Article
Pharmacology & Pharmacy
Laura D. Manzanares, Joseph David, Xingsheng Ren, Lenore K. Yalom, Enzo B. Piccolo, Yalda Dehghan, Aidan J. David, Stephen B. Hanauer, Ronen Sumagin
Summary: This study demonstrates the potential therapeutic role of atovaquone in promoting resolution of mucosal inflammation in ulcerative colitis by reducing neutrophil accumulation and suppressing their migration.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Ammar Hassanzadeh Keshteli, Rosica Valcheva, Cheryl Nickurak, Heekuk Park, Rupasri Mandal, Kendall van Diepen, Karen I. Kroeker, Sander Veldhuyzen van Zanten, Brendan Halloran, David S. Wishart, Karen L. Madsen, Levinus A. Dieleman
Summary: The study reveals that dietary modifications, including increased intake of anti-inflammatory foods and decreased intake of pro-inflammatory foods, are associated with metabolic and microbial changes in ulcerative colitis patients in clinical remission, effectively preventing subclinical inflammation.
Article
Gastroenterology & Hepatology
Le Liu, Liping Liang, Chenghai Yang, Youlian Zhou, Ye Chen
Summary: The study demonstrated that Fusobacterium nucleatum-derived extracellular vesicles induce epithelial cell death and gut barrier disruption in ulcerative colitis, potentially through the activation of receptor-interacting protein kinase 1 (RIPK1). These findings provide insights for further investigation of the disease.
Article
Surgery
Ryuichi Kuwahara, Hiroki Ikeuchi, Toshihiro Bando, Yoshiko Goto, Yuki Horio, Tomohiro Minagawa, Motoi Uchino
Summary: There are few reports comparing the outcomes of elderly ulcerative colitis (UC) patients undergoing colectomy for elderly-onset UC (EO) and nonelderly-onset UC (NEO). This study aimed to analyze the differences between EO and NEO patients who underwent UC-related surgery. The results showed that EO patients had poorer outcomes, including higher rates of emergency surgery and postoperative complications, compared to NEO patients.
Article
Multidisciplinary Sciences
Tomomitsu Tahara, Kazuya Takahama, Sayumi Tahara, Noriyuki Horiguchi, Kohei Funasaka, Yoshihito Nakagawa, Tomoyuki Shibata, Tetsuya Tsukamoto, Hiro-o Ieda, Toshiro Fukui, Makoto Naganuma, Naoki Ohmiya
Summary: Lymphoid follicles hyperplasia (LH) is a small, round, yellowish-white nodules sometimes found in the normal colon. LH is associated with food hypersensitivity and bowel symptoms and histologically characterized as intense infiltration of lymphocytes or plasmacytes. This study investigated the presence of LH in the normal colonic mucosa and its association with the incidence of colorectal lesions including colorectal cancer, adenoma, and hyperplastic polyp.
Article
Immunology
Jing Yang, Xin Guan, Simeng He, Lixiu Ge, Qiaoying Gao, Xiaoyang Wu
Summary: The study investigates the protective influence of FTY720 on inflammation in a DSS-induced colitis model. The results demonstrate that FTY720 improves the aberrant immune response by trapping T cells and inhibiting the polarization of M1 macrophages in colitis mice. Additionally, the depletion of CCR2 does not affect the protective effect of FTY720 on colonic injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Dong-Hao Li, Zheng-Peng Li, Yan Zhang, Guan-Zhou Zhou, Rong-Rong Ren, Hui-Jun Zhao, Na-Na Zhang, Jian-Feng Li, Li-Hua Peng, Yun-Sheng Yang
Summary: The presence of Fusobacterium nucleatum (F.nucleatum) and its invasive virulence gene fadA increased in patients with ulcerative colitis, especially in those with severe colitis and pancolitis. Strains of F.nucleatum carrying the virulence gene fadA are suggested to play a role in the pathogenesis of UC.
MICROBIAL PATHOGENESIS
(2021)
Review
Gastroenterology & Hepatology
Mathurin Fumery, Clara Yzet, Denis Chatelain, Thierry Yzet, Franck Brazier, Jean-Philippe Lemouel, David Laharie, Charles Sabbagh
Summary: The management of colorectal stricture complicating inflammatory bowel disease remains challenging, with surgery as the 'gold standard' treatment associated with high morbidity. Current therapeutic strategies for colonic strictures are based on a low level of evidence and applied by analogy with the treatment of ileal strictures.
JOURNAL OF CROHNS & COLITIS
(2021)
Review
Gastroenterology & Hepatology
Jay Pravda
Summary: This study provides an evidence-based analysis of the causal role of colonic epithelial hydrogen peroxide (H2O2) in the pathogenesis and relapse of ulcerative colitis (UC). Novel therapy targeting the removal of H2O2 mediated chemotactic signal has shown promising results in achieving complete histologic resolution of colitis in refractory patients. It challenges the current treatment guidelines based on immune suppression in UC patients.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Medicine, Research & Experimental
Paulo da Silva Watanabe, Andreza Manzato Cavichioli, Joana D'Arc de Lima Mendes, Rubina Aktar, Madusha Peiris, L. Ashley Blackshaw, Eduardo Jose de Almeida Araujo
Summary: This study evaluated the anatomical and functional changes in the colon during the development of acute and chronic DSS-induced UC in mice. The results showed that UC caused thickening of the colonic wall, fibrosis, and reduction in tuft cells, leading to abnormal colonic motility. Further studies may focus on stimulating tuft cell hyperplasia to reduce damage caused by UC.
Article
Cell Biology
Huazhi Zhang, Zhihui Cui, Du Cheng, Yanyun Du, Xiaoli Guo, Ru Gao, Jianwen Chen, Wanwei Sun, Ruirui He, Xiaojian Ma, Qianwen Peng, Bradley N. Martin, Wei Yan, Yueguang Rong, Chenhui Wang
Summary: The gene RNF186 has been identified in genome-wide association studies as a susceptibility gene for ulcerative colitis, and it plays a crucial role in autophagy activation in colonic epithelial cells and intestinal homeostasis by regulating the ubiquitination of EPHB2. The absence of RNF186 and EPHB2 leads to a more severe phenotype in a colitis model, while treatment with ephrin-B1-Fc recombinant protein shows promise as a potential therapy for inflammatory bowel diseases.
Article
Medicine, General & Internal
Takahiro Miyazu, Natsuki Ishida, Yusuke Asai, Satoshi Tamura, Shinya Tani, Mihoko Yamade, Yasushi Hamaya, Moriya Iwaizumi, Satoshi Osawa, Takahisa Furuta, Satoshi Baba, Ken Sugimoto
Summary: The effect of eosinophilic infiltration on the treatment course for ulcerative colitis (UC) is not completely understood. This study found that short-term steroid administration in UC patients with high eosinophilic infiltration in the colonic mucosa can lead to clinical and endoscopic improvement.
Article
Engineering, Environmental
Lifen Wang, Jiawei Xu, Pengpeng Xue, Jiayi Liu, Lanzi Luo, Deli Zhuge, Qing Yao, Xiaokun Li, Yingzheng Zhao, Helin Xu
Summary: The thermo-sensitive hydrogel P-DA, inspired by mussel adhesion, showed good mechanical strength, delayed erosion, and stronger tissue adhesion, leading to improved mucosal absorption of therapeutic proteins. This system also enhanced the therapeutic effect of EGF on ulcerative colitis, with restoration of colonic morphology and function without fibrosis, possibly through polarization of macrophages from an inflammatory to anti-inflammatory phenotype.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Gastroenterology & Hepatology
Heather J. Galipeau, Alberto Caminero, Williams Turpin, Miriam Bermudez-Brito, Alba Santiago, Josie Libertucci, Marco Constante, Juan Antonio Raygoza Garay, Gaston Rueda, Sarah Armstrong, Alex Clarizio, Michelle Smith, Michael G. Surette, Premysl Bercik, Kenneth Croitoru, Elena F. Verdu
Summary: Increased fecal proteolytic activity was found before the clinical diagnosis of UC, which may serve as a noninvasive biomarker of inflammation associated with changes in gut microbiota. The study suggests potential therapeutic targets for at-risk populations based on antiprotease treatments.
Review
Pharmacology & Pharmacy
A. Quesada-Simo, A. Garrido-Marin, P. Nos, S. Gil-Perotin
Summary: Multiple sclerosis (MS) and inflammatory bowel disease (IBD) are autoimmune disorders that cause inflammation in the brain and gastrointestinal (GI) tract, respectively. While they share common pathogenic mechanisms, their immune responses to treatment differ. Anti-CD20 therapies effectively control inflammation in MS but may cause bowel inflammation in susceptible individuals. This review explores the association between immunity in MS and IBD, the impact of anti-CD20 therapies on the gut microenvironment, and recommendations for early detection and management of GI toxicities in MS patients undergoing B-cell depletion.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Gastroenterology & Hepatology
Manabu Onimaru, Haruhiro Ino, Robert Bechara, Mayo Tanabe, Mary Raina Angell Abad, Akiko Ueno, Yuto Shimamura, Kazuya Sumi, Haruo Ikeda, Hiroaki Ito
DIGESTIVE ENDOSCOPY
(2020)
Article
Gastroenterology & Hepatology
Yugo Iwaya, Haruhiro Inoue, Enrique Rodriguez de Santiago, Mary Raina Angeli Abad, Yusuke Fujiyoshi, Akiko Ueno, Mayo Tanabe, Kazuya Sumi, Hideomi Tomida, Masaki Ominami, Haruo Ikeda, Manabu Onimaru, Yuto Shimamura
DIGESTIVE ENDOSCOPY
(2020)
Article
Gastroenterology & Hepatology
Kazuya Sumi, Haruhiro Inoue, Yasutoshi Kobayashi, Yugo Iwaya, Mary Raina Angeli Abad, Yusuke Fujiyoshi, Yuto Shimamura, Haruo Ikeda, Manabu Onimaru
Summary: Anti-reflux mucosectomy is an effective minimally invasive therapy for patients with PPI-refractory GERD, significantly improving symptom scores and allowing some patients to discontinue PPI. Although AET and DeMeester scores improved significantly post-ARMS, there was no significant improvement in proximal extent.
DIGESTIVE ENDOSCOPY
(2021)
Article
Gastroenterology & Hepatology
Yusuke Fujiyoshi, Haruhiro Inoue, Mary Raina Angeli Abad, Enrique Rodriguez de Santiago, Yohei Nishikawa, Takuki Sakaguchi, Akiko Toshimori, Yuto Shimamura, Mayo Tanabe, Kazuya Sumi, Ryusuke Kimura, Shinya Izawa, Haruo Ikeda, Manabu Onimaru
Summary: This study demonstrates that second-look endoscopy after POEM on postoperative day 1 can identify and treat newly-detected adverse events that may lead to severe complications. It is highly recommended that SE should be conducted before oral ingestion in all cases, especially in patients with intraoperative adverse events and longer operation time to prevent potential complications.
DIGESTIVE ENDOSCOPY
(2021)
Letter
Gastroenterology & Hepatology
Kazuya Sumi, Haruhiro Inoue
DIGESTIVE ENDOSCOPY
(2021)
Article
Gastroenterology & Hepatology
Yuto Shimamura, Haruhiro Inoue, Enrique Rodriguez de Santiago, Mary Raina Angeli Abad, Yusuke Fujiyoshi, Akiko Toshimori, Mayo Tanabe, Kazuya Sumi, Yugo Iwaya, Haruo Ikeda, Manabu Onimaru
Summary: The Endoscopic Pressure Study Integrated System (EPSIS) is a new diagnostic tool for GERD that shows good accuracy in diagnosing the condition by assessing intragastric pressure waveform patterns. In this study, analysis of EPSIS parameters, specifically pressure difference and waveform gradient, demonstrated high diagnostic accuracy for abnormal acid reflux in patients with GERD symptoms.
DIGESTIVE ENDOSCOPY
(2021)
Article
Gastroenterology & Hepatology
Yuto Shimamura, Haruhiro Inoue, Enrique Rodriguez de Santiago, Mary Raina Angeli Abad, Yusuke Fujiyoshi, Akiko Toshimori, Mayo Tanabe, Kazuya Sumi, Yugo Iwaya, Haruo Ikeda, Manabu Onimaru, Miki Kushima, Kenichi Goda
Summary: This study aimed to evaluate the diagnostic yield of the fourth-generation EC for esophageal squamous lesions, revealing acceptable diagnostic accuracy and reliability in both experts and non-experts, especially when diagnosing SCC lesions.
DIGESTIVE ENDOSCOPY
(2021)
Article
Gastroenterology & Hepatology
Haruhiro Inoue, Mayo Tanabe, Yuto Shimamura, Enrique Rodriguez de Santiago, Yusuke Fujiyoshi, Akiko Toshimori, Mary Raina Angeli Abad, Yohei Nishikawa, Kosuke Nashida, Kazuya Sumi, Haruo Ikeda, Manabu Onimaru, Naoyuki Uragami
Summary: The study demonstrated the feasibility and effectiveness of the loop 9 method in achieving complete and sustained closure of therapeutic endoscopy-related GI defects, with a closure rate of 100% and a sustained closure rate of 90%.
Article
Gastroenterology & Hepatology
Kazuya Sumi, Haruhiro Inoue, Ryohei Ando, Mary Raina Angeli Fujiyoshi, Yusuke Fujiyoshi, Mayo Tanabe, Yuto Shimamura, Manabu Onimaru
Summary: Antireflux mucosectomy (ARMS) is a minimally invasive endoscopic procedure that has long-term efficacy in treating GERD and reducing dependence on PPI. It is also effective in patients with reflux hypersensitivity.
DIGESTIVE ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Haruo Ikeda, Haruhiro Inoue, Mary Raina Angeli Abad, Yusuke Fujiyoshi, Yohei Nishikawa, Akiko Toshimori, Mayo Tanabe, Yuto Shimamura, Kazuya Sumi, Yugo Iwaya, Anastassios Manolakis, Manabu Onimaru
Summary: Congenital esophageal stenosis (CES) in adults is a rare disorder presenting as achalasia, particularly in the distal esophagus. This study identified salient features of CES in adults and demonstrated favorable short-term outcomes of peroral endoscopic myotomy (POEM) for CES patients.
ANNALS OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Manabu Onimaru, Haruhiro Inoue, Yusuke Fujiyoshi, Mary Raina Angeli Abad, Yohei Nishikawa, Akiko Toshimori, Yuto Shimamura, Mayo Tanabe, Kazuya Sumi, Haruo Ikeda
Summary: This study aimed to present the long-term clinical results of per-oral endoscopic myotomy (POEM) over 10 years and evaluate the technique and outcomes at the institution where it was first used in clinical settings. The results showed favorable clinical outcomes of POEM over 10 years, suggesting that POEM plays a significant role in the treatment of achalasia, even in patients who required additional treatments.
ENDOSCOPY INTERNATIONAL OPEN
(2021)
Meeting Abstract
Gastroenterology & Hepatology
Yuto Shimamura, Haruhiro Inoue, Enrique Rodriguez de Santiago, Mary Raina Angeli Abad, Yusuke Fujiyoshi, Takuki Sakaguchi, Kazuya Sumi, Ryusuke Kimura, Shinya Izawa, Haruo Ikeda, Manabu Onimaru
GASTROINTESTINAL ENDOSCOPY
(2020)
Meeting Abstract
Gastroenterology & Hepatology
Yuto Shimamura, Haruhiro Inoue, Enrique Rodriguez de Santiago, Mary Raina Angeli Abad, Yusuke Fujiyoshi, Yohei Nishikawa, Takuki Sakaguchi, Akiko Ueno, Mayo Tanabe, Kazuya Sumi, Ryusuke Kimura, Shinya Izawa, Haruo Ikeda, Manabu Onimaru
GASTROINTESTINAL ENDOSCOPY
(2020)
Meeting Abstract
Gastroenterology & Hepatology
Mayo Tanabe, Haruhiro Inoue, Mary Raina Angeli Abad, Yusuke Fujiyoshi, Yohei Nishikawa, Takuki Sakaguchi, Akiko Ueno, Yuto Shimamura, Kazuya Sumi, Ryusuke Kimura, Shinya Izawa, Haruo Ikeda, Manabu Onimaru
GASTROINTESTINAL ENDOSCOPY
(2020)
Article
Gastroenterology & Hepatology
Haruhiro Inoue, Mayo Tanabe, Enrique Rodriguez de Santiago, Mary Raina Angeli Abad, Yuto Shimamura, Yusuke Fujiyoshi, Akiko Ueno, Kazuya Sumi, Hideomi Tomida, Yugo Iwaya, Haruo Ikeda, Manabu Onimaru
ENDOSCOPY INTERNATIONAL OPEN
(2020)