Article
Biochemistry & Molecular Biology
Rana I. Mahmood, Amal Kh. Abbass, Nurhanani Razali, Ali Z. Al-Saffar, Jameel R. Al-Obaidi
Summary: The research revealed that lectin conjugated with CaCO(3)NPs could alter the abundance of multiple proteins in breast cancer cells, mainly affecting pathways associated with breast cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Multidisciplinary Sciences
Anna Daily, Prashanth Ravishankar, Steve Harms, V. Suzanne Klimberg
Summary: This study identified protein biomarkers with altered expression levels in tear samples from women diagnosed with breast cancer. Through LC-MS/MS analysis, 14 potential biomarkers were identified and validated by ELISA. The results showed significantly higher expression of S100A8 and S100A9 in breast cancer patients, while Galectin-3 binding protein had increased expression in the control group. These findings support the use of tear proteins in detecting systemic diseases such as breast cancer.
Article
Oncology
Maria del Pilar Chantada-Vazquez, Mercedes Conde-Amboage, Lucia Grana-Lopez, Sergio Vazquez-Estevez, Susana B. Bravo, Cristina Nunez
Summary: The goal of this study was to identify circulating proteins as biomarkers for predicting response to neoadjuvant chemotherapy in HER2-positive breast cancer patients. Proteomics techniques were used to analyze serum samples and identify potential biomarkers. The study found that serum biomarker profiles can be used to predict treatment response and outcome.
Review
Oncology
Anca-Narcisa Neagu, Danielle Whitham, Emma Buonanno, Avalon Jenkins, Teodora Alexa-Stratulat, Bogdan Ionel Tamba, Costel C. Darie
Summary: Breast cancer is a complex and multi-faceted disease that poses a challenge for precision diagnostic and personalized oncology in the new era. Proteomics technologies play a crucial role in the discovery of diagnostic, prognostic, and predictive biomarkers for breast cancer.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Medicine, General & Internal
Kamala Vanarsa, Jessica Castillo, Long Wang, Kyung Hyun Lee, Claudia Pedroza, Yair Lotan, Chandra Mohan
Summary: This study identified potential biomarkers for bladder cancer diagnosis and disease progression using aptamer screening and systems biology analysis. Urine d-dimer showed high sensitivity (97%) for bladder cancer diagnosis, while urine IL-8 and IgA were associated with disease progression. These biomarkers could be used for initial triage and patient follow-up, reducing the need for invasive cystoscopy-based diagnostic methods.
Article
Multidisciplinary Sciences
Sophia Harlid, Justin Harbs, Robin Myte, Carl Brunius, Marc J. Gunter, Richard Palmqvist, Xijia Liu, Bethany Van Guelpen
Summary: This study evaluated protein biomarkers in relation to colorectal cancer risk using prospectively collected plasma samples. The main validation analysis did not show statistically significant proteins, but exploratory subgroup analyses found associations between certain proteins and colon or rectal cancer risk. Adding protein markers to basic risk predictive models modestly improved performance.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Amy L. George, Sadr ul Shaheed, Chris W. Sutton
Summary: Nipple aspirate fluid (NAF) shows promising potential as a non-invasive source of early detection biomarkers for breast cancer, by identifying a multitude of proteins representing the changing breast microenvironment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Maudy Walraven, Siamack Sabrkhany, Jaco C. Knol, Henk Dekker, Inge de Reus, Sander R. Piersma, Thang Pham, Arjan W. Griffioen, Henk J. Broxterman, Mirjam Oude Egbrink, Henk M. W. Verheul, Connie R. Jimenez
Summary: Platelets are potential sources of cancer biomarkers, with the proteome being affected in cancer patients. Additionally, anticancer treatment significantly alters the platelet proteome, as observed in a small group of patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Bethany Geary, Erin Peat, Sarah Dransfield, Natalie Cook, Fiona Thistlethwaite, Donna Graham, Louise Carter, Andrew Hughes, Matthew G. Krebs, Anthony D. Whetton
Summary: TARGET (tumour characterisation to guide experimental targeted therapy) aims to match cancer patients entering early phase clinical trials to the best treatment based on their genetics, reducing the need for recruiting more patients. The study developed a Wellness Score using blood samples to predict patient survival more accurately than traditional performance status measurements. This score showed promising results in predicting overall survival and warrants further evaluation in larger patient populations.
Article
Biochemical Research Methods
Carine Steiner, Pierre Lescuyer, Paul Cutler, Jean-Christophe Tille, Axel Ducret
Summary: The identification of clinically relevant biomarkers is a challenge in oncology. Liquid chromatography coupled to multiple reaction monitoring mass spectrometry (LC-MRM/MS) is an effective technique for measuring proteins in formalin-fixed paraffin-embedded (FFPE) tissues. LC-MRM/MS can accurately quantify a large number of proteins and identify potential biomarkers in tumor samples.
MOLECULAR & CELLULAR PROTEOMICS
(2022)
Article
Oncology
Stanley Ly, Vivek Anand, Fouad El-Dana, Khoa Nguyen, Yiming Cai, Shirong Cai, Helen Piwnica-Worms, Debasish Tripathy, Aysegul A. Sahin, Michael Andreeff, Venkata Lokesh Battula
Summary: GD2 is expressed in around 60% of primary TNBC tumors at variable levels and is associated with worse overall survival of patients with TNBC. Treatment with dinutuximab significantly decreased adhesion and migration of TNBC cells, inhibited mTOR signaling, and reduced tumor growth in both cell-line xenografts and PDX models. Our data provide proof-of-concept for the critical role of GD2 in BCSCs and demonstrate the potential of dinutuximab as a novel therapeutic approach for TNBC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Medicine, Research & Experimental
Pengyu Liu, Wenxuan Wang, Fei Wang, Jiaqi Fan, Jinan Guo, Tao Wu, Dongliang Lu, Qingchun Zhou, Zhuohao Liu, Yuliang Wang, Zhiqun Shang, Franky Leung Chan, Wei Yang, Xin Li, Shan-Chao Zhao, Qingyou Zheng, Dinglan Wu
Summary: In this study, proteomic and metabolomic analysis of exosomes from prostate cancer (PCa) patients was performed. Several potential biomarkers for PCa and castration resistant prostate cancer (CRPC) were identified, including the proteins LRG1 and ITIH3. Metabolomic evaluation also revealed differentially expressed metabolites. These findings suggest the potential of exosomal proteins and metabolites as markers for CRPC and confirm the important role of the protein LRG1 in PCa progression.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Johannes F. Fahrmann, Hiroyuki Katayama, Ehsan Irajizad, Ashish Chakraborty, Taketo Kato, Xiangying Mao, Soyoung Park, Eunice Murage, Leona Rusling, Chuan-Yih Yu, Yinging Cai, Fu Chung Hsiao, Jennifer B. Dennison, Hai Tran, Edwin Ostrin, David O. Wilson, Jian-Min Yuan, Jody Vykoukal, Samir Hanash
Summary: The study identified novel circulating proteins associated with SCLC development, including oncogenic MYC and YAP1 signatures, as well as inflammatory markers indicating increased risk of disease. These findings highlight the potential utility of blood-based markers for early detection of SCLC.
Review
Oncology
Karama Asleh, Nazia Riaz, Torsten O. Nielsen
Summary: As the field of translational 'omics has progressed, refined classifiers at both genomic and proteomic levels have emerged to decipher the heterogeneity of breast cancer in a clinically-applicable way. The integration of 'omics knowledge at the DNA, RNA and protein levels is further expanding biologic understanding of breast cancer and opportunities for customized treatment. Recent advances in omics-based genomics and proteomics diagnostics, single cell analysis approaches, and targeted therapeutics development have provided valuable insights into the molecular subtyping of triple negative breast cancer and potential treatment strategies.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Embla Boden, Jesper Andreasson, Gabriel Hirdman, Malin Malmsjo, Sandra Lindstedt
Summary: This study analyzes blood samples from patients with non-small cell lung cancer (NSCLC) to diagnose and monitor the disease. The results suggest that certain proteins, such as MIC-A/B and FASLG, increase after surgery, indicating the removal of cancer cells. The level of HGF initially increases postoperatively but later decreases, potentially indicating the removal of malignant cells. Additionally, low levels of FASLG may serve as a prognostic biomarker for relapse or death in NSCLC patients.
Article
Engineering, Multidisciplinary
Manjit Singh, Rajesh Kumar Gupta
Summary: This study reconsiders the optimal classifications of Lie algebras of some well-known equations under their group of inner automorphism, demonstrating explicit isomorphism between Lie algebras and sub-algebras that have already been classified. The use of such isomorphism proves beneficial for classifying Lie algebras with dimension <= 4, utilizing previously available classifications. Additionally, examples of Lie algebras are considered for explicit isomorphism, further enhancing the understanding of their classifications.
INTERNATIONAL JOURNAL OF NONLINEAR SCIENCES AND NUMERICAL SIMULATION
(2021)
Article
Green & Sustainable Science & Technology
Manoj Kumar, Ritu Dogra, Mahesh Narang, Manjit Singh, Sushant Mehan
Summary: The study developed an efficient planter for paddy growing areas in India through laboratory testing and on-field evaluation. The inclined plate metering mechanism performed best under specific parameters, with hopper fill level being the main factor affecting planter efficiency.
Review
Biochemistry & Molecular Biology
Manjit Singh, Marc C. Albertsen, A. Mark Cigan
Summary: This review discusses the progress in characterization of nuclear genetic male sterility (NGMS) in wheat and its advantages in hybrid wheat varieties, compared to chemical hybridizing agents (CHAs) and cytoplasmic male sterility (CMS). Four wheat genes, such as Ms1, Ms5, TaMs26 and TaMs45, have been characterized for their contribution to male fertility, with potential for commercial-scale hybrid seed production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Management
Gedif Tessema Sinshaw, Atul Shiva, Manjit Singh
Summary: The study showed that ethical leadership has a significant direct impact on administrative innovation and knowledge process capability, and that knowledge process capability also significantly influences administrative innovation. The study also revealed the partial mediating role of knowledge process capability in linking ethical leadership to administrative innovation, contributing a new dimension to the existing literature on ethical leadership.
JOURNAL OF MANAGEMENT DEVELOPMENT
(2021)
Article
Business, Finance
Pooja Mehta, Manjit Singh, Manju Mittal, Himanshu Singla
Summary: This study examines the serial mediation effect of attitude toward SRI and SIE on the relationship between knowledge about SRI and intention to invest in SRI, with the moderating effect of religiosity. The findings indicate that religiosity has a significant interaction effect with SIE. The study highlights the potential for the development of SRI in India, where religious values dominate investors' beliefs.
QUALITATIVE RESEARCH IN FINANCIAL MARKETS
(2022)
Article
Mathematics
Manjit Singh, Shou-Fu Tian
Summary: In this work, a member of the Manakov-Santini hierarchy is investigated using Lie group analysis and the multiplier approach. It is shown that the 11-dimensional Lie algebra for the MS system is completely solvable. The construction of inequivalent subalgebras in one and two dimensions is discussed, and these subalgebras are used to obtain reductions and exact solutions. In addition to Lie symmetry analysis, a set of non-trivial conservation laws is obtained.
INDIAN JOURNAL OF PURE & APPLIED MATHEMATICS
(2023)
Article
Biotechnology & Applied Microbiology
Manjit Singh, Manish Kumar, Kara E. Califf, A. Mark Cigan
Summary: This study demonstrates the successful application of transcriptional gene silencing (TGS) in wheat, using a promoter inverted repeat (pIR) to silence anther-specific genes and induce male sterility. The pIRs achieve TGS by DNA methylation of homologous promoter sequences, effectively suppressing transcription. This approach provides an alternative to gene knockout strategies for hybrid wheat breeding and seed production.
PLANT BIOTECHNOLOGY JOURNAL
(2022)
Proceedings Paper
Materials Science, Multidisciplinary
Sanjeev Kumar, Satish Kumar, Rajesh Sharma, Manjit Singh, Rajdeep Singh
Summary: In this paper, the surface micro-hardness of cryogenically treated titanium alloys was predicted using the PMEDM process, ANN approach, and Taguchi methodology. The control parameters, such as pulse off-time and peak current, were found to significantly influence the micro-hardness and surface properties. The ANN predicted values of micro-hardness were in good agreement with the actual experimental values.
MATERIALS TODAY-PROCEEDINGS
(2022)
Proceedings Paper
Materials Science, Multidisciplinary
Gurkirat Singh, Manjit Singh, Ravinder Singh, Sachin Mohal, Satish Kumar, Sanjeev Kumar
Summary: Fluid and heat transfer in porous medium have significant implications in industrial applications. This paper presents a numerical approach for solving the coupled problem of fluid and heat transfer in porous media and develops a mathematical model based on Darcy's extension law, energy equations, and constitutive relationship.
MATERIALS TODAY-PROCEEDINGS
(2022)
Proceedings Paper
Materials Science, Multidisciplinary
Manjit Singh, Chanpreet Singh, D. Gangacharyulu
Summary: The flow of water through unsaturated soil with four stable packing arrangements was numerically studied. The study found that the different packing arrangements resulted in variations in water content, hydraulic conductivity, and effective hydraulic conductivity.
MATERIALS TODAY-PROCEEDINGS
(2022)
Proceedings Paper
Materials Science, Multidisciplinary
Sachin Mohal, Saurabh Chaitanya, Manjit Singh, Rachin Goyal, Amresh Kumar, Gaurav Saini
Summary: Stainless steel (316) is widely used due to its high strength to weight ratio, toughness, and tensile strength. Submerged arc welding has been found suitable for welding this type of material, with welding current being the most crucial parameter.
MATERIALS TODAY-PROCEEDINGS
(2022)
Article
Surgery
Arvinder Singh Maan, Gurkiran Kaur, Rabia Arora, Jasmeet Kaur, Kamana Jyotsna Devi, Manjit Singh
Summary: In this case report, we present the rare occurrence of a complicated nasal septal abscess progressing to sinusitis, orbital, and intracranial complications. Due to COVID-19 lockdown restrictions and fear of infection, the patient presented late for treatment, highlighting the importance of timely healthcare access.
INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY
(2022)
Article
Surgery
Kulwinder Singh Sandhu, Satinder Pal Singh, Oshin Thomas, Priyanka Choudhary, Arvinder Singh, Manjit Singh
Summary: This study compared the long term outcome of endoscopic septoplasty with microdebrider assisted inferior turbinoplasty (MAIT) versus medial flap turbinoplasty (MFT). The results showed that MFT was more effective in improving nasal obstruction and nasal airway patency compared to MAIT, with lower risk of complications. Long term follow up of MAIT is needed as further treatment may be required.
INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY
(2022)
Article
Otorhinolaryngology
Kulwinder Singh Sandhu, Gurkiran Kaur, Oshin Thomas, Khaiko Lolia Mao, Stuti Mahajan, Manjit Singh
Summary: Foreign body ingestion, especially denture ingestion, is not uncommon in adults, with the potential for fatal complications if left untreated. In this case report, the challenges and protocol for managing a 60-year-old patient with COVID-19 who accidentally ingested dentures are presented.
Article
Mathematics, Applied
Manjit Singh
Summary: The nonlinear variable coefficient Zakharov-Kuznetsov (Vc-ZK) equation is derived using reductive perturbation technique for ion-acoustic solitary waves in magnetized three-component dusty plasma. Generalized symmetries of the equation are investigated using a compatibility method, leading to the discovery of new symmetries and group invariant solutions. Furthermore, nontrivial local conservation laws of the equation are also explored.
COMPUTATIONAL METHODS FOR DIFFERENTIAL EQUATIONS
(2021)
