Article
Endocrinology & Metabolism
Yu-Shan Hsieh, Min-Chun Yeh, Yan-Yu Lin, Shuen-Fu Weng, Chung-Huei Hsu, Chen-Ling Huang, Yu-Pei Lin, A-Young Han
Summary: This study identifies the significance of serum lactate dehydrogenase (LDH) level in T2DM patients and investigates its relationship with other variables.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Tingting Cai, Yun Hu, Bo Ding, Rengna Yan, Bingli Liu, Ling Cai, Ting Jing, Lanlan Jiang, Xiaojing Xie, Yuming Wang, Huiying Wang, Yunting Zhou, Ke He, Lan Xu, Liang Chen, Cheng Cheng, Jianhua Ma
Summary: This study aimed to explore the chronic effects of metformin on testosterone levels in men with type 2 diabetes mellitus. The results showed that after 3-month treatment, testosterone levels decreased in the metformin group, especially total and free testosterone levels. In the subgroup with improved blood glucose, the control group had a significant increase in testosterone levels compared to the metformin group.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Annika Vestergaard Kvist, Mohamad I. Nasser, Peter Vestergaard, Morten Frost, Andrea M. Burden
Summary: A study in Denmark from 1997 to 2017 found that the incidence rates of fractures were higher in patients with type 1 and type 2 diabetes compared to those without diabetes, except for foot fractures. The incidence of hip fractures decreased by 35.2%, 47.0%, and 23.4% in patients with type 1 diabetes, type 2 diabetes, and without diabetes, respectively, over the last 5 years. However, vertebral fractures increased by 14.8%, 18.5%, and 38.9% in the same groups. After age adjustment, patients with type 1 diabetes still had a higher risk of fractures compared to those without diabetes, while patients with type 2 diabetes had a risk similar to those without diabetes.
Article
Endocrinology & Metabolism
Lixia Huo, Hui Li, Ming Zhu, Yang Liu, Lingyan Ren, Jia Hu, Xiaoyi Wang
Summary: This study found that dysbiosis of gut microbiota occurs in early-stage DKD patients, and the reduction of short-chain fatty acid-producing bacteria is associated with the accumulation of TMA and UACR.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Immunology
Rong Lin, Yu-Wei Lin, Mei-Hsiu Chen
Summary: This article reports a 39-year-old woman who developed fulminant type 1 diabetes following SARS-CoV-2 vaccination. The patient had low glycohemoglobin levels, hyperglycemia, and diabetic ketoacidosis. Initial misdiagnosis as type 2 diabetes led to a second episode of ketoacidosis. This case highlights the importance of recognizing vaccine-related fulminant T1DM for clinicians.
Article
Chemistry, Analytical
Rui Su, Shuchen Xin, Xiangzhe Zhou, Feng Liu, Yongqian Zhang, Yulin Deng
Summary: Glycated albumin (GA) is a biomarker for diagnosing prediabetes and diabetes. Three promising peptide biomarkers were found for diagnosing type 2 diabetes mellitus (T2DM) using mass spectrometry.
Article
Dentistry, Oral Surgery & Medicine
Qingqing He, Zhixiang Mu, Annie Shrestha, Chao Wang, Si Wang, Han Tang, Yihan Li, Jinlin Song, Ping Ji, Yuanding Huang, Tao Chen
Summary: The study successfully established a T2DM-PI model in rats, characterized by abundant inflammatory cell infiltration and bone resorption, providing a new model for investigating the initiation, progression, and intervention of T2DM-PI.
Review
Endocrinology & Metabolism
Li-Mei Li, Bei-Ge Jiang, Liang-Liang Sun
Summary: Diabetes is a highly heterogeneous metabolic disease with different types and clinical manifestations. Distinguishing between types and defining subtypes is a major challenge in precise treatment. T2D is the main type of diabetes, and certain gene variants have been shown to increase the risk of T2D. HNF1 alpha gene mutations can cause different types of diabetes and exhibit high polymorphism.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Shih-Chun Pan, Ching-Chun Huang, Bing-Yu Chen, Wei-Shan Chin, Yue Leon Guo
Summary: This study aimed to determine whether air pollutants modify the effects of gestational diabetes mellitus (GDM) on the occurrence of diabetes mellitus (DM). The results showed that exposure to high levels of PM2.5 and O-3 increases the risk of DM, and GDM acts synergistically with PM2.5 exposure in DM development.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Endocrinology & Metabolism
Rui Min, Yancheng Xu, Bocheng Peng
Summary: This study evaluated the clinical value of glycosylated hemoglobin (HbA1c) in newly diagnosed ketosis-prone type 2 diabetes (KPD). The results showed that HbA1c was correlated with ketosis, insulin, and islet function. Patients with HbA1c > 10.15% were more likely to develop KPD.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Yao Chen, Lilin Yao, Shuheng Zhao, Mengchu Xu, Siwei Ren, Lu Xie, Lei Liu, Yin Wang
Summary: This study used machine learning to build aging and disease models, revealing a close relationship between oxidative aging and type 2 diabetes mellitus (T2DM). The results identified key factors such as nutritional metabolism, inflammation response, mitochondrial function, and protein homeostasis in the interplay between oxidative aging and T2DM. The study integrated various risk factors in T2DM and confirmed the theories of oxi-inflamm-aging and cellular senescence.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Yujiao Li, Xiaobing Ji, Wenji Ni, Yong Luo, Bo Ding, Jianhua Ma, Jian Zhu
Summary: The study found that in newly diagnosed type 2 diabetic patients, low serum albumin and microalbuminuria levels are closely associated with kidney failure progression, indicating a relatively fast progression of chronic kidney disease. Multivariable logistic regression analysis revealed a strong correlation between these two indicators and kidney failure progression.
Article
Nutrition & Dietetics
Lulu Wang, Xue Liu, Jian Hou, Dandan Wei, Pengling Liu, Keliang Fan, Li Zhang, Luting Nie, Xing Li, Wenqian Huo, Tao Jing, Wenjie Li, Chongjian Wang, Zhenxing Mao
Summary: This study found a negative correlation between serum vitamin D and impaired fasting glucose (IFG) and type 2 diabetes mellitus (T2DM), as well as a negative correlation between serum 25(OH)D-2 and total 25(OH)D levels. The lipid profile, specifically total cholesterol (TC) and triglyceride (TG), partially mediated the relationship between vitamin D and IFG or T2DM. Additionally, there were interactive effects of serum 25(OH)D-2, total 25(OH)D, and testosterone on T2DM in females.
Article
Cardiac & Cardiovascular Systems
Tian Li, Rui Providencia, Nan Mu, Yue Yin, Mai Chen, Yishi Wang, Manling Liu, Lu Yu, Chunhu Gu, Heng Ma
Summary: This study found that T2DM patients treated with metformin did not show a lower risk of all-cause mortality or cardiovascular mortality compared to untreated T2DM patients. Further, the combination of metformin with another hypoglycemic drug was associated with a higher risk of all-cause and cardiovascular mortality.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Endocrinology & Metabolism
Che Bian, Yuxia Wang, Jia Li, Jing Gao, Zhilin Luan, Xiaohui Cui, Huiwen Ren
Summary: The levels of fasting serum fructose and ketohexokinase were found to increase with urinary albumin creatinine ratios and serum uric acid levels in patients with type 2 diabetes mellitus. The study also showed a positive correlation between fasting serum fructose and ketohexokinase levels with urinary albumin creatinine ratios and serum uric acid levels.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Medicine, General & Internal
Beata Szymanska, Zofia Marchewka, Brygida Knysz, Agnieszka Piwowar
Summary: This study measured the levels of low molecular weight proteins in urine of HIV-infected patients and found that certain protein levels are of significance in assessing kidney damage in HIV patients during antiretroviral therapy.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Immunology
Beata Jankowska-Polanska, Kathie Sarzynska, Eddie Czwojdzinski, Natalia Swiatoniowska-Lonc, Krzysztof Dudek, Agnieszka Piwowar
Summary: The role of medical personnel in promoting vaccination and pro-health attitudes is crucial for protection against COVID-19. A study assessed the attitudes of healthcare workers and medical students towards preventive vaccinations against COVID-19 and found that young medical students had a more positive attitude, while students expressed higher concerns about the vaccine's side effects and contracting the virus.
Article
Cell Biology
Izabela Kokot, Sylwester Mazurek, Agnieszka Piwowar, Roman Szostak, Marcin Jedryka, Ewa Maria Kratz
Summary: Endometriosis is a common gynecological disease for young women, but there is no specific biomarker for diagnosis. A study using infrared spectroscopy and discriminant analysis successfully differentiated three groups: women with endometriosis, women with other gynecological disorders, and healthy women.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Immunology
Monika Stepien, Malgorzata Zalewska, Brygida Knysz, Natalia Swiatoniowska-Lonc, Beata Jankowska-Polanska, Lukasz Laczmanski, Agnieszka Piwowar, Amadeusz Kuzniarski
Summary: The aim of this study was to evaluate and compare the effectiveness of different vaccines in Poland's mass vaccination program and investigate the most common side effects. The study found that 100% of patients responded to the vaccines, with convalescents having higher antibody levels after the first dose but a decrease after the second dose. Moderna vaccine generated the highest antibody titers after both doses, and fever was identified as a significant factor in higher antibody levels.
Article
Biochemistry & Molecular Biology
Justyna Niepsuj, Grzegorz Franik, Pawel Madej, Agnieszka Piwowar, Anna Bizon
Summary: In women with polycystic ovary syndrome (PCOS), factors such as body mass index, waist-to-hip ratio, age, and glucose concentration significantly affect oxLDL-C and FRAP levels. Furthermore, there is a correlation between FRAP and oxLDL-C levels in the whole group and in insulin-sensitive women. Additionally, the concentration of Anti-Mullerian hormone is negatively related to oxLDL-C and FRAP levels.
Review
Biochemistry & Molecular Biology
Justyna Chojdak-Lukasiewicz, Anna Bizon, Marta Waliszewska-Prosol, Agnieszka Piwowar, Slawomir Budrewicz, Anna Pokryszko-Dragan
Summary: This study reviews the role of SIRTs in the physiology and pathology of the central nervous system (CNS) and discusses their crucial involvement in neuroinflammation, neurodegeneration, and metabolic alterations. The understanding of SIRTs' role in various CNS diseases provides an opportunity to identify relevant markers of disease progression and potential therapeutic targets.
Article
Oncology
Kamila Boszkiewicz, Helena Moreira, Ewa Sawicka, Anna Szyjka, Agnieszka Piwowar
Summary: Progressive industrialization, urbanization, and consumerism have led to increased contamination of the environment with endocrine-disrupting compounds (EDCs), which play a crucial role in the rise of hormone-dependent cancers, including breast cancer. This study aimed to investigate the impact of exposure to specific xenoestrogens, commonly found in daily life (aluminum in antiperspirants and deodorants; chromium (III) in dietary supplements and drugs), on the effectiveness of hormone therapy in breast cancer treatment. In vitro tests were conducted on breast cancer cell lines exposed to xenoestrogens, drugs, and their combinations, and the results showed that such exposure can impair the efficacy of hormone therapy.
Article
Biochemistry & Molecular Biology
Anna Bizon, Justyna Chojdak-Lukasiewicz, Aleksandra Koltuniuk, Slawomir Budrewicz, Anna Pokryszko-Dragan, Agnieszka Piwowar
Summary: This study evaluated oxidative stress parameters in the serum of patients with relapsing-remitting multiple sclerosis (RRMS), and found associations between these parameters and clinical/laboratory markers. AOPP and FRAP concentrations were higher in male patients. There were correlations between AOPP and inflammation markers, and differences in AOPP among subgroups receiving different treatments.
Article
Medicine, Research & Experimental
Monika Stepien, Natalia Swiatoniowska-Lonc, Brygida Knysz, Beata Jankowska-Polanska, Amadeusz Kuzniarski, Agnieszka Piwowar, Malgorzata Zalewska
Summary: This study aimed to evaluate the levels of anti-SARS-CoV-2 immunoglobulin G (IgG) antibodies in convalescents and individuals without a past infection, and to assess socio-clinical factors associated with participants' humoral responses. The results showed the presence of anti-SARS-CoV-2 IgG antibodies in convalescents and in some individuals without a past infection, and the antibody levels were related to the severity of the symptoms.
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Kamila Boszkiewicz, Agnieszka Piwowar
Summary: One-third of breast cancer patients with diabetes have a 40% higher risk of mortality. Metalloestrogens may reduce the effectiveness of aromatase inhibitors (AIs), but high glucose conditions have a greater impact on their activity. Therefore, controlling hyperglycemia and individualized treatment regimens may have important therapeutic implications for cancer patients with diabetes.
ACTA POLONIAE PHARMACEUTICA
(2023)
Article
Public, Environmental & Occupational Health
Agnieszka Piwowar, Eddie Czwojdzinski, Zofia Marchewka, Aleksandra Adamczuk, Natalia Swiatoniowska-Lonc, Beata Jankowska-Polanska
Summary: The study found that treatment satisfaction and adherence are important factors in the pharmaceutical treatment of patients with ischemic heart disease. Factors influencing patient adherence include family history, anemia, drug side effects, and satisfaction with treatment. Increasing patient awareness of treatment should be an important goal for future educational activities.
INTERNATIONAL JOURNAL OF OCCUPATIONAL MEDICINE AND ENVIRONMENTAL HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Anna Bizon, Justyna Chojdak-Lukasiewicz, Slawomir Budrewicz, Anna Pokryszko-Dragan, Agnieszka Piwowar
Summary: This study aimed to investigate the alterations in the antioxidant balance in patients with RRMS and the factors influencing it. The study included 161 patients and 29 healthy individuals, and measured the activity of SOD, GPx, and CAT, as well as the concentration of IL-6, LPO, TOS, and TAS. The results showed decreased GPx activity and increased CAT activity in patients with RRMS compared to the control group, and these activities were influenced by gender and disease-modifying therapies. The findings suggest that enhancing GPx activity may be a potential therapeutic strategy for mitigating oxidative stress in RRMS.
Article
Pharmacology & Pharmacy
Anna Bizon, Agnieszka Piwowar
Summary: The expression of recombinant paraoxonase 1 (PON1) in the human embryonic kidney (HEK293F) cell line was investigated. It was demonstrated that the HEK293F platform is useful for obtaining recombinant human PON1 protein. The addition of high-density lipoprotein increased serum arylesterase and lactonase activity of PON1, while low-density lipoprotein, copper ions, and iron ions decreased PON1 activity.
ACTA POLONIAE PHARMACEUTICA
(2023)
Article
Medicine, Research & Experimental
Monika Stepien, Natalia Swiatoniowska-Lonc, Brygida Knysz, Beata Jankowska-Polanska, Amadeusz Kuzniarski, Agnieszka Piwowar, Malgorzata Zalewska
Summary: This study aimed to evaluate the levels of anti-SARS-CoV-2 IgG antibodies in convalescents and individuals not previously infected, and to assess factors associated with participants' humoral responses. The results showed the presence of antibodies in some convalescents and previously uninfected individuals, but also observed that some individuals did not have detectable antibodies despite a previous infection.
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Kathie Sarzynska, Eddie Czwojdzinski, Amadeusz Kuzniarski, Sadri Rayad, Agnieszka Piwowar, Beata Jankowska-Polanska
Summary: This study assessed the knowledge of 482 medical students on COVID-19 and found generally low levels of awareness. There were significant differences in knowledge between students from different medical faculties. Additional educational programs and prevention strategies have led to a decrease in the number of administrative procedures (isolation or quarantine) applied.
ARCHIVES OF PUBLIC HEALTH
(2022)
