SB203580—A Potent p38 MAPK Inhibitor Reduces the Profibrotic Bronchial Fibroblasts Transition Associated with Asthma

Effect of zymosan on the expression and function of the gap-junction protein connexin 43 in human corneal fibroblasts

(2021) Xiao-Shuo Zheng et al.   International Journal of Ophthalmology

Responsiveness of human bronchial fibroblasts and epithelial cells from asthmatic and non-asthmatic donors to the transforming growth factor-β1 in epithelial-mesenchymal trophic unit model

(2021) Milena Paw et al.   BMC Molecular and Cell Biology

JNK and p38 Inhibitors Prevent Transforming Growth Factor-β1-Induced Myofibroblast Transdifferentiation in Human Graves’ Orbital Fibroblasts

(2021) Tzu-Yu Hou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Collagen I Modifies Connexin-43 Hemichannel Activity via Integrin α2β1 Binding in TGFβ1-Evoked Renal Tubular Epithelial Cells

(2021) Joe A. Potter et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cardiac fibrosis: Myofibroblast-mediated pathological regulation and drug delivery strategies

(2021) Mengrui Liu et al.   ADVANCED DRUG DELIVERY REVIEWS

Mechanical stress influences the morphology and function of human uterosacral ligament fibroblasts and activates the p38 MAPK pathway

(2021) Yapei Zhu et al.   INTERNATIONAL UROGYNECOLOGY JOURNAL

Interleukin-17A induces renal fibrosis through the ERK and Smad signaling pathways

(2020) Cheng-Hao Weng et al.   BIOMEDICINE & PHARMACOTHERAPY

Platycodin D alleviates liver fibrosis and activation of hepatic stellate cells by regulating JNK/c-JUN signal pathway

(2020) Yong-mei Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Transcriptomic changes involved in the dedifferentiation of myofibroblasts derived from the lung of a patient with idiopathic pulmonary fibrosis

(2020) Kenichi Suzuki et al.   Molecular Medicine Reports

Airway mechanical compression: its role in asthma pathogenesis and progression

(2020) Punnam Chander Veerati et al.   European Respiratory Review

Enhanced asthma-related fibroblast to myofibroblast transition is the result of profibrotic TGF-β/Smad2/3 pathway intensification and antifibrotic TGF-β/Smad1/5/(8)9 pathway impairment

(2020) Dawid Wnuk et al.   Scientific Reports

Asthma-derived fibroblast to myofibroblast transition is enhanced in comparison to fibroblasts derived from non-asthmatic patients in 3D in vitro culture due to Smad2/3 signalling

(2020) Dawid Wnuk et al.   ACTA BIOCHIMICA POLONICA

Bronchoconstriction: a potential missing link in airway remodelling

(2020) Michael J. O'Sullivan et al.   Open Biology

Ablation of aryl hydrocarbon receptor promotes angiotensin II-induced cardiac fibrosis through enhanced c-Jun/HIF-1α signaling

(2019) Sahoko Ichihara et al.   ARCHIVES OF TOXICOLOGY

Extracellular Matrix Component Remodeling in Respiratory Diseases: What Has Been Found in Clinical and Experimental Studies?

(2019) Juliana T. Ito et al.   Cells

Sputum transcriptomics implicates increased p38 signalling activity in severe asthma

(2019) Katherine J. Baines et al.   RESPIROLOGY

New insights into TGF-β/Smad signaling in tissue fibrosis

(2018) He-He Hu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Fibroblast-to-myofibroblast transition in bronchial asthma

(2018) Marta Michalik et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Fenofibrate Reduces the Asthma-Related Fibroblast-To-Myofibroblast Transition by TGF-Β/Smad2/3 Signaling Attenuation and Connexin 43-Dependent Phenotype Destabilization

(2018) Milena Paw et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanical signals activate p38 MAPK pathway-dependent reinforcement of actin via mechanosensitive HspB1

(2017) Laura Hoffman et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy promotes degradation of internalized collagen and regulates distribution of focal adhesions to suppress cell adhesion

(2017) Shinichi Kawano et al.   Biology Open

Connexin 43 Hemichannels Regulate the Expression of Wound Healing-Associated Genes in Human Gingival Fibroblasts

(2017) Rana Tarzemany et al.   Scientific Reports

Curcumin suppresses transforming growth factor-β1-induced cardiac fibroblast differentiation via inhibition of Smad-2 and p38 MAPK signaling pathways

(2016) HUZI LIU et al.   Experimental and Therapeutic Medicine

Skin fibrosis: Models and mechanisms

(2016) N.N. Do et al.   Current Research in Translational Medicine

Mechanical Strain Causes Adaptive Change in Bronchial Fibroblasts Enhancing Profibrotic and Inflammatory Responses

(2016) Wiparat Manuyakorn et al.   PLoS One

Effects of geniposide on hepatocytes undergoing epithelial–mesenchymal transition in hepatic fibrosis by targeting TGFβ/Smad and ERK-MAPK signaling pathways

(2015) Ji-Hyun Park et al.   BIOCHIMIE

Corticosteroid insensitive alveolar macrophages from asthma patients; synergistic interaction with a p38 mitogen-activated protein kinase (MAPK) inhibitor

(2015) Simon Lea et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Phospho-p38 MAPK Expression in COPD Patients and Asthmatics and in Challenged Bronchial Epithelium

(2015) Davide Vallese et al.   RESPIRATION

MAPK inhibitors differently modulate TGF-β/Smad signaling in HepG2 cells

(2015) A. Boye et al.   TUMOR BIOLOGY

Undifferentiated Bronchial Fibroblasts Derived from Asthmatic Patients Display Higher Elastic Modulus than Their Non-Asthmatic Counterparts

(2015) Michal Sarna et al.   PLoS One

p38 MAP Kinase Inhibitor Suppresses Transforming Growth Factor-β2–Induced Type 1 Collagen Production in Trabecular Meshwork Cells

(2015) Miyuki Inoue-Mochita et al.   PLoS One

Roles of p38 MAPK and JNK in TGF-β1-induced Human Alveolar Epithelial to Mesenchymal Transition

(2013) Hai-hua Chen et al.   ARCHIVES OF MEDICAL RESEARCH

Regulation of cardiovascular connexins by mechanical forces and junctions

(2013) Merlijn J. Meens et al.   CARDIOVASCULAR RESEARCH

Bradykinin-induced asthmatic fibroblast/myofibroblast activities via bradykinin B2 receptor and different MAPK pathways

(2013) Federica Sabatini et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Interleukin-1β upregulates matrix metalloproteinase-13 gene expression via c-Jun N-terminal kinase and p38 MAPK pathways in rat hepatic stellate cells

(2013) NING TANG et al.   Molecular Medicine Reports

TRPV1 Potentiates TGFβ-Induction of Corneal Myofibroblast Development through an Oxidative Stress-Mediated p38-SMAD2 Signaling Loop

(2013) Yuanquan Yang et al.   PLoS One

Integrin-dependent force transmission to the extracellular matrix by  -actinin triggers adhesion maturation

(2013) P. Roca-Cusachs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Berberine Inhibits Myofibroblast Differentiation in Nasal Polyp-Derived Fibroblasts via the p38 Pathway

(2012) You-Mi Moon et al.   PHYTOTHERAPY RESEARCH

Mechanical stress-activated integrin  5 1 induces opening of connexin 43 hemichannels

(2012) N. Batra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MEK-ERK Pathway Modulation Ameliorates Pulmonary Fibrosis Associated with Epidermal Growth Factor Receptor Activation

(2011) Satish K. Madala et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

p38 Mitogen-Activated Protein Kinase Pathways in Asthma and COPD

(2011) Kian Fan Chung   CHEST

Inhibition of the p38 MAPK pathway ameliorates renal fibrosis in an NPHP2 mouse model

(2011) Noriyuki Sugiyama et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Transition of asthmatic bronchial fibroblasts to myofibroblasts is inhibited by cell–cell contacts

(2011) Marta Michalik et al.   RESPIRATORY MEDICINE

Transient Frictional Slip between Integrin and the ECM in Focal Adhesions under Myosin II Tension

(2010) Yvonne Aratyn-Schaus et al.   CURRENT BIOLOGY

Effect of p38 MAPK inhibition on corticosteroid suppression of cytokine release in severe asthma

(2009) P. Bhavsar et al.   EUROPEAN RESPIRATORY JOURNAL