Effect of zinc supplementation on insulin secretion: interaction between zinc and SLC30A8 genotype in Old Order Amish

Loss-of-function mutations in SLC30A8 protect against type 2 diabetes

(2014) Jason Flannick et al.   NATURE GENETICS

Interactions Between Zinc Transporter-8 Gene (SLC30A8) and Plasma Zinc Concentrations for Impaired Glucose Regulation and Type 2 Diabetes

(2013) Zhilei Shan et al.   DIABETES

Systematic identification of interaction effects between genome- and environment-wide associations in type 2 diabetes mellitus

(2013) Chirag J. Patel et al.   HUMAN GENETICS

The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance

(2013) Motoyuki Tamaki et al.   JOURNAL OF CLINICAL INVESTIGATION

Current Genetic Data Do Not Improve the Prediction of Type 2 Diabetes Mellitus: The CoLaus Study

(2012) Rémy Schmid et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Zinc and glycemic control: A meta-analysis of randomised placebo controlled supplementation trials in humans

(2012) Jasmine Capdor et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Effects of zinc supplementation on diabetes mellitus: a systematic review and meta-analysis

(2012) R Jayawardena et al.   Diabetology & Metabolic Syndrome

Total Zinc Intake May Modify the Glucose-Raising Effect of a Zinc Transporter (SLC30A8) Variant: A 14-Cohort Meta-analysis

(2011) S. Kanoni et al.   DIABETES

Association of the SLC30A8 missense polymorphism R325W with proinsulin levels at baseline and after lifestyle, metformin or troglitazone intervention in the Diabetes Prevention Program

(2011) A. R. Majithia et al.   DIABETOLOGIA

Characterization of the human SLC30A8 promoter and intronic enhancer

(2011) Lynley D Pound et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Common Variants in 40 Genes Assessed for Diabetes Incidence and Response to Metformin and Lifestyle Intervention in the Diabetes Prevention Program

(2010) K. A. Jablonski et al.   DIABETES

Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion

(2010) N. Wijesekara et al.   DIABETOLOGIA

Meta-analysis and functional effects of the SLC30A8 rs13266634 polymorphism on isolated human pancreatic islets

(2010) Stéphane Cauchi et al.   MOLECULAR GENETICS AND METABOLISM

Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

(2010) Kaixin Zhou et al.   NATURE GENETICS

SLC30A8 polymorphism and type 2 diabetes risk: Evidence from 27 study groups

(2010) Y.L. Jing et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

A low-risk ZnT-8 allele (W325) for post-transplantation diabetes mellitus is protective against cyclosporin A-induced impairment of insulin secretion

(2010) I Kim et al.   PHARMACOGENOMICS JOURNAL

Three-dimensional structure of β-cell-specific zinc transporter, ZnT-8, predicted from the type 2 diabetes-associated gene variant SLC30A8 R325W

(2010) Rob NM Weijers   Diabetology & Metabolic Syndrome

Deletion of the mouseSlc30a8gene encoding zinc transporter-8 results in impaired insulin secretion

(2009) Lynley D. Pound et al.   BIOCHEMICAL JOURNAL

Reduced-Function SLC22A1 Polymorphisms Encoding Organic Cation Transporter 1 and Glycemic Response to Metformin: A GoDARTS Study

(2009) K. Zhou et al.   DIABETES

Association of 18 Confirmed Susceptibility Loci for Type 2 Diabetes With Indices of Insulin Release, Proinsulin Conversion, and Insulin Sensitivity in 5,327 Nondiabetic Finnish Men

(2009) A. Stancakova et al.   DIABETES

Confirmation of Multiple Risk Loci and Genetic Impacts by a Genome-Wide Association Study of Type 2 Diabetes in the Japanese Population

(2009) F. Takeuchi et al.   DIABETES

Insulin Storage and Glucose Homeostasis in Mice Null for the Granule Zinc Transporter ZnT8 and Studies of the Type 2 Diabetes-Associated Variants

(2009) T. J. Nicolson et al.   DIABETES

Prospective Study of Zinc Intake and Risk of Type 2 Diabetes in Women

(2009) Q. Sun et al.   DIABETES CARE

Down-Regulation of ZnT8 Expression in INS-1 Rat Pancreatic Beta Cells Reduces Insulin Content and Glucose-Inducible Insulin Secretion

(2009) Yi Fu et al.   PLoS One

Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice

(2009) K. Lemaire et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Copper, Chromium, Manganese, Iron, Nickel, and Zinc Levels in Biological Samples of Diabetes Mellitus Patients

(2008) Tasneem Gul Kazi et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion

(2008) K. Kirchhoff et al.   DIABETOLOGIA

The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients—the EUGENE2 study

(2008) T. W. Boesgaard et al.   DIABETOLOGIA

Genotype Score in Addition to Common Risk Factors for Prediction of Type 2 Diabetes

(2008) James B. Meigs et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical Risk Factors, DNA Variants, and the Development of Type 2 Diabetes

(2008) Valeriya Lyssenko et al.   NEW ENGLAND JOURNAL OF MEDICINE