Emerging immune therapies in type 1 diabetes and pancreatic islet transplantation

Mycobacterial diseases and antitumour necrosis factor therapy in USA

(2012) KL Winthrop et al.   ANNALS OF THE RHEUMATIC DISEASES

TCR affinity and specificity requirements for human regulatory T-cell function

(2012) G. Plesa et al.   BLOOD

Long-Term Remission of Diabetes in NOD Mice Is Induced by Nondepleting Anti-CD4 and Anti-CD8 Antibodies

(2012) Z. Yi et al.   DIABETES

Rapamycin/IL-2 Combination Therapy in Patients With Type 1 Diabetes Augments Tregs yet Transiently Impairs  -Cell Function

(2012) S. A. Long et al.   DIABETES

Administration of CD4+CD25highCD127- Regulatory T Cells Preserves  -Cell Function in Type 1 Diabetes in Children

(2012) N. Marek-Trzonkowska et al.   DIABETES CARE

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

(2012) Ken T. Coppieters et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Differential Risk of Tuberculosis Reactivation among Anti-TNF Therapies Is Due to Drug Binding Kinetics and Permeability

(2012) M. Fallahi-Sichani et al.   JOURNAL OF IMMUNOLOGY

Monoclonal TCR-redirected tumor cell killing

(2012) Nathaniel Liddy et al.   NATURE MEDICINE

Low-Dose Interleukin-2 and HCV-Induced Vasculitis

(2012)   NEW ENGLAND JOURNAL OF MEDICINE

Improved Preservation of Residual Beta Cell Function by Atorvastatin in Patients with Recent Onset Type 1 Diabetes and High CRP Levels (DIATOR Trial)

(2012) Alexander Strom et al.   PLoS One

The Use of Canakinumab, a Novel IL-1β Long-Acting Inhibitor, in Refractory Adult-Onset Still's Disease

(2012) Apostolos Kontzias et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Combination therapy with InsB9-23 peptide immunization and CTLA4-IgG does not reverse diabetes in NOD mice

(2011) Darius A. Schneider et al.   CLINICAL IMMUNOLOGY

Synergistic Reversal of Type 1 Diabetes in NOD Mice With Anti-CD3 and Interleukin-1 Blockade: Evidence of Improved Immune Regulation

(2011) V. Ablamunits et al.   DIABETES

C-Peptide Response and HLA Genotypes in Subjects With Recent-Onset Type 1 Diabetes After Immunotherapy With DiaPep277

(2011) Raffaella Buzzetti et al.   DIABETES

Evidence That Nasal Insulin Induces Immune Tolerance to Insulin in Adults With Autoimmune Diabetes

(2011) S. Fourlanos et al.   DIABETES

Stepwise or Linear Decrease in Penetrance of Type 1 Diabetes With Lower-Risk HLA Genotypes Over the Past 40 Years

(2011) Andrea K. Steck et al.   DIABETES

Long-Term Outcome of Individuals Treated With Oral Insulin: Diabetes Prevention Trial-Type 1 (DPT-1) oral insulin trial

(2011) K. Vehik et al.   DIABETES CARE

Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetope

(2011) Carolin Daniel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Peptide-MHC-based nanovaccines for the treatment of autoimmunity: a “one size fits all” approach?

(2011) Xavier Clemente-Casares et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Anti-CD3 antibodies for type 1 diabetes: beyond expectations

(2011) Jean-François Bach   LANCET

Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial

(2011) Tihamer Orban et al.   LANCET

Regulatory T-Cell Responses to Low-Dose Interleukin-2 in HCV-Induced Vasculitis

(2011) David Saadoun et al.   NEW ENGLAND JOURNAL OF MEDICINE

Preliminary studies related to anti-interleukin-1β therapy in children with newly diagnosed type 1 diabetes

(2011) Kathryn M. Sumpter et al.   PEDIATRIC DIABETES

The anti-insulin trimolecular complex in type 1 diabetes

(2011) Aaron W Michels et al.   Current Opinion in Endocrinology Diabetes and Obesity

Effects of atorvastatin on the regeneration of pancreatic β-cells after streptozotocin treatment in the neonatal rodent

(2010) K. C. Marchand et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Islet Transplantation in Type 1 Diabetics Using an Immunosuppressive Protocol Based on the Anti-LFA-1 Antibody Efalizumab

(2010) A. M. Posselt et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Residual Insulin Production and Pancreatic  -Cell Turnover After 50 Years of Diabetes: Joslin Medalist Study

(2010) H. A. Keenan et al.   DIABETES

Dimorphic histopathology of long-standing childhood-onset diabetes

(2010) R. Gianani et al.   DIABETOLOGIA

Generation and expansion of regulatory human CD4+ T-cell clones specific for pancreatic islet autoantigens

(2010) James A. Dromey et al.   JOURNAL OF AUTOIMMUNITY

IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells

(2010) Yenkel Grinberg-Bleyer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ex Vivo–Expanded Human Regulatory T Cells Prevent the Rejection of Skin Allografts in a Humanized Mouse Model

(2010) Fadi Issa et al.   TRANSPLANTATION

Islet Transplantation in Type 1 Diabetic Patients Using Calcineurin Inhibitor-Free Immunosuppressive Protocols Based on T-Cell Adhesion or Costimulation Blockade

(2010) Andrew M. Posselt et al.   TRANSPLANTATION

Progression to Diabetes in Relatives of Type 1 Diabetic Patients: Mechanisms and Mode of Onset

(2009) E. Ferrannini et al.   DIABETES

No Effect of the Altered Peptide Ligand NBI-6024 on  -Cell Residual Function and Insulin Needs in New-Onset Type 1 Diabetes

(2009) M. Walter et al.   DIABETES CARE

Etanercept Treatment in Children With New-Onset Type 1 Diabetes: Pilot randomized, placebo-controlled, double-blind study

(2009) L. Mastrandrea et al.   DIABETES CARE

Combination therapy with a dipeptidyl peptidase-4 inhibitor and a proton pump inhibitor restores normoglycaemia in non-obese diabetic mice

(2009) W. L. Suarez-Pinzon et al.   DIABETOLOGIA

Autoantigen-specific regulatory T cells induced in patients with type 1 diabetes mellitus by insulin B-chain immunotherapy

(2009) Tihamer Orban et al.   JOURNAL OF AUTOIMMUNITY

Mechanisms maintaining peripheral tolerance

(2009) Daniel L Mueller   NATURE IMMUNOLOGY

Rituximab, B-Lymphocyte Depletion, and Preservation of Beta-Cell Function

(2009) Mark D. Pescovitz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Preimplantation of an Immunoprotective Device Can Lower the Curative Dose of Islets to That of Free Islet Transplantation—Studies in a Rodent Model

(2009) Anne K. Sörenby et al.   TRANSPLANTATION

Real-Time Bioluminescence Imaging of Macroencapsulated Fibroblasts Reveals Allograft Protection in Rhesus Monkeys (Macaca mulatta)

(2009) Alice F. Tarantal et al.   TRANSPLANTATION

Analysis of islet inflammation in human type 1 diabetes

(2008) A. Willcox et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Combination Therapy With Glucagon-Like Peptide-1 and Gastrin Restores Normoglycemia in Diabetic NOD Mice

(2008) W. L. Suarez-Pinzon et al.   DIABETES

HLA DR-DQ Haplotypes and Genotypes and Type 1 Diabetes Risk: Analysis of the Type 1 Diabetes Genetics Consortium Families

(2008) H. Erlich et al.   DIABETES

GAD Treatment and Insulin Secretion in Recent-Onset Type 1 Diabetes

(2008) Johnny Ludvigsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Curative and   cell regenerative effects of  1-antitrypsin treatment in autoimmune diabetic NOD mice

(2008) M. Koulmanda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alpha-1 Antitrypsin Treatment of Spontaneously Diabetic Nonobese Diabetic Mice Receiving Islet Allografts

(2008) A. Pileggi et al.   TRANSPLANTATION PROCEEDINGS

High definition profiling of autoantibodies to glutamic acid decarboxylases GAD65/GAD67 in stiff-person syndrome

(2007) Peter D. Burbelo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS