Selective inhibition of 12-lipoxygenase protects islets and beta cells from inflammatory cytokine-mediated beta cell dysfunction

Synthesis and Structure–Activity Relationship Studies of 4-((2-Hydroxy-3-methoxybenzyl)amino)benzenesulfonamide Derivatives as Potent and Selective Inhibitors of 12-Lipoxygenase

(2014) Diane K. Luci et al.   JOURNAL OF MEDICINAL CHEMISTRY

12-Lipoxygenase Promotes Obesity-Induced Oxidative Stress in Pancreatic Islets

(2014) S. A. Tersey et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeting inflammation in the treatment of type 2 diabetes: time to start

(2014) Marc Y. Donath   NATURE REVIEWS DRUG DISCOVERY

Interaction between cytokines and inflammatory cells in islet dysfunction, insulin resistance and vascular disease

(2013) Y. Imai et al.   DIABETES OBESITY & METABOLISM

Is there a role for the adaptive immune system in pancreatic beta cell failure in type 2 diabetes?

(2013) Clara Westwell-Roper et al.   DIABETOLOGIA

Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials

(2013) Antoinette Moran et al.   LANCET

Type 1 diabetes

(2013) Mark A Atkinson et al.   LANCET

Regulation of NOX-1 expression in beta cells: A positive feedback loop involving the Src-kinase signaling pathway

(2013) J.R. Weaver et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Deletion of 12/15-Lipoxygenase Alters Macrophage and Islet Function in NOD-Alox15null Mice, Leading to Protection against Type 1 Diabetes Development

(2013) Shamina M. Green-Mitchell et al.   PLoS One

The pancreatic β cell and type 1 diabetes: innocent bystander or active participant?

(2013) Scott A. Soleimanpour et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A role for aberrant protein palmitoylation in FFA-induced ER stress and β-cell death

(2012) Aaron C. Baldwin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Islet  -Cell Endoplasmic Reticulum Stress Precedes the Onset of Type 1 Diabetes in the Nonobese Diabetic Mouse Model

(2012) S. A. Tersey et al.   DIABETES

Production and function of IL-12 in islets and beta cells

(2012) D. A. Taylor-Fishwick et al.   DIABETOLOGIA

Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunction

(2012) Jessica R. Weaver et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines

(2012) Décio L. Eizirik et al.   PLoS Genetics

Peripheral and Islet Interleukin-17 Pathway Activation Characterizes Human Autoimmune Diabetes and Promotes Cytokine-Mediated  -Cell Death

(2011) S. Arif et al.   DIABETES

Discovery of Potent and Selective Inhibitors of Human Platelet-Type 12- Lipoxygenase

(2011) Victor Kenyon et al.   JOURNAL OF MEDICINAL CHEMISTRY

12-Lipoxygenase Products Reduce Insulin Secretion and β-Cell Viability in Human Islets

(2010) K. Ma et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Functional and pathological roles of the 12- and 15-lipoxygenases

(2010) Anca D. Dobrian et al.   PROGRESS IN LIPID RESEARCH

A Practical Guide to Rodent Islet Isolation and Assessment

(2009) Jeffrey D. Carter et al.   BIOLOGICAL PROCEDURES ONLINE

12/15-Lipoxygenase Is Required for the Early Onset of High Fat Diet-Induced Adipose Tissue Inflammation and Insulin Resistance in Mice

(2009) Dorothy D. Sears et al.   PLoS One

12-Lipoxygenase-knockout mice are resistant to inflammatory effects of obesity induced by western diet

(2008) Craig S. Nunemaker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Lessons From the First Comprehensive Molecular Characterization of Cell Cycle Control in Rodent Insulinoma Cell Lines

(2008) I. Cozar-Castellano et al.   DIABETES