Article
Gastroenterology & Hepatology
Alexander S. Thomas, Yongmei Huang, Wooil Kwon, Beth A. Schrope, Kazuki Sugahara, John A. Chabot, Jason D. Wright, Michael D. Kluger
Summary: This study determines the prevalence, timing, and predictors of diabetes and exocrine pancreatic insufficiency after pancreatectomy, providing important information for preoperative counseling and risk management strategies.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Surgery
Ahmad Hamad, J. Madison Hyer, Varna Thayaparan, Aneesa Salahuddin, Jordan M. Cloyd, Timothy M. Pawlik, Aslam Ejaz
Summary: This study aimed to determine the long-term incidence of pancreatogenic diabetes mellitus (P-DM) and its clinical impact after partial pancreatic resection. The results showed that approximately one in five patients developed P-DM after the surgery. Risk factors for developing P-DM included male sex, undergoing a distal pancreatectomy, having a malignant diagnosis, a family history of diabetes, and being classified as prediabetic in the preoperative setting.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2022)
Review
Biochemistry & Molecular Biology
Ioanna Kokkinopoulou, Andriana Diakoumi, Paraskevi Moutsatsou
Summary: Research shows that stress and depression increase the risk of Type 2 Diabetes by impairing the negative feedback of Glucocorticoid in patients, leading to HPA axis hyperactivity and hypercortisolism. Glucocorticoid Receptor has a key role in regulating glucose homeostasis in peripheral tissues, while impaired signaling in Peripheral Blood Mononuclear Cells of T2D patients is linked to metabolic disturbances. Further investigation into selective modulation of GR signaling in T2D therapy is warranted.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Sachiko Yamamoto-Kataoka, Sayaka Shimizu, Hajime Yamazaki, Katsuhiro Murakami, Daisuke Nishizaki, Shunichi Fukuhara, Nobuya Inagaki, Yosuke Yamamoto
Summary: A preoperative prediction model for new-onset diabetes mellitus after partial pancreatectomy was developed in this retrospective cohort study. The analysis included factors such as preoperative age, body mass index, hemoglobin A1c level, blood glucose level, and indication for partial pancreatectomy. The model could help patients and surgeons make better decisions regarding the necessity of partial pancreatectomy.
Article
Endocrinology & Metabolism
Louise Granlund, Anders Hedin, Miriam Wahlhuetter, Peter Seiron, Olle Korsgren, Oskar Skog, Marcus Lundberg
Summary: This study showed that acinar nuclei density is preserved and no acinar atrophy is found in type 1 diabetes. The expression of digestive enzymes is evenly distributed, with occasional amylase-negative regions in formalin-fixed tissues. Transcriptional alterations in type 1 diabetes in the acinar tissue, independent of the distance from islets, were also identified. The enrichment of gene sets Myc Targets V2 and Estrogen Response Early may be linked to the increased incidence of pancreatic cancer in type 1 diabetes.
BMJ OPEN DIABETES RESEARCH & CARE
(2021)
Article
Surgery
Peter Balaz, Robert Gurlich, Lukas Havluj, David Girsa, Adam Whitley, Katerina Lawrie
Summary: This study aims to compare the short-term and long-term outcomes of different surgical techniques (partial resection and segmental resection) in the treatment of pancreatic cancer patients. The results showed that the median survival period was 29 months in the partial resection group and 10 months in the segmental resection group, indicating a shorter survival period in the segmental resection group. Although the survival period is shorter in the segmental resection group, it is often the only way to safely remove pancreatic tumors with negative resection margins.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Rosa Klotz, Constanze Schilling, Charlotte Kuner, Ulf Hinz, Ulla Klaiber, Magdalena Holze, Christine Tjaden, Martin Loos, Markus W. Buechler, Thilo Hackert
Summary: This study compared the short- and long-term outcomes of central pancreatectomy (CP) versus distal pancreatectomy (DP) in the treatment of benign or low-grade malignant lesions located in the neck and body of the pancreas. The results showed that CP was associated with a higher risk of postpancreatectomy hemorrhage (PPH), but had better endocrine long-term outcomes and comparable perioperative mortality compared to DP.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Surgery
Bo Hyung Yoon, Su Mae Ang, Andre Alabd, Kevin Furlong, Charles J. Yeo, Harish Lavu, Jordan M. Winter
Summary: The study found that PDA-associated T3cDM has a distinctive presentation phenotype compared to medical patients with conventional T2DM. Greater attention to associated signs, symptoms, and biochemical data could identify patients at risk for harboring an underlying pancreatic malignancy and trigger diagnostic pathways leading to earlier PDA diagnosis and treatment.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Jiliang Shen, Jiasheng Cao, Jie He, Hong Yu, Mingyu Chen
Summary: This study aimed to investigate the correlation between surgery-related factors and the incidence of new-onset diabetes mellitus (NODM) after distal pancreatectomy. The results showed that there was no significant correlation between NODM and operative blood loss, spleen preservation, surgical method, postoperative ALB and HB, and postoperative pathology. However, there was a significant correlation between NODM and postoperative pancreatic volume or resected pancreatic volume ratio. Resected pancreatic volume ratio was identified as a predictive risk factor for NODM.
Article
Endocrinology & Metabolism
Shuzo Imamura, Fumimaru Niwano, Naru Babaya, Yoshihisa Hiromine, Ippei Matsumoto, Keiko Kamei, Yuta Yoshida, Yasunori Taketomo, Sawa Yoshida, Yoshifumi Takeyama, Shinsuke Noso, Norikazu Maeda, Hiroshi Ikegami
Summary: Glucose tolerance worsens after distal pancreatectomy, leading to an increased incidence of diabetes. Reduced insulin secretion is a key factor in the development of diabetes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Nutrition & Dietetics
Shula Shazman
Summary: This study developed a personalized recommendation system based on analysis of multiple human studies, aiming to improve T2DM risk parameters. The system provides tailored IF interventions suggestions for individuals with pre-diabetes and diabetes. The study revealed key features for reducing blood glucose levels, such as weight in females and age in males.
Article
Oncology
Anna Badowska-Kozakiewicz, Marta Fudalej, Daria Kwasniewska, Marek Durlik, Anna Nasierowska-Guttmejer, Agata Mormul, Emilia Wloszek, Aleksandra Czerw, Tomasz Banas, Andrzej Deptala
Summary: This study aims to describe the prevalence of diabetes mellitus (DM) among patients with pancreatic ductal adenocarcinoma (PDAC), analyze the association between DM occurrence and clinicopathological factors, and detect variables influencing overall survival. The study found that DM is prevalent among pancreatic cancer patients and that patients with DM receiving palliative chemotherapy have higher median overall survival.
Review
Endocrinology & Metabolism
Nour Mesto, Jamileh Movassat, Cecile Tourrel-Cuzin
Summary: This article reviews the role of P2-type purinergic signaling in the regulation of pancreatic beta-cell functional plasticity, which could be a promising novel therapeutic approach for the treatment of type 2 diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Kymberleigh A. Pagel, Hoyin Chu, Rashika Ramola, Rafael F. Guerrero, Judith H. Chung, Samuel Parry, Uma M. Reddy, Robert M. Silver, Jonathan G. Steller, Lynn M. Yee, Ronald J. Wapner, Matthew W. Hahn, Sriraam Natarajan, David M. Haas, Predrag Radivojac
Summary: This cohort study found that the addition of polygenic risk scores (PRS) was associated with the stratified risk of gestational diabetes (GD) diagnosis among high-risk patient subgroups, suggesting the benefits of targeted PRS ascertainment to encourage early intervention.
Article
Gastroenterology & Hepatology
Kaitlin Shaw, Alexander S. Thomas, Vilma Rosario, Wooil Kwon, Beth A. Schrope, Kazuki Sugahara, John A. Chabot, Jeanine M. Genkinger, Michael D. Kluger
Summary: This study found that the quality of life for patients with pancreatogenic diabetes after pancreatic surgery is similar to non-diabetic patients. The impact of diabetes on quality of life was found to be influenced by the pathology type.