Article
Biochemistry & Molecular Biology
Carolina Gutierrez-Repiso, Teresa Maria Linares-Pineda, Andres Gonzalez-Jimenez, Francisca Aguilar-Lineros, Sergio Valdes, Federico Soriguer, Gemma Rojo-Martinez, Francisco J. Tinahones, Sonsoles Morcillo
Summary: This study found that DNA methylation status is associated with the stability/worsening of the MHO phenotype, identifying two potential biomarkers for transitioning to an unhealthy state and highlighting immune system-related pathways as therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Marica Franzago, Lucrezia Pilenzi, Sara Di Rado, Ester Vitacolonna, Liborio Stuppia
Summary: The prevalence of obesity has significantly increased worldwide, and it is closely related to the higher incidence of chronic diseases in older adults. Epigenetic clocks can reflect an individual's health status, and obesity and other environmental factors can accelerate the process of epigenetic aging, increasing the risk of age-related diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yen My Vuu, Chris-Tiann Roberts, Mojgan Rastegar
Summary: DNA methylation is a well-studied epigenetic modification involved in various biological processes, including cellular morphology and function control. MeCP2, a key protein binding to methylated DNA in the brain, plays a crucial role in neurodevelopmental disorders and aberrant brain function. Recently, MeCP2-associated neurodevelopmental disorders have been linked to neurometabolic abnormalities, suggesting the involvement of MeCP2 in brain metabolism. This review aims to outline the metabolic defects in MeCP2-associated neurodevelopmental disorders and provide an updated overview for future therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Bonnie Ho-Yee Yeung, Kelly Griffiths, Liron Berger, Omkar Paudel, Mi-Kyung Shin, Liangyou Rui, James S. K. Sham, Vsevolod Y. Polotsky, Wan-Yee Tang
Summary: The study found that obesity-related elevated leptin levels are associated with hypertension, and leptin can increase blood pressure by regulating Trpm7 channels in carotid body glomus cells, affecting the occurrence and development of hypertension. Epigenetic changes are reversible, and targeting epigenetic modifications of Trpm7 may serve as a new therapeutic approach for treating obesity-induced hypertension.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Microbiology
Patrizia D'Aquila, Francesco De Rango, Ersilia Paparazzo, Giuseppe Passarino, Dina Bellizzi
Summary: Adaptive antibiotic resistance is a transient metabolic adaptation of bacteria in response to low concentrations of antibiotics. Epigenetic modifications triggered by low concentrations of various antibiotics may modulate the sensitivity of bacteria to antibiotics. Understanding the molecular mechanisms behind adaptive resistance can suggest strategies to avoid it.
MICROBIOLOGY SPECTRUM
(2023)
Article
Multidisciplinary Sciences
Harry MacKay, Chathura J. Gunasekara, Kit-Yi Yam, Dollada Srisai, Hari Krishna Yalamanchili, Yumei Li, Rui Chen, Cristian Coarfa, Robert A. Waterland
Summary: Recent studies have confirmed that obesity is primarily a neurodevelopmental disease influenced by nutrition during critical ontogenic windows. This study examines the role of epigenetic mechanisms in establishing and maintaining the brain's energy balance circuitry, specifically in the hypothalamic arcuate nucleus. The results indicate that postnatal epigenetic maturation is cell type and sex specific, occurring in genomic regions associated with body mass index heritability. These findings provide valuable insights into the limited ontogenic windows for developmental programming of obesity and the sex differences in sensitivity, and offer a resource for epigenetic analysis of energy balance programming.
Article
Cell Biology
Keren Xu, Shaobo Li, Ivo S. Muskens, Natalina Elliott, Swe Swe Myint, Priyatama Pandey, Helen M. Hansen, Libby M. Morimoto, Alice Y. Kang, Xiaomei Ma, Catherine Metayer, Beth A. Mueller, Irene Roberts, Kyle M. Walsh, Steve Horvath, Joseph L. Wiemels, Adam J. Smith
Summary: The study revealed that accelerated epigenetic aging in the blood of Down syndrome (DS) patients begins prenatally and is associated with somatic GATA1 mutations. DS newborns showed a significant increase in DNAmSkinBloodClock, but were not associated with epigenetic gestational age acceleration.
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang
Summary: Increasing evidence suggests that the intrauterine environment affects fetal hypothalamic energy intake, and maternal inulin intervention can modify offspring lipid metabolism through gene methylation in the hypothalamus feeding circuit.
Article
Biochemistry & Molecular Biology
Jiao Wang, Yushuo Xiao, Chengyu Liu, Yixue Huang, Robert B. Petersen, Ling Zheng, Kun Huang
Summary: MeCP2 plays a crucial role in both neurological and non-neurological disorders, including causing Rett syndrome in the former and cardiac dysfunction, liver injury, respiratory disorders, and other conditions in the latter. Research suggests that MeCP2 can influence various physiological and pathological processes in a DNA methylation-dependent or independent manner.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Review
Immunology
Kathrin L. L. Braband, Tamara Kaufmann, Stefan Floess, Mangge Zou, Jochen Huehn, Michael Delacher
Summary: Regulatory T cells in non-lymphoid tissues play a critical role in maintaining self-tolerance, promoting organ homeostasis, and tissue repair. This review summarizes recent research on the differentiation of tissue Treg cells and highlights the importance of epigenetic remodeling in this process.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Olivier Lavoie, Natalie Jane Michael, Alexandre Caron
Summary: The discovery of leptin in 1994 provided new opportunities to understand energy balance and glucose metabolism. However, the prevailing model of the leptin-melanocortin system is outdated. Recent advances have shown that leptin directly acts on ARC POMC neurons to regulate glucose metabolism, while non-POMC neurons mediate its effects on energy balance.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Cell Biology
Christy Anne Foster, Malcolm Barker-Kamps, Marlon Goering, Amit Patki, Hemant K. Tiwari, Sylvie Mrug
Summary: Obesity is associated with an increased risk of Type 2 diabetes, cardiovascular disease, cancer, and age-related disorders. This study focused on the relationship between obesity and DNA methylation (DNAm) in young adulthood, and found that higher BMI and waist circumference were associated with accelerated epigenetic aging, with different effects in males and females.
Review
Biochemistry & Molecular Biology
Immacolata Cristina Nettore, Fabiana Franchini, Giuseppe Palatucci, Paolo Emidio Macchia, Paola Ungaro
Summary: Research has shown a possible association between obesity and endocrine-disrupting chemicals, which can interfere with energy metabolism and adipose tissue structure regulation. Early exposure to these chemicals may induce epigenetic modifications, making individuals susceptible to obesity and other diseases.
Review
Biochemistry & Molecular Biology
Qiong Wu, Anders E. Berglund, Arnold B. Etame
Summary: Glioblastoma is highly resistant to standard therapies and the durability of response to the best chemotherapy agent, Temozolomide, is often short-lived due to tumor resistance. The need for therapies that can provide synergy to chemoradiation is urgent, as adaptive resistance evolution in GBM is facilitated through treatment-induced epigenetic modifications. Understanding and targeting these epigenetic modifications associated with GBM resistance is a top priority.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Plant Sciences
Kajal Samantara, Aalok Shiv, Lorenna Lopes de Sousa, Karansher Singh Sandhu, Parichita Priyadarshini, Sourav Ranjan Mohapatra
Summary: Epigenetics is an important mechanism that can help plants cope with various stressors by altering gene expression without involving changes in DNA sequences. It provides diversity to aid plants in responding to the impacts of climate change.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2021)