Article
Gastroenterology & Hepatology
Shekhar Singh Jadaun, Rohit Mehtani, Ana Hasnain, Sushant Bhatia, Vikash Moond, Mukesh Kumar, Vikash Kuhad, Shweta Singh, Shaleen Agarwal, Subhash Gupta, Sanjiv Saigal
Summary: This retrospective study analyzed the outcomes of living donor liver transplant (LDLT) in primary sclerosing cholangitis (PSC) at a tertiary liver transplant center in north India. The study found that LDLT in PSC can achieve good long-term outcomes, but there is a risk of PSC recurrence in approximately one-fifth of patients.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Fuat H. Saner, Alexandra Frey, Bjoern-Ole Stueben, Dieter P. Hoyer, Katharina Willuweit, Martina Daniel, Jassin Rashidi-Alavieh, Jurgen W. Treckmann, Hartmut H. Schmidt
Summary: In this retrospective study of 82 patients who underwent liver transplantation for primary sclerosing cholangitis (PSC), the authors assessed morbidity, survival rates, PSC recurrence, and the impact of donor characteristics in long-term follow-up. The study showed that PSC patients had excellent 10-year survival rates and a lower lab-MELD score was associated with longer survival. Donor characteristics did not affect patient survival.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Nobuhisa Akamatsu, Kiyoshi Hasegawa, Hiroto Egawa, Hideki Ohdan, Atsushi Yoshizawa, Norihiro Kokudo, Susumu Tazuma, Atsushi Tanaka, Hajime Takikawa
Summary: The study investigated risk factors for PSC recurrence post liver transplantation, identifying donor age, cyclosporine use, type of immunosuppressive agent, postoperative biliary complications, and active intestinal bowel disease as significant factors. Donor age >=45 years and mono or no immunosuppressive agent 1-year post LT were independently associated with higher risk of recurrence in the final multivariate Cox regression model. These findings were consistent in sub-analysis of ABO-identical/compatible adult living donor LT cases.
TRANSPLANT INTERNATIONAL
(2021)
Article
Gastroenterology & Hepatology
Fernanda Onofrio, Katina Zheng, Cherry Xu, Shiyi Chen, Wei Xu, Mary Vyas, Katie Bingham, Keyur Patel, Leslie Lilly, Mark Cattral, Nazia Selzner, Elmar Jaeckel, Cynthia Tsien, Aliya Gulamhusein, Gideon M. Hirschfield, Mamatha Bhat
Summary: This study retrospectively analyzed the clinical trajectory of patients with primary sclerosing cholangitis (PSC) referred for liver transplantation assessment. The results showed that most patients were able to undergo transplantation through living donor transplantation, indicating that the conventional MELD-Na scoring system may not adequately address the disease burden of PSC patients.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Gastroenterology & Hepatology
Fernanda Onofrio, Katina Zheng, Cherry Xu, Shiyi Chen, Wei Xu, Mary Vyas, Katie Bingham, Keyur Patel, Leslie Lilly, Mark Cattral, Nazia Selzner, Elmar Jaeckel, Cynthia Tsien, Aliya Gulamhusein, Gideon M. Hirschfield, Mamatha Bhat
Summary: This retrospective cohort study examined the clinical trajectory of primary sclerosing cholangitis (PSC) patients referred for liver transplantation (LT) at a transplant center. The findings showed that most PSC patients were listed and transplanted, primarily through living donor transplantation. The study supports the concern that the current MELD-Na allocation system does not adequately address the needs of PSC patients.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Surgery
Thijmen Visseren, Nicole Stephanie Erler, Wojciech Grzegorz Polak, Rene Adam, Vincent Karam, Florian Wolfgang Rudolf Vondran, Bo-Goran Ericzon, Douglas Thorburn, Jan Nicolaas Maria IJzermans, Andreas Paul, Frans van der Heide, Pavel Taimr, Petr Nemec, Jacques Pirenne, Renato Romagnoli, Herold Johnny Metselaar, Sarwa Darwish Murad
Summary: Recurrence of PSC after liver transplantation has a significant negative impact on both graft and patient survival, leading to a higher number of re-transplants and a 33% decrease in 10-year graft survival.
TRANSPLANT INTERNATIONAL
(2021)
Article
Virology
Shu-Hsien Lin, Kun-Ta Wu, Chih-Chi Wang, Ting-Ting Liu, Hock-Liew Eng, King-Wah Chiu
Summary: This study focused on the clinical significance of endoscopic biopsy-proven CMV colitis in patients following living donor liver transplantation. The study found that the incidence of CMV colitis after living donor liver transplantation was very low, and endoscopic biopsy with immunohistochemistry staining could improve the diagnostic accuracy.
Article
Medicine, General & Internal
Esli Medina-Morales, Mohamed Ismail, Romelia Barba Bernal, Yazan Abboud, Leandro Sierra, Daniela Goyes, Ana Marenco-Flores, Behnam Saberi, Vilas Patwardhan, Alan Bonder
Summary: This study compares the outcomes of living donor liver transplant (LDLT) and deceased donor liver transplant (DDLT) in patients with primary biliary cholangitis (PBC). The results show that LDLT has superior patient survival compared to DDLT, and there is no significant difference in graft survival between the two methods. The study also identifies predictors of poor post-transplant outcomes in PBC patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Marko J. Vannas, Fredrik Aberg, Arno Nordin, Eija Tukiainen, Johanna Savikko, Helena Isoniemi
Summary: The objective of this study was to investigate the short-term and long-term morbidity after liver transplantation in patients with primary sclerosing cholangitis. The results showed that a 1-year Comprehensive Complication Index (CCI) cutoff of 42 could significantly predict post-transplant survival. Factors such as cholangitis, infections, hypertension, Model for End-stage Liver Disease scores, and body mass indices were found to be associated with high CCI.
Article
Gastroenterology & Hepatology
Damjana Bogatic, Robert Bryant, Kate D. Lynch, Samuel P. Costello
Summary: Primary sclerosing cholangitis (PSC) is a progressive liver disease with poor prognosis and no effective therapies to prevent progression. This study evaluated potential medical therapies that may exert their effects in PSC by modulation of the gut-liver axis.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Eric F. Martin
Summary: The number of liver transplantation for primary biliary cholangitis (PBC) has decreased over the years, but it remains an important and curative option for progressive PBC patients. Recent studies from the Global PBC Study Group have provided valuable insights into the changes in PBC before and after liver transplantation.
CLINICS IN LIVER DISEASE
(2022)
Article
Gastroenterology & Hepatology
Qiaoyan Liu, Bo Li, Yikang Li, Yiran Wei, Bingyuan Huang, Jubo Liang, Zhengrui You, You Li, Qiwei Qian, Rui Wang, Jun Zhang, Ruiling Chen, Zhuwan Lyu, Yong Chen, Mingxia Shi, Xiao Xiao, Qixia Wang, Qi Miao, Jing-Yuan Fang, Merrill Eric Gershwin, Min Lian, Xiong Ma, Ruqi Tang
Summary: Comparative analysis of gut microbiome and metabolome in IgG4-SC and PSC patients revealed distinct host-microbe interactions that may contribute to disease pathogenesis, highlighting the uniqueness of IgG4-SC.
Article
Surgery
Hillary J. Braun, Ana Marie Torres, Finesse Louie, Sandy Weinberg, Sang-Mo Kang, Nancy L. Ascher, John P. Roberts
Summary: Living donor liver transplantation (LDLT) is more common in Asia than in North America, where living donor kidney transplantation, including paired exchanges for ABO-incompatible pairs, is prevalent. The first liver paired exchange (LPE) in the United States, completed over two consecutive days, was initiated by a non-directed donor and benefited an ABO-incompatible pair. This innovative approach demonstrates the feasibility of LPE in centers with experience in LDLT, offering new possibilities for transplantation in cases of ABO incompatibility.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Review
Gastroenterology & Hepatology
Johannes R. Hov, Tom H. Karlsen
Summary: This Review explores the links between Primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD), and the mechanisms related to the gut-liver axis. It is found that the gut microbiota in people with PSC differs from that of healthy individuals, but the specific microbial factors that differentiate PSC from IBD without PSC are poorly understood. The potential existence of a specific unknown factor related to the gut-liver axis as a cause of PSC is postulated.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ji-Won Park, Jung-Hee Kim, Sung-Eun Kim, Jang Han Jung, Myoung-Kuk Jang, Sang-Hoon Park, Myung-Seok Lee, Hyoung-Su Kim, Ki Tae Suk, Dong Joon Kim
Summary: Cholangiopathies are various biliary diseases that affect the biliary epithelium and can lead to cholestasis and liver cirrhosis. Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are the most important progressive cholangiopathies in adults, with research focusing on genetic risk, epigenetic changes, dysregulated mucosal immunity, and altered biliary epithelial cell function. Understanding the molecular pathogenesis of these diseases can help clinicians prevent and treat them more effectively.
Article
Cardiac & Cardiovascular Systems
Takanori Ikeda, Takeshi Yamashita, Masaharu Akao, Hirotsugu Atarashi, Yukihiro Koretsune, Ken Okumura, Wataru Shimizu, Hiroyuki Tsutsui, Kazunori Toyoda, Atsushi Hirayama, Masahiro Yasaka, Takenori Yamaguchi, Satoshi Teramukai, Tetsuya Kimura, Jumpei Kaburagi, Atsushi Takita, Hiroshi Inoue
Summary: Active cancer does not affect the incidence of stroke/systemic embolic events in elderly patients with non-valvular atrial fibrillation (NVAF), but patients with cancer have a higher incidence of major bleeding events and all-cause death compared to those without cancer.
CIRCULATION JOURNAL
(2022)
Article
Oncology
Motohiro Tamiya, Kei Fujikawa, Hidekazu Suzuki, Toshihide Yokoyama, Takeshi Uenami, Akihiro Tamiya, Yuki Sato, Go Saito, Junji Uchida, Mitsunori Morita, Tomonori Hirashima, Yasushi Fukuda, Masaki Kanazu, Kazutaka Hosoya, Takuji Suzuki, Kiyonobu Ueno, Daichi Fujimoto, Toru Kumagai, Satoshi Teramukai
Summary: The study found that predicting the acquisition of T790M mutation is crucial for treatment selection in NSCLC patients with EGFR mutations. CART can identify different patient subgroups based on certain background variables, aiding in the selection of the most appropriate first-line EGFR-TKI treatment.
INVESTIGATIONAL NEW DRUGS
(2022)
Article
Oncology
Ayako Muramatsu, Tsutomu Kobayashi, Yuka Kawaji-Kanayama, Hitoji Uchiyama, Nana Sasaki, Nobuhiko Uoshima, Mitsushige Nakao, Ryoichi Takahashi, Kazuho Shimura, Hiroto Kaneko, Miki Kiyota, Katsuya Wada, Yoshiaki Chinen, Koichi Hirakawa, Shin-ichi Fuchida, Chihiro Shimazaki, Shinsuke Mizutani, Taku Tsukamoto, Yuji Shimura, Masafumi Taniwaki, Satoshi Teramukai, Junya Kuroda
Summary: Carfilzomib (CFZ) is a powerful therapy for relapsed/refractory multiple myeloma (RRMM), but it often leads to cardiovascular adverse events (CVAEs). This study found that hypertension is the most common CFZ-related CVAE and suggested that baseline serum interleukin-6 level can predict CFZ-induced hypertension.
LEUKEMIA & LYMPHOMA
(2022)
Article
Cardiac & Cardiovascular Systems
Sachiko Yamazaki, Satoshi Numata, Hidetake Kawajiri, Kaichiro Manabe, Koki Ikemoto, Satoshi Teramukai, Hitoshi Yaku
SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Takeshi Yamashita, Masaharu Akao, Hirotsugu Atarashi, Takanori Ikeda, Yukihiro Koretsune, Ken Okumura, Wataru Shimizu, Shinya Suzuki, Hiroyuki Tsutsui, Kazunori Toyoda, Atsushi Hirayama, Masahiro Yasaka, Takenori Yamaguchi, Satoshi Teramukai, Tetsuya Kimura, Yoshiyuki Morishima, Atsushi Takita, Hiroshi Inoue
Summary: This study evaluated the impact of polypharmacy on 2-year outcomes in elderly patients with non-valvular atrial fibrillation. The results showed that patients receiving more medications were older, had poorer renal function, and had more comorbidities. Moreover, with increasing medications, the incidence rates of stroke, bleeding, and other adverse events significantly increased.
CIRCULATION JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Yoshiaki Matsuura, Motohiro Nishimura, Kinya Furuichi, Rina Hirohashi, Satoshi Teramukai, Junichi Shimada, Masayoshi Inoue
Summary: This study investigated the clinical significance and influence of lipiodol spreading during CT-guided marking on VATS surgery. The results showed that lipiodol spreading did not directly affect surgery and complications, but it served as a sign of intrathoracic pleural adhesion, which could lead to prolonged surgical duration and increased bleeding.
GENERAL THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Letter
Geriatrics & Gerontology
Masahiro Akishita, Shinya Suzuki, Hiroshi Inoue, Masaharu Akao, Hirotsugu Atarashi, Takanori Ikeda, Yukihiro Koretsune, Ken Okumura, Wataru Shimizu, Hiroyuki Tsutsui, Kazunori Toyoda, Atsushi Hirayama, Masahiro Yasaka, Takenori Yamaguchi, Satoshi Teramukai, Tetsuya Kimura, Yoshiyuki Morishima, Atsushi Takita, Takeshi Yamashita
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2022)
Correction
Cardiac & Cardiovascular Systems
Hiroshi Inoue, Takeshi Yamashita, Masaharu Akao, Hirotsugu Atarashi, Takanori Ikeda, Ken Okumura, Yukihiro Koretsune, Wataru Shimizu, Hiroyuki Tsutsui, Kazunori Toyoda, Atsushi Hirayama, Masahiro Yasaka, Takenori Yamaguchi, Masahiro Akishita, Naoyuki Hasebe, Kazuomi Kario, Yuji Mizokami, Ken Nagata, Masato Nakamura, Yasuo Terauchi, Takatsugu Yamamoto, Satoshi Teramukai, Tetsuya Kimura, Jumpei Kaburagi, Atsushi Takita
JOURNAL OF CARDIOLOGY
(2022)
Article
Pathology
Akihiko Sugimoto, Akihiko Yoshizawa, Akihiko Yoshida, Jin Kono, Atsuro Sawada, Masakazu Fujimoto, Sachiko Minamiguchi, Takashi Kobayashi, Hironori Haga
Summary: This case describes a primary retroperitoneal GNET in a 38-year-old woman who presented with a month-long fever and increased serum IL-6 level. The tumor showed several unusual features, including the presence of peripheral lymphoid cuff and focal pseudoangiomatous spaces. The tumor cells were positive for S100 protein and SOX10 and negative for melanocytic markers. Fluorescent in situ hybridization revealed EWSR1 and CREM gene rearrangements, consistent with EWSR1::CREM fusion, which has never been reported in GNET. The patient lived with recurrent lesions for 8 months, adding to the evolving understanding of GNET.
Article
Gastroenterology & Hepatology
Takuji Kawamura, Masau Sekiguchi, Hiroyuki Takamaru, Yasuhiko Mizuguchi, Go Horiguchi, Masayuki Kato, Kiyonori Kobayashi, Miwa Sada, Yasushi Oda, Akira Yokoyama, Takahiro Utsumi, Yosuke Tsuji, Daisuke Ohki, Yoji Takeuchi, Satoki Shichijo, Hiroaki Ikematsu, Koji Matsuda, Satoshi Teramukai, Nozomu Kobayashi, Takahisa Matsuda, Yutaka Saito, Kiyohito Tanaka
Summary: This study aims to explore whether the reasonable detection rate of endoscopically diagnosed lesions as adenomas can be calculated and used as a surrogate colonoscopy quality indicator. By analyzing a database generated from colonoscopy reports, it was found that the number of endoscopic adenomas was higher than pathological adenomas primarily due to non-resection during the examination. The overall polyp detection rate, endoscopic ADR, and pathological ADR were 56.4%, 48.0%, and 32.7% respectively.
DIGESTIVE ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Tetsuya Tajima, Koichiro Hata, Hironori Haga, Jiro Kusakabe, Shoichi Kageyama, Kimiko Yurugi, Rie Hishida, Xiangdong Zhao, Momoko Nishikori, Miki Nagao, Akifumi Takaori-Kondo, Shinji Uemoto, Etsuro Hatano
Summary: Antibody-mediated rejection (AMR) is a difficult-to-treat rejection that occurs after ABO blood-type incompatible (ABOi) or donor-specific antibody (DSA)-positive liver transplantation. The use of pretransplant rituximab has reduced the development of AMR, but the risk factors for AMR in the rituximab era are still unclear in both ABOi living-donor LT and preformed DSA-positive LT.
LIVER TRANSPLANTATION
(2023)
Article
Pathology
Hiroya Nakamura, Takashi Matsuzaki, Ken R. Ito, Ryota Nakagawa, Lurica M. Asano, Hinako Nishikido, Hironori Haga, Tatsuki R. Kataoka
Summary: Mast cells surround foam cells, suggesting their involvement in xanthoma formation. Coculturing THP-1 or U937 monocytes with LUVA mast cell line upregulated their uptake of oxidized low-density lipoprotein (oxLDL). Positive staining for intracellular cell adhesion molecule-1 (ICAM-1) at the borders between mast cells and foam cells was seen in pathological specimens of xanthelasma palpebrarum and in cocultures. Administration of anti-ICAM-1 blocking antibody inhibited the increase in oxLDL uptake by THP-1 or U937 monocytes cocultured with LUVA.
PATHOLOGY INTERNATIONAL
(2023)
Article
Urology & Nephrology
Takahisa Yoshikawa, Akiko Oguchi, Naoya Toriu, Yuki Sato, Takashi Kobayashi, Osamu Ogawa, Hironori Haga, Satoko Sakurai, Takuya Yamamoto, Yasuhiro Murakawa, Motoko Yanagita
Summary: Ectopic lymphoid structures called tertiary lymphoid tissues (TLTs) develop in kidney diseases and worsen renal prognosis. Single-nucleus RNA sequencing and validation experiments reveal that TLTs amplify inflammation in injured kidneys by promoting proinflammatory phenotypes of surrounding cells. These findings shed light on TLT pathology and suggest potential therapeutic targets.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Pathology
Akio Osakada, Masakazu Fujimoto, Chiyuki Ueshima, Yo Kaku, Momoko Nishikori, Norihito Inoue, Kengo Takeuchi, Hironori Haga
Summary: DUSP22-rearranged primary cutaneous anaplastic large-cell lymphoma (pcALCL) has a biphasic histological pattern, but the positivity rate of the biphasic pattern in DUSP22-rearranged pcALCL is unknown. LEF1 expression in >75% of tumor cells is associated with DUSP22-rearrangement in systemic ALCL, but whether this association applies to pcALCL remains unclear.
PATHOLOGY INTERNATIONAL
(2023)
Article
Cardiac & Cardiovascular Systems
Takanori Ikeda, Takeshi Yamashita, Masaharu Akao, Hirotsugu Atarashi, Yukihiro Koretsune, Ken Okumura, Wataru Shimizu, Shinya Suzuki, Hiroyuki Tsutsui, Kazunori Toyoda, Atsushi Hirayama, Masahiro Yasaka, Takenori Yamaguchi, Satoshi Teramukai, Tetsuya Kimura, Yoshiyuki Morishima, Atsushi Takita, Hiroshi Inoue
Summary: This exploratory study used the ANAFIE dataset to assess the relationship between resting heart rate during AF and clinical outcomes in Japanese elderly NVAF patients. The results showed that a heart rate >= 110 bpm was associated with a significantly higher incidence of cardiac events, and the risk was higher in patients with non-paroxysmal AF.
JOURNAL OF CARDIOLOGY
(2023)
