Cathepsin S inhibitors: 2004 – 2010

Inhibition of Invariant Chain Processing, Antigen-Induced Proliferative Responses, and the Development of Collagen-Induced Arthritis and Experimental Autoimmune Encephalomyelitis by a Small Molecule Cysteine Protease Inhibitor

(2014) P. L. Podolin et al.   JOURNAL OF IMMUNOLOGY

Identification and pre-clinical testing of a reversible cathepsin protease inhibitor reveals anti-tumor efficacy in a pancreatic cancer model

(2010) Benelita Tina Elie et al.   BIOCHIMIE

2-Phenyl-9H-purine-6-carbonitrile derivatives as selective cathepsin S inhibitors

(2010) Jiaqiang Cai et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors

(2010) Jiaqiang Cai et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors: Part 1

(2010) Alice Lee-Dutra et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

4-(3-Trifluoromethylphenyl)-pyrimidine-2-carbonitrile as cathepsin S inhibitors: N3, not N1 is critically important

(2010) Jiaqiang Cai et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors. Part 2: Modification of P3, P4, and P5 regions

(2010) John J.M. Wiener et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Diazinones as P2 replacements for pyrazole-based cathepsin S inhibitors

(2010) Michael K. Ameriks et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Thioether acetamides as P3 binding elements for tetrahydropyrido-pyrazole cathepsin S inhibitors

(2010) Danielle K. Wiener et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin K inhibitors

(2010) Zoran Rankovic et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Recent Advances in the Design of Cathepsin S Inhibitors

(2010) John J. M. Wiener et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

5-Aminopyrimidin-2-ylnitriles as Cathepsin K inhibitors

(2009) Andrew D. Morley et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design of selective Cathepsin inhibitors

(2009) Paul A. Bethel et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pyrazole-based cathepsin S inhibitors with arylalkynes as P1 binding elements

(2009) Michael K. Ameriks et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pyrazole-based arylalkyne cathepsin S inhibitors. Part II: Optimization of cellular potency

(2009) Michael K. Ameriks et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Dipeptidyl nitrile inhibitors of Cathepsin L

(2009) Nabil Asaad et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Solid-phase parallel synthesis and SAR of 4-amidofuran-3-one inhibitors of cathepsin S: Effect of sulfonamides P3 substituents on potency and selectivity

(2008) Susana Ayesa et al.   BIOORGANIC & MEDICINAL CHEMISTRY

4-Amino-2-cyanopyrimidines: Novel scaffold for nonpeptidic cathepsin S inhibitors

(2008) Osamu Irie et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Overcoming hERG issues for brain-penetrating cathepsin S inhibitors: 2-Cyanopyrimidines. Part 2

(2008) Osamu Irie et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of selective and nonpeptidic cathepsin S inhibitors

(2008) Osamu Irie et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K

(2008) Jacques Yves Gauthier et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cysteine cathepsin S as an immunomodulatory target: present and future trends

(2008) Suman Gupta et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Discovery of Orally Bioavailable Cathepsin S Inhibitors for the Reversal of Neuropathic Pain

(2008) Osamu Irie et al.   JOURNAL OF MEDICINAL CHEMISTRY

Simple fabrication of functionalized surface with polyethylene glycol microstructure and glycidyl methacrylate moiety for the selective immobilization of proteins and cells

(2008) Hwan-Moon Song et al.   KOREAN JOURNAL OF CHEMICAL ENGINEERING

Inhibitors of proteases and amide hydrolases that employ an α-ketoheterocycle as a key enabling functionality

(2007) Bruce E. Maryanoff et al.   BIOORGANIC & MEDICINAL CHEMISTRY