Review
Biochemistry & Molecular Biology
Han-Chow E. Koh, Chao Cao, Bettina Mittendorfer
Summary: Plasma insulin clearance plays an important role in determining plasma insulin concentration and is closely related to excess adiposity, insulin sensitivity, and type 2 diabetes. The lower insulin clearance rate observed in people with obesity is not a compensatory response to insulin resistance, but directly linked to insulin sensitivity. Additionally, postprandial insulin clearance decreases due to increased delivery of insulin to tissues that clear insulin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Motonori Sato, Yoshifumi Tamura, Hideyoshi Kaga, Nozomu Yamasaki, Mai Kiya, Satoshi Kadowaki, Daisuke Sugimoto, Takashi Funayama, Yuki Someya, Saori Kakehi, Shuko Nojiri, Hiroaki Satoh, Ryuzo Kawamori, Hirotaka Watada
Summary: The study showed that SGLT2i tofogliflozin did not affect the metabolic clearance rate of insulin, but could improve glycated hemoglobin levels and reduce body weight.
Article
Endocrinology & Metabolism
Zhi-Hui Song, Xing-Long Wang, Xiao-Feng Wang, Jing Liu, Sang-Quzhen Luo, Shan-Shan Xu, Xiao Cheng, Jie Bai, Li-ming Dong, Chao Zhang, Jian-Bo Zhou
Summary: There is a gap between the current medication treatment management of Chinese inpatients with type 2 diabetes and the guidelines, especially in the application of GLP-1RAs and SGLT-2i in patients with concomitant ASCVD, diabetic nephropathy, and renal insufficiency. Physicians and pharmacists should pay more attention to achieving blood pressure and LDL-c standards in type 2 diabetic patients and provide timely interventions.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Medicine, General & Internal
Ehtasham Ahmad, Soo Lim, Roberta Lamptey, David R. Webb, Melanie J. Davies
Summary: Type 2 diabetes accounts for nearly 90% of global diabetes cases, with an increasing number of affected individuals, particularly among young people. Early detection and proactive management are crucial for preventing complications and reducing mortality. Technology and precision medicine offer potential improvements to treatment outcomes but face significant barriers.
Editorial Material
Biochemistry & Molecular Biology
Roy W. Beck
Summary: Automated insulin delivery systems, used in type 1 diabetes, hold promise for patients with type 2 diabetes and are expected to have a significant impact on public health.
Review
Endocrinology & Metabolism
Markku Laakso, Lilian Fernandes Silva
Summary: Statins are commonly used to prevent cardiovascular disease events, but they also increase the risk of type 2 diabetes. These two diseases share common genetic and environmental factors. Studies have confirmed the association between statin treatment and type 2 diabetes, and the purpose of this review is to summarize the important findings and describe the mechanisms behind the increased risk.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Roy Harper, Eran Bashan, Kevin J. Williams, Sajitha Sritharan, Mark Willis, Deanna J. Marriott, Israel Hodish
Summary: Through retrospective analysis, it was found that the commonly used 50-50 ratio between basal and total daily bolus insulin does not generally apply to stable patients with type 2 diabetes. Therefore, this ratio should not be used as an ongoing treatment guide.
DIABETES OBESITY & METABOLISM
(2023)
Article
Medicine, General & Internal
Silva A. Arslanian, Tamara Hannon, Philip Zeitler, Lily C. Chao, Claudia Boucher-Berry, Margarita Barrientos-Perez, Elise Bismuth, Sergio Dib, Jang Ik Cho, David Cox
Summary: In this 26-week trial, researchers found that once-weekly treatment with dulaglutide has significant efficacy in improving glycemic control among youths with type 2 diabetes.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
Silva A. Arslanian, Tamara Hannon, Philip Zeitler, Lily C. Chao, Claudia Boucher-Berry, Margarita Barrientos-Perez, Elise Bismuth, Sergio Dib, Jang Ik Cho, David Cox
Summary: The incidence of type 2 diabetes mellitus is increasing among youths. Treatment with dulaglutide at a once-weekly dose of 0.75 mg or 1.5 mg was superior to placebo in improving glycemic control through 26 weeks among youths with type 2 diabetes, without an effect on BMI.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Nutrition & Dietetics
Jessica Lewgood, Barbara Oliveira, Marie Korzepa, Scott C. Forbes, Jonathan P. Little, Leigh Breen, Robert Bailie, Darren G. Candow
Summary: The prevalence of Type 2 diabetes (T2D) is increasing and creating a large economic burden. This review critically evaluates the effects of various dietary strategies on diabetes management as well as examines several purported supplements aiming to improve glucose control and body composition.
Article
Endocrinology & Metabolism
Christophe E. M. De Block, Jolijn Van Cauwenberghe, Niels Bochanen, Eveline Dirinck
Summary: Over the past 100 years since the discovery of insulin, insulin preparations have significantly improved, from animal insulins to human insulins to insulin analogues. The advent of ultra-rapid-acting insulin analogues has provided a new possibility for achieving strict glucose control while maintaining convenience in insulin therapy.
DIABETES OBESITY & METABOLISM
(2022)
Review
Nutrition & Dietetics
Stephanie K. Nishi, Effie Viguiliouk, Cyril W. C. Kendall, David J. A. Jenkins, Frank B. Hu, John L. Sievenpiper, Alessandro Atzeni, Anoop Misra, Jordi Salas-Salvado
Summary: Diabetes is a global concern affecting a significant proportion of adults, and nut consumption has been associated with positive health outcomes. There is evidence suggesting that nut consumption may play a role in preventing and managing type 2 diabetes, although more research is needed to confirm these findings.
Review
Biochemistry & Molecular Biology
Lixiang Zhai, Jiayan Wu, Yan Y. Lam, Hiu Yee Kwan, Zhao-Xiang Bian, Hoi Leong Xavier Wong
Summary: Type 2 diabetes is a metabolic disorder characterized by insulin resistance and impaired insulin secretion leading to high blood sugar levels. Disturbances in gut microbiota play a significant role in the development of insulin resistance in T2D. Research on gut microbial metabolites and probiotics-based therapeutic strategies show promise in alleviating insulin resistance in T2D by modulating gut microbiota.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Sevgican Demir, Peter P. Nawroth, Stephan Herzig, Bilges Ekim Ustunel
Summary: Type 2 diabetes is a chronic metabolic disorder characterized by insulin resistance and high blood sugar levels, with complications affecting various organs. Effective therapies are lacking, and further research on novel treatment targets is needed to pave the way for potential prevention and treatment of this disease.
Review
Oncology
Tiffany Scully, Abora Ettela, Derek LeRoith, Emily Jane Gallagher
Summary: Obesity and type 2 diabetes are both linked to increased cancer risk, with metabolic abnormalities playing a key role in the relationship and progression of cancer. Multiple mechanisms, including insulin signaling, lipid and glucose metabolism, as well as changes in adipose tissue, are proposed to be involved in the association between obesity, diabetes, and cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Manuel Puig-Domingo, Alfonso Soto, Eva Venegas, Ricardo Vilchez, Concepcion Blanco, Fernando Cordido, Tomas Lucas, Monica Marazuela, Rosa Casany, Guillem Cuatrecasas, Carmen Fajardo, Maria Angeles Galvez, Silvia Maraver, Tomas Martin, Enrique Romero, Miguel Paja, Antonio Pico, Ignacio Bernabeu, Eugenia Resmini
ENDOCRINOLOGIA Y NUTRICION
(2016)
Letter
Primary Health Care
Alba Nadal-Manez, Rosa Casan-Fernandez, Francisco Javier Sanz-Gallur, Maria Gracia Cardona-Rovira
Letter
Endocrinology & Metabolism
Maria Gracia Cardona-Rovira, Rosa Casan-Fernandez, Javier Sanz-Gallur, Elena Almonacid-Folch, Alba Nadal-Manez
ENDOCRINOLOGIA DIABETES Y NUTRICION
(2019)
Article
Oncology
O Juan, A Albert, F Ordoño, R Casany, V Carañana, JM Campos, V Alberola
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2002)
Article
Oncology
O Juan, JM Campos, V Carañana, JJ Sanchez, R Casañ, V Alberola
SUPPORTIVE CARE IN CANCER
(2001)