Diacylglycerol acyltransferase 1 inhibition with AZD7687 alters lipid handling and hormone secretion in the gut with intolerable side effects: a randomized clinical trial
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Title
Diacylglycerol acyltransferase 1 inhibition with AZD7687 alters lipid handling and hormone secretion in the gut with intolerable side effects: a randomized clinical trial
Authors
Keywords
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Journal
DIABETES OBESITY & METABOLISM
Volume 16, Issue 4, Pages 334-343
Publisher
Wiley
Online
2013-10-12
DOI
10.1111/dom.12221
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Note: Only part of the references are listed.- Pharmacological inhibition to examine the role of DGAT1 in dietary lipid absorption in rodents and humans
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- DGAT1 mutation is linked to a congenital diarrheal disorder
- (2012) Joel T. Haas et al. JOURNAL OF CLINICAL INVESTIGATION
- Intestinal DGAT1 deficiency reduces postprandial triglyceride and retinyl ester excursions by inhibiting chylomicron secretion and delaying gastric emptying
- (2012) Gene P. Ables et al. JOURNAL OF LIPID RESEARCH
- The BUME method: a novel automated chloroform-free 96-well total lipid extraction method for blood plasma
- (2012) Lars Löfgren et al. JOURNAL OF LIPID RESEARCH
- Design and Optimization of Pyrazinecarboxamide-Based Inhibitors of Diacylglycerol Acyltransferase 1 (DGAT1) Leading to a Clinical Candidate Dimethylpyrazinecarboxamide Phenylcyclohexylacetic Acid (AZD7687)
- (2012) Jonas G. Barlind et al. JOURNAL OF MEDICINAL CHEMISTRY
- Fibroblast Growth Factor 19 and 7α-Hydroxy-4-Cholesten-3-one in the Diagnosis of Patients With Possible Bile Acid Diarrhea
- (2012) Sanjeev S Pattni et al. Clinical and Translational Gastroenterology
- Rapid Tachyphylaxis of the Glucagon-Like Peptide 1-Induced Deceleration of Gastric Emptying in Humans
- (2011) M. A. Nauck et al. DIABETES
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- DGAT1 deficiency decreases PPAR expression and does not lead to lipotoxicity in cardiac and skeletal muscle
- (2011) Li Liu et al. JOURNAL OF LIPID RESEARCH
- Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight gain, hyperlipidemia and hepatic steatosis in db/db mice
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- Low dose of the liver X receptor agonist, AZ876, reduces atherosclerosis in APOE*3Leiden mice without affecting liver or plasma triglyceride levels
- (2010) JWA van der Hoorn et al. BRITISH JOURNAL OF PHARMACOLOGY
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- Validation of Diacyl Glycerolacyltransferase I as a Novel Target for the Treatment of Obesity and Dyslipidemia Using a Potent and Selective Small Molecule Inhibitor
- (2008) Gang Zhao et al. JOURNAL OF MEDICINAL CHEMISTRY
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