Heart Failure in Type 1 Diabetes: A Complication of Concern? A Narrative Review

Heart failure (HF) has been a hot topic in diabetology in the last few years, mainly due to the central role of sodium-glucose cotransporter 2 inhibitors (iSGLT2) in the prevention and treatment of cardiovascular disease and heart failure. It is well known that HF is a common complication in diabetes. However, most of the knowledge about it and the evidence of cardiovascular safety trials with antidiabetic drugs refer to type 2 diabetes (T2D). The epidemiology, etiology, and pathophysiology of HF in type 1 diabetes (T1D) is still not well studied, though there are emerging data about it since life expectancy for T1D has increased in the last decades and there are more elderly patients with T1D. The association of T1D and HF confers a worse prognosis than in T2D, thus it is important to investigate the characteristics, risk factors, and pathophysiology of this disease in order to effectively design prevention strategies and therapeutic tools.

Automated summary

HF and iSGLT2 have been key topics in diabetology, with a focus on T2D, but research on HF in T1D is lacking. Understanding the characteristics, risk factors, and pathophysiology of HF in T1D is crucial for developing effective prevention strategies and therapies. The association between T1D and HF has a worse prognosis compared to T2D, highlighting the need for further exploration in this area.