Article
Ophthalmology
Jianqiang Lin, Kaixuan Cui, Yue Xu, Xiaoyu Tang, Yuxun Shi, Xi Lu, Boyu Yang, Qingjing He, Shanshan Yu, Xiaoling Liang
Summary: The study found that CD146 is involved in retinal neovascularization via the VEGFR2 pathway. Anti-CD146 may provide a new direction for the treatment of PDR and other ocular neovascular diseases.
ACTA OPHTHALMOLOGICA
(2022)
Article
Multidisciplinary Sciences
Teresa Tsai, Mohannad Alwees, Mohammad Ali Asaad, Janine Theile, Vinodh Kakkassery, H. Burkhard Dick, Tim Schultz, Stephanie C. Joachim
Summary: This study aimed to elucidate the pathophysiology of diabetic retinopathy by comparing protein alterations in the vitreous of patients at different stages. The results showed up-regulated levels of various proteins in the vitreous of proliferative diabetic retinopathy patients, including VEGF-A, PIGF, Angiopoietin-1, Angiopoietin-2, IL-1β, and IL-8. Correlation analysis revealed a strong positive correlation between Angiopoietin-2 and VEGF-A levels, as well as a positive correlation between Angiopoietin-1 and VEGF-A. These findings contribute to the future detection and treatment of the disease.
Article
Medicine, Research & Experimental
Shikha Upreti, Seema Sen, Tapas Chandra Nag, Madhumita P. Ghosh
Summary: This study aims to investigate the combined effect of L-Dopa and IGF-1 on diabetic retinopathy, and found that it has a protective effect on the retina and attenuates angiogenesis by modulating VEGF and IGF-1 receptor levels. This is the first report on the synergistic effect of L-Dopa+IGF-1 in a rat model of diabetic retinopathy.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Ahmed M. Abu El-Asrar, Mohd I. Nawaz, Ajmal Ahmad, Luna Dillemans, Mairaj Siddiquei, Eef Allegaert, Priscilla W. Gikandi, Gert De Hertogh, Ghislain Opdenakker, Sofie Struyf
Summary: This study aimed to investigate the role of the CD40-CD40 ligand (CD40L) pathway in inflammation-mediated angiogenesis in proliferative diabetic retinopathy (PDR). The results showed that CD40L and CD40 levels were significantly increased in PDR vitreous samples. CD40L and CD40 expression were observed in vascular endothelial cells, leukocytes, and myofibroblasts in epiretinal membranes. Moreover, the researchers found that sCD40L increased retinal vascular permeability and upregulated the expression of VEGF, ICAM-1, and VCAM-1. The study also demonstrated that TNF-alpha and VEGF could regulate the expression of CD40 in HRMECs and Muller cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Dean F. Loporchio, Emily K. Tam, Jane Cho, Jaeyoon Chung, Gyungah R. Jun, Weiming Xia, Marissa G. Fiorello, Nicole H. Siegel, Steven Ness, Thor D. Stein, Manju L. Subramanian
Summary: This study compared the vitreous cytokine profiles of patients with proliferative diabetic retinopathy (PDR) to those without PDR. Novel increases in IL-15 and IL-16, along with expected VEGF, were observed in the vitreous humor of patients with PDR. Additionally, elevations of ICAM-1, VCAM-1, SAA, IL-8, and CRP were confirmed in the vitreous of PDR patients, as previously described.
Review
Medicine, General & Internal
Yuxian Lin, Xiaowei Zheng, Qiujie Chen, Ruibin Wu
Summary: This study aims to evaluate the clinical efficacy of anti-VEGF therapy versus PRP for patients with PDR through a meta-analysis, providing a reliable theoretical basis for future research.
Review
Ophthalmology
Saagar Pandit, Allen C. Ho, Yoshihiro Yonekawa
Summary: This review discusses recent advances in imaging, medical, and surgical management of proliferative diabetic retinopathy (PDR). Ultra-widefield fluorescein angiography has improved characterization of peripheral lesions and their progression. Individualized treatment plans and earlier surgical intervention may benefit patients in terms of visual recovery.
CURRENT OPINION IN OPHTHALMOLOGY
(2023)
Article
Endocrinology & Metabolism
Zhikun Yang, Yu Di, Junjie Ye, Weihong Yu, Zijian Guo
Summary: The purpose of this study was to evaluate the optimal timing of intravitreal conbercept (IVC) treatment before pars plana vitrectomy (PPV) in patients with severe proliferative diabetic retinopathy (PDR). The study found that IVC treatment administered 7 days prior to surgery had better effectiveness and lower vitreous VEGF concentration.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tamar Azrad-Leibovich, Alon Zahavi, Moran Friedman Gohas, Myles Brookman, Orit Barinfeld, Orkun Muhsinoglu, Shalom Michowiz, Dror Fixler, Nitza Goldenberg-Cohen
Summary: In this study, diabetic retinopathy in two mouse models and the response to anti-VEGF injection were characterized. The results showed significant retinal vasculopathy and increased retinal thickness in diabetic mice, along with changes in gene expression related to diabetes. Anti-VEGF treatment reduced retinal thickness. Therefore, the study found that mouse models can facilitate the development of treatment modalities for diabetic retinopathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Rui Ding, Shicong Zhu, Xiaoyan Zhao, Rensong Yue
Summary: This meta-analysis evaluated the relationship between circulating levels of VEGFs and diabetic peripheral neuropathy (DPN). The results showed that VEGF levels were significantly increased in DPN patients compared to diabetic patients without DPN and healthy individuals. However, there was no evidence to support the correlation between VEGF levels and the risk of DPN.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Xiao Xie, Chao Lian, Zhiping Zhang, Meng Feng, Wenqi Wang, Xiaomeng Yuan, Yanmei Shi, Tingting Liu
Summary: This meta-analysis compared the long-term efficacy and safety of intravitreal aflibercept injection (IAI) for diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR). The results showed that IAI treatment group had better visual acuity improvement and central subfield thickness reduction compared to other treatment groups.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Li Chen, Jing Feng, Yanhong Shi, Fuxiao Luan, Fang Ma, Yingjie Wang, Weiqiang Yang, Yong Tao
Summary: In patients with proliferative diabetic retinopathy, intravitreal ranibizumab (IVR) injection significantly reduced EPO levels but did not reach normal levels; there was no significant difference in VEGF levels between the IVR group and the control group. The expressions of EPO and VEGF were significantly reduced in the IVR group compared to the Non-IVR group in fluorescence immunostaining.
FRONTIERS IN MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Bo Zhang, Zhulin Zhou, Bingjie Zhang, Dan Wang
Summary: Diabetic retinopathy is the leading cause of visual impairment and blindness, particularly proliferative diabetic retinopathy at severe stages. A systematic network meta-analysis was conducted to evaluate various treatments for proliferative diabetic retinopathy. Results indicated that ranibizumab alone and laser + ranibizumab were the most effective in improving visual scores, with decreased central retinal thickness observed in the laser combined with ranibizumab group. Further high-quality randomized controlled trials are needed to verify correlations and ensure longer-term efficacy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Ophthalmology
Jinghong Dong, Lingfei Hu, Chenhao Li, Rongrong Zhang, Minmin Zheng, Xueji Wu, Changfan Wu
Summary: This study investigated the effect of high myopia on the expression of retinal osteopontin (OPN) and integrin alpha V beta 3 receptor in guinea pigs, and determined the relationship between high myopia and diabetic retinopathy. The results showed that high myopia may reduce the expression of OPN and integrin alpha V beta 3 receptor in the retina of diabetic guinea pigs, which could be attributed to the influence of high myopia on neovascularization in diabetic retinopathy.
OPHTHALMIC RESEARCH
(2022)
Article
Oncology
Jack Lawler
Summary: Considerable progress has been made in understanding angiogenesis in normal and tumor tissue. The success of anti-angiogenic treatments has been limited so far, but it is expected to improve with the development of therapies targeting other pathways and a better understanding of resistance.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Ophthalmology
Yukiko Nagahara, Shizuka Koh, Yoshihiro Oshita, Takashi Nagano, Hidetoshi Mano, Kohji Nishida, Hitoshi Watanabe
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
(2017)
Letter
Ophthalmology
So Goto, Naoyuki Maeda, Shizuka Koh, Kazuhiko Ohnuma, Kenichi Hayashi, Ikko Iehisa, Toru Noda, Kohji Nishida
Article
Ophthalmology
Andrew Winegarner, Noriyasu Hashida, Shizuka Koh, Kohji Nishida
Article
Multidisciplinary Sciences
Masahito Yoshihara, Yuzuru Sasamoto, Ryuhei Hayashi, Yuki Ishikawa, Motokazu Tsujikawa, Yoshihide Hayashizaki, Masayoshi Itoh, Hideya Kawaji, Kohji Nishida
SCIENTIFIC REPORTS
(2017)
Article
Cell Biology
Masahito Yoshihara, Ryoko Araki, Yasuji Kasama, Misato Sunayama, Masumi Abe, Kohji Nishida, Hideya Kawaji, Yoshihide Hayashizaki, Yasuhiro Murakawa
Letter
Ophthalmology
Yumi Noguchi, Tatsuhiko Sato, Miho Kumoi, Noriyasu Hashida, Kohji Nishida
CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE
(2018)
Article
Multidisciplinary Sciences
Atsuya Miki, Yasushi Ikuno, Robert N. Weinreb, Junko Yokoyama, Tomoko Asai, Shinichi Usui, Kohji Nishida
Article
Ophthalmology
Takanori Matsuoka, Kazunobu Asao, Noriyasu Hashida, Kohji Nishida
CASE REPORTS IN OPHTHALMOLOGY
(2017)
Article
Ophthalmology
Shizuka Koh, Yasushi Inoue, Shintaro Ochi, Yoshihiro Takai, Naoyuki Maeda, Kohji Nishida
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2017)
Article
Ophthalmology
Koji Uesugi, Hirokazu Sakaguchi, Yasutaka Hayashida, Ryuhei Hayashi, Koichi Baba, Yuya Suganuma, Hidenori Yokoi, Motokazu Tsujikawa, Kohji Nishida
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2017)
Article
Ophthalmology
Asaki Suzaki, Naoyuki Maeda, Mutsumi Fuchihata, Shizuka Koh, Kohji Nishida, Takashi Fujikado
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2017)
Article
Ophthalmology
Shizuka Koh, Naoyuki Maeda, Chikako Ikeda, Sanae Asonuma, Mai Ogawa, Takahiro Hiraoka, Tetsuro Oshika, Kohji Nishida
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2017)
Article
Ophthalmology
Taku Wakabayashi, Tatsuhiko Sato, Chikako Hara-Ueno, Yoko Fukushima, Kaori Sayanagi, Nobuhiko Shiraki, Miki Sawa, Yasushi Ikuno, Hirokazu Sakaguchi, Kohji Nishida
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2017)
Article
Ophthalmology
Reiko Kobayashi, Noriyasu Hashida, Takeshi Soma, Shizuka Koh, Atsuya Miki, Shinichi Usui, Naoyuki Maeda, Kohji Nishida
Letter
Ophthalmology
Shizuka Koh, Norio Sakai, Naoyuki Maeda, Kohji Nishida
ACTA OPHTHALMOLOGICA
(2018)
