Article
Biochemistry & Molecular Biology
Xiaomao Luo, Huiling Zhang, Xiaorui Cao, Ding Yang, Yi Yan, Jiayin Lu, Xiaonan Wang, Haidong Wang
Summary: Endurance training increases Fgf21 levels, promotes fiber-type conversion in skeletal muscle, and improves muscle health and reduces fatigue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Jiao Li, Jing Chang, Jinghan Wang, Dapeng Xu, Minwei Yang, Yongsheng Jiang, Junfeng Zhang, Xiaohua Jiang, Yongwei Sun
Summary: Although HOXA10 has been shown to play an important role in pancreatic development, its involvement in pancreatic ductal adenocarcinoma (PDAC) progression remains unclear. In this study, we found that HOXA10 expression increased in PDAC with higher tumor stage and poor patient survival. HOXA10 promoted PDAC cell proliferation, colony formation, and xenograft growth by activating the NF-kappa B signaling pathway. Specifically, HOXA10 up-regulated IKK beta gene transcription and sustained NF-kappa B activation in PDAC cells. Our findings suggest that HOXA10 functions as an oncoprotein in PDAC and may serve as a potential prognosis biomarker.
Article
Oncology
Yanyan Feng, Chuanyu Sun, Lifeng Zhang, Hongyuan Wan, Hangsheng Zhou, Yongquan Chen, Lijie Zhu, Guowei Xia, Yuanyuan Mi
Summary: The coatomer protein complex subunit beta 2 (COPB2) plays an important role in prostate cancer by promoting the proliferation and invasion of cancer cells through the regulation of the MAPK/TGF-beta signaling pathway. COPB2 could potentially serve as a new biomarker for diagnosis and monitoring of prostate cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Xinyuan Liu, Jian Xu, Bingbing Shen, Jichuan Xu, Jianxin Jiang
Summary: Pancreatic cancer (PC) is the fourth leading cause of cancer-related death worldwide, with a survival rate below 5%. Abnormal proliferation and distant metastasis are major challenges for the diagnosis and treatment of PC, making it crucial for researchers to understand the molecular mechanisms underlying PC proliferation and metastasis. This study found that USP33, a member of the deubiquitinating enzyme family, is upregulated in PC samples and cells, and its high expression is associated with poor prognosis. Functional experiments showed that USP33 overexpression promotes PC cell proliferation, migration, and invasion, while inhibition of USP33 has the opposite effect. The study also identified TGFBR2 as a potential binding protein of USP33 and revealed a positive feedback loop between USP33 and the TGF-beta signaling pathway.
CELL DEATH & DISEASE
(2023)
Article
Environmental Sciences
Chung-Yuan Lee, Yung-Chuan Ho, Chiao-Wen Lin, Min-Chieh Hsin, Po-Hui Wang, Ya-Cheng Tang, Shun-Fa Yang, Yi-Hsuan Hsiao
Summary: The synthetic curcumin analog, EF-24, has been shown to have enhanced bioavailability and stronger anti-inflammatory and anti-cancer activity compared to curcumin. This study investigated the effects of EF-24 on TPA-induced cellular migration of cervical cancer and found that EF-24 significantly reduced cellular migration and invasion. Further analysis revealed that EF-24 modulated MMP-9 expression by inhibiting the phosphorylation of the p38 signaling pathway. These findings suggest that EF-24 may have potential as a chemopreventive agent for cervical cancer.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Anatomy & Morphology
Ziyu Dai, Bin Xie, Baishuang Yang, Xi Chen, Chengping Hu, Qiong Chen
Summary: The study shows that KANK3 gene is down-regulated in lung adenocarcinoma tissues, and its expression level is closely related to the prognosis of lung adenocarcinoma patients. Overexpression of KANK3 significantly inhibits the proliferation, invasion, and migration ability of lung adenocarcinoma cells, while silencing of KANK3 enhances these abilities. Further experiments prove that KANK3 regulates the proliferation and metastasis of lung adenocarcinoma cells through the p38 MAPK signaling pathway.
Article
Cell Biology
Yan Deng, Ling Li, Jia-Hui Zhu, Pei-Pei Li, Yi-Xuan Deng, Hong-Hong Luo, Yuan-Yuan Yang, Bai-Cheng He, Yuxi Su
Summary: This study demonstrates that overexpression of COX-2 enhances BMP9's osteogenic ability through upregulation of TGF-beta 1, resulting in the activation of p38 signaling pathway in MSCs.
Article
Biochemistry & Molecular Biology
Jenq-Lin Yang, Weng-Ling Lin, Shun-Ban Tai, Yi-Siang Ciou, Chih-Ling Chung, Jih-Jung Chen, Pei-Feng Liu, Ming-Wei Lin, Chun-Lin Chen
Summary: Sinulariolide (SC-1), a natural extract from Sinularia flexibilis, has anti-inflammatory, anti-proliferative, and anti-migratory effects. The molecular pathway behind its anti-inflammatory effects remains unclear. In this study, we investigated the effects of SC-1 on TGF beta-induced IL-6 release. We found that SC-1 inhibited TGF beta-induced IL-6 secretion through the suppression of p38 MAPK signaling and subsequent inhibition of NF-kappa B nuclear translocation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Pengbo Guo, Juan Xu, Hao Liang, Li Xu, Wanying Gao, Ziman Chen, Yuan Gao, Maojun Zhang, Guangfu Yu, Zhujun Shao
Summary: This study reveals the protective role of estrogen in Neisseria meningitidis infection and its mechanism in regulating inflammatory cytokine release. The results suggest that estrogen receptor beta (ER beta) may be involved in the modulation of the inflammatory response in N. meningitidis infection.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Milena Paw, Dawid Wnuk, Kinga Nit, Sylwia Bobis-Wozowicz, Rafal Szychowski, Alicja Slusarczyk, Zbigniew Madeja, Marta Michalik
Summary: The study demonstrates the significant impact of p38 MAPK inhibition on the FMT potential of HBFs derived from asthmatic patients, resulting in the attenuation of myofibroblast-related markers. These findings highlight the importance of p38 kinase in FMT efficiency and bronchial wall remodeling in asthma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Qun-Guang Jiang, Cheng-Feng Xiong, Yun-Xia Lv
Summary: Kin17 is significantly upregulated in thyroid cancer, where it functions as an oncogene by activating the p38 MAPK signaling pathway to promote cell proliferation, migration, and invasion, while also affecting the sensitivity of cancer cells to Doxorubicin.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Han Na Park, Min Ji Song, Young Eun Choi, Dong Hun Lee, Jin Ho Chung, Seung-Taek Lee
Summary: LRG1 plays a role in skin repair and fibrosis by stimulating the TGF-β signaling pathway. It increases type I collagen secretion and decreases matrix metalloproteinase-1 secretion in fibroblasts. LRG1 can activate the TGF-β pathway and promote collagen deposition while reducing its degradation, potentially slowing down skin aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ji Sue Baik, You Na Seo, Young-Choon Lee, Joo Mi Yi, Man Hee Rhee, Moon-Taek Park, Sung Dae Kim
Summary: This study demonstrates that ionizing radiation activates the p38 MAPK-NLRC4-caspase-1 pathway in macrophages, leading to increased IL-1 beta production in response to lipopolysaccharide treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Kaizhou Jin, Chen Liu, He Cheng, Qinglin Fei, Qiuyi Huang, Zhiwen Xiao, Xianjun Yu, Weiding Wu
Summary: This study uncovered RAP2 as a novel predictive marker and therapeutic target for pancreatic cancer. High expression of RAP2 was associated with unfavorable prognosis, and silencing RAP2 inhibited the invasion of pancreatic cancer cells. Furthermore, TGF-beta 1 was found to regulate the expression of RAP2 through the transcription factor c-Myc.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Cell Biology
Rui Lin, Xunxia Bao, Hui Wang, Sibo Zhu, Zhongyan Liu, Quanning Chen, Kaixing Ai, Baomin Shi
Summary: The mechanism of TRPM2 in pancreatic cancer involves the activation of PKC/MAPK pathways, leading to enhanced proliferation, migration, and invasion abilities of PA cells. TRPM2 is negatively correlated with overall survival and progression-free survival time in PA patients, while its expression increases with tumor stage. Inhibitors of PKC/MEK significantly inhibit PA cell growth, suggesting a potential therapeutic target for pancreatic cancer.
CELL DEATH & DISEASE
(2021)
