Article
Pharmacology & Pharmacy
Fu-Shun Yen, James Cheng-Chung Wei, Lu-Ting Chiu, Chih-Cheng Hsu, Chii-Min Hwu
Summary: In patients with both type 2 diabetes mellitus and chronic obstructive pulmonary disease, the use of metformin is associated with a lower risk of cardiovascular disease, and the longer the duration of metformin use, the lower the risk. Further prospective studies are needed to verify these findings.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Raija Lithovius, Anni A. Antikainen, Stefan Mutter, Erkka Valo, Carol Forsblom, Valma Harjutsalo, Niina Sandholm, Per-Henrik Groop
Summary: This study explores the use of a genetic risk score (GRS) for coronary artery disease (CAD) risk prediction in individuals with type 1 diabetes. The GRS showed similar predictive performance to established clinical markers and was more effective in younger individuals.
Review
Medicine, General & Internal
Ana Maria Gomez-Perez, Miguel Damas-Fuentes, Isabel Cornejo-Pareja, Francisco J. Tinahones
Summary: HF and iSGLT2 have been key topics in diabetology, with a focus on T2D, but research on HF in T1D is lacking. Understanding the characteristics, risk factors, and pathophysiology of HF in T1D is crucial for developing effective prevention strategies and therapies. The association between T1D and HF has a worse prognosis compared to T2D, highlighting the need for further exploration in this area.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Chike C. Nwabuo, Duke Appiah, Henrique T. Moreira, Henrique D. Vasconcellos, Yuichiro Yano, Jared P. Reis, Ravi Shah, Venkatesh L. Murthy, Norrina B. Allen, Stephen Sidney, Paul Muntner, Cora E. Lewis, Donald M. Lloyd-Jones, Pamela J. Schreiner, Samuel S. Gidding, Joao A. C. Lima
Summary: The study found that cumulative blood pressure in young adults is associated with the risk of heart failure, coronary heart disease, stroke, and cardiovascular diseases. Cumulative blood pressure provides incremental prognostic value and improves risk reclassification for cardiovascular diseases when compared to single blood pressure assessments or changes in blood pressure.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Article
Peripheral Vascular Disease
Vibhu Parcha, Gargya Malla, Rajat Kalra, Peng Li, Ambarish Pandey, Khurram Nasir, Garima Arora, Pankaj Arora
Summary: The study evaluated the use of coronary artery calcium (CAC) score to guide hypertension therapy in individuals without cardiovascular disease. Results showed that among those with CAC>0, there was a higher risk of incident cardiovascular events in individuals with elevated BP or low-risk stage 1 hypertension, as well as in those with high-risk stage 1 or stage 2 hypertension. The study suggests that utilizing CAC score may help personalize cardiovascular risk reduction strategies in individuals where current guidelines do not recommend treatment.
Article
Cardiac & Cardiovascular Systems
Gabriel Gimenez-Perez, Clara Vinals, Manel Mata-Cases, Bogdan Vlacho, Jordi Real, Josep Franch-Nadal, Emilio Ortega, Didac Mauricio
Summary: This study investigates the characteristics of first-ever cardiovascular events in patients with type 1 diabetes and reveals differences according to age and sex. The most frequent event overall is peripheral vascular disease, while heart failure is more common in women and in older age groups. Higher HbA1c levels are associated with incident CVD only in patients younger than 55/60 years.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Joao Sergio Neves, Marta Borges-Canha, Francisco Vasques-Novoa, Jennifer B. Green, Lawrence A. Leiter, Christopher B. Granger, Davide Carvalho, Adelino Leite-Moreira, Adrian F. Hernandez, Stefano Del Prato, John J. V. McMurray, Joao Pedro Ferreira Md
Summary: This study aimed to evaluate the effects of GLP-1 receptor agonists (GLP-1 RAs) on cardiovascular outcomes in patients with type 2 diabetes (T2D) treated with or without SGLT2 inhibitors. The results showed that GLP-1 RAs reduced cardiovascular events independently of SGLT2 inhibitor use, suggesting that the combination of GLP-1 RAs with SGLT2 inhibitors may further reduce cardiovascular risk.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Fu-Shun Yen, James Cheng-Chung Wei, Lu-Ting Chiu, Chih-Cheng Hsu, Ming-Chih Hou, Chii-Min Hwu
Summary: In patients with type 2 diabetes and cirrhosis, the use of thiazolidinedione (TZD) was associated with significantly higher risks of major adverse cardiovascular events (MACE) compared to nonusers. Therefore, the potential cardiovascular complications should be taken into consideration when prescribing TZDs to patients with type 2 diabetes and cirrhosis.
LIVER INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Eiichiro Kanda, Atsushi Suzuki, Masaki Makino, Hiroo Tsubota, Satomi Kanemata, Koichi Shirakawa, Toshitaka Yajima
Summary: A novel machine learning model was developed to predict the risk of developing CKD/HF in early-stage T2DM patients, showing good predictive performance in external validation. Early diagnosis and intervention based on ML models may improve the prognosis of high-risk patients.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Fu-Shun Yen, James Cheng-Chung Wei, Ying-Hsiu Shih, Chih-Cheng Hsu, Chii-Min Hwu
Summary: This study compared the risks of cardiovascular morbidity and mortality between patients with and without microvascular diseases in type 2 diabetes (T2D), as well as between matched patients with microvascular diseases. The results showed that patients with microvascular diseases had a significantly higher risk of cardiovascular morbidity and mortality compared to those without microvascular diseases. Among the matched patients, diabetic retinopathy was significantly associated with stroke development, while diabetic neuropathy was significantly associated with stroke and heart failure development.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Arnaud D. Kaze, Sebhat Erqou, Prasanna Santhanam, Alain G. Bertoni, Rexford S. Ahima, Gregg C. Fonarow, Justin B. Echouffo-Tcheugui
Summary: This study found that greater variability in adiposity indices in individuals with type 2 diabetes was associated with a higher risk of incident heart failure, independently of traditional risk factors and baseline adiposity levels.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Atsuhiko Kawabe, Takanori Yasu, Takeshi Morimoto, Akihiro Tokushige, Shin-ichi Momomura, Kenichi Sakakura, Koichi Node, Taku Inoue, Shinichiro Ueda
Summary: This study showed that a higher white blood cell count is predictive of hospitalization for heart failure, all-cause death, and acute myocardial infarction in patients with Type 2 diabetes mellitus and coronary artery disease. However, no significant association was found between white blood cell count and the risk of stroke.
Article
Health Care Sciences & Services
Fiona Bragg, Jim Halsey, Yu Guo, Hua Zhang, Ling Yang, Xiaohui Sun, Pei Pei, Yiping Chen, Huaidong Du, Canqing Yu, Robert Clarke, Jun Lv, Junshi Chen, Liming Li, Zhengming Chen
Summary: The study found that uncontrolled hypertension is common in Chinese adults with type 2 diabetes, leading to a significant increase in cardiovascular disease risk. Each 10 mmHg higher usual SBP was associated with increased risks of cardiovascular death, major coronary events, ischemic stroke, and intracerebral haemorrhage. The research suggests that controlling hypertension could prevent a large number of cardiovascular-related deaths.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2021)
Article
Multidisciplinary Sciences
Judit Hodrea, Adar Saeed, Agnes Molnar, Attila Fintha, Adrienn Barczi, Laszlo J. Wagner, Attila J. Szabo, Andrea Fekete, Dora B. Balogh
Summary: This study investigated the role of SGLT2 inhibitor dapagliflozin (DAPA) in preventing cardiovascular complications induced by diabetes. The results showed that DAPA reduced blood glucose levels, mitigated aortic intima-media thickening, and prevented cardiac hypertrophy, myocardial damage, cardiac inflammation, and fibrosis. These findings support the preventive and protective role of SGLT2 inhibitors in diabetes-associated cardiovascular disease.
Article
Endocrinology & Metabolism
Yilu Lin, Hui Shao, Lizheng Shi, Amanda H. Anderson, Vivian Fonseca
Summary: This study aimed to predict the risk of heart failure among patients with diabetes using a scoring algorithm. The model showed good discrimination and calibration in predicting the risk of heart failure, and age, healthcare utilization, and cardiovascular disease-related variables were found to be the strongest predictors. The model can be easily applied in clinical practice for risk stratification.
DIABETES OBESITY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Fanny Jansson Sigfrids, Per-Henrik Groop, Valma Harjutsalo
Summary: This study examined the incidence and temporal trends of albuminuria in type 1 diabetes patients in Finland. The cumulative incidence of severe albuminuria decreased over time, while the incidence of moderate albuminuria remained stable. These findings are important for understanding the complications of type 1 diabetes.
LANCET DIABETES & ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Niina Sandholm, Joanne B. Cole, Viji Nair, Xin Sheng, Hongbo Liu, Emma Ahlqvist, Natalie van Zuydam, Emma H. Dahlstrom, Damian Fermin, Laura J. Smyth, Rany M. Salem, Carol Forsblom, Erkka Valo, Valma Harjutsalo, Eoin P. Brennan, Gareth J. McKay, Darrell Andrews, Ross Doyle, Helen C. Looker, Robert G. Nelson, Colin Palmer, Amy Jayne McKnight, Catherine Godson, Alexander P. Maxwell, Leif Groop, Mark I. McCarthy, Matthias Kretzler, Katalin Susztak, Joel N. Hirschhorn, Jose C. Florez, Per-Henrik Groop
Summary: By performing meta-analysis of previous genome-wide association studies (GWAS) on diabetic kidney disease (DKD) and integrating the results with renal transcriptomics datasets, novel genetic factors and genes contributing to DKD have been identified.
Article
Endocrinology & Metabolism
Anna Syreeni, Emma H. Dahlstrom, Stefanie Hagg-Holmberg, Carol Forsblom, Marika I. Eriksson, Valma Harjutsalo, Jukka Putaala, Per-Henrik Groop, Niina Sandholm, Lena M. Thorn
Summary: This study aimed to investigate the relationship between the haptoglobin Hp1/2 genotype and stroke in individuals with type 1 diabetes. The results showed that the haptoglobin genotypes had no association with the risk of stroke or survival after stroke in this cohort.
Letter
Endocrinology & Metabolism
Erika B. Parente, Stefan Mutter, Lena M. Thorn, Valma Harjutsalo, Per-Henrik Groop
Article
Endocrinology & Metabolism
Patrik Smidtslund, Fanny Jansson Sigfrids, Anni Ylinen, Nina Elonen, Valma Harjutsalo, Per-Henrik Groop, Lena M. Thorn
Summary: This study aims to investigate the prognosis after a first-ever myocardial infarction (MI) in individuals with type 1 diabetes and how different MI- and diabetes-related factors affect the prognosis and risk of secondary cardiovascular events. The study found that individuals with type 1 diabetes have a high cardiovascular and diabetes-related mortality after their first-ever MI, and poor kidney function is associated with high mortality and excessive risk of secondary cardiovascular events.
Article
Genetics & Heredity
Niina Sandholm, Ronja Hotakainen, Jani K. Haukka, Fanny Jansson Sigfrids, Emma H. Dahlstrom, Anni A. Antikainen, Erkka Valo, Anna Syreeni, Elina Kilpelainen, Anastasia Kytola, Aarno Palotie, Valma Harjutsalo, Carol Forsblom, Per-Henrik Groop
Summary: The study identified variants associated with lipoproteins and lipids, as well as rare loss-of-function protein-altering variants, suggesting novel therapeutic targets for preventing cardiovascular disease.
Review
Endocrinology & Metabolism
Drazenka Pongrac Barlovic, Valma Harjutsalo, Per-Henrik Groop
Summary: Type 1 diabetes is a complex disease with dynamic changes in insulin need. The FinnDiane Study in Finland has provided valuable insights into the effects of exercise and nutrition on glycemic control and the development of diabetes complications in individuals with type 1 diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Correction
Cardiac & Cardiovascular Systems
Anniina Tynjala, Valma Harjutsalo, Fanny Jansson Sigfrids, Per-Henrik Groop, Daniel Gordin
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Anniina Tynjala, Valma Harjutsalo, Fanny Jansson Sigfrids, Per-Henrik Groop, Daniel Gordin
Summary: This study investigated the association between long-term glycemic variability and arterial stiffness in patients with type 1 diabetes. The results showed that the variability of HbA1c was significantly correlated with arterial stiffness. Importantly, this association was independent of the HbA1c mean.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Multidisciplinary Sciences
Anmol Kumar, Stefan Mutter, Erika B. Parente, Valma Harjutsalo, Raija Lithovius, Sinnakaruppan Mathavan, Markku Lehto, Timo P. Hiltunen, Kimmo K. Kontula, Per-Henrik Groop
Summary: This study investigated the effect of L-type calcium channel blockers (LTCCBs) on VEGF concentrations in retinal cells and human serum, and evaluated the association between LTCCB usage and risk of severe diabetic eye disease (SDED). The results showed that LTCCBs increase VEGF concentrations in retinal cells and human serum, but they are not associated with the risk of SDED in adults with type 1 diabetes.
Article
Health Care Sciences & Services
Valma Harjutsalo, Milla Kallio, Carol Forsblom, Per-Henrik Groop, FinnDiane Study Grp
Summary: This study investigated the impact of diabetic nephropathy and diabetic retinopathy on the risk of chronic limb threatening ischemia (CLTI) in patients with type 1 diabetes. It found that diabetic nephropathy and severe diabetic retinopathy were key risk factors for CLTI in these patients.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Meeting Abstract
Endocrinology & Metabolism
R. Lithovius, S. Mutter, E. B. Parente, V. Harjutsalo, P. -H. Groop
Meeting Abstract
Endocrinology & Metabolism
E. B. Parente, S. Mutter, C. Forsblom, V. Harjutsalo, P. -H. Groop
Meeting Abstract
Endocrinology & Metabolism
S. Satuli-Autere, V. Harjutsalo, M. Eriksson, S. Hagg-Holmberg, H. Ohman, P. -H. Groop, L. Thorn
Meeting Abstract
Endocrinology & Metabolism
A. Ylinen, S. Hagg-Holmberg, S. Mutter, S. Satuli-Autere, V. Harjutsalo, C. Forsblom, P. -H. Groop, L. M. Thorn
