Article
Plant Sciences
Ah-Won Kwak, Jin Woo Park, Seung-On Lee, Jin-Young Lee, Ji-hye Seo, Goo Yoon, Mee-Hyun Lee, Joon-Seok Choi, Jung-Hyun Shim
Summary: This study found that Isolinderalactone (ILL) can exert its anticancer effect in colorectal cancer (CRC) cells sensitive and resistant to oxaliplatin (Ox) by inducing ROS-mediated apoptosis through JNK/p38 MAPK signaling pathways. This provides a new insight into therapeutic strategies targeting drug-resistant CRC.
Article
Environmental Sciences
Won-Young Lee, Hyun-Jung Park
Summary: T-2 toxin induces reproductive toxicity and germ cell damage. It reduces testicular germ cell number and downregulates their corresponding markers, but increases Sertoli cell markers and steroidogenic enzyme expression. T-2 toxin also decreases cell viability, increases apoptosis, and triggers ROS-mediated JNK/p38-MAPK signaling pathway, leading to mitochondrial dysfunction and apoptotic cell death in germ cells.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Cell Biology
Ling Liu, Yihao Xing, Mengyao Cao, Jinglei Xu, Jingjing Chen
Summary: JS-K induces apoptosis in hepatocellular carcinoma cells by activating JNK and p38 MAPK and inhibiting the Raf/MEK/ERK signaling pathway.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Ah-Won Kwak, Woo-Keun Kim, Seung-On Lee, Goo Yoon, Seung-Sik Cho, Ki-Taek Kim, Mee-Hyun Lee, Yung Hyun Choi, Jin-Young Lee, Jin Woo Park, Jung-Hyun Shim
Summary: This study aims to investigate the antitumor potential and molecular mechanism of Licochalcone B (LCB) in human colorectal cancer cells. The results demonstrate that LCB has a potential therapeutic effect against colorectal cancer cells through the ROS-mediated JNK/p38 MAPK signaling pathway, making it a promising anticancer therapeutic and prophylactic agent.
Article
Neurosciences
Jing Zhao, Meini Le, Jie Li, Qiong Huang, Haocong Chen, Wenyi Zhang, Huiwen Mao, Qing Sun, Aiguo Li, Yingmin Zhao, Lingling Yu, Mingjiang Yi, Jie Wang, Xinyuan Li, Guangming Zhang, Jun Ma, Xiaohua Dong
Summary: LINC00938 acts as a neuroprotective factor to inhibit oxidative stress and cell apoptosis in the central nervous system under hypoxic-ischemic encephalopathy (HIE) conditions.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tingting Li, Hui Bai, Liang Yang, Weiguang Hao, Shengjuan Wei, Peishi Yan
Summary: Low temperature exposure can inhibit proliferation and cell cycle progression and induce apoptosis through activation of p38 MAPK and JNK signaling pathways in bovine subcutaneous preadipocytes.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2023)
Article
Medicine, Research & Experimental
Xiangye Bu, Wenqing Xia, Xiaonan Wang, Shan Lu, Yue Gao
Summary: Butylphthalide can reduce nerve cell apoptosis in rats with cerebral infarction by inhibiting the JNK/p38 MAPK signaling pathway, thereby exerting a protective effect.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Oncology
Koichi Nakamura, Kunihiro Asanuma, Takayuki Okamoto, Takahiro Iino, Tomohito Hagi, Tomoki Nakamura, Akihiro Sudo
Summary: The combination of everolimus and bortezomib has shown synergistic antiproliferative and apoptotic effects against fibrosarcoma and osteosarcoma, suppressing pulmonary metastases. Everolimus and bortezomib inhibit tumor growth via the JNK/p38/ERK MAPK and AKT pathways. This combination therapy shows promise as a new therapeutic strategy for bone and soft tissue sarcomas.
Article
Medicine, Research & Experimental
Yingsi Huang, Shuhua Li, Huaxin Chen, Long Feng, Weixiu Yuan, Tao Han
Summary: Butorphanol reduces neuronal inflammatory response and apoptosis by inhibiting the p38/JNK/ATF2/p53 signaling pathway, providing a new direction for the treatment of spinal cord injury.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Food Science & Technology
Yue Zhao, Qingqing Jiang, Limin Guo, Daming Fan, Mingfu Wang, Yueliang Zhao
Summary: Glycidol is a food contaminant found in refined edible oils and various thermally processed foods, which induces cell cycle arrest, apoptosis, and autophagy in HUVECs. The toxicity effects of glycidol are mediated through activation of the ERK/JNK/p38 signaling pathways, and these effects can be attenuated by apigenin-7 (API-C8) through inhibition of the same pathways.
CURRENT RESEARCH IN FOOD SCIENCE
(2023)
Article
Cell Biology
Xi Chen, Weijie Ma, Ye Yao, Qi Zhang, Jinghua Li, Xiaoling Wu, Chengjie Mei, Xiang Jiang, Yiran Chen, Ganggang Wang, Kunlei Wang, Yingyi Liu, Yonghua Guo, Zhisu Liu, Yufeng Yuan
Summary: The study identified SDPR as a tumor suppressor in HCC by promoting apoptosis through the activation of the ASK1-JNK/p38 MAPK signaling pathways. This inhibits tumor growth and migration by enhancing cell apoptosis.
CELL DEATH & DISEASE
(2021)
Article
Pharmacology & Pharmacy
Na Lin, Hui Lin, Qi Yang, Wenqiang Lu, Zhenzhu Sun, Shimin Sun, Liping Meng, Jufang Chi, Hangyuan Guo
Summary: Recent studies have shown that elevated levels of SGLT1 in diabetic cardiomyopathy (DCM) patients. Inhibition of SGLT1 appeared to attenuate apoptosis in DCM through the JNK and p38 pathways. SGLT1 can serve as a marker for diagnosing DCM, and its inhibition can suppress DCM development by reducing apoptosis via the JNK and p38 pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biology
Yingyu Zhou, Tomohiro Takano, Xuyang Li, Yimei Wang, Rong Wang, Zhangliang Zhu, Masaru Tanokura, Takuya Miyakawa, Satoshi Hachimura
Summary: Beta-elemene regulates the balance of proinflammatory cytokines in mouse white adipose tissue through MAPK signaling, affecting the imbalance of M1-M2 macrophages and inhibiting the phosphorylation of MAPK pathways. These results suggest that beta-elemene may be a potential therapeutic medicine for macrophage-mediated chronic diseases.
COMMUNICATIONS BIOLOGY
(2022)
Article
Oncology
Siting Li, Yuexin Hu, Ouxuan Liu, Xiao Li, Bei Lin
Summary: The study found that MCP-4 is highly expressed in ovarian cancer tissues and is associated with patient prognosis. MCP-4 overexpression promotes cell migration and invasion in ovarian cancer, inhibits apoptosis, and activates the p38 MAPK signaling pathway.
FRONTIERS IN ONCOLOGY
(2022)
Article
Plant Sciences
Xin Guo, Yun-Da Yao, Jun-Li Kang, Fu-Kang Luo, Xi-Jun Mu, Yan-Yu Zhang, Ming-Tai Chen, Meng-Nan Liu, Chi-Chou Lao, Zi-Hao Tan, Yu-Feng Huang, You-Hua Xu, Ying Xie, Peng Wu, Hua Zhou
Summary: This study isolated an active compound, IT24, from Iris tectorum and demonstrated its anti-inflammatory effects. IT24 exerts its anti-inflammatory effects by inhibiting mPGES-1 and the p38/JNK pathway, and has potential as an mPGES-1 inhibitor for the prevention and treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Philip D. Home, Rory J. McCrimmon, Julio Rosenstock, Matthias Bluher, Katrin Pegelow, Lydie Melas-Melt, Khier Djaballah, Francesco Giorgino
Summary: The aim of this study was to investigate the impact of baseline participant characteristics on the outcomes of the SoliMix study. The findings showed that the treatment effects of iGlarLixi were consistent across various baseline characteristics, supporting its use as an effective and well-tolerated treatment option for people with type 2 diabetes.
DIABETES OBESITY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Sergio Di Molfetta, Irene Caruso, Angelo Cignarelli, Annalisa Natalicchio, Sebastio Perrini, Luigi Laviola, Francesco Giorgino
Summary: This study aimed to evaluate the effect of professional continuous glucose monitoring (p-CGM)-based care on glucose control in type 1 and type 2 diabetes patients. The use of p-CGM was found to significantly reduce glycated haemoglobin (HbA1c) levels without increasing hypoglycaemia compared to standard care.
DIABETES OBESITY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Irene Caruso, Nicola Marrano, Giuseppina Biondi, Valentina Annamaria Genchi, Rossella D'Oria, Gian Pio Sorice, Sebastio Perrini, Angelo Cignarelli, Annalisa Natalicchio, Luigi Laviola, Francesco Giorgino
Summary: Hyperglucagonemia contributes to the pathogenesis of type 2 diabetes and its complications. Glucagon regulates glucose homeostasis and can affect weight, liver disease, peripheral neuropathy, and retinopathy. However, its role in diabetic nephropathy and cardiovascular system is uncertain. This review aims to summarize the current understanding and calls for further research on modulating glucagon signaling for new antidiabetic drugs.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Nicola Marrano, Giuseppina Biondi, Anna Borrelli, Martina Rella, Tommaso Zambetta, Ludovico Di Gioia, Mariangela Caporusso, Giancarlo Logroscino, Sebastio Perrini, Francesco Giorgino, Annalisa Natalicchio
Summary: Type 2 diabetes and Alzheimer's disease are major health issues with a close relationship. Lipotoxicity may be the missing link connecting the pathogenesis of these two diseases. Obesity, the main cause of lipotoxicity, is a major risk factor for both conditions. This review provides a comprehensive overview of the common molecular pathways activated by lipotoxicity in type 2 diabetes and Alzheimer's disease, suggesting potential new therapeutic perspectives.
Article
Endocrinology & Metabolism
Sue D. D. Pedersen, Francesco Giorgino, Guillermo Umpierrez, Vivian T. T. Thieu, Angel Rodriguez, Claudia Nicolay, Laura Fernandez Lando, Chrisanthi A. A. Karanikas, Jacek Kiljanski
Summary: This study assessed the relationship between HbA1c and body weight reductions in tirzepatide treatment. In the SURPASS clinical trials, significant reductions in HbA1c were observed for participants treated with tirzepatide at all doses, and weight loss was associated with these reductions. Furthermore, a modest but statistically significant association between HbA1c and body weight changes was observed in several trials, indicating that both weight-independent and weight-dependent mechanisms contribute to the improvement in glycaemic control induced by tirzepatide.
DIABETES OBESITY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Andrea Iannone, Patrizia Natale, Suetonia C. Palmer, Antonio Nicolucci, Maria Rendina, Francesco Giorgino, Luigi Laviola, Alfredo Di Leo, Giovanni F. M. Strippoli
Summary: A systematic review found that drugs approved for weight management in adults with obesity or overweight were more effective in reducing body weight and waist circumference compared to other drugs, with no significant differences in cardiovascular death risk.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Raffaele Napoli, Cesare Berra, Andrei-Mircea Catarig, Chiara Di Loreto, Emily Donatiello, Tina Landsvig Berentzen, Dario Pitocco, Francesco Giorgino
Summary: The SURE Italy study investigated the use of once-weekly semaglutide in patients with type 2 diabetes in routine clinical practice. The study found that this treatment method led to significant improvements in glycated hemoglobin, body weight, and other outcomes, with a good safety profile.
DIABETES OBESITY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Matthias Blueher, Mohini Aras, Louis J. Aronne, Rachel L. Batterham, Francesco Giorgino, Linong Ji, Kirsi H. Pietilainen, Oliver Schnell, Elena Tonchevska, John P. H. Wilding
Summary: Obesity is a chronic disease with increasing prevalence worldwide and is associated with various health risks. The treatment of obesity includes behavioral interventions, pharmacotherapy, and bariatric surgery, but long-term weight maintenance is challenging. Recent advances in understanding the pathophysiology of obesity have led to the development of novel and effective therapies, such as semaglutide and tirzepatide, which have shown promising weight loss effects and improvement in cardiometabolic risk factors. These new agents may bridge the gap between traditional treatments and achieve better outcomes in obesity management.
DIABETES OBESITY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Gabriella Garruti, Jacek Baj, Angelo Cignarelli, Sebastio Perrini, Francesco Giorgino
Summary: Current perspectives suggest that an impaired balance, fetal malnutrition, and exposure to endocrine-disrupting compounds contribute to obesity and impaired insulin function. Additionally, the liver plays a crucial role in maintaining glucose balance through hepatokines, bile acids, and ketone bodies. Recent studies have revealed that bile acids and ketone bodies act as endocrine molecules that regulate key metabolic pathways and mediate inflammation and oxidative stress. This review focuses on the role of hepatokines, bile acids, and ketone bodies in obesity, diabetes prevention and management, and explores their potential as therapeutic approaches for metabolic and aging-related diseases.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Francesco Giorgino, Bruno Guerci, Martin Fuechtenbusch, Jeremie Lebrec, Kristina Boye, Marco Orsini Federici, Elke Heitmann, Anne Dib, Maria Yu, Helene Sapin, Luis-Emilio Garcia-Perez
Summary: The TROPHIES study presented the final results, indicating that patients initiating dulaglutide had a longer duration without significant treatment changes and higher treatment persistence compared to those initiating liraglutide. Both drugs showed similar and clinically meaningful reductions in glycated haemoglobin (HbA1c) and weight.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Kristina S. Boye, Jeremie Lebrec, Anne Dib, Elke Heitmann, Marco Orsini Federici, Maria Yu, Helene Sapin, Annabel Barrett, Bruno Guerci, Francesco Giorgino, Martin Fuechtenbusch, Luis-Emilio Garcia-Perez
Summary: This study reports the health-related patient-reported outcomes (PROs) of patients with T2D initiating their first injectable glucose-lowering medication (GLM) with two common GLP-1RAs. The results show that dulaglutide had more significant improvements in PRO scores compared to liraglutide, and patients were more satisfied with the injection device of dulaglutide.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Sergio Di Molfetta, Luigi Laviola, Annalisa Natalicchio, Anna Leonardini, Angelo Cignarelli, Erminio Bonizzoni, Elena Acmet, Francesco Giorgino
Summary: The study investigates the benefits of using the Personalized Treatment Tool (PTT) in managing non-insulin treated type 2 diabetes patients. The PTT assists diabetologists in evaluating patients' clinical characteristics and self-monitoring blood glucose data. Results show significant improvements in glucose control and variability in patients using the PTT.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Andrology
Daniele Santi, Angelo Cignarelli, Matteo Baldi, Andrea Sansone, Giorgia Spaggiari, Manuela Simoni, Giovanni Corona
Summary: This meta-analysis found that alcohol consumption is associated with a significant reduction in total testosterone, free testosterone, and sex hormone binding globulin levels in healthy men. It also found an increase in estradiol levels. However, these effects were only observed in men with chronic alcohol consumption and not in those with recognized alcohol use disorder or after acute alcohol intake.