022)
Review
Medicine, General & Internal
Guang Yang, Zhimin Xue, Yuan Zhao
Summary: This study aims to investigate whether erythropoietin reduces the risk of death and improves neurodevelopmental disorders in infants with HIE. The results are expected to provide important references for clinical practice.