Article
Gastroenterology & Hepatology
Alexander M. Fagenson, Elizabeth M. Gleeson, Fatima Nabi, Kwan N. Lau, Henry A. Pitt
Summary: The study found that patients undergoing partial hepatectomy or with metastatic disease had increased postoperative complications when a Pringle Maneuver was performed, along with a significant increase in operative time.
Article
Chemistry, Analytical
Chiara Maria Vitale, Arjen Lommen, Carolin Huber, Kevin Wagner, Borja Garlito Molina, Rosalie Nijssen, Elliott James Price, Marco Blokland, Frederike van Tricht, Hans G. J. Mol, Martin Krauss, Laurent Debrauwer, Olga Pardo, Nuria Leon, Jana Klanova, Jean-Philippe Antignac
Summary: A set of QA/QC criteria for nontargeted measurement of pesticide exposure markers in human urine has been proposed and applied in the HBM4EU project. The criteria include monitoring signal intensities, mass accuracy, and retention times of selected markers. The results show high repeatability and accuracy of the data. This is the first time that harmonized QA/QC criteria have been used to assess the quality of nontargeted analysis of human samples across multiple laboratories.
ANALYTICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Junya Matsumi, Tetsufumi Sato
Summary: Propofol has a greater hepatoprotective effect than sevoflurane in patients undergoing elective hepatectomies, as evidenced by lower postoperative transaminase levels.
Article
Pharmacology & Pharmacy
Tongxi Zhuang, Xinhua Liu, Wen Wang, Jing Song, Le Zhao, Lili Ding, Li Yang, Mingmei Zhou
Summary: The study indicates that herbal polyphenols and flavonoids have multiple beneficial effects on obesity caused by chronic metabolic disorders, and the combination of CQR has significant therapeutic effects in combating obesity. Through urinary metabolomic analysis, it was found that CQR has a significant impact on the metabolites of HFD-induced obese rats.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Environmental Sciences
Shiyuan Zhao, Haitao Zhong, Chunmei Geng, Hongjia Xue, Changshui Wang, Wenxue Sun, Ruili Dang, Wenxiu Han, Pei Jiang
Summary: In this study, gas chromatography-mass spectrometry was used to investigate the toxic mechanisms of ACR in the main target tissues of rats, revealing 14 metabolic pathways related to amino acid, fatty acid, purine, and energy metabolism. The study suggests that the toxic mechanism of ACR may involve oxidative stress, inflammation, amino acid metabolism, and energy disorders.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Shiyuan Zhao, Jinxiu Guo, Hongjia Xue, Junjun Meng, Dadi Xie, Xi Liu, Qingqing Yu, Haitao Zhong, Pei Jiang
Summary: This study used gas chromatography-mass spectrometry to investigate the effects of fluoride exposure on metabolites in different organs. Potential biomarkers and affected metabolic pathways related to the mechanism of fluorosis were identified.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Pharmacology & Pharmacy
Yanru Zhu, Feng Wang, Jiatong Han, Yunli Zhao, Miao Yu, Mingyan Ma, Zhiguo Yu
Summary: This study investigated the preventive effect and mechanism of L-theanine on depression in juvenile rats. The results confirmed the preventive effect of L-theanine and identified potential biomarkers related to its treatment. Overall, L-theanine achieved significant preventive results on depression by regulating various aspects of the body, such as amino acids, lipids, and inflammation.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2023)
Article
Chemistry, Analytical
Teresa S. McMillen, Andrew Leslie, Kenneth Chisholm, Susanne Penny, Jeffrey Gallant, Alejandro Cohen, Arik Drucker, James P. Fawcett, Devanand M. Pinto
Summary: This study presents a comprehensive and quantitatively robust method for metabolomic analysis, using HILIC and RP stationary phases combined with positive and negative electrospray ionization. The method allows for complete analysis of a single sample in as little as 40 minutes and has been validated with clinical samples.
ANALYTICA CHIMICA ACTA
(2023)
Article
Plant Sciences
Ziqian Wu, Shiyan Qian, Liangcai Zhao, Zaiheng Zhang, Chengcheng Song, Ling Chen, Hongchang Gao, Wenzong Zhu
Summary: Our study aimed to investigate the interventional effects of XXMD on a rat model of cerebral ischemia/reperfusion. XXXD treatment improved neurological deficits and reduced cerebral infarct areas. Pathological staining showed improvements in Nissl bodies, NeuN and MCT2 expression, and decreased TUNEL expression. NMR analysis revealed varying improvements in lactate, acetate, NAA, glutamate, and GABA levels in different brain regions.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Oncology
Zhiyong Guo, Jinghong Xu, Shanzhou Huang, Meixian Yin, Qiang Zhao, Weiqiang Ju, Dongping Wang, Ningxin Gao, Changjun Huang, Lu Yang, Maogen Chen, Zhiheng Zhang, Zebin Zhu, Linhe Wang, Caihui Zhu, Yixi Zhang, Yunhua Tang, Haitian Chen, Kunpeng Liu, Yuting Lu, Yi Ma, Anbin Hu, Yinghua Chen, Xiaofeng Zhu, Xiaoshun He
Summary: Ischemia-free liver transplantation can avoid graft ischemia-reperfusion injury and has the potential to improve transplant outcomes and organ utilization.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Qingying Si, Jinxiu Guo, Xiumei Yang, Yujin Guo, Linlin Wu, Dadi Xie, Pei Jiang
Summary: This study investigated the metabolic alterations in streptozotocin-induced diabetic rats using gas chromatography-mass spectrometry analysis. The results showed differential expression of metabolites in the serum, heart, liver, kidney, cortex, renal lipid, hippocampus, and brown fat tissues of diabetic rats compared to control rats. Metabolic pathway analysis revealed that these alterations mainly involved amino acid metabolism, organic acid metabolism, sugar metabolism, and lipid metabolism.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Eva Baranovicova, Dagmar Kalenska, Maria Kovalska, Jan Lehotsky
Summary: The study examines the impact of forebrain ischemia on metabolic alterations in the hippocampus and blood plasma, indicating the feasibility of re-establishing glutamatergic transmission three days after an ischemic event and the potential role of semi-ketotic state in brain tissue revitalization.
NEUROCHEMISTRY INTERNATIONAL
(2022)
Article
Nutrition & Dietetics
Douglas Ikedo Machado, Eloiza de Oliveira Silva, Sara Ventura, Maria de Fatima Fernandes Vattimo
Summary: Chronic kidney disease (CKD) and acute kidney injury (AKI) are global health problems that affect over 850 million people. Diabetes mellitus (DM) increases the susceptibility to AKI. Curcumin has shown positive effects in diabetic rats with AKI, improving renal function and reducing oxidative stress.
Review
Chemistry, Analytical
Joao Raul Belinato, Vinicius Ricardo Acquaro, Luciana Teresa Dias Cappelini, Fabio Augusto
Summary: The interest in bioactive compounds from microorganisms has increased since the first discovery, with microorganisms being a key source of biomolecules with diverse applications. While conventional sample preparation techniques are still widely used, microextraction techniques show promise in overcoming limitations and promoting a deeper understanding of complex systems and the discovery of new molecules.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Zhanxuan E. Wu, Marlena C. Kruger, Garth J. S. Cooper, Ivana R. Sequeira, Anne-Thea McGill, Sally D. Poppitt, Karl Fraser
Summary: Untargeted metabolomics of blood samples has been widely used to study metabolic alterations in diseases and identify biomarkers. This study found that the concentration of metabolites in plasma was more reflective of the liver profile than muscle or adipose tissue, highlighting the importance of considering the metabolomic relationship between different tissues and plasma.